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The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor p... See more...
Aliases for TIRAP Gene
Aliases for TIRAP Gene
External Ids for TIRAP Gene
- HGNC: 17192
- NCBI Entrez Gene: 114609
- Ensembl: ENSG00000150455
- OMIM®: 606252
- UniProtKB/Swiss-Prot: P58753
Previous GeneCards Identifiers for TIRAP Gene
- GC11P128153
- GC11P127665
- GC11P126186
- GC11P125690
- GC11P125658
- GC11P122098
- GC11P126153
- GC11P126282
Summaries for TIRAP Gene
-
The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
GeneCards Summary for TIRAP Gene
TIRAP (TIR Domain Containing Adaptor Protein) is a Protein Coding gene. Diseases associated with TIRAP include Bacteremia 1 and Malaria. Among its related pathways are Bacterial infections in CF airways and Diseases associated with the TLR signaling cascade. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein binding, bridging.
UniProtKB/Swiss-Prot Summary for TIRAP Gene
-
Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.
Additional gene information for TIRAP Gene
- HGNC (17192)
- NCBI Entrez Gene (114609)
- Ensembl (ENSG00000150455)
- OMIM® (606252)
- UniProtKB/Swiss-Prot (P58753)
- Open Targets Platform(ENSG00000150455)
- Monarch Initiative
- Search for TIRAP at DataMed
- Search for TIRAP at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TIRAP Gene
Genomics for TIRAP Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for TIRAP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TIRAP on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TIRAP
- Top Transcription factor binding sites by QIAGEN in the TIRAP gene promoter:
-
- AREB6
- c-Ets-1
- E47
- FOXI1
- HFH-3
- HOXA3
- HSF1 (long)
- IRF-7A
- Tal-1beta
Genomic Locations for TIRAP Gene
Latest Assembly
- chr11:126,283,065-126,298,845
- (GRCh38/hg38)
- Size:
- 15,781 bases
- Orientation:
- Plus strand
Previous Assembly
- chr11:126,152,988-126,164,828
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 11,841 bases
- Orientation:
- Plus strand
- chr11:126,152,960-126,168,740
- (GRCh37/hg19 by Ensembl)
- Size:
- 15,781 bases
- Orientation:
- Plus strand
Genomic View for TIRAP Gene
Genes around TIRAP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q24.2 by HGNC
- 11q24.2 by Entrez Gene
- 11q24.2 by Ensembl
TIRAP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TIRAP Gene
Proteins for TIRAP Gene
-
Protein details for TIRAP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P58753-TIRAP_HUMAN
- Recommended name:
- Toll/interleukin-1 receptor domain-containing adapter protein
- Protein Accession:
- P58753
- B3KW65
- Q56UH9
- Q56UI0
- Q8N5E5
Protein attributes for TIRAP Gene
- Size:
- 221 amino acids
- Molecular mass:
- 23883 Da
- Quaternary structure:
-
- Homodimer. Also forms heterodimers with MYD88. May interact with PIK3AP1 (By similarity). Interacts with TLR4 and IRAK2 via their respective TIR domains. Interacts with BMX and TBK1. Interacts with EIF2AK2. Does not interact with IRAK1, nor TLR9.
- (Microbial infection) In case of infection, interacts with Brucella protein BtpA.
Three dimensional structures from OCA and Proteopedia for TIRAP Gene
Protein Expression for TIRAP Gene
Post-translational modifications for TIRAP Gene
- Phosphorylated by IRAK1 and IRAK4. Also phosphorylated by BTK.
