Aliases for TIRAP Gene
Aliases for TIRAP Gene
- TIR Domain Containing Adaptor Protein 2 3 5
- MyD88 Adapter-Like Protein 3 4
- Adaptor Protein Wyatt 3 4
- MyD88-2 3 4
- MAL 3 4
- Toll-Interleukin 1 Receptor (TIR) Domain-Containing Adaptor Protein 2
- Toll-Interleukin 1 Receptor (TIR) Domain Containing Adaptor Protein 3
- Toll/Interleukin-1 Receptor Domain-Containing Adapter Protein 3
External Ids for TIRAP Gene
- HGNC: 17192
- Entrez Gene: 114609
- Ensembl: ENSG00000150455
- OMIM: 606252
- UniProtKB: P58753
Previous GeneCards Identifiers for TIRAP Gene
- GC11P128153
- GC11P127665
- GC11P126186
- GC11P125690
- GC11P125658
- GC11P122098
- GC11P126153
Summaries for TIRAP Gene
-
The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
GeneCards Summary for TIRAP Gene
TIRAP (TIR Domain Containing Adaptor Protein) is a Protein Coding gene. Diseases associated with TIRAP include Bacteremia 1 and Invasive Pneumococcal Disease, Recurrent Isolated, 1. Among its related pathways are Bacterial infections in CF airways and Akt Signaling. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein binding, bridging.
UniProtKB/Swiss-Prot for TIRAP Gene
-
Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.
Additional gene information for TIRAP Gene
- Monarch Initiative
- Search for TIRAP at DataMed
- Search for TIRAP at HumanCyc
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIRAP Gene
Genomics for TIRAP Gene
GeneHancer (GH) Regulatory Elements for TIRAP Gene
Promoters and enhancers for TIRAP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around TIRAP on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the TIRAP gene promoter:
Regulatory Element Products
Genomic Locations for TIRAP Gene
Genomic Locations for TIRAP Gene
- chr11:126,281,893-126,298,845
- (GRCh38/hg38)
- Size:
- 16,953 bases
- Orientation:
- Plus strand
- chr11:126,152,960-126,168,740
- (GRCh37/hg19)
Genomic View for TIRAP Gene
Genes around TIRAP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q24.2 by Ensembl
- 11q24.2 by Entrez Gene
- 11q24.2 by HGNC
TIRAP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TIRAP Gene
Proteins for TIRAP Gene
-
Protein details for TIRAP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P58753-TIRAP_HUMAN
- Recommended name:
- Toll/interleukin-1 receptor domain-containing adapter protein
- Protein Accession:
- P58753
- B3KW65
- Q56UH9
- Q56UI0
- Q8N5E5
Protein attributes for TIRAP Gene
- Size:
- 221 amino acids
- Molecular mass:
- 23883 Da
- Quaternary structure:
-
- Homodimer. Also forms heterodimers with MYD88. May interact with PIK3AP1 (By similarity). Interacts with TLR4 and IRAK2 via their respective TIR domains. Interacts with BMX and TBK1. Interacts with EIF2AK2. Does not interact with IRAK1, nor TLR9.
Three dimensional structures from OCA and Proteopedia for TIRAP Gene
Protein Expression for TIRAP Gene
Post-translational modifications for TIRAP Gene
- Phosphorylated by IRAK1 and IRAK4. Also phosphorylated by BTK.
