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Aliases for TIPRL Gene

Aliases for TIPRL Gene

  • TOR Signaling Pathway Regulator 2 3 5
  • Putative MAPK-Activating Protein PM10 3 4
  • Type 2A-Interacting Protein 3 4
  • TIP41-Like Protein 3 4
  • TIP 3 4
  • TIP41, TOR Signaling Pathway Regulator-Like (S. Cerevisiae) 2
  • TIP41, TOR Signaling Pathway Regulator-Like 3
  • TIPRL1 3
  • TIP41 3

External Ids for TIPRL Gene

Previous GeneCards Identifiers for TIPRL Gene

  • GC01P164880
  • GC01P166414
  • GC01P139392

Summaries for TIPRL Gene

Entrez Gene Summary for TIPRL Gene

  • TIPRL is an inhibitory regulator of protein phosphatase-2A (PP2A) (see PPP2CA; MIM 176915), PP4 (see PPP4C; MIM 602035), and PP6 (see PPP6C; MIM 612725) (McConnell et al., 2007 [PubMed 17384681]).[supplied by OMIM, Nov 2010]

GeneCards Summary for TIPRL Gene

TIPRL (TOR Signaling Pathway Regulator) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TIPRL Gene

  • May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AFX phosphorylated on Ser-140 (gamma-H2AFX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair.

Additional gene information for TIPRL Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIPRL Gene

Genomics for TIPRL Gene

GeneHancer (GH) Regulatory Elements for TIPRL Gene

Promoters and enhancers for TIPRL Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J168177 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 611.6 +0.5 479 3 ZFX CC2D1A ELF3 SIX5 ZNF148 NKRF POLR2A MLLT1 CEBPG GTF2F1 TIPRL MPZL1 POU2F1 GPR161 MPC2 RPL34P1 GC01M168113
GH01J168135 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 20.1 -42.0 -42044 3.2 ZFX MLLT1 ZSCAN21 SP7 PRDM1 MZF1 GLIS2 POLR2A PKNOX1 IKZF1 GPR161 TIPRL SFT2D2 MPC2 GC01M168079 GC01M168113
GH01J167718 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.3 -457.3 -457343 5.8 CC2D1A ZFX SP1 CTCF ELF3 CBFA2T2 ZNF148 NKRF MLLT1 ZNF121 MPZL1 GC01M167719 ENSG00000232194 ENSG00000250762 TIPRL
GH01J168202 Enhancer 1 Ensembl ENCODE 23.7 +24.5 24469 1.6 CEBPG ZNF644 KAT8 HMG20B SOX13 CEBPA GATAD2A RCOR2 IRF2 CEBPB TIPRL SFT2D2 MPC2 RPL34P1 GC01M168113
GH01J168225 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.9 +48.2 48156 4.8 ZFX ELF3 ZKSCAN8 MNT ZNF148 NKRF POLR2A ZNF121 GTF2F1 CSDE1 TBX19 SFT2D2 RNU6-1310P TIPRL MPZL1 PIR32870 GC01P168246 GC01M168113
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TIPRL on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TIPRL gene promoter:
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta
  • AP-2gamma
  • Cdc5
  • Evi-1
  • FOXJ2 (long isoform)
  • Nkx2-5
  • Pbx1a

Genomic Locations for TIPRL Gene

Genomic Locations for TIPRL Gene
chr1:168,178,845-168,202,114
(GRCh38/hg38)
Size:
23,270 bases
Orientation:
Plus strand
chr1:168,148,171-168,171,352
(GRCh37/hg19)
Size:
23,182 bases
Orientation:
Plus strand

Genomic View for TIPRL Gene

Genes around TIPRL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIPRL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIPRL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIPRL Gene

Proteins for TIPRL Gene

  • Protein details for TIPRL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75663-TIPRL_HUMAN
    Recommended name:
    TIP41-like protein
    Protein Accession:
    O75663
    Secondary Accessions:
    • B2R8V3
    • Q5HYB2
    • Q8IZ86

    Protein attributes for TIPRL Gene

    Size:
    272 amino acids
    Molecular mass:
    31444 Da
    Quaternary structure:
    • Isoform 1 interacts with PPP2CA. Isoform 2 does not interact with PPP2CA. Interacts with PPP2CB, PPP4C and PPP6C. Interacts with IGBP1; the interaction is dependent on PPP2CA. Associates with a protein phosphatase 2A PP2A(C):IGBP1 complex. Interacts with PPP4C and PPP4R2.

    Three dimensional structures from OCA and Proteopedia for TIPRL Gene

    Alternative splice isoforms for TIPRL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TIPRL Gene

Post-translational modifications for TIPRL Gene

  • Ubiquitination at isoforms=267, posLast=128128, isoforms=2106, isoforms=284, isoforms=207, and isoforms=2117
  • Modification sites at PhosphoSitePlus

Other Protein References for TIPRL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TIPRL Gene

Domains & Families for TIPRL Gene

Gene Families for TIPRL Gene

Protein Domains for TIPRL Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TIPRL Gene

GenScript: Design optimal peptide antigens:
  • Type 2A-interacting protein (TIPRL_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75663

UniProtKB/Swiss-Prot:

TIPRL_HUMAN :
  • Belongs to the TIP41 family.
Family:
  • Belongs to the TIP41 family.
genes like me logo Genes that share domains with TIPRL: view

Function for TIPRL Gene

Molecular function for TIPRL Gene

UniProtKB/Swiss-Prot Function:
May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AFX phosphorylated on Ser-140 (gamma-H2AFX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair.