- Polyubiquitinated. Polyubiquitination follows phosphorylation by BTK and leads to TIRAP degradation.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for TIRAP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences TIRAP Antibody (LS-B1414) and TIRAP Antibody (LS-B1840)
- G Biosciences Immunotag™ TIRAP Antibody
-
Custom Antibody ServicesOriGene Antibodies for TIRAP
- Novus Biologicals Antibodies for TIRAP
-
Abcam antibodies for TIRAP
- Invitrogen Antibodies for TIRAP (AFLGC-TIRAP)
- antibodies-online: Show 31 available TIRAP Antibodies ranked by validation data
- Compare Top TIRAP Antibodies
-
Recommended
- 114 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 8 IHC Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 37 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 4 IHC (p) Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 25 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
-
Boster Bio Antibodies for TIRAP
-
Custom Antibody ServicesProSci Antibodies for TIRAP
- toll-interleukin 1 receptor (TIR) domain containing adaptor protein [3155]
- toll-interleukin 1 receptor (TIR) domain containing adaptor protein [3157]
- toll-interleukin 1 receptor (TIR) domain containing adaptor protein [37-143]
- toll-interleukin 1 receptor (TIR) domain containing adaptor protein [48-979]
- toll-interleukin 1 receptor (TIR) domain containing adaptor protein [46-500]
- toll-interleukin 1 receptor (TIR) domain containing adaptor protein [46-501]
-
Santa Cruz Biotechnology (SCBT) Antibodies for TIRAP
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for TIRAP
- Origene Custom Protein Services for TIRAP
- ProSpec Recombinant Proteins for TIRAP
-
Abcam proteins for TIRAP
Assay products for research
No data available for DME Specific Peptides for TIRAP Gene
Domains & Families for TIRAP Gene
Gene Families for TIRAP Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for TIRAP Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for TIRAP Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA, FLJ93639, Homo sapiens toll-interleukin 1 receptor (TIR) domain containingadaptor protein (TIRAP), transcript variant 2, mRNA (Q56UH9_HUMAN)
- MyD88 adapter-like protein (TIRAP_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TIRAP Gene
Function for TIRAP Gene
Molecular function for TIRAP Gene
- UniProtKB/Swiss-Prot Function:
- Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.
Phenotypes From GWAS Catalog for TIRAP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005080 | protein kinase C binding | IPI | 17161867 |
| GO:0005515 | protein binding | IPI | 11544529 |
| GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding | ISS | -- |
| GO:0030674 | protein binding, bridging | NAS | 19509286 |
| GO:0035662 | Toll-like receptor 4 binding | IPI | 19509286 |
Phenotypes for TIRAP Gene
- MGI mutant phenotypes for TIRAP:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for TIRAP:
Animal Models for TIRAP Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for TIRAP - Starting at $85 >
- * TIRAP CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for TIRAP
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TIRAP
-
Santa Cruz Biotechnology (SCBT) CRISPR for TIRAP
miRNA for TIRAP Gene
- miRTarBase miRNAs that target TIRAP
-
- hsa-miR-145-5p (MIRT004748)
- mmu-miR-342-3p (MIRT577521)
- mmu-miR-433-3p (MIRT577522)
- mmu-miR-465a-5p (MIRT577523)
- mmu-miR-465c-5p (MIRT577524)
- mmu-miR-465b-5p (MIRT577525)
- mmu-miR-877-5p (MIRT577526)
- mmu-miR-129-5p (MIRT577527)
- mmu-miR-129-1-3p (MIRT577528)
- mmu-miR-129-2-3p (MIRT577529)
- mmu-miR-3085-3p (MIRT577530)
- mmu-miR-3064-5p (MIRT577531)
- mmu-miR-1896 (MIRT585667)
- hsa-miR-3157-5p (MIRT674487)
- hsa-miR-1228-3p (MIRT674488)
- hsa-miR-3187-3p (MIRT674489)
- hsa-miR-4435 (MIRT674490)
- hsa-miR-588 (MIRT674491)
- hsa-miR-4701-5p (MIRT674492)
- hsa-miR-548s (MIRT674493)
- hsa-miR-640 (MIRT674494)
- hsa-miR-203b-3p (MIRT674495)
- hsa-miR-7158-3p (MIRT674496)
- hsa-miR-378a-5p (MIRT674497)
- hsa-miR-8086 (MIRT674498)
- hsa-miR-4755-3p (MIRT674499)
- hsa-miR-6821-3p (MIRT674500)
- hsa-miR-6790-3p (MIRT674501)
- hsa-miR-4680-5p (MIRT674502)
- hsa-miR-4635 (MIRT674503)
- hsa-miR-3934-5p (MIRT674504)
- hsa-miR-764 (MIRT674505)
- hsa-miR-125a-3p (MIRT674506)
- hsa-miR-1285-3p (MIRT737036)
- hsa-miR-196a-3p (MIRT738651)
- hsa-miR-25-3p (MIRT739369)