- Polyubiquitinated. Polyubiquitination follows phosphorylation by BTK and leads to TIRAP degradation.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for TIRAP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for TIRAP
- Novus Biologicals Antibodies for TIRAP
-
Abcam antibodies for TIRAP
-
Cloud-Clone Corp. Antibodies for TIRAP
- Invitrogen Antibodies for TIRAP
- antibodies-online: Search results for 144 available TIRAP Antibodies ranked by validation data
- Compare Top TIRAP Antibodies
-
Recommended
- 3 IHC (p) Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 25 WB Antibodies (anti-rat)
- 2 IHC Antibodies (anti-mouse)
- 4 IHC (p) Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 35 WB Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 97 WB Antibodies (anti-human)
- GeneTex TIRAP antibody for TIRAP
-
Santa Cruz Biotechnology (SCBT) Antibodies for TIRAP
Protein Products
-
OriGene Purified Proteins for TIRAP
- Search Origene for MassSpec and Protein Over-expression Lysates for TIRAP
- Origene Custom Protein Services for TIRAP
- ProSpec Recombinant Proteins for TIRAP
-
Cloud-Clone Corp. Proteins for TIRAP
- Search GeneTex for Proteins for TIRAP
-
Abcam proteins for TIRAP
Assay Products
-
Cloud-Clone Corp. Assay Kits for TIRAP
No data available for DME Specific Peptides for TIRAP Gene
Domains & Families for TIRAP Gene
Gene Families for TIRAP Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for TIRAP Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for TIRAP Gene
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for TIRAP Gene
Function for TIRAP Gene
Molecular function for TIRAP Gene
- UniProtKB/Swiss-Prot Function:
- Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.
Phenotypes From GWAS Catalog for TIRAP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005080 | protein kinase C binding | IPI | 17161867 |
| GO:0005515 | protein binding | IPI | 11544529 |
| GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding | ISS | -- |
| GO:0030674 | protein binding, bridging | NAS | 19509286 |
| GO:0035662 | Toll-like receptor 4 binding | IPI | 19509286 |
Phenotypes for TIRAP Gene
- MGI mutant phenotypes for TIRAP:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for TIRAP:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for TIRAP
-
-
ViGene Biosciences lentiviral particle packaged cDNA for TIRAP gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TIRAP gene
- Search ViGene Biosciences for TIRAP
CRISPR Products
-
OriGene CRISPR knockouts for TIRAP
- genomics-online: gRNA clones - Search results for 93 available TIRAP gene related products
- Overview of 93 available TIRAP gene related products
- Applied Biological Materials CRISPR for TIRAP
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TIRAP
- GenScript: Design CRISPR guide RNA sequences for TIRAP
miRNA for TIRAP Gene
- miRTarBase miRNAs that target TIRAP
-
- hsa-mir-145-5p (MIRT004748)
- hsa-mir-3157-5p (MIRT674487)
- hsa-mir-1228-3p (MIRT674488)
- hsa-mir-3187-3p (MIRT674489)
- hsa-mir-4435 (MIRT674490)
- hsa-mir-588 (MIRT674491)
- hsa-mir-4701-5p (MIRT674492)
- hsa-mir-548s (MIRT674493)
- hsa-mir-640 (MIRT674494)
- hsa-mir-203b-3p (MIRT674495)
- hsa-mir-7158-3p (MIRT674496)
- hsa-mir-378a-5p (MIRT674497)
- hsa-mir-8086 (MIRT674498)
- hsa-mir-4755-3p (MIRT674499)
- hsa-mir-6821-3p (MIRT674500)
- hsa-mir-6790-3p (MIRT674501)
- hsa-mir-4680-5p (MIRT674502)
- hsa-mir-4635 (MIRT674503)
- hsa-mir-3934-5p (MIRT674504)
- hsa-mir-764 (MIRT674505)
- hsa-mir-125a-3p (MIRT674506)
- hsa-mir-1285-3p (MIRT737036)
- hsa-mir-196a-3p (MIRT738651)
- hsa-mir-25-3p (MIRT739369)
- hsa-mir-3187-5p (MIRT740931)
- hsa-mir-32-5p (MIRT741262)
- hsa-mir-363-3p (MIRT741814)
- hsa-mir-367-3p (MIRT742130)
- hsa-mir-4325 (MIRT744084)
- hsa-mir-508-5p (MIRT749623)
- hsa-mir-5189-5p (MIRT749892)
- hsa-mir-5586-3p (MIRT750996)
- hsa-mir-612 (MIRT752234)
- hsa-mir-6512-3p (MIRT753236)
- hsa-mir-661 (MIRT753565)
- hsa-mir-6720-5p (MIRT753768)
- hsa-mir-6849-3p (MIRT757554)
- hsa-mir-6860 (MIRT757865)
- hsa-mir-766-3p (MIRT759622)
- hsa-mir-7703 (MIRT759720)
- hsa-mir-92a-3p (MIRT760632)
- hsa-mir-92b-3p (MIRT760660)
- hsa-mir-939-3p (MIRT760730)
- hsa-mir-1304-3p (MIRT762433)
- hsa-mir-1915-3p (MIRT763435)
