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This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family of proteins, and acts as a tight junction adaptor protein that also regulates adherens junctions. Tight junctions regulate the movement of ions and macromolecules between endothelial and epithelial cells. The multidomain structure of this scaffold protein, including a postsynaptic density 95/d... See more...
Aliases for TJP1 Gene
Aliases for TJP1 Gene
External Ids for TJP1 Gene
- HGNC: 11827
- Entrez Gene: 7082
- Ensembl: ENSG00000104067
- OMIM: 601009
- UniProtKB: Q07157
Previous GeneCards Identifiers for TJP1 Gene
- GC15M025498
- GC15M022747
- GC15M027572
- GC15M027708
- GC15M027779
- GC15M029991
- GC15M007657
Summaries for TJP1 Gene
-
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family of proteins, and acts as a tight junction adaptor protein that also regulates adherens junctions. Tight junctions regulate the movement of ions and macromolecules between endothelial and epithelial cells. The multidomain structure of this scaffold protein, including a postsynaptic density 95/disc-large/zona occludens (PDZ) domain, a Src homology (SH3) domain, a guanylate kinase (GuK) domain and unique (U) motifs all help to co-ordinate binding of transmembrane proteins, cytosolic proteins, and F-actin, which are required for tight junction function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
GeneCards Summary for TJP1 Gene
TJP1 (Tight Junction Protein 1) is a Protein Coding gene. Diseases associated with TJP1 include Nephrotic Syndrome, Type 1 and Celiac Disease 1. Among its related pathways are Vesicle-mediated transport and Signaling by Hippo. Gene Ontology (GO) annotations related to this gene include protein domain specific binding and protein C-terminus binding. An important paralog of this gene is ENSG00000285130.
UniProtKB/Swiss-Prot Summary for TJP1 Gene
-
TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates to the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity).
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TJP1 Gene
Genomics for TJP1 Gene
GeneHancer (GH) Regulatory Elements for TJP1 Gene
Promoters and enhancers for TJP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TJP1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the TJP1 gene promoter:
-
- AML1a
- AP-4
- E47
- Elk-1
- GATA-1
- HNF-3beta
- Msx-1
- Pbx1a
- RORalpha1
Genomic Locations for TJP1 Gene
Genomic Locations for TJP1 Gene
- chr15:29,699,367-29,968,865
- (GRCh38/hg38)
- Size:
- 269,499 bases
- Orientation:
- Minus strand
- chr15:29,991,571-30,261,068
- (GRCh37/hg19)
- Size:
- 269,498 bases
- Orientation:
- Minus strand
Genomic View for TJP1 Gene
Genes around TJP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q13.1 by HGNC
- 15q13.1 by Entrez Gene
- 15q13.1 by Ensembl
TJP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TJP1 Gene
Proteins for TJP1 Gene
-
Protein details for TJP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q07157-ZO1_HUMAN
- Recommended name:
- Tight junction protein ZO-1
- Protein Accession:
- Q07157
- B4E3K1
- Q2NKP3
- Q4ZGJ6
Protein attributes for TJP1 Gene
- Size:
- 1748 amino acids
- Molecular mass:
- 195459 Da
- Quaternary structure:
-
- Homodimer (PubMed:17928286). Forms heterodimers (via the PDZ2 domain) with TJP2 and TJP3 (PubMed:9792688, PubMed:17928286, PubMed:16737969). Interacts with OCLN, CALM, claudins, CGN/cingulin, CXADR, GJA12, GJD3 and UBN1 (PubMed:7798316, PubMed:11734628, PubMed:12023291, PubMed:12154091, PubMed:15183511, PubMed:18823282, PubMed:20200156). Interacts (via ZU5 domain) with CDC42BPB and MYZAP (PubMed:20093627, PubMed:21240187). Interacts (via PDZ domain) with GJA1 (PubMed:18636092). Interacts (via PDZ domains) with ANKRD2 (PubMed:22016770). Interacts with BVES (via the C-terminus cytoplasmic tail) (By similarity). Interacts with HSPA4 and KIRREL1 (By similarity). Interacts with DLL1 (By similarity). Interacts with USP53 (via the C-terminal region) (By similarity). Interacts (via ABR region) with F-actin (PubMed:9792688, PubMed:12354695, PubMed:20930113). Interacts with DNMBP (via C-terminal domain); required for the apical cell-cell junction localization of DNMBP (PubMed:17015620).