- hsa-miR-3187-5p (MIRT740931)
- hsa-miR-32-5p (MIRT741262)
- hsa-miR-363-3p (MIRT741814)
- hsa-miR-367-3p (MIRT742130)
- hsa-miR-4325 (MIRT744084)
- hsa-miR-508-5p (MIRT749623)
- hsa-miR-5189-5p (MIRT749892)
- hsa-miR-5586-3p (MIRT750996)
- hsa-miR-612 (MIRT752234)
- hsa-miR-6512-3p (MIRT753236)
- hsa-miR-661 (MIRT753565)
- hsa-miR-6720-5p (MIRT753768)
- hsa-miR-6849-3p (MIRT757554)
- hsa-miR-6860 (MIRT757865)
- hsa-miR-766-3p (MIRT759622)
- hsa-miR-7703 (MIRT759720)
- hsa-miR-92a-3p (MIRT760632)
- hsa-miR-92b-3p (MIRT760660)
- hsa-miR-939-3p (MIRT760730)
- hsa-miR-1304-3p (MIRT762433)
- hsa-miR-1915-3p (MIRT763435)
- hsa-miR-3155a (MIRT765062)
- hsa-miR-3155b (MIRT765067)
- hsa-miR-4726-3p (MIRT771667)
- hsa-miR-4772-3p (MIRT772212)
- hsa-miR-484 (MIRT772584)
- hsa-miR-5001-3p (MIRT772911)
- hsa-miR-5571-5p (MIRT774679)
- hsa-miR-6736-3p (MIRT778052)
- hsa-miR-6764-5p (MIRT778524)
- hsa-miR-6778-3p (MIRT778834)
- hsa-miR-6787-3p (MIRT779210)
- hsa-miR-6791-3p (MIRT779298)
- hsa-miR-6829-3p (MIRT779986)
- hsa-miR-6836-3p (MIRT780055)
- hsa-miR-6840-3p (MIRT780190)
- hsa-miR-6890-3p (MIRT781150)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TIRAP
- Browse OriGene Inhibitory RNA Products For TIRAP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TIRAP
Clone products for research
- Applied Biological Materials (abm): Clones for TIRAP - Starting at $45 >
- * TIRAP as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG225270
- MG225272
- MG225273
- MG225275
- MR225270
- MR225270L3
- MR225270L4
- MR225272
- MR225272L3
- MR225272L4
- MR225273
- MR225273L3
- MR225273L4
- MR225275
- MR225275L3
- MR225275L4
- RC207162
- RC207162L1
- RC207162L2
- RC207162L3
- RC207162L4
- RC224866
- RC224866L3
- RC224866L4
- RG207162
- RG224866
- MR225270L3V
- MR225270L4V
- MR225272L3V
- MR225272L4V
- MR225273L3V
- MR225273L4V
- MR225275L3V
- MR225275L4V
- RC207162L1V
- RC207162L2V
- RC207162L3V
- RC207162L4V
- RC224866L3V
- RC224866L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TIRAP
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TIRAP
Cell Lines for research
-
Horizon Cell Lines for TIRAP
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TIRAP Gene
Localization for TIRAP Gene
Subcellular locations from UniProtKB/Swiss-Prot for TIRAP Gene
- Cytoplasm. Cell membrane. Membrane. Note=Colocalizes with DAB2IP at the plasma membrane.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytosol | 5 |
| nucleus | 4 |
| endosome | 3 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| golgi apparatus | 1 |
- Cytokinetic bridge (2)
- Cytosol (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA,IDA | 19948740 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0030139 | endocytic vesicle | ISS | -- |
Pathways & Interactions for TIRAP Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated TLR4 signalling | ||
| 2 | Diseases associated with the TLR signaling cascade | ||
| 3 | Toll-like Receptor Signaling Pathway |
.37
|
|
| 4 | Toll-Like receptor Signaling Pathways |
Mucin expression in CF via TLRs, EGFR signaling pathways
.42
Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
.33
|
|
| 5 | Bacterial infections in CF airways |
Bacterial infections in CF airways
.78
Immune response Bacterial infections in normal airways
.78
|
Immune response TLR signaling pathways
.46
|
Pathways by source for TIRAP Gene
5 BioSystems pathways for TIRAP Gene
18 Reactome pathways for TIRAP Gene
8 KEGG pathways for TIRAP Gene
5 GeneGo (Thomson Reuters) pathways for TIRAP Gene
- Bacterial infections in CF airways
- Immune response Bacterial infections in normal airways
- Immune response TLR signaling pathways
- Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
- Mucin expression in CF via TLRs, EGFR signaling pathways
2 R&D Systems pathways for TIRAP Gene
5 Qiagen pathways for TIRAP Gene
- Tec Kinases Signaling
- TLR-TRIF Pathway
- Toll Comparative Pathway
- Toll-Like Receptors Pathway
- TRAF Pathway
1 GeneTex pathway for TIRAP Gene
Interacting Proteins for TIRAP Gene
Selected Interacting proteins:
P58753-TIRAP_HUMAN
ENSP00000376445
for TIRAP Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for TIRAP
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002376 | immune system process | IEA | -- |
| GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | TAS | 19509286 |
