This gene encodes a member of the poly(ADP-ribose) polymerase superfamily. Studies of the mouse ortholog have shown that the encoded protein catalyzes histone poly(ADP-ribosyl)ation and may be involved in T-cell function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010] See more...

Aliases for TIPARP Gene

Aliases for TIPARP Gene

  • TCDD Inducible Poly(ADP-Ribose) Polymerase 2 3 5
  • ADP-Ribosyltransferase Diphtheria Toxin-Like 14 3 4
  • Protein Mono-ADP-Ribosyltransferase TIPARP 3 4
  • Poly [ADP-Ribose] Polymerase 7 3 4
  • ARTD14 3 4
  • PARP7 3 4
  • TCDD-Inducible Poly [ADP-Ribose] Polymerase 4
  • TCDD-Inducible Poly(ADP-Ribose) Polymerase 2
  • EC 2.4.2.- 4
  • PART14 3
  • PARP-7 4

External Ids for TIPARP Gene

Previous GeneCards Identifiers for TIPARP Gene

  • GC03P157713
  • GC03P157875
  • GC03P156391
  • GC03P153788

Summaries for TIPARP Gene

Entrez Gene Summary for TIPARP Gene

  • This gene encodes a member of the poly(ADP-ribose) polymerase superfamily. Studies of the mouse ortholog have shown that the encoded protein catalyzes histone poly(ADP-ribosyl)ation and may be involved in T-cell function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

GeneCards Summary for TIPARP Gene

TIPARP (TCDD Inducible Poly(ADP-Ribose) Polymerase) is a Protein Coding gene. Diseases associated with TIPARP include Retinitis Pigmentosa 3 and Retinitis Pigmentosa. Gene Ontology (GO) annotations related to this gene include NAD+ ADP-ribosyltransferase activity and enhancer binding. An important paralog of this gene is PARP12.

UniProtKB/Swiss-Prot Summary for TIPARP Gene

  • ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate, aspartate and cysteine residues on target proteins (PubMed:23275542, PubMed:25043379, PubMed:30373764). Acts as a negative regulator of AHR by mediating mono-ADP-ribosylation of AHR, leading to inhibit transcription activator activity of AHR (PubMed:23275542, PubMed:30373764).

Gene Wiki entry for TIPARP Gene

Additional gene information for TIPARP Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TIPARP Gene

Genomics for TIPARP Gene

GeneHancer (GH) Regulatory Elements for TIPARP Gene

Promoters and enhancers for TIPARP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TIPARP on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TIPARP

Top Transcription factor binding sites by QIAGEN in the TIPARP gene promoter:
  • GATA-6
  • Max
  • POU2F1
  • POU2F1a
  • RORalpha2
  • STAT3
  • TBP
  • TGIF

Genomic Locations for TIPARP Gene

Genomic Locations for TIPARP Gene
chr3:156,673,235-156,706,770
(GRCh38/hg38)
Size:
33,536 bases
Orientation:
Plus strand
chr3:156,391,024-156,424,559
(GRCh37/hg19)
Size:
33,536 bases
Orientation:
Plus strand

Genomic View for TIPARP Gene

Genes around TIPARP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIPARP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIPARP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIPARP Gene

Proteins for TIPARP Gene

  • Protein details for TIPARP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z3E1-PARPT_HUMAN
    Recommended name:
    Protein mono-ADP-ribosyltransferase TIPARP
    Protein Accession:
    Q7Z3E1
    Secondary Accessions:
    • D3DNK6
    • Q68CY9
    • Q86VP4
    • Q9Y4P7

    Protein attributes for TIPARP Gene

    Size:
    657 amino acids
    Molecular mass:
    76227 Da
    Quaternary structure:
    • Interacts with AHR.

neXtProt entry for TIPARP Gene

Post-translational modifications for TIPARP Gene

No data available for DME Specific Peptides for TIPARP Gene

Domains & Families for TIPARP Gene

Gene Families for TIPARP Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for TIPARP Gene

