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Aliases for TLDC2 Gene

Aliases for TLDC2 Gene

  • TBC/LysM-Associated Domain Containing 2 2 3 5
  • TBC/LysM-Associated Domain-Containing Protein 2 3 4
  • Chromosome 20 Open Reading Frame 118 2
  • TLD Domain-Containing Protein 2 3
  • Hypothetical Protein LOC140711 2
  • TLD Domain Containing 2 2
  • C20orf118 3

External Ids for TLDC2 Gene

Previous HGNC Symbols for TLDC2 Gene

  • C20orf118

Previous GeneCards Identifiers for TLDC2 Gene

  • GC20P035505

Summaries for TLDC2 Gene

GeneCards Summary for TLDC2 Gene

TLDC2 (TBC/LysM-Associated Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is OXR1.

Additional gene information for TLDC2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLDC2 Gene

Genomics for TLDC2 Gene

GeneHancer (GH) Regulatory Elements for TLDC2 Gene

Promoters and enhancers for TLDC2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I036875 Promoter/Enhancer 1.5 EPDnew ENCODE dbSUPER 550.8 -0.1 -135 1.6 PKNOX1 MLX ZSCAN4 ARID4B DMAP1 ZNF48 ZSCAN9 ATF7 IKZF2 MXD4 TLDC2 DSN1 C20orf24 RN7SL156P
GH20I037288 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10 +413.8 413826 2.8 HDGF PKNOX1 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 MANBAL RPN2 TTI1 CTNNBL1 DSN1 TLDC2 GC20P037271 PIR39095 GC20M037240
GH20I036772 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.1 -102.1 -102061 3.1 SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B DSN1 NDRG3 RPN2 AAR2 CTNNBL1 TLDC2 GC20P036795
GH20I037093 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10 +219.3 219335 2.9 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ENSG00000269846 RBL1 RPN2 MROH8 ENSG00000232406 TTI1 SOGA1 NDRG3 AAR2 CTNNBL1
GH20I037411 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 12.1 +536.1 536056 2 HDAC1 ARNT ZSCAN4 KLF17 YBX1 ZNF48 ZNF207 ZNF548 RUNX3 MCM3 RBL1 DSN1 RPN2 NNAT CTNNBL1 VSTM2L TLDC2 TGIF2 DLGAP4-AS1 SOGA1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TLDC2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TLDC2 Gene

Genomic Locations for TLDC2 Gene
18,115 bases
Plus strand

Genomic View for TLDC2 Gene

Genes around TLDC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLDC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLDC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLDC2 Gene

Proteins for TLDC2 Gene

  • Protein details for TLDC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TLD domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • B3KVU8

    Protein attributes for TLDC2 Gene

    215 amino acids
    Molecular mass:
    23912 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TLDC2 Gene

Post-translational modifications for TLDC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TLDC2 Gene

No data available for DME Specific Peptides for TLDC2 Gene

Domains & Families for TLDC2 Gene

Gene Families for TLDC2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TLDC2 Gene


Suggested Antigen Peptide Sequences for TLDC2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the OXR1 family.
  • Belongs to the OXR1 family.
genes like me logo Genes that share domains with TLDC2: view

Function for TLDC2 Gene

Phenotypes for TLDC2 Gene

genes like me logo Genes that share phenotypes with TLDC2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TLDC2 Gene

Localization for TLDC2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TLDC2 gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for TLDC2 Gene

Pathways & Interactions for TLDC2 Gene

SuperPathways for TLDC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TLDC2 Gene


No data available for Pathways by source and SIGNOR curated interactions for TLDC2 Gene

Drugs & Compounds for TLDC2 Gene

No Compound Related Data Available

Transcripts for TLDC2 Gene

mRNA/cDNA for TLDC2 Gene

(5) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TLDC2 Gene

TBC/LysM-associated domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TLDC2 Gene

No ASD Table

Relevant External Links for TLDC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TLDC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TLDC2 Gene

mRNA differential expression in normal tissues according to GTEx for TLDC2 Gene

This gene is overexpressed in Colon - Transverse (x15.3), Small Intestine - Terminal Ileum (x13.4), and Kidney - Cortex (x7.0).

NURSA nuclear receptor signaling pathways regulating expression of TLDC2 Gene:


SOURCE GeneReport for Unigene cluster for TLDC2 Gene:

genes like me logo Genes that share expression patterns with TLDC2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TLDC2 Gene

Orthologs for TLDC2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TLDC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TLDC2 33 34
  • 99.69 (n)
(Bos Taurus)
Mammalia TLDC2 33 34
  • 86.05 (n)
(Canis familiaris)
Mammalia TLDC2 33 34
  • 84.81 (n)
(Rattus norvegicus)
Mammalia Tldc2 33
  • 83.02 (n)
(Mus musculus)
Mammalia Tldc2 33 16 34
  • 82.08 (n)
(Ornithorhynchus anatinus)
Mammalia TLDC2 34
  • 75 (a)
(Monodelphis domestica)
Mammalia TLDC2 34
  • 70 (a)
(Gallus gallus)
Aves TLDC2 33 34
  • 66.27 (n)
(Anolis carolinensis)
Reptilia TLDC2 34
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tldc2 33
  • 57.05 (n)
(Danio rerio)
Actinopterygii TLDC2 34
  • 13 (a)
fruit fly
(Drosophila melanogaster)
Insecta mtd 34
  • 7 (a)
(Caenorhabditis elegans)
Secernentea lmd-3 34
  • 9 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL078W 33
  • 51.57 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E19449g 33
  • 45.56 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OXR1 33 36
  • 43.33 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU02394 33
  • 44.33 (n)
Species where no ortholog for TLDC2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TLDC2 Gene

Gene Tree for TLDC2 (if available)
Gene Tree for TLDC2 (if available)

Paralogs for TLDC2 Gene

Paralogs for TLDC2 Gene

(3) SIMAP similar genes for TLDC2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TLDC2: view

Variants for TLDC2 Gene

Sequence variations from dbSNP and Humsavar for TLDC2 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs114791229 likely-benign, Chilblain Lupus, Aicardi Goutieres syndrome 36,892,644(+) T/C genic_downstream_transcript_variant, intron_variant
rs115645414 likely-benign, Chilblain Lupus, Aicardi Goutieres syndrome 36,892,887(+) G/A/C 3_prime_UTR_variant, genic_downstream_transcript_variant
rs116489517 likely-benign, Chilblain Lupus, Aicardi Goutieres syndrome 36,891,924(+) G/C genic_downstream_transcript_variant, intron_variant
rs138927042 likely-benign, Chilblain Lupus, Aicardi Goutieres syndrome 36,892,861(+) G/T genic_downstream_transcript_variant, splice_acceptor_variant
rs143588093 uncertain-significance, Chilblain Lupus, Aicardi Goutieres syndrome 36,892,692(+) C/A/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TLDC2 Gene

Variant ID Type Subtype PubMed ID
esv3645741 CNV gain 21293372
nsv1057845 CNV gain 25217958
nsv585944 CNV loss 21841781

Variation tolerance for TLDC2 Gene

Residual Variation Intolerance Score: 94.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.69; 57.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TLDC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLDC2 Gene

Disorders for TLDC2 Gene

Additional Disease Information for TLDC2

No disorders were found for TLDC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TLDC2 Gene

Publications for TLDC2 Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  5. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3

Products for TLDC2 Gene

Sources for TLDC2 Gene

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