| GO:0006954 | inflammatory response | IEA | -- |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007166 | cell surface receptor signaling pathway | ISS | -- |
Drugs & Compounds for TIRAP Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Ustekinumab | Approved, Investigational | Pharma | 151 |
Transcripts for TIRAP Gene
mRNA/cDNA for TIRAP Gene
- 5 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000392678 1264 nts (view in UCSC)
- ENST00000392679 2189 nts (view in UCSC)
- ENST00000392680 2068 nts (view in UCSC)
- ENST00000462401 545 nts (view in UCSC)
- ENST00000467006 567 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for TIRAP - Starting at $85 >
- * TIRAP CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for TIRAP
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TIRAP
-
Santa Cruz Biotechnology (SCBT) CRISPR for TIRAP
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TIRAP
- Browse OriGene Inhibitory RNA Products For TIRAP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TIRAP
Clone products for research
- Applied Biological Materials (abm): Clones for TIRAP - Starting at $45 >
- * TIRAP as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG225270
- MG225272
- MG225273
- MG225275
- MR225270
- MR225270L3
- MR225270L4
- MR225272
- MR225272L3
- MR225272L4
- MR225273
- MR225273L3
- MR225273L4
- MR225275
- MR225275L3
- MR225275L4
- RC207162
- RC207162L1
- RC207162L2
- RC207162L3
- RC207162L4
- RC224866
- RC224866L3
- RC224866L4
- RG207162
- RG224866
- MR225270L3V
- MR225270L4V
- MR225272L3V
- MR225272L4V
- MR225273L3V
- MR225273L4V
- MR225275L3V
- MR225275L4V
- RC207162L1V
- RC207162L2V
- RC207162L3V
- RC207162L4V
- RC224866L3V
- RC224866L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TIRAP
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TIRAP
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9a | · | 9b | · | 9c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - |
Relevant External Links for TIRAP Gene
- GeneLoc Exon Structure for
- TIRAP
Expression for TIRAP Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Stomach (Gastrointestinal Tract)
This gene is overexpressed in Monocytes (34.5), CD4 Tcells (20.5), and Placenta (14.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TIRAP Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TIRAP
SOURCE GeneReport for Unigene cluster for TIRAP Gene:
Hs.537126mRNA Expression by UniProt/SwissProt for TIRAP Gene:
P58753-TIRAP_HUMAN
Tissue specificity:
Highly expressed in liver, kidney, spleen, skeletal muscle and heart. Also detected in peripheral blood leukocytes, lung, placenta, small intestine, thymus, colon and brain.
Evidence on tissue expression from TISSUES for TIRAP Gene
- Spleen(4.5)
- Blood(4.5)
- Lymph node(4.5)
- Nervous system(4.4)
- Heart(2.5)
- Kidney(2.4)
- Muscle(2.3)
- Intestine(2.2)
- Liver(2.1)
- Bone marrow(2.1)
- Skin(2.1)
Primer products for research
-
OriGene qPCR primer pairs for TIRAP
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TIRAP Gene
Orthologs for TIRAP Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | TIRAP 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | TIRAP 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | TIRAP 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Tirap 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Tirap 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | TIRAP 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | TIRAP 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | TIRAP 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | TIRAP 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100491693 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | tirap 30 31 |
|
OneToOne |
- Species where no ortholog for TIRAP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for TIRAP Gene
- ENSEMBL:
- Gene Tree for TIRAP (if available)
- TreeFam:
- Gene Tree for TIRAP (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TIRAP: view image
Paralogs for TIRAP Gene
No data available for Paralogs for TIRAP Gene
Variants for TIRAP Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for TIRAP Gene
- TIRAP_HUMAN-P58753
- Genetic variations in TIRAP may influence susceptibility or resistance to invasive pneumococcal disease, malaria [MIM:611162], and tuberculosis [MIM:607948]. It may define the bacteremia susceptibility locus 1 (BACTS1) [MIM:614382].
