TIPRL is an inhibitory regulator of protein phosphatase-2A (PP2A) (see PPP2CA; MIM 176915), PP4 (see PPP4C; MIM 602035), and PP6 (see PPP6C; MIM 612725) (McConnell et al., 2007 [PubMed 17384681]).[supplied by OMIM, Nov 2010] See more...

Aliases for TIPRL Gene

Aliases for TIPRL Gene

  • TOR Signaling Pathway Regulator 2 3 5
  • Putative MAPK-Activating Protein PM10 3 4
  • Type 2A-Interacting Protein 3 4
  • TIP41-Like Protein 3 4
  • TIP 3 4
  • TIP41, TOR Signaling Pathway Regulator-Like (S. Cerevisiae) 2
  • TIP41, TOR Signaling Pathway Regulator-Like 3
  • TIPRL1 3
  • TIP41 3

External Ids for TIPRL Gene

Previous GeneCards Identifiers for TIPRL Gene

  • GC01P164880
  • GC01P166414
  • GC01P139392

Summaries for TIPRL Gene

Entrez Gene Summary for TIPRL Gene

  • TIPRL is an inhibitory regulator of protein phosphatase-2A (PP2A) (see PPP2CA; MIM 176915), PP4 (see PPP4C; MIM 602035), and PP6 (see PPP6C; MIM 612725) (McConnell et al., 2007 [PubMed 17384681]).[supplied by OMIM, Nov 2010]

GeneCards Summary for TIPRL Gene

TIPRL (TOR Signaling Pathway Regulator) is a Protein Coding gene. Diseases associated with TIPRL include Alzheimer Disease 15 and Cardiomyopathy, Dilated, 1E.

UniProtKB/Swiss-Prot Summary for TIPRL Gene

  • May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AFX phosphorylated on Ser-140 (gamma-H2AFX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair.

Additional gene information for TIPRL Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TIPRL Gene

Genomics for TIPRL Gene

GeneHancer (GH) Regulatory Elements for TIPRL Gene

Promoters and enhancers for TIPRL Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J168177 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 511.6 +0.5 479 3 ZBTB40 ZNF217 EP300 CTCF ZSCAN5C SIN3A NRF1 POLR2G PHF8 JUND TIPRL GPR161 MPC2 HSALNG0008270
GH01J168134 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 20 -42.6 -42644 3.6 EP300 ZSCAN5C PHF8 ZNF639 ZBTB10 ZBTB26 SAP30 EZH2 HDAC2 MXI1 GPR161 lnc-MPC2-1 TIPRL SFT2D2 MPC2
GH01J167713 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.8 -460.3 -460262 11.2 HNRNPK ZBTB40 EP300 CTCF SIN3A TCF12 MYC POLR2G USF1 SP1 MPZL1 POU2F1 TADA1 DUTP6 TIPRL ENSG00000232194 ENSG00000250762 CREG1 lnc-ADCY10-1 TRP-AGG2-1
GH01J168225 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 10.9 +48.3 48256 4.6 ZBTB40 EP300 NRF1 TCF12 POLR2G GTF2E2 PHF8 ZFX ZNF639 ZNF10 TBX19 NONHSAG003392.2 SFT2D2 lnc-GPR161-2 RNU6-1310P TIPRL piR-31871
GH01J168202 Enhancer 0.9 Ensembl ENCODE 23.7 +24.5 24469 1.6 EP300 TEAD1 ZKSCAN8 CEBPB MAFK ZGPAT BCL6 CEBPG MITF RXRA HSALNG0008270 TIPRL SFT2D2 MPC2 piR-56451-011
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TIPRL on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TIPRL

Top Transcription factor binding sites by QIAGEN in the TIPRL gene promoter:
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta
  • AP-2gamma
  • Cdc5
  • Evi-1
  • FOXJ2 (long isoform)
  • Nkx2-5
  • Pbx1a

Genomic Locations for TIPRL Gene

Genomic Locations for TIPRL Gene
chr1:168,178,845-168,202,114
(GRCh38/hg38)
Size:
23,270 bases
Orientation:
Plus strand
chr1:168,148,171-168,171,352
(GRCh37/hg19)
Size:
23,182 bases
Orientation:
Plus strand

Genomic View for TIPRL Gene

Genes around TIPRL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIPRL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIPRL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIPRL Gene

Proteins for TIPRL Gene

  • Protein details for TIPRL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75663-TIPRL_HUMAN
    Recommended name:
    TIP41-like protein
    Protein Accession:
    O75663
    Secondary Accessions:
    • B2R8V3
    • Q5HYB2
    • Q8IZ86

    Protein attributes for TIPRL Gene

    Size:
    272 amino acids
    Molecular mass:
    31444 Da
    Quaternary structure:
    • Isoform 1 interacts with PPP2CA. Isoform 2 does not interact with PPP2CA. Interacts with PPP2CB, PPP4C and PPP6C. Interacts with IGBP1; the interaction is dependent on PPP2CA. Associates with a protein phosphatase 2A PP2A(C):IGBP1 complex. Interacts with PPP4C and PPP4R2.

    Three dimensional structures from OCA and Proteopedia for TIPRL Gene

    Alternative splice isoforms for TIPRL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TIPRL Gene

Post-translational modifications for TIPRL Gene

  • Ubiquitination at Lys84, Lys106, Lys117, Lys128, Lys207, and Lys267
  • Modification sites at PhosphoSitePlus

Other Protein References for TIPRL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TIPRL Gene

Domains & Families for TIPRL Gene

Gene Families for TIPRL Gene

Protein Domains for TIPRL Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TIPRL Gene

GenScript: Design optimal peptide antigens:
  • Type 2A-interacting protein (TIPRL_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75663

UniProtKB/Swiss-Prot:

TIPRL_HUMAN :
  • Belongs to the TIP41 family.
Family:
  • Belongs to the TIP41 family.
genes like me logo Genes that share domains with TIPRL: view

Function for TIPRL Gene

Molecular function for TIPRL Gene

UniProtKB/Swiss-Prot Function:
May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AFX phosphorylated on Ser-140 (gamma-H2AFX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair.