- hsa-mir-3155a (MIRT765062)
- hsa-mir-3155b (MIRT765067)
- hsa-mir-4726-3p (MIRT771667)
- hsa-mir-4772-3p (MIRT772212)
- hsa-mir-484 (MIRT772584)
- hsa-mir-5001-3p (MIRT772911)
- hsa-mir-5571-5p (MIRT774679)
- hsa-mir-6736-3p (MIRT778052)
- hsa-mir-6764-5p (MIRT778524)
- hsa-mir-6778-3p (MIRT778834)
- hsa-mir-6787-3p (MIRT779210)
- hsa-mir-6791-3p (MIRT779298)
- hsa-mir-6829-3p (MIRT779986)
- hsa-mir-6836-3p (MIRT780055)
- hsa-mir-6840-3p (MIRT780190)
- hsa-mir-6890-3p (MIRT781150)
miRNA Products
- Search ViGene Biosciences for TIRAP
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TIRAP
- Browse OriGene Inhibitory RNA Products For TIRAP
- genomics-online: shRNA clones - Search results for 93 available TIRAP gene related products
- Overview of 93 available TIRAP gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TIRAP gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for TIRAP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TIRAP
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for TIRAP
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- Browse cDNA clones at Cloud-Clone Corp.
-
Cloud-Clone Corp. primers for TIRAP
Cell Line Products
-
Horizon Cell Lines for TIRAP
-
ViGene Biosciences adenoviral particle packaged cDNA for TIRAP gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TIRAP gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TIRAP gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TIRAP Gene
Localization for TIRAP Gene
Subcellular locations from UniProtKB/Swiss-Prot for TIRAP Gene
- Cytoplasm. Cell membrane. Membrane. Note=Colocalizes with DAB2IP at the plasma membrane.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytosol | 5 |
| nucleus | 4 |
| endosome | 2 |
- Cytokinetic bridge (2)
- Cytosol (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IDA,IEA | 19948740 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0030139 | endocytic vesicle | ISS | -- |
Pathways & Interactions for TIRAP Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated TLR4 signalling | ||
| 2 | Diseases associated with the TLR signaling cascade | ||
| 3 | Bacterial infections in CF airways | ||
| 4 | Toll-like receptor signaling pathway | ||
| 5 | Toll Comparative Pathway |
.61
|
|
Pathways by source for TIRAP Gene
1 GeneTex pathway for TIRAP Gene
4 BioSystems pathways for TIRAP Gene
18 Reactome pathways for TIRAP Gene
5 KEGG pathways for TIRAP Gene
5 GeneGo (Thomson Reuters) pathways for TIRAP Gene
5 Qiagen pathways for TIRAP Gene
Interacting Proteins for TIRAP Gene
Selected Interacting proteins:
P58753-TIRAP_HUMAN
ENSP00000376445
for TIRAP Gene via
IID
STRING
UniProtKB
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | TAS | 19509286 |
| GO:0006954 | inflammatory response | IEA | -- |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007166 | cell surface receptor signaling pathway | ISS | -- |
| GO:0007250 | activation of NF-kappaB-inducing kinase activity | IMP | 24275656 |
Transcripts for TIRAP Gene
mRNA/cDNA for TIRAP Gene
- (9) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (65) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TIRAP Gene
- Toll-interleukin 1 receptor (TIR) domain containing adaptor protein:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for TIRAP
- genomics-online: gRNA clones - Search results for 93 available TIRAP gene related products
- Overview of 93 available TIRAP gene related products
- Applied Biological Materials CRISPR for TIRAP
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TIRAP
- GenScript: Design CRISPR guide RNA sequences for TIRAP
miRNA Products
- Search ViGene Biosciences for TIRAP
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TIRAP
- Browse OriGene Inhibitory RNA Products For TIRAP
- genomics-online: shRNA clones - Search results for 93 available TIRAP gene related products
- Overview of 93 available TIRAP gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TIRAP gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for TIRAP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TIRAP
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for TIRAP
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- Browse cDNA clones at Cloud-Clone Corp.