Blocks:
  • Zn-finger, C-x8-C-x5-C-x3-H type
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TIPARP Gene

GenScript: Design optimal peptide antigens:
  • Poly [ADP-ribose] polymerase 7 (PARPT_HUMAN)
  • TIPARP protein (Q05BQ2_HUMAN)
genes like me logo Genes that share domains with TIPARP: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TIPARP Gene

Function for TIPARP Gene

Molecular function for TIPARP Gene

UniProtKB/Swiss-Prot Function:
ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate, aspartate and cysteine residues on target proteins (PubMed:23275542, PubMed:25043379, PubMed:30373764). Acts as a negative regulator of AHR by mediating mono-ADP-ribosylation of AHR, leading to inhibit transcription activator activity of AHR (PubMed:23275542, PubMed:30373764).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide; Xref=Rhea:RHEA:54424, Rhea:RHEA-COMP:9867, Rhea:RHEA-COMP:13832, ChEBI:CHEBI:17154, ChEBI:CHEBI:29961, ChEBI:CHEBI:57540, ChEBI:CHEBI:138102; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide; Xref=Rhea:RHEA:58224, Rhea:RHEA-COMP:10208, Rhea:RHEA-COMP:15089, ChEBI:CHEBI:17154, ChEBI:CHEBI:29973, ChEBI:CHEBI:57540, ChEBI:CHEBI:142540; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-cysteinyl-[protein] + NAD(+) = H(+) + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-[protein]; Xref=Rhea:RHEA:56612, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:14624, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:29950, ChEBI:CHEBI:57540, ChEBI:CHEBI:140607; Evidence=. ;.
UniProtKB/Swiss-Prot EnzymeRegulation:
ADP-ribosyltransferase activity is inhibited by PJ34; inhibition is however not specific to TIPARP and other PARP-domain containing proteins are also inhibited by PJ34 (PubMed:30373764). Partially inhibited by KU0058948 (PubMed:30373764).

Enzyme Numbers (IUBMB) for TIPARP Gene

Phenotypes From GWAS Catalog for TIPARP Gene

Gene Ontology (GO) - Molecular Function for TIPARP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003950 NAD+ ADP-ribosyltransferase activity IDA 23275542
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0035326 enhancer binding IDA 23275542
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TIPARP: view
genes like me logo Genes that share phenotypes with TIPARP: view

Animal Models for TIPARP Gene

MGI Knock Outs for TIPARP:
  • Tiparp Tiparp<tm1b(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TIPARP Gene

Localization for TIPARP Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIPARP Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TIPARP gene
Compartment Confidence
nucleus 5
cytoskeleton 3
plasma membrane 2
extracellular 2
mitochondrion 2
cytosol 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TIPARP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 23275542
genes like me logo Genes that share ontologies with TIPARP: view

Pathways & Interactions for TIPARP Gene

PathCards logo

SuperPathways for TIPARP Gene

No Data Available

Interacting Proteins for TIPARP Gene

;

Gene Ontology (GO) - Biological Process for TIPARP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001570 vasculogenesis IEA --
GO:0001822 kidney development IEA --
GO:0006471 protein ADP-ribosylation IDA 30373764
GO:0006807 nitrogen compound metabolic process IEA --
GO:0008209 androgen metabolic process IEA --
genes like me logo Genes that share ontologies with TIPARP: view

No data available for Pathways by source and SIGNOR curated interactions for TIPARP Gene

Drugs & Compounds for TIPARP Gene

(2) Drugs for TIPARP Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotinamide Approved, Investigational Pharma 526,526
NAD Experimental Pharma Full agonist, Agonist, Activator 0
genes like me logo Genes that share compounds with TIPARP: view