- SequenceCaution:
-
- Sequence=AAA02891.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for TJP1 Gene
Protein Expression for TJP1 Gene
Post-translational modifications for TJP1 Gene
- Phosphorylated at tyrosine redidues in response to epidermal growth factor (EGF) (PubMed:19332538, PubMed:7542259). This response is dependent on an intact actin microfilament system (PubMed:7542259). Dephosphorylated by PTPRJ (PubMed:19332538).
-
Ubiquitination at Lys553, Lys695, Lys702, Lys1189, and Lys1601
- NX_Q07157 (NX_Q07157-1)
- Modification sites at PhosphoSitePlus
Other Protein References for TJP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ ZO 1 Antibody and Immunotag™ TJP1 Antibody
- NSJ Bioreagents ZO-1 Antibody
- Atlas Antibodies Anti-TJP1 Antibody (HPA001636) and Anti-TJP1 Antibody (HPA001637)
-
Creative Diagnostics
- GeneTex Anti-ZO-1 antibody and Anti-ZO-1 antibody [N1N2], N-term
-
Custom Antibody ServicesOriGene Antibodies for TJP1
- Novus Biologicals Antibodies for TJP1
-
Abcam antibodies for TJP1
- Invitrogen Antibodies for TJP1 (AFLGC-TJP1)
- antibodies-online: Show 29 available TJP1 Antibodies ranked by validation data
- Compare Top TJP1 Antibodies
-
Recommended
- 88 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 2 IF Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 1 IHC Antibody (anti-human)
- 1 SimWes Antibody (anti-human)
- 27 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 1 FACS Antibody (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 20 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- 1 FACS Antibody (anti-rat)
- 1 IHC Antibody (anti-rat)
-
Boster Bio Antibodies for TJP1
-
Santa Cruz Biotechnology (SCBT) Antibodies for TJP1
- Sino Biological Antibodies for TJP1
Protein Products
- Atlas Antibodies PrEST Antigen TJP1 (APrEST83051) and PrEST Antigen TJP1 (APrEST83050)
- Creative Biomart Recombinant Human TJP1 Protein, His-tagged and Recombinant Human TJP1 Protein, MYC/DDK-tagged
-
OriGene Purified Proteins for TJP1
- Search Origene for MassSpec and Protein Over-expression Lysates for TJP1
- Origene Custom Protein Services for TJP1
-
Abcam proteins for TJP1
Assay Products
- Aviva Systems Biology TJP1 ELISA Kit (Human) (OKDD00562) and TJP1 ELISA Kit (Human) (OKCD00320)
- antibodies-online: Show 50 available TJP1 Elisa Kits ranked by validation data
- Compare Top TJP1 Elisa Kits
-
Quality Products:
- ABIN1117497
- ABIN578077
- ABIN415292
- ABIN1572755
- ABIN5524731
- ABIN5669409
- ABIN510592
- ABIN5659255
- ABIN2539649
- ABIN4973316
- ABIN1117499
- ABIN5524732
- ABIN5670228
- ABIN628223
- ABIN2951872
- ABIN5073132
- ABIN1161837
- ABIN858476
- ABIN432660
- ABIN1117498
- ABIN5524733
- ABIN2851579
- ABIN627413
- ABIN5659256
- ABIN6254708
- ABIN2539650
- ABIN2951873
- ABIN996295
- ABIN1161835
No data available for DME Specific Peptides for TJP1 Gene
Domains & Families for TJP1 Gene
Gene Families for TJP1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for TJP1 Gene
Suggested Antigen Peptide Sequences for TJP1 Gene
- GenScript: Design optimal peptide antigens:
-
- Tight junction protein ZO-1 (A9CQZ8_HUMAN)
- Tight junction protein ZO-1 (Q9H317_HUMAN)
- Zonula occludens protein 1 (ZO1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q07157UniProtKB/Swiss-Prot:
ZO1_HUMAN :- The 244-aa domain between residues 633 and 876 is the primary occludin (OCLN)-binding site and is required for stable association with the tight junction (PubMed:9792688).
- Belongs to the MAGUK family.
- Domain:
-
- The 244-aa domain between residues 633 and 876 is the primary occludin (OCLN)-binding site and is required for stable association with the tight junction (PubMed:9792688).
- The C-terminal region (residues 1151-1372) is an actin-binding region (ABR) that interacts directly with F-actin and plays an important role in the localization of TJP1 at junctions (PubMed:9792688, PubMed:12354695, PubMed:20930113). The ABR is also required for the localization to puncta at the free edge of cells before initiation of cell-cell contact (PubMed:12354695). The ABR is also necessary for TJP1 recruitment to podosomes (PubMed:20930113).
