Aliases for TLCD5 Gene

Aliases for TLCD5 Gene

  • TLC Domain Containing 5 2 3 5
  • Transmembrane Protein 136 2 3 4
  • TLC Domain-Containing Protein 5 3 4
  • TMEM136 3 4
  • MGC17839 2
  • TLCD5 5

External Ids for TLCD5 Gene

Previous HGNC Symbols for TLCD5 Gene

  • TMEM136

Summaries for TLCD5 Gene

GeneCards Summary for TLCD5 Gene

TLCD5 (TLC Domain Containing 5) is a Protein Coding gene. Diseases associated with TLCD5 include Exfoliation Syndrome and Phacogenic Glaucoma.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TLCD5 Gene

Genomics for TLCD5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TLCD5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J120324 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 617 +1.0 1030 4.2 PRDM10 ZNF629 ZNF512 KDM1A ZNF692 BACH1 LARP7 ZSCAN4 RBFOX2 POLR2A TLCD5 ARHGEF12 lnc-TRIM29-4
GH11J120347 Enhancer 1.1 ENCODE dbSUPER 63.5 +22.1 22061 1.1 PRDM10 ZNF629 ZNF512 ZNF692 ZNF300 PRDM1 ZIC2 ZNF776 ZSCAN4 PKNOX1 TLCD5 TBCEL TECTA THY1 ARHGEF12 ENSG00000274303 GRIK4
GH11J120334 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 25.3 +13.0 13049 8.5 SP1 HNRNPL GATAD2A CTCF PRDM10 REST ZNF629 TFE3 LEF1 IKZF1 ARHGEF12 TLCD5 THY1 ENSG00000254561 ENSG00000274303 GRIK4
GH11J120390 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 23.5 +66.3 66305 3.2 GATAD2A FOXA1 RBFOX2 SP1 SOX13 MAFF YY1 KDM1A MAFK ZNF205 ARHGEF12 TLCD5 TBCEL BMPR1AP2 piR-57461-038 GRIK4
GH11J120354 Enhancer 1.1 Ensembl ENCODE dbSUPER 25.1 +28.5 28505 2.8 GATAD2A ZNF629 TCF7L2 HMBOX1 ZXDB OSR2 ZNF580 ZNF205 NCOR1 FOXP1 TLCD5 ARHGEF12 ENSG00000274303 GRIK4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TLCD5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TLCD5

Genomic Locations for TLCD5 Gene

Genomic Locations for TLCD5 Gene
8,391 bases
Plus strand
8,554 bases
Plus strand

Genomic View for TLCD5 Gene

Genes around TLCD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLCD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLCD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLCD5 Gene

Proteins for TLCD5 Gene

  • Protein details for TLCD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TLC domain-containing protein 5
    Protein Accession:
    Secondary Accessions:
    • B4DGQ4
    • B4E230
    • Q8IZ79

    Protein attributes for TLCD5 Gene

    245 amino acids
    Molecular mass:
    27859 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TLCD5 Gene


neXtProt entry for TLCD5 Gene

Post-translational modifications for TLCD5 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TLCD5 Gene

Domains & Families for TLCD5 Gene

Gene Families for TLCD5 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TLCD5 Gene

  • TRAM, LAG1 and CLN8 homology
  • High potential iron-sulfur protein

Suggested Antigen Peptide Sequences for TLCD5 Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane protein 136 (TM136_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TLCD5 family.
  • Belongs to the TLCD5 family.
genes like me logo Genes that share domains with TLCD5: view

Function for TLCD5 Gene

Phenotypes From GWAS Catalog for TLCD5 Gene

genes like me logo Genes that share phenotypes with TLCD5: view

Animal Models for TLCD5 Gene

MGI Knock Outs for TLCD5:
  • Tlcd5 Tlcd5<tm1.1(KOMP)Vlcg>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TLCD5

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TLCD5 Gene

Localization for TLCD5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLCD5 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TLCD5 gene
Compartment Confidence
plasma membrane 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TLCD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TLCD5: view

Pathways & Interactions for TLCD5 Gene

PathCards logo

SuperPathways for TLCD5 Gene

No Data Available

Interacting Proteins for TLCD5 Gene

Gene Ontology (GO) - Biological Process for TLCD5 Gene


No data available for Pathways by source and SIGNOR curated interactions for TLCD5 Gene

Drugs & Compounds for TLCD5 Gene

No Compound Related Data Available

Transcripts for TLCD5 Gene

mRNA/cDNA for TLCD5 Gene

8 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TLCD5

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TLCD5 Gene

No ASD Table

Relevant External Links for TLCD5 Gene

GeneLoc Exon Structure for

Expression for TLCD5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TLCD5

SOURCE GeneReport for Unigene cluster for TLCD5 Gene:


Evidence on tissue expression from TISSUES for TLCD5 Gene

  • Nervous system(4.6)
  • Pancreas(4)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TLCD5 Gene

Orthologs for TLCD5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TLCD5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM136 30 31
  • 99.5 (n)
(Canis familiaris)
Mammalia TMEM136 30 31
  • 90.92 (n)
(Monodelphis domestica)
Mammalia TMEM136 31
  • 90 (a)
(Bos Taurus)
Mammalia TMEM136 30 31
  • 89.52 (n)
(Mus musculus)
Mammalia Tmem136 30 31
  • 88.84 (n)
Tlcd5 17
(Rattus norvegicus)
Mammalia Tmem136 30
  • 88.03 (n)
(Ornithorhynchus anatinus)
Mammalia TMEM136 31
  • 84 (a)
(Gallus gallus)
Aves TMEM136 31
  • 72 (a)
LOC100857845 30
  • 70.88 (n)
(Anolis carolinensis)
Reptilia TMEM136 31
  • 67 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100489109 30
  • 68.43 (n)
(Danio rerio)
Actinopterygii LOC100537789 30
  • 64.79 (n)
TMEM136 (3 of 3) 31
  • 58 (a)
tmem136b 31
  • 57 (a)
tmem136a 31
  • 56 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 41 (a)
Species where no ortholog for TLCD5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TLCD5 Gene

Gene Tree for TLCD5 (if available)
Gene Tree for TLCD5 (if available)
Evolutionary constrained regions (ECRs) for TLCD5: view image

Paralogs for TLCD5 Gene

No data available for Paralogs for TLCD5 Gene

Variants for TLCD5 Gene

Additional dbSNP identifiers (rs#s) for TLCD5 Gene

Structural Variations from Database of Genomic Variants (DGV) for TLCD5 Gene

Variant ID Type Subtype PubMed ID
esv1582263 CNV insertion 17803354
esv2457390 CNV insertion 19546169
esv2533688 CNV deletion 19546169
esv2549681 CNV deletion 19546169
nsv1129158 CNV insertion 24896259
nsv1134181 CNV deletion 24896259

Variation tolerance for TLCD5 Gene

Residual Variation Intolerance Score: 72.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.19; 23.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TLCD5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TLCD5 Gene

Disorders for TLCD5 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TLCD5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
exfoliation syndrome
  • xfs
phacogenic glaucoma
iris disease
  • iris diseases
- elite association - COSMIC cancer census association via MalaCards
Search TLCD5 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with TLCD5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TLCD5 Gene

Publications for TLCD5 Gene

  1. Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci. (PMID: 28553957) Aung T … Khor CC (Nature genetics 2017) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. (PMID: 29987050) Xiao T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2018) 3
  4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3

Products for TLCD5 Gene

Sources for TLCD5 Gene