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TIRAP Gene
| SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs8177374 | Protective: Bacteremia, resistance to; Mycobacterium tuberculosis, protection against; Invasive pneumococcal disease, protection against; Malaria, resistance to. - | 126,292,948(+) |
C/Tp.Ser180Leu NM_148910.2(TIRAP):c.539C>T (p.Ser180Leu) |
MISSENSE | |
| rs3802813 | - |
p.Ser55Asn |
|||
| rs7932976 | - |
p.Val197Ile |
|||
| rs8177369 | - |
p.Ala9Pro |
|||
| rs8177399 | - |
p.Arg13Trp |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2660319 | CNV | deletion | 23128226 |
| esv2664251 | CNV | deletion | 23128226 |
| esv2762950 | CNV | loss | 21179565 |
| esv3628001 | CNV | loss | 21293372 |
| esv3628002 | CNV | loss | 21293372 |
| nsv556530 | CNV | loss | 21841781 |
| nsv826122 | CNV | loss | 20364138 |
Residual Variation Intolerance Score:
89.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.46;
71.54% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TIRAP Gene
SNP Genotyping and Copy Number Assays for research
Disorders for TIRAP Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| bacteremia 1 |
|
|
| malaria |
|
|
| pertussis |
|
|
| bacteriuria |
|
|
| pelvic inflammatory disease |
|
|
Search TIRAP in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TIRAP
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for TIRAP Gene
Publications for TIRAP Gene
- A polymorphism in Toll-interleukin 1 receptor domain containing adaptor protein is associated with susceptibility to meningeal tuberculosis. (PMID: 16991088) Hawn TR … Aderem A (The Journal of infectious diseases 2006) 3 23 41 74
- Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. (PMID: 11544529) Fitzgerald KA … O'Neill LA (Nature 2001) 2 3 4 23
- AIP1 functions as Arf6-GAP to negatively regulate TLR4 signaling. (PMID: 19948740) Wan T … Min W (The Journal of biological chemistry 2010) 3 4 23
- A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling. (PMID: 19509286) Nagpal K … Golenbock DT (The Journal of biological chemistry 2009) 3 4 23
- Low frequency of the TIRAP S180L polymorphism in Africa, and its potential role in malaria, sepsis, and leprosy. (PMID: 19602285) Hamann L … Schumann RR (BMC medical genetics 2009) 3 4 41
ExternalLinks
Products for TIRAP Gene
- Custom Antibody ServicesOriGene Antibodies for TIRAP
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for TIRAP
- Origene Custom Protein Services for TIRAP
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TIRAP
- Browse OriGene Inhibitory RNA Products For TIRAP
- OriGene qPCR primer pairs for TIRAP
- OriGene CRISPR knockouts for TIRAP
- MG225270
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- MR225270
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- RC207162
- RC207162L1
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- RC207162L1V
- RC207162L2V
- RC207162L3V
- RC207162L4V
- RC224866L3V
- RC224866L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For TIRAP
- Sino Biological Human cDNA Clone for TIRAP
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for TIRAP
- Novus Biologicals proteins and lysates for TIRAP
- Browse Antibodies
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- Abcam antibodies for TIRAP
- Abcam proteins for TIRAP
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- Browse Primary Antibodies
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- VectorBuilder Custom and pre-made DNA vectors for TIRAP (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for TIRAP (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for TIRAP (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for TIRAP CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for TIRAP
- antibodies-online: Show 31 available TIRAP Antibodies ranked by validation data
- Compare Top TIRAP Antibodies
- Recommended
- 114 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 8 IHC Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 37 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 4 IHC (p) Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 25 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- antibodies-online: Show 13 available TIRAP Elisa Kits ranked by validation data
- Compare Top TIRAP Elisa Kits
- antibodies-online: Show 7 available TIRAP Proteins ranked by validation data
- Compare Top TIRAP Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for TIRAP
- Search Santa Cruz Biotechnology (SCBT) for TIRAP siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TIRAP
- Custom Antibody ServicesProSci Antibodies for TIRAP
- toll-interleukin 1 receptor (TIR) domain containing adaptor protein [3155]
- toll-interleukin 1 receptor (TIR) domain containing adaptor protein [3157]
- toll-interleukin 1 receptor (TIR) domain containing adaptor protein [37-143]
- toll-interleukin 1 receptor (TIR) domain containing adaptor protein [48-979]
- toll-interleukin 1 receptor (TIR) domain containing adaptor protein [46-500]
- toll-interleukin 1 receptor (TIR) domain containing adaptor protein [46-501]
- Search for TIRAP Proteins at ProSci
- Horizon Cell Lines for TIRAP
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TIRAP
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TIRAP
- Search GeneCopoeia for miRNA 3'UTR Target clone products for TIRAP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TIRAP
- Boster Bio Antibodies for TIRAP
- Browse Boster Bio ELISA Kits
Sources for TIRAP Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB