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Aliases for TLDC1 Gene

Aliases for TLDC1 Gene

  • TBC/LysM-Associated Domain Containing 1 2 3 5
  • KIAA1609 2 3 4
  • TBC/LysM-Associated Domain-Containing Protein 1 3 4
  • TLD Domain Containing 1 2 3
  • TLD Domain-Containing Protein 1 3

External Ids for TLDC1 Gene

Previous HGNC Symbols for TLDC1 Gene

  • KIAA1609

Summaries for TLDC1 Gene

GeneCards Summary for TLDC1 Gene

TLDC1 (TBC/LysM-Associated Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is OXR1.

Additional gene information for TLDC1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLDC1 Gene

Genomics for TLDC1 Gene

GeneHancer (GH) Regulatory Elements for TLDC1 Gene

Promoters and enhancers for TLDC1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I084498 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 572 +51.1 51102 8.4 HDGF PKNOX1 CLOCK ARID4B NEUROD1 SIN3A DMAP1 ZNF2 ZBTB7B SLC30A9 TLDC1 ENSG00000260300 KLHL36 ATP2C2-AS1 HSBP1 ENSG00000261243
GH16I084553 Enhancer 0.6 Ensembl ENCODE 550.8 +0.2 158 1.5 ZBTB33 NR2F2 TLDC1 COTL1 ENSG00000261243
GH16I084555 Enhancer 0.6 ENCODE 550.8 -1.9 -1926 1.2 MEIS2 ZNF263 MXI1 RFX1 HLF CEBPB MAFG BMI1 SP1 POLR2A TLDC1 GC16P084565
GH16I084552 Enhancer 0.2 Ensembl 550.8 +1.7 1744 0.6 TLDC1 ENSG00000261243
GH16I085518 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 18.8 -968.6 -968618 8.2 CLOCK MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 ZNF548 NFYC SSRP1 ENSG00000270184 KLHL36 RNU1-103P RN7SL381P ZDHHC7 CRISPLD2 GSE1 TLDC1 ENSG00000260859 EMC8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TLDC1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TLDC1 Gene

Genomic Locations for TLDC1 Gene
77,686 bases
Minus strand

Genomic View for TLDC1 Gene

Genes around TLDC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLDC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLDC1 Gene

Proteins for TLDC1 Gene

  • Protein details for TLDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TLD domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • Q8IZ64
    • Q9HCG3
    • Q9NTE8

    Protein attributes for TLDC1 Gene

    456 amino acids
    Molecular mass:
    50994 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB13435.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for TLDC1 Gene

Post-translational modifications for TLDC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TLDC1 Gene

Domains & Families for TLDC1 Gene

Gene Families for TLDC1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for TLDC1 Gene


Suggested Antigen Peptide Sequences for TLDC1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TLDC1: view

No data available for UniProtKB/Swiss-Prot for TLDC1 Gene

Function for TLDC1 Gene

Phenotypes From GWAS Catalog for TLDC1 Gene

Gene Ontology (GO) - Molecular Function for TLDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with TLDC1: view

Phenotypes for TLDC1 Gene

GenomeRNAi human phenotypes for TLDC1:
genes like me logo Genes that share phenotypes with TLDC1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TLDC1 Gene

Localization for TLDC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLDC1 Gene

Membrane. Cytoplasm.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TLDC1 gene
Compartment Confidence
lysosome 5
nucleus 3
cytosol 3
plasma membrane 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TLDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 24223779
GO:0005765 lysosomal membrane HDA,IDA 17897319
GO:0016020 membrane IDA,IEA 24223779
genes like me logo Genes that share ontologies with TLDC1: view

Pathways & Interactions for TLDC1 Gene

SuperPathways for TLDC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TLDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903204 negative regulation of oxidative stress-induced neuron death IEA --
genes like me logo Genes that share ontologies with TLDC1: view

No data available for Pathways by source and SIGNOR curated interactions for TLDC1 Gene

Drugs & Compounds for TLDC1 Gene

No Compound Related Data Available

Transcripts for TLDC1 Gene

Unigene Clusters for TLDC1 Gene

TBC/LysM-associated domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TLDC1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^
SP1: - - - - -
SP2: - - - -
SP4: - - -
SP5: - - - -
SP6: - - -
SP8: -
SP9: - -

ExUns: 11

Relevant External Links for TLDC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TLDC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TLDC1 Gene

mRNA differential expression in normal tissues according to GTEx for TLDC1 Gene

This gene is overexpressed in Esophagus - Mucosa (x4.1).