Phenotypes From GWAS Catalog for TIPRL Gene

Gene Ontology (GO) - Molecular Function for TIPRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16085932
genes like me logo Genes that share ontologies with TIPRL: view
genes like me logo Genes that share phenotypes with TIPRL: view

Animal Models for TIPRL Gene

MGI Knock Outs for TIPRL:
  • Tiprl Tiprl<tm1.1(KOMP)Vlcg>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TIPRL

Clone Products

  • Applied Biological Materials (abm): Clones for TIPRL - Now 50% OFF >
  • * TIPRL as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * TIPRL tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TIPRL Gene

Localization for TIPRL Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIPRL Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TIPRL gene
Compartment Confidence
cytosol 4
nucleus 2
cytoskeleton 1
extracellular 0
mitochondrion 0
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Vesicles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TIPRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IBA 21873635
genes like me logo Genes that share ontologies with TIPRL: view

Pathways & Interactions for TIPRL Gene

PathCards logo

SuperPathways for TIPRL Gene

No Data Available

Gene Ontology (GO) - Biological Process for TIPRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000077 DNA damage checkpoint IMP 17384681
GO:0007165 signal transduction IBA 21873635
GO:0031929 TOR signaling IBA 21873635
GO:0032515 negative regulation of phosphoprotein phosphatase activity IDA 17384681
genes like me logo Genes that share ontologies with TIPRL: view

No data available for Pathways by source and SIGNOR curated interactions for TIPRL Gene

Drugs & Compounds for TIPRL Gene

No Compound Related Data Available

Transcripts for TIPRL Gene

mRNA/cDNA for TIPRL Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(85) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for TIPRL Gene

TIP41, TOR signaling pathway regulator-like (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TIPRL

Clone Products

  • Applied Biological Materials (abm): Clones for TIPRL - Now 50% OFF >
  • * TIPRL as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * TIPRL tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for TIPRL Gene

No ASD Table

Relevant External Links for TIPRL Gene

GeneLoc Exon Structure for
TIPRL
ECgene alternative splicing isoforms for
TIPRL

Expression for TIPRL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TIPRL Gene

Protein differential expression in normal tissues from HIPED for TIPRL Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TIPRL Gene



Protein tissue co-expression partners for TIPRL Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TIPRL Gene:

TIPRL

SOURCE GeneReport for Unigene cluster for TIPRL Gene:

Hs.209431

Evidence on tissue expression from TISSUES for TIPRL Gene

  • Lung(4.2)
  • Muscle(4.2)
genes like me logo Genes that share expression patterns with TIPRL: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TIPRL Gene

Orthologs for TIPRL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TIPRL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TIPRL 35 34
  • 99.75 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TIPRL 35 34
  • 94.24 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TIPRL 35 34
  • 93.98 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 91 (a)
OneToMany
-- 35
  • 90 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tiprl 34
  • 90.92 (n)
mouse
(Mus musculus)
Mammalia Tiprl 17 35 34
  • 90.8 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TIPRL 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves TIPRL 35 34
  • 77.28 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TIPRL 35
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tiprl 34
  • 72.24 (n)
zebrafish
(Danio rerio)
Actinopterygii tiprl 35 34
  • 65.4 (n)
OneToOne
zgc66327 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002657 34
  • 52.91 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9578 35 34
  • 48.09 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ZK688.9 35 34
  • 49.24 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TIP41 35 34
  • 50.28 (n)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR174C 34
  • 47.41 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E06139g 34
  • 47.19 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G34270 34
  • 50.91 (n)
rice
(Oryza sativa)
Liliopsida Os03g0760600 34
  • 52.42 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU00109 34
  • 51.35 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1543 35
  • 47 (a)
OneToOne
Species where no ortholog for TIPRL was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TIPRL Gene

ENSEMBL:
Gene Tree for TIPRL (if available)
TreeFam:
Gene Tree for TIPRL (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TIPRL: view image

Paralogs for TIPRL Gene

No data available for Paralogs for TIPRL Gene

Variants for TIPRL Gene

Sequence variations from dbSNP and Humsavar for TIPRL Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000113715 -- 168,182,243(+) G/A intron_variant
rs1000187322 -- 168,194,958(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000301209 -- 168,189,102(+) C/G intron_variant
rs1000306552 -- 168,178,293(+) TTT/T/TT/TTTT upstream_transcript_variant
rs1000467935 -- 168,182,010(+) G/A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TIPRL Gene

Variant ID Type Subtype PubMed ID
esv32660 CNV loss 17666407
nsv1078878 OTHER inversion 25765185

Variation tolerance for TIPRL Gene

Residual Variation Intolerance Score: 32.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.15; 23.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TIPRL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TIPRL

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIPRL Gene

Disorders for TIPRL Gene

Additional Disease Information for TIPRL

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TIPRL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIPRL Gene

Publications for TIPRL Gene

  1. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PMID: 12761501) Matsuda A … Sugano S (Oncogene 2003) 2 3 4 58
  2. TIPRL Inhibits Protein Phosphatase 4 Activity and Promotes H2AX Phosphorylation in the DNA Damage Response. (PMID: 26717153) Rosales KR … Kong M (PloS one 2015) 3 4 58
  3. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. (PMID: 19064610) Cheung CL … Kung AW (Human molecular genetics 2009) 3 45 58
  4. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PMID: 19536175) Ehret GB … Chakravarti A (European journal of human genetics : EJHG 2009) 3 45 58
  5. Identification of a PP2A-interacting protein that functions as a negative regulator of phosphatase activity in the ATM/ATR signaling pathway. (PMID: 17384681) McConnell JL … Wadzinski BE (Oncogene 2007) 3 4 58

Products for TIPRL Gene

Sources for TIPRL Gene

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