Phenotypes From GWAS Catalog for TIPRL Gene

Gene Ontology (GO) - Molecular Function for TIPRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16085932
genes like me logo Genes that share ontologies with TIPRL: view
genes like me logo Genes that share phenotypes with TIPRL: view

Animal Models for TIPRL Gene

MGI Knock Outs for TIPRL:
  • Tiprl Tiprl<tm1.1(KOMP)Vlcg>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TIPRL

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TIPRL Gene

Localization for TIPRL Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIPRL Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TIPRL gene
Compartment Confidence
cytosol 4
nucleus 3
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Vesicles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TIPRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IBA 21873635
genes like me logo Genes that share ontologies with TIPRL: view

Pathways & Interactions for TIPRL Gene

PathCards logo

SuperPathways for TIPRL Gene

No Data Available

Gene Ontology (GO) - Biological Process for TIPRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000077 DNA damage checkpoint IMP 17384681
GO:0007165 signal transduction IBA 21873635
GO:0032515 negative regulation of phosphoprotein phosphatase activity IDA 17384681
GO:0043666 regulation of phosphoprotein phosphatase activity IEA --
genes like me logo Genes that share ontologies with TIPRL: view

No data available for Pathways by source and SIGNOR curated interactions for TIPRL Gene

Drugs & Compounds for TIPRL Gene

No Compound Related Data Available

Transcripts for TIPRL Gene

mRNA/cDNA for TIPRL Gene

2 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TIPRL

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIPRL Gene

No ASD Table

Relevant External Links for TIPRL Gene

GeneLoc Exon Structure for
TIPRL

Expression for TIPRL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TIPRL Gene

Protein differential expression in normal tissues from HIPED for TIPRL Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TIPRL Gene



Protein tissue co-expression partners for TIPRL Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TIPRL

SOURCE GeneReport for Unigene cluster for TIPRL Gene:

Hs.209431

Evidence on tissue expression from TISSUES for TIPRL Gene

  • Lung(4.2)
  • Muscle(4.2)
genes like me logo Genes that share expression patterns with TIPRL: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TIPRL Gene

Orthologs for TIPRL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TIPRL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TIPRL 31 30
  • 99.75 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TIPRL 31 30
  • 94.24 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TIPRL 31 30
  • 93.98 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 91 (a)
OneToMany
-- 31
  • 90 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tiprl 30
  • 90.92 (n)
mouse
(Mus musculus)
Mammalia Tiprl 17 31 30
  • 90.8 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TIPRL 31
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves TIPRL 31 30
  • 77.28 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TIPRL 31
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tiprl 30
  • 72.24 (n)
zebrafish
(Danio rerio)
Actinopterygii tiprl 31 30
  • 65.4 (n)
OneToOne
zgc66327 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002657 30
  • 52.91 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9578 31 30
  • 48.09 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ZK688.9 31 30
  • 49.24 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TIP41 31 30
  • 50.28 (n)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR174C 30
  • 47.41 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E06139g 30
  • 47.19 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G34270 30
  • 50.91 (n)
rice
(Oryza sativa)
Liliopsida Os03g0760600 30
  • 52.42 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU00109 30
  • 51.35 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1543 31
  • 47 (a)
OneToOne
Species where no ortholog for TIPRL was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TIPRL Gene

ENSEMBL:
Gene Tree for TIPRL (if available)
TreeFam:
Gene Tree for TIPRL (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TIPRL: view image

Paralogs for TIPRL Gene

No data available for Paralogs for TIPRL Gene

Variants for TIPRL Gene

Additional dbSNP identifiers (rs#s) for TIPRL Gene

Structural Variations from Database of Genomic Variants (DGV) for TIPRL Gene

Variant ID Type Subtype PubMed ID
esv32660 CNV loss 17666407
nsv1078878 OTHER inversion 25765185

Variation tolerance for TIPRL Gene

Residual Variation Intolerance Score: 32.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.15; 23.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TIPRL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TIPRL

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TIPRL Gene

Disorders for TIPRL Gene

MalaCards: The human disease database

(3) MalaCards diseases for TIPRL Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search TIPRL in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TIPRL

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TIPRL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TIPRL Gene

Publications for TIPRL Gene

  1. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PMID: 12761501) Matsuda A … Sugano S (Oncogene 2003) 2 3 4 54
  2. TIPRL Inhibits Protein Phosphatase 4 Activity and Promotes H2AX Phosphorylation in the DNA Damage Response. (PMID: 26717153) Rosales KR … Kong M (PloS one 2015) 3 4 54
  3. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PMID: 19536175) Ehret GB … Chakravarti A (European journal of human genetics : EJHG 2009) 3 41 54
  4. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. (PMID: 19064610) Cheung CL … Kung AW (Human molecular genetics 2009) 3 41 54
  5. Identification of a PP2A-interacting protein that functions as a negative regulator of phosphatase activity in the ATM/ATR signaling pathway. (PMID: 17384681) McConnell JL … Wadzinski BE (Oncogene 2007) 3 4 54

Products for TIPRL Gene

  • Signalway ELISA kits for TIPRL
  • Signalway Proteins for TIPRL

Sources for TIPRL Gene