Aliases for TIPARP Gene
External Ids for TIPARP Gene
Previous GeneCards Identifiers for TIPARP Gene
This gene encodes a member of the poly(ADP-ribose) polymerase superfamily. Studies of the mouse ortholog have shown that the encoded protein catalyzes histone poly(ADP-ribosyl)ation and may be involved in T-cell function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
GeneCards Summary for TIPARP Gene
TIPARP (TCDD Inducible Poly(ADP-Ribose) Polymerase) is a Protein Coding gene. Diseases associated with TIPARP include Retinitis Pigmentosa 3 and Retinitis Pigmentosa. Gene Ontology (GO) annotations related to this gene include NAD+ ADP-ribosyltransferase activity and enhancer binding. An important paralog of this gene is PARP12.
UniProtKB/Swiss-Prot Summary for TIPARP Gene
ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate, aspartate and cysteine residues on target proteins (PubMed:23275542, PubMed:25043379, PubMed:30373764). Acts as a negative regulator of AHR by mediating mono-ADP-ribosylation of AHR, leading to inhibit transcription activator activity of AHR (PubMed:23275542, PubMed:30373764).