-
Cloud-Clone Corp. primers for TIRAP
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9a | · | 9b | · | 9c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - |
Expression for TIRAP Gene
This gene is overexpressed in Monocytes (34.5), CD4 Tcells (20.5), and Placenta (14.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TIRAP Gene
NURSA nuclear receptor signaling pathways regulating expression of TIRAP Gene:
TIRAPSOURCE GeneReport for Unigene cluster for TIRAP Gene:
Hs.537126mRNA Expression by UniProt/SwissProt for TIRAP Gene:
P58753-TIRAP_HUMAN
Tissue specificity:
Highly expressed in liver, kidney, spleen, skeletal muscle and heart. Also detected in peripheral blood leukocytes, lung, placenta, small intestine, thymus, colon and brain.
Evidence on tissue expression from TISSUES for TIRAP Gene
- Blood(4.4)
- Spleen(4.4)
- Lymph node(4.3)
- Nervous system(4.1)
Primer Products
-
OriGene qPCR primer pairs for TIRAP
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TIRAP Gene
Orthologs for TIRAP Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TIRAP 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | TIRAP 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | TIRAP 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Tirap 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Tirap 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | TIRAP 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | TIRAP 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | TIRAP 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | TIRAP 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100491693 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | tirap 33 34 |
|
- Species where no ortholog for TIRAP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for TIRAP Gene
No data available for Paralogs for TIRAP Gene
Variants for TIRAP Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for TIRAP Gene
- TIRAP_HUMAN-P58753
- Genetic variations in TIRAP may influence susceptibility or resistance to invasive pneumococcal disease [MIM:610799], malaria [MIM:611162], and tuberculosis [MIM:607948]. It may define the bacteremia susceptibility locus 1 (BACTS1) [MIM:614382].
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs8177374 | protective, Invasive pneumococcal disease, protection against, Malaria, resistance to, Mycobacterium tuberculosis, protection against, Bacteremia, resistance to | 126,292,948(+) | C/T | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
| rs1000316851 | -- | 126,288,156(+) | A/C | genic_upstream_transcript_variant, intron_variant, non_coding_transcript_variant, upstream_transcript_variant | |
| rs1000339157 | -- | 126,294,684(+) | A/G | 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant | |
| rs1000448835 | -- | 126,283,139(+) | T/A | 5_prime_UTR_variant, coding_sequence_variant, genic_upstream_transcript_variant, missense_variant, non_coding_transcript_variant | |
| rs1000475176 | -- | 126,294,286(+) | T/A | 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2660319 | CNV | deletion | 23128226 |
| esv2664251 | CNV | deletion | 23128226 |
| esv2762950 | CNV | loss | 21179565 |
| esv3628001 | CNV | loss | 21293372 |
| esv3628002 | CNV | loss | 21293372 |
| nsv556530 | CNV | loss | 21841781 |
| nsv826122 | CNV | loss | 20364138 |
Residual Variation Intolerance Score:
89.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.46;
71.54% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TIRAP Gene
SNP Genotyping and Copy Number Assay Products
Disorders for TIRAP Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| bacteremia 1 |
|
|
| invasive pneumococcal disease, recurrent isolated, 1 |
|
|
| malaria |
|
|
| pelvic inflammatory disease |
|
|
| epiglottitis |
|
|
Search TIRAP in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TIRAP
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for TIRAP Gene
Publications for TIRAP Gene
- Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. (PMID: 11544529) Fitzgerald KA … O'Neill LA (Nature 2001) 2 3 4 22 58
- AIP1 functions as Arf6-GAP to negatively regulate TLR4 signaling. (PMID: 19948740) Wan T … Min W (The Journal of biological chemistry 2010) 3 4 22 58
- A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling. (PMID: 19509286) Nagpal K … Golenbock DT (The Journal of biological chemistry 2009) 3 4 22 58