Protein differential expression in normal tissues from HIPED for TLDC1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.9) and Breast (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TLDC1 Gene

Protein tissue co-expression partners for TLDC1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TLDC1 Gene:


SOURCE GeneReport for Unigene cluster for TLDC1 Gene:


Evidence on tissue expression from TISSUES for TLDC1 Gene

  • Nervous system(4.5)
  • Kidney(4.1)
genes like me logo Genes that share expression patterns with TLDC1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TLDC1 Gene

Orthologs for TLDC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TLDC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TLDC1 33 34
  • 98.9 (n)
(Canis familiaris)
Mammalia TLDC1 33 34
  • 81.61 (n)
(Bos Taurus)
Mammalia TLDC1 33 34
  • 79.05 (n)
(Rattus norvegicus)
Mammalia Tldc1 33
  • 74.86 (n)
(Mus musculus)
Mammalia Tldc1 33 16 34
  • 73.42 (n)
(Ornithorhynchus anatinus)
Mammalia TLDC1 34
  • 62 (a)
(Monodelphis domestica)
Mammalia TLDC1 34
  • 46 (a)
(Gallus gallus)
Aves KIAA1609 33 34
  • 64.69 (n)
(Anolis carolinensis)
Reptilia TLDC1 34
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tldc1 33
  • 57.76 (n)
(Danio rerio)
Actinopterygii tldc1 33 34
  • 54.98 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5149 34
  • 31 (a)
(Caenorhabditis elegans)
Secernentea eak-7 34
  • 23 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G06260 33
  • 41.98 (n)
(Oryza sativa)
Liliopsida Os12g0157200 33
  • 48.77 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 45 (a)
Species where no ortholog for TLDC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TLDC1 Gene

Gene Tree for TLDC1 (if available)
Gene Tree for TLDC1 (if available)

Paralogs for TLDC1 Gene

Paralogs for TLDC1 Gene

(3) SIMAP similar genes for TLDC1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with TLDC1: view

Variants for TLDC1 Gene

Sequence variations from dbSNP and Humsavar for TLDC1 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000054319 -- 84,503,292(-) G/A intron_variant
rs1000130190 -- 84,497,657(-) A/C intron_variant
rs1000185260 -- 84,506,222(-) T/C upstream_transcript_variant
rs1000239932 -- 84,482,439(-) A/C intron_variant
rs1000273711 -- 84,484,117(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TLDC1 Gene

Variant ID Type Subtype PubMed ID
dgv169n21 CNV loss 19592680
dgv3057n100 CNV loss 25217958
dgv5262n54 CNV loss 21841781
dgv549e214 CNV gain 21293372
esv2714828 CNV deletion 23290073
esv2714830 CNV deletion 23290073
esv2714831 CNV deletion 23290073
esv3303917 CNV mobile element insertion 20981092
esv3389512 CNV insertion 20981092
esv3639429 CNV gain 21293372
esv3892928 CNV loss 25118596
esv3892929 CNV loss 25118596
nsv1058049 CNV loss 25217958
nsv1059640 CNV loss 25217958
nsv1061004 CNV loss 25217958
nsv1064308 CNV loss 25217958
nsv1065249 CNV gain 25217958
nsv457600 CNV loss 19166990
nsv483044 CNV gain 15286789
nsv573425 CNV loss 21841781
nsv573430 CNV loss 21841781
nsv573454 CNV loss 21841781
nsv833311 CNV loss 17160897

Variation tolerance for TLDC1 Gene

Residual Variation Intolerance Score: 96.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.12; 69.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TLDC1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLDC1 Gene

Disorders for TLDC1 Gene

Additional Disease Information for TLDC1

No disorders were found for TLDC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TLDC1 Gene

Publications for TLDC1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
  2. Protein N-myristoylation plays a critical role in the endoplasmic reticulum morphological change induced by overexpression of protein Lunapark, an integral membrane protein of the endoplasmic reticulum. (PMID: 24223779) Moriya K … Utsumi T (PloS one 2013) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. (PMID: 27432908) Li X … Wang W (Molecular & cellular proteomics : MCP 2016) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for TLDC1 Gene

Sources for TLDC1 Gene

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