Aliases for TK1 Gene
External Ids for TK1 Gene
Previous GeneCards Identifiers for TK1 Gene
The protein encoded by this gene is a cytosolic enzyme that catalyzes the addition of a gamma-phosphate group to thymidine. This creates dTMP and is the first step in the biosynthesis of dTTP, which is one component required for DNA replication. The encoded protein, whose levels fluctuate depending on the cell cycle stage, can act as a low activity dimer or a high activity tetramer. High levels of this protein have been used as a biomarker for diagnosing and categorizing many types of cancers. [provided by RefSeq, Oct 2016]
GeneCards Summary for TK1 Gene
TK1 (Thymidine Kinase 1) is a Protein Coding gene. Diseases associated with TK1 include Colorectal Cancer 2 and Lung Cancer. Among its related pathways are Pyrimidine metabolism (KEGG) and E2F transcription factor network. Gene Ontology (GO) annotations related to this gene include identical protein binding and thymidine kinase activity.