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Aliases for TLCD2 Gene

Aliases for TLCD2 Gene

  • TLC Domain Containing 2 2 3 5
  • TLC Domain-Containing Protein 2 3 4

External Ids for TLCD2 Gene

Previous GeneCards Identifiers for TLCD2 Gene

  • GC17M001560
  • GC17M001505
  • GC17M001606

Summaries for TLCD2 Gene

GeneCards Summary for TLCD2 Gene

TLCD2 (TLC Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is TLCD1.

UniProtKB/Swiss-Prot for TLCD2 Gene

  • Regulates the composition and fluidity of the plasma membrane (PubMed:30509349). Inhibits the incorporation of membrane-fluidizing phospholipids containing omega-3 long-chain polyunsaturated fatty acids (LCPUFA) and thereby promotes membrane rigidity (PubMed:30509349). Does not appear to have any effect on LCPUFA synthesis (PubMed:30509349).

Additional gene information for TLCD2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLCD2 Gene

Genomics for TLCD2 Gene

GeneHancer (GH) Regulatory Elements for TLCD2 Gene

Promoters and enhancers for TLCD2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J001709 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.3 -3.8 -3770 10.3 ZNF652 SP1 CC2D1A ZFX ELF3 CTCF MNT SIX5 CBFA2T2 ZNF148 WDR81 GC17M001714 MIR22 SMYD4 PRPF8 GEMIN4 RPA1 SERPINF2 METTL16 DPH1
GH17J001721 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.6 -13.6 -13636 4.1 ZNF652 SP1 ZFX ELF3 MNT CBFA2T2 ZNF148 NKRF MLLT1 ZNF121 WDR81 SMYD4 PRPF8 RPA1 DPH1 RN7SL608P METTL16 SERPINF2 TLCD2 ENSG00000263050
GH17J001729 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 19.6 -20.3 -20285 2.4 ZFX CBFA2T2 NCOA3 BACH1 ZNF600 ATF1 ZNF341 ZNF316 EP300 SCRT2 SMYD4 RPA1 TLCD2 METTL16 PRPF8 SERPINF2 TSR1 HNRNPA1P16 SMG6 DPH1
GH17J001647 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12.1 +60.7 60747 3.8 HDGF SP1 ZFX ELF3 CTCF MNT CBFA2T2 NKRF POLR2A GTF2F1 RILP SMYD4 HNRNPA1P16 METTL16 SMG6 DPH1 TLCD2 MIR22 MIR22HG WDR81
GH17J001782 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 11.7 -73.0 -72982 3 CTCF ZNF121 ZSCAN21 SP1 RAD21 RXRA REST ZNF692 TRIM22 ATF3 SMYD4 SERPINF1 SERPINF2 RPA1 MIR22 MIR22HG WDR81 TLCD2 PIR53033
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TLCD2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TLCD2 gene promoter:
  • CUTL1
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • HEN1
  • Hlf
  • Olf-1

Genomic Locations for TLCD2 Gene

Genomic Locations for TLCD2 Gene
chr17:1,702,790-1,710,377
(GRCh38/hg38)
Size:
7,588 bases
Orientation:
Minus strand
chr17:1,606,084-1,613,732
(GRCh37/hg19)
Size:
7,649 bases
Orientation:
Minus strand

Genomic View for TLCD2 Gene

Genes around TLCD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLCD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLCD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLCD2 Gene

Proteins for TLCD2 Gene

  • Protein details for TLCD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NGC4-TLCD2_HUMAN
    Recommended name:
    TLC domain-containing protein 2
    Protein Accession:
    A6NGC4

    Protein attributes for TLCD2 Gene

    Size:
    264 amino acids
    Molecular mass:
    28733 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TLCD2 Gene

Post-translational modifications for TLCD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TLCD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TLCD2 Gene

Domains & Families for TLCD2 Gene

Gene Families for TLCD2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TLCD2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TLCD2 Gene

GenScript: Design optimal peptide antigens:
  • TLC domain-containing protein 2 (TLCD2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NGC4

UniProtKB/Swiss-Prot:

TLCD2_HUMAN :
  • Belongs to the TLCD family.
Family:
  • Belongs to the TLCD family.
genes like me logo Genes that share domains with TLCD2: view

Function for TLCD2 Gene

Molecular function for TLCD2 Gene

UniProtKB/Swiss-Prot Function:
Regulates the composition and fluidity of the plasma membrane (PubMed:30509349). Inhibits the incorporation of membrane-fluidizing phospholipids containing omega-3 long-chain polyunsaturated fatty acids (LCPUFA) and thereby promotes membrane rigidity (PubMed:30509349). Does not appear to have any effect on LCPUFA synthesis (PubMed:30509349).