Transcripts for TIPARP Gene

mRNA/cDNA for TIPARP Gene

3 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIPARP Gene

No ASD Table

Relevant External Links for TIPARP Gene

GeneLoc Exon Structure for
TIPARP

Expression for TIPARP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TIPARP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TIPARP

SOURCE GeneReport for Unigene cluster for TIPARP Gene:

Hs.744050

Evidence on tissue expression from TISSUES for TIPARP Gene

  • Nervous system(4.8)
  • Spleen(2.6)
  • Lung(2.4)
  • Lymph node(2.2)
  • Bone marrow(2)
  • Liver(2)
genes like me logo Genes that share expression patterns with TIPARP: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TIPARP Gene

Orthologs for TIPARP Gene

This gene was present in the common ancestor of chordates.

Orthologs for TIPARP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TIPARP 31 30
  • 99.64 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TIPARP 31 30
  • 94.06 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TIPARP 31 30
  • 92.99 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tiparp 17 31 30
  • 90.55 (n)
rat
(Rattus norvegicus)
Mammalia Tiparp 30
  • 90.24 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TIPARP 31
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TIPARP 31
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves TIPARP 31 30
  • 72.7 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TIPARP 31
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tiparp 30
  • 65.18 (n)
Str.10375 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.9867 30
zebrafish
(Danio rerio)
Actinopterygii tiparp 31 30
  • 60.04 (n)
OneToOne
Species where no ortholog for TIPARP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TIPARP Gene

ENSEMBL:
Gene Tree for TIPARP (if available)
TreeFam:
Gene Tree for TIPARP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TIPARP: view image

Paralogs for TIPARP Gene

Paralogs for TIPARP Gene

(2) SIMAP similar genes for TIPARP Gene using alignment to 5 proteins:

  • PARPT_HUMAN
  • C9JXM5_HUMAN
  • G5E9W1_HUMAN
  • H7C5K7_HUMAN
  • Q05BQ2_HUMAN
genes like me logo Genes that share paralogs with TIPARP: view

Variants for TIPARP Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TIPARP Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
708663 Benign: not provided 156,704,724(+) A/C SYNONYMOUS_VARIANT
735353 Benign: not provided 156,694,015(+) T/C INTRON_VARIANT
rs17854621 - p.Arg406Ser

Additional dbSNP identifiers (rs#s) for TIPARP Gene

Structural Variations from Database of Genomic Variants (DGV) for TIPARP Gene

Variant ID Type Subtype PubMed ID
nsv954498 CNV duplication 24416366

Variation tolerance for TIPARP Gene

Residual Variation Intolerance Score: 14.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.43; 28.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TIPARP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TIPARP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIPARP Gene

Disorders for TIPARP Gene

MalaCards: The human disease database

(2) MalaCards diseases for TIPARP Gene - From: DISEASES

Disorder Aliases PubMed IDs
retinitis pigmentosa 3
  • rp3
retinitis pigmentosa
  • retinitis pigmentosa 1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TIPARP

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TIPARP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TIPARP Gene

Publications for TIPARP Gene

  1. Identification and characterization of human TIPARP gene within the CCNL amplicon at human chromosome 3q25.31. (PMID: 12851707) Katoh M … Katoh M (International journal of oncology 2003) 2 3 4 23 54
  2. Characterization of TCDD-inducible poly-ADP-ribose polymerase (TIPARP/ARTD14) catalytic activity. (PMID: 30373764) Gomez A … Matthews J (The Biochemical journal 2018) 3 4 54
  3. Family-wide analysis of poly(ADP-ribose) polymerase activity. (PMID: 25043379) Vyas S … Chang P (Nature communications 2014) 3 4 54
  4. 2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation. (PMID: 23275542) MacPherson L … Matthews J (Nucleic acids research 2013) 3 4 54
  5. A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24. (PMID: 20852632) Goode EL … Ovarian Cancer Association Consortium (OCAC) (Nature genetics 2010) 3 41 54

Products for TIPARP Gene

Sources for TIPARP Gene