Aliases for TKTL2 Gene
External Ids for TKTL2 Gene
Previous GeneCards Identifiers for TKTL2 Gene
GeneCards Summary for TKTL2 Gene
TKTL2 (Transketolase Like 2) is a Protein Coding gene. Diseases associated with TKTL2 include Uremic Neuropathy and Wernicke-Korsakoff Syndrome. Among its related pathways are Metabolism and Carbon metabolism. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor and transketolase activity. An important paralog of this gene is TKTL1.
UniProtKB/Swiss-Prot Summary for TKTL2 Gene
Plays an essential role in total transketolase activity and cell proliferation in cancer cells; after transfection with anti-TKTL1 siRNA, total transketolase activity dramatically decreases and proliferation was significantly inhibited in cancer cells. Plays a pivotal role in carcinogenesis.