Phenotypes From GWAS Catalog for TLCD2 Gene

Animal Model Products

CRISPR Products

miRNA for TLCD2 Gene

miRTarBase miRNAs that target TLCD2

Clone Products

  • Applied Biological Materials (abm): Clones for TLCD2 - Now 50% OFF >
  • * TLCD2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * TLCD2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TLCD2 Gene

Localization for TLCD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLCD2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TLCD2 gene
Compartment Confidence
plasma membrane 5
nucleus 2
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TLCD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 30509349
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TLCD2: view

Pathways & Interactions for TLCD2 Gene

PathCards logo

SuperPathways for TLCD2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TLCD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007009 plasma membrane organization IMP 30509349
GO:0055091 phospholipid homeostasis IMP 30509349
GO:0071709 membrane assembly IMP 30509349
GO:0097035 regulation of membrane lipid distribution IMP 30509349
genes like me logo Genes that share ontologies with TLCD2: view

No data available for Pathways by source and SIGNOR curated interactions for TLCD2 Gene

Drugs & Compounds for TLCD2 Gene

No Compound Related Data Available

Transcripts for TLCD2 Gene

mRNA/cDNA for TLCD2 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for TLCD2 Gene

TLC domain containing 2:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for TLCD2 - Now 50% OFF >
  • * TLCD2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * TLCD2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for TLCD2 Gene

No ASD Table

Relevant External Links for TLCD2 Gene

GeneLoc Exon Structure for
TLCD2
ECgene alternative splicing isoforms for
TLCD2

Expression for TLCD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TLCD2 Gene

mRNA differential expression in normal tissues according to GTEx for TLCD2 Gene

This gene is overexpressed in Colon - Transverse (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of TLCD2 Gene:

TLCD2

SOURCE GeneReport for Unigene cluster for TLCD2 Gene:

Hs.531005

Evidence on tissue expression from TISSUES for TLCD2 Gene

  • Lung(2.2)
  • Liver(2)
genes like me logo Genes that share expression patterns with TLCD2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TLCD2 Gene

Orthologs for TLCD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TLCD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TLCD2 35 34
  • 98.83 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TLCD2 35 34
  • 82.7 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TLCD2 35 34
  • 82.58 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tlcd2 34
  • 78.38 (n)
mouse
(Mus musculus)
Mammalia Tlcd2 17 35 34
  • 77.47 (n)
oppossum
(Monodelphis domestica)
Mammalia TLCD2 35
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves TLCD2 35
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TLCD2 35
  • 41 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tlcd2 35
  • 36 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y48G8AL.13 35
  • 22 (a)
ManyToMany
Y63D3A.8 35
  • 19 (a)
ManyToMany
K12H6.6 35
  • 18 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 27 (a)
OneToMany
Species where no ortholog for TLCD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TLCD2 Gene

ENSEMBL:
Gene Tree for TLCD2 (if available)
TreeFam:
Gene Tree for TLCD2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TLCD2: view image

Paralogs for TLCD2 Gene

(1) SIMAP similar genes for TLCD2 Gene using alignment to 1 proteins:

  • TLCD2_HUMAN
genes like me logo Genes that share paralogs with TLCD2: view

Variants for TLCD2 Gene

Sequence variations from dbSNP and Humsavar for TLCD2 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000072368 -- 1,710,432(-) G/A/C upstream_transcript_variant
rs1000073451 -- 1,709,560(-) G/C coding_sequence_variant, missense_variant
rs1000315653 -- 1,705,605(-) C/G 3_prime_UTR_variant
rs1000659602 -- 1,712,141(-) TTTTTTT/TTTTTTTT upstream_transcript_variant
rs1000813418 -- 1,707,294(-) T/C 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for TLCD2 Gene

Variant ID Type Subtype PubMed ID
esv3639697 CNV loss 21293372
nsv470568 CNV loss 18288195
nsv516886 CNV loss 19592680
nsv827856 CNV gain 20364138
nsv9490 CNV loss 18304495

Variation tolerance for TLCD2 Gene

Gene Damage Index Score: 2.64; 45.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TLCD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TLCD2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLCD2 Gene

Disorders for TLCD2 Gene

Additional Disease Information for TLCD2

No disorders were found for TLCD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TLCD2 Gene

Publications for TLCD2 Gene

  1. Membrane fluidity is regulated by the C. elegans transmembrane protein FLD-1 and its human homologs TLCD1/2. (PMID: 30509349) Ruiz M … Pilon M (eLife 2018) 3 4 58
  2. When do Lasses (longevity assurance genes) become CerS (ceramide synthases)?: Insights into the regulation of ceramide synthesis. (PMID: 16793762) Pewzner-Jung Y … Futerman AH (The Journal of biological chemistry 2006) 2 3 58
  3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 3 4 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta GD … Pelletier L (Cell 2015) 3 58

Products for TLCD2 Gene

Sources for TLCD2 Gene

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