- Low frequency of the TIRAP S180L polymorphism in Africa, and its potential role in malaria, sepsis, and leprosy. (PMID: 19602285) Hamann L … Schumann RR (BMC medical genetics 2009) 3 4 44 58
- Polymorphic variation in TIRAP is not associated with susceptibility to childhood TB but may determine susceptibility to TBM in some ethnic groups. (PMID: 19693265) Dissanayeke SR … Levin M (PloS one 2009) 3 22 44 58
Products for TIRAP Gene
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- Custom Antibody ServicesOriGene Antibodies for TIRAP
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- ProSpec Recombinant Proteins for TIRAP
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- Browse Knockouts at Cloud-Clone Corp.
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- Cloud-Clone Corp. disease models service
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- Cloud-Clone Corp. primers for TIRAP
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- Cyagen custom Knockout/knockin (KOKI) mouse models for TIRAP
- VectorBuilder custom plasmid, inducible vectors for TIRAP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TIRAP
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 144 available TIRAP Antibodies ranked by validation data
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- 97 WB Antibodies (anti-human)
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- 3 IHC Antibodies (anti-human)
- 35 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 4 IHC (p) Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 25 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- antibodies-online: Search results for 11 available TIRAP Elisa Kits ranked by validation data
- Compare Top TIRAP Elisa Kits
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- antibodies-online: Search results for 7 available TIRAP Proteins ranked by validation data
- Compare Top TIRAP Proteins
- GeneTex TIRAP antibody for TIRAP
- Search GeneTex for Proteins for TIRAP
- ViGene Biosciences adenoviral particle packaged cDNA for TIRAP gene
- ViGene Biosciences lentiviral particle packaged cDNA for TIRAP gene
- ViGene Biosciences ready-to-package AAV shRNAs for TIRAP gene
- Search ViGene Biosciences for TIRAP
- Santa Cruz Biotechnology (SCBT) Antibodies for TIRAP
- Search Santa Cruz Biotechnology (SCBT) for TIRAP siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TIRAP
- Horizon Cell Lines for TIRAP
- genomics-online: cdna clones - Search results for 93 available TIRAP gene related products
- Overview of 93 available TIRAP gene related products
- orf clones - Search results for 93 available TIRAP gene related products
- Overview of 93 available TIRAP gene related products
- genomics-online: gRNA clones - Search results for 93 available TIRAP gene related products
- Overview of 93 available TIRAP gene related products
- genomics-online: primer clones - Search results for 93 available TIRAP gene related products
- Overview of 93 available TIRAP gene related products
- genomics-online: shRNA clones - Search results for 93 available TIRAP gene related products
- Overview of 93 available TIRAP gene related products
Sources for TIRAP Gene
- (1) GeneCards
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- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
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- (7) GeneLoc
- (8) Gene Wiki
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- (23) PharmGKB
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- (28) ASD
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- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
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- (36) SGD
- (37) FlyBase
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- (39) Pseudogene
- (40) DGV
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- (42) GenAtlas
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- (47) Atlas
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- (52) HUGE
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- (54) Leiden
- (55) miRBase
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- (58) PubMed
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- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
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- (105) Taconic Biosciences
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- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
