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This gene is a member of the family of dihydroxyacetone kinases, which have a protein structure distinct from other kinases. The product of this gene phosphorylates dihydroxyacetone, and also catalyzes the formation of riboflavin 4',5'-phosphate (aka cyclin FMN) from FAD. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2017]
TKFC (Triokinase And FMN Cyclase) is a Protein Coding gene. Diseases associated with TKFC include Taeniasis and Cysticercosis. Among its related pathways are Carbon metabolism and Fructose metabolism. Gene Ontology (GO) annotations related to this gene include glycerone kinase activity and triokinase activity.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003824 | catalytic activity | IEA | -- |
GO:0004371 | glycerone kinase activity | IEA,IDA | 4688871 |
GO:0005515 | protein binding | IPI | 17600090 |
GO:0005524 | ATP binding | IEA | -- |
GO:0016301 | kinase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | HDA | 21630459 |
GO:0005829 | cytosol | TAS | -- |
GO:0070062 | extracellular exosome | HDA | 19056867 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways | ||
2 | Fructose metabolism | ||
3 | Metabolism |
.40
|
|
4 | Innate Immune System |
.61
|
|
5 | Carbon metabolism |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006071 | glycerol metabolic process | IEA | -- |
GO:0008152 | metabolic process | IEA | -- |
GO:0016310 | phosphorylation | IEA | -- |
GO:0019563 | glycerol catabolic process | IBA | 21873635 |
GO:0039534 | negative regulation of MDA-5 signaling pathway | IDA | 17600090 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor | 58-64-0 |
|
||
glyceraldehyde |
|
56-82-6 |
|
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP14: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP15: | - |
ExUns: | 11c | ^ | 12 | ^ | 13a | · | 13b | · | 13c | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19 | ^ | 20 | ^ | 21a | · | 21b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||||
SP2: | |||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||
SP4: | |||||||||||||||||||||||||||||
SP5: | |||||||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||||
SP7: | |||||||||||||||||||||||||||||
SP8: | |||||||||||||||||||||||||||||
SP9: | |||||||||||||||||||||||||||||
SP10: | |||||||||||||||||||||||||||||
SP11: | |||||||||||||||||||||||||||||
SP12: | |||||||||||||||||||||||||||||
SP13: | |||||||||||||||||||||||||||||
SP14: | |||||||||||||||||||||||||||||
SP15: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | DAK 33 32 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | DAK 33 32 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | DAK 33 32 |
|
OneToOne | |
rat (Rattus norvegicus) |
Mammalia | Dak 32 |
|
||
mouse (Mus musculus) |
Mammalia | Dak 33 32 |
|
OneToOne | |
Tkfc 17 |
|
||||
oppossum (Monodelphis domestica) |
Mammalia | DAK 33 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | DAK 33 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | -- 33 |
|
OneToMany | |
DAK 32 |
|
||||
-- 33 |
|
OneToMany | |||
lizard (Anolis carolinensis) |
Reptilia | DAK 33 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | dak 32 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | dak 33 32 |
|
OneToOne | |
worm (Caenorhabditis elegans) |
Secernentea | W02H5.8 33 32 |
|
OneToOne | |
A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AER139C 32 |
|
||
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | DAK2 33 |
|
OneToMany | |
DAK1 33 |
|
OneToMany | |||
thale cress (Arabidopsis thaliana) |
eudicotyledons | AT3G17770 32 |
|
||
rice (Oryza sativa) |
Liliopsida | Os03g0719300 32 |
|
||
Os.46088 32 |
|
||||
bread mold (Neurospora crassa) |
Ascomycetes | NCU04400 32 |
|
SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000059022 | -- | 61,335,536(+) | G/T | intron_variant | |
rs1000205947 | -- | 61,342,357(+) | C/T | intron_variant | |
rs1000367641 | -- | 61,335,813(+) | A/T | intron_variant | |
rs1000683231 | -- | 61,334,253(+) | C/G | 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
rs1001022368 | -- | 61,351,520(+) | A/C | genic_downstream_transcript_variant, intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv662n106 | CNV | deletion | 24896259 |
esv1545620 | CNV | deletion | 17803354 |
esv1969466 | CNV | deletion | 18987734 |
esv2497950 | CNV | deletion | 19546169 |
esv2744588 | CNV | deletion | 23290073 |
esv3293 | CNV | loss | 18987735 |
esv3547872 | CNV | deletion | 23714750 |
esv5881 | CNV | loss | 19470904 |
nsv1070461 | CNV | deletion | 25765185 |
nsv1147756 | CNV | deletion | 26484159 |
nsv428259 | CNV | gain+loss | 18775914 |
nsv832177 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
taeniasis |
|
|
cysticercosis |
|
|
reading disorder |
|
|