- The second PDZ domain (PDZ2) mediates homodimerization and heterodimerization with TJP2 and TJP3 (PubMed:9792688, PubMed:17928286).
- Family:
-
- Belongs to the MAGUK family.
Function for TJP1 Gene
Molecular function for TJP1 Gene
- UniProtKB/Swiss-Prot Function:
- TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates to the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity).
- GENATLAS Biochemistry:
- tight junction (zonula occludens) protein ZO-1,also expressed in adherens junctions,200kDa,localized in the glomerulus predominantly to points where the slit diaphragm is inserted into the lateral cell membrane of the foot process with homology to yeast guanylate kinase and Drosophila lethal discs large tumor suppressor protein
Phenotypes From GWAS Catalog for TJP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI,IEA | 9707407 |
| GO:0005516 | calmodulin binding | IEA | -- |
| GO:0008022 | protein C-terminus binding | IEA | -- |
| GO:0019904 | protein domain specific binding | IEA | -- |
| GO:0045296 | cadherin binding | HDA | 25468996 |
Phenotypes for TJP1 Gene
- MGI mutant phenotypes for TJP1:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for TJP1:
-
- Synthetic lethal with imatinib mesylate
- Decreased HPV16-GFP infection
- Decreased viability
- no effect
- Increased human cytomegalovirus (HCMV) strain AD169 replication
- Increased vaccinia virus (VACV) infection
- Resistant to vaccinia virus (VACV-A4L) infection
- Increased gamma-H2AX phosphorylation
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability after Maraba virus infection
- Increased Sindbis virus (SINV) infection
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
-
OriGene CRISPR knockouts for TJP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TJP1
- genomics-online: gRNA clones - Search for available TJP1 gRNA products
- Overview of 100 available TJP1 gene related products
- Applied Biological Materials (abm): CRISPR Clones for TJP1 - Select products 50% OFF >
- * TJP1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * TJP1 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for TJP1
miRNA for TJP1 Gene
- miRTarBase miRNAs that target TJP1
-
- hsa-mir-212-3p (MIRT004341)
- hsa-mir-155-5p (MIRT020884)
- hsa-mir-615-3p (MIRT039699)
- hsa-mir-324-3p (MIRT042969)
- hsa-mir-17-5p (MIRT050793)
- hsa-let-7b-5p (MIRT051942)
- hsa-mir-105-5p (MIRT438931)
- hsa-mir-4799-5p (MIRT553625)
- hsa-mir-194-5p (MIRT553626)
- hsa-mir-383-3p (MIRT553627)
- hsa-mir-548c-3p (MIRT553628)
- hsa-mir-103a-3p (MIRT553629)
- hsa-mir-107 (MIRT553630)
- hsa-mir-379-3p (MIRT553631)
- hsa-mir-411-3p (MIRT553632)
- hsa-mir-802 (MIRT698459)
- hsa-mir-4801 (MIRT698460)
- hsa-mir-5700 (MIRT698461)
- hsa-mir-4731-3p (MIRT698462)
- hsa-mir-5582-3p (MIRT698463)
- hsa-mir-548x-3p (MIRT698464)
- hsa-mir-548j-3p (MIRT698465)
- hsa-mir-548aq-3p (MIRT698466)
- hsa-mir-548am-3p (MIRT698467)
- hsa-mir-548aj-3p (MIRT698468)
- hsa-mir-548ah-3p (MIRT698469)
- hsa-mir-548ae-3p (MIRT698470)
- hsa-mir-548z (MIRT698471)
- hsa-mir-548h-3p (MIRT698472)
- hsa-mir-548d-3p (MIRT698473)
- hsa-mir-548bb-3p (MIRT698474)
- hsa-mir-548ac (MIRT698475)
- hsa-mir-212-5p (MIRT732222)
- hsa-mir-34c-5p (MIRT735047)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for TJP1
- Browse OriGene Inhibitory RNA Products For TJP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TJP1
- genomics-online: shRNA clones - Search for available TJP1 shRNA products
- Overview of 100 available TJP1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for TJP1
- Addgene plasmids for TJP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TJP1
- genomics-online: cdna clones - Search for available TJP1 CDNA products
- Overview of 100 available TJP1 gene related products
- orf clones - Search for available TJP1 ORF products
- Overview of 100 available TJP1 gene related products
- Applied Biological Materials (abm): Clones for TJP1 - Select products 50% OFF >
- * TJP1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * TJP1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Cell Line Products
-
Horizon Cell Lines for TJP1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TJP1 Gene
Localization for TJP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TJP1 Gene
- Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, tight junction. Cell junction. Cell junction, gap junction. Cell projection, podosome. Note=Moves from the cytoplasm to the cell membrane concurrently with cell-cell contact (PubMed:7798316). At podosomal sites, is predominantly localized in the ring structure surrounding the actin core (PubMed:20930113). {ECO:0000269 PubMed:20930113, ECO:0000269 PubMed:7798316}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytosol | 5 |
| cytoskeleton | 4 |
| nucleus | 3 |
| extracellular | 2 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cell Junctions (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002102 | podosome | IEA | -- |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005737 | cytoplasm | IDA | 11734628 |
| GO:0005829 | cytosol | IDA,TAS | -- |
| GO:0005886 | plasma membrane | IDA,TAS | -- |
Pathways & Interactions for TJP1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways | ||
| 2 | Sertoli-Sertoli Cell Junction Dynamics |
Germ Cell-Sertoli Cell Junction Dynamics
.38
Sertoli-Sertoli Cell Junction Dynamics
.38
|
Epithelial Tight Junctions
.36
|
| 3 | Apoptotic cleavage of cellular proteins | ||
| 4 | Insulin receptor recycling | ||
| 5 | CDK-mediated phosphorylation and removal of Cdc6 |
.31
|
|
Pathways by source for TJP1 Gene
2 BioSystems pathways for TJP1 Gene
12 Reactome pathways for TJP1 Gene
7 KEGG pathways for TJP1 Gene
3 GeneGo (Thomson Reuters) pathways for TJP1 Gene
4 R&D Systems pathways for TJP1 Gene
- Blood-Brain Barrier and Immune Cell Transmigration: CCL2/MCP-1 Signaling Pathways
- Blood-Brain Barrier and Immune Cell Transmigration: ICAM-1/CD54 Signaling Pathways
- Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways
- Blood-Brain Barrier and Immune Cell Transmigration: VEGF Signaling Pathways
5 Qiagen pathways for TJP1 Gene
- Epithelial Adherens Junctions
- Epithelial Tight Junctions
- Germ Cell-Sertoli Cell Junction Dynamics
- Sertoli-Sertoli Cell Junction Dynamics
- Signaling in Gap Junctions
2 Cell Signaling Technology pathways for TJP1 Gene
Interacting Proteins for TJP1 Gene
Selected Interacting proteins:
Q07157-ZO1_HUMAN
ENSP00000281537
for TJP1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for TJP1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007043 | cell-cell junction assembly | TAS | 8486731 |
| GO:0007605 | sensory perception of sound | IEA | -- |
| GO:0032496 | response to lipopolysaccharide | IEA | -- |
| GO:0035329 | hippo signaling | TAS | -- |
| GO:0042493 | response to drug | IEA | -- |
Drugs & Compounds for TJP1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
- Atlas Antibodies PrEST Antigen TJP1 (APrEST83051) and PrEST Antigen TJP1 (APrEST83050)
- Creative Biomart Recombinant Human TJP1 Protein, His-tagged and Recombinant Human TJP1 Protein, MYC/DDK-tagged
Transcripts for TJP1 Gene
mRNA/cDNA for TJP1 Gene
- (9) REFSEQ mRNAs :
- (28) Additional mRNA sequences :
- (255) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000346128 7950 bps (ENST00000346128.10)
- ENST00000356107 6747 bps (ENST00000356107.10)
- ENST00000400007 1032 bps (ENST00000400007.8)
- ENST00000400011 6764 bps (ENST00000400011.6)
- ENST00000462916 698 bps (ENST00000462916.1)
CRISPR Products
-
OriGene CRISPR knockouts for TJP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TJP1
- genomics-online: gRNA clones - Search for available TJP1 gRNA products
- Overview of 100 available TJP1 gene related products
- Applied Biological Materials (abm): CRISPR Clones for TJP1 - Select products 50% OFF >
- * TJP1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * TJP1 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for TJP1
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for TJP1
- Browse OriGene Inhibitory RNA Products For TJP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TJP1
- genomics-online: shRNA clones - Search for available TJP1 shRNA products
- Overview of 100 available TJP1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for TJP1
- Addgene plasmids for TJP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TJP1
- genomics-online: cdna clones - Search for available TJP1 CDNA products
- Overview of 100 available TJP1 gene related products
- orf clones - Search for available TJP1 ORF products
- Overview of 100 available TJP1 gene related products
- Applied Biological Materials (abm): Clones for TJP1 - Select products 50% OFF >
- * TJP1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * TJP1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15a | · | 15b | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b | · | 19c | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
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| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
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| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: |
| ExUns: | 20 | ^ | 21 | ^ | 22 | ^ | 23a | · | 23b | ^ | 24 | ^ | 25 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||
| SP2: | |||||||||||||
| SP3: | |||||||||||||
| SP4: | |||||||||||||
| SP5: | |||||||||||||
| SP6: | |||||||||||||
| SP7: | |||||||||||||
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| SP9: | |||||||||||||
| SP10: | |||||||||||||
| SP11: |
Expression for TJP1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Epithelial Cells
- Early Ameloblasts Dental Enamel
- Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
- Mature Choroid Plexus Cells Choroid Plexus
- Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
- Inner Enamel Epithelial Cells Dental Enamel
-
Eye (Sensory Organs)
- Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
- Endothelial Cells Corneal Endothelium
- Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
- Mature Endothelial Cells Corneal Endothelium
- Retinal Pigmented Epithelium Progenitor Cells Retinal Pigmented Epithelium
-
Tooth (Integumentary System)
- Early Ameloblasts Dental Enamel
- Dental Papilla Cells Dental Papilla
- Inner Enamel Epithelial Cells Dental Enamel
- Stellate Reticulum Cells Dental Core
- Outer Enamel Epithelial Cells Dental Enamel
-
Inner Cell Mass (Early Embryo)
- Zygote Zygote
- Inner Cell Mass Cells Inner Cell Mass
- 2-Cell Embryo Zygote
- Morula Cells Morula
- 8-Cell Embryo Morula
-
Endothelium (Cardiovascular System)
- Endothelial Cells Corneal Endothelium
- Mature Endothelial Cells Corneal Endothelium
- Human corneal endothelial cells
- Endothelial cells (family)
- Human umbilical vein endothelial cells (HUVEC)
- NULL (Nervous System)
-
Zygote (Early Embryonic Tissues)
- Zygote Zygote
- 2-Cell Embryo Zygote
- Morula Cells Morula
- 8-Cell Embryo Morula
- 4-Cell Embryo Zygote
-
Trophoblast (Extraembryonic Tissues)
- Zygote Zygote
- 2-Cell Embryo Zygote
- Morula Cells Morula
- 8-Cell Embryo Morula
- 4-Cell Embryo Zygote
- Brain (Nervous System)
- Kidney (Urinary System)
-
Ovary (Reproductive System)
- Ovarian Mesenchymal Stroma Cells Ovary Interstitium
- Oviduct
- Blood (Hematopoietic System)
- Mesenchymal Stem Cells
- Umbilical Cord (Extraembryonic Tissues)
-
Limb (Muscoskeletal System)
- Prechondrocytic Mesenchymal Cells Zeugopod
-
Bone (Muscoskeletal System)
- Prechondrocytic Mesenchymal Cells Zeugopod
-
Cartilage (Muscoskeletal System)
- Prechondrocytic Mesenchymal Cells Zeugopod
-
Gonad (Reproductive System)
- Primordial Germ Cells Primitive Gonad
- Thyroid (Endocrine System)
- Intestine (Gastrointestinal Tract)
- Pancreas (Endocrine System)
- Lung (Respiratory System)
- Liver (Hepatobiliary System)
-
Uterus (Reproductive System)
-
Placenta (Extraembryonic Tissues)
-
Testis (Reproductive System)
-
Esophagus (Gastrointestinal Tract)
This gene is overexpressed in Testis (10.7), Gallbladder (6.9), and Fetal ovary (6.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TJP1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of TJP1 Gene:
TJP1SOURCE GeneReport for Unigene cluster for TJP1 Gene:
Hs.743990mRNA Expression by UniProt/SwissProt for TJP1 Gene:
Q07157-ZO1_HUMAN
Tissue specificity:
The alpha-containing isoform is found in most epithelial cell junctions. The short isoform is found both in endothelial cells and the highly specialized epithelial junctions of renal glomeruli and Sertoli cells of the seminiferous tubules.
Evidence on tissue expression from TISSUES for TJP1 Gene
- Liver(4.6)
- Nervous system(4.6)
- Heart(3.4)
- Intestine(3.4)
- Kidney(3.3)
- Eye(3.2)
- Blood(3.1)
- Lung(3.1)
- Muscle(2.6)
- Skin(2.4)
- Spleen(2.2)
- Pancreas(2.1)
- Stomach(2.1)
Primer Products
-
OriGene qPCR primer pairs for TJP1
-
OriGene qPCR primer pairs and template standards for TJP1
- genomics-online: primer clones - Search for available TJP1 Primer products
- Overview of 100 available TJP1 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TJP1 Gene
Orthologs for TJP1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TJP1 33 32 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | TJP1 33 32 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 33 |
|
OneToMany | |
| -- 33 |
|
OneToMany | |||
| mouse (Mus musculus) |
Mammalia | Tjp1 17 33 32 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Tjp1 32 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 33 |
|
OneToMany | |
| -- 33 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | ZO1 33 |
|
OneToOne | |
| TJP1 32 |
|
||||
| chicken (Gallus gallus) |
Aves | TJP1 33 32 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | TJP1 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | tjp1 32 |
|
||
| Str.718 32 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.14146 32 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | tjp1a 33 32 |
|
OneToMany | |
| tjp1b 33 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | pyd 33 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | zoo-1 33 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 33 |
|
OneToMany | |
| Cin.1605 32 |
|
||||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.1605 32 |
|
- Species where no ortholog for TJP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for TJP1 Gene
- ENSEMBL:
- Gene Tree for TJP1 (if available)
- TreeFam:
- Gene Tree for TJP1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TJP1: view image
Paralogs for TJP1 Gene
(9) SIMAP similar genes for TJP1 Gene using alignment to 10 proteins:
- ZO1_HUMAN
- A9CQZ8_HUMAN
- G3V1L9_HUMAN
- G5E9E7_HUMAN
- H0Y3R8_HUMAN
- H0YKB1_HUMAN
- H0YLT6_HUMAN
- J3QKQ9_HUMAN
- L0R559_HUMAN
- Q9H317_HUMAN
Pseudogenes.org Pseudogenes for TJP1 Gene
Variants for TJP1 Gene
| SNP ID | Clin | Chr 15 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000006477 | -- | 29,866,503(-) | A/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000014429 | -- | 29,805,764(-) | T/C | intron_variant | |
| rs1000051309 | -- | 29,917,647(-) | G/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000052937 | -- | 29,745,196(-) | C/T | intron_variant | |
| rs1000056857 | -- | 29,937,278(-) | C/T | genic_upstream_transcript_variant, intron_variant |
Residual Variation Intolerance Score:
3.62% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.75;
83.21% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TJP1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TJP1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TJP1 Gene
Disorders for TJP1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| nephrotic syndrome, type 1 |
|
|
| celiac disease 1 |
|
|
| inflammatory bowel disease |
|
|
| macular degeneration, age-related, 1 |
|
|
| acute vascular insufficiency of intestine |
|
|
Search TJP1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TJP1
No data available for UniProtKB/Swiss-Prot and Genatlas for TJP1 Gene
Publications for TJP1 Gene
- Density-enhanced phosphatase 1 regulates phosphorylation of tight junction proteins and enhances barrier function of epithelial cells. (PMID: 19332538) Sallee JL … Burridge K (The Journal of biological chemistry 2009) 3 4 23 56
- Evidence for a functional interaction between cingulin and ZO-1 in cultured cells. (PMID: 12023291) D'Atri F … Citi S (The Journal of biological chemistry 2002) 3 4 23 56
- The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton. (PMID: 9792688) Fanning AS … Anderson JM (The Journal of biological chemistry 1998) 3 4 23 56
- Epidermal growth factor induces tyrosine phosphorylation and reorganization of the tight junction protein ZO-1 in A431 cells. (PMID: 7542259) Van Itallie CM … Anderson JM (Journal of cell science 1995) 3 4 23 56
- Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions. (PMID: 7798316) Furuse M … Tsukita S (The Journal of cell biology 1994) 3 4 23 56
ExternalLinks
Products for TJP1 Gene
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- Overview of 100 available TJP1 gene related products
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- Boster Bio Antibodies for TJP1
- Browse Boster Bio ELISA Kits
Sources for TJP1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
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- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
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- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
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- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
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- (142) DataMed
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- (144) genomics-online
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- (146) EPDnew
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- (150) GeneCopoeia
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