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Aliases for TIPARP Gene

Aliases for TIPARP Gene

  • TCDD Inducible Poly(ADP-Ribose) Polymerase 2 3 5
  • ADP-Ribosyltransferase Diphtheria Toxin-Like 14 3 4
  • Poly [ADP-Ribose] Polymerase 7 3 4
  • ARTD14 3 4
  • PARP7 3 4
  • TCDD-Inducible Poly [ADP-Ribose] Polymerase 3
  • TCDD-Inducible Poly(ADP-Ribose) Polymerase 2
  • EC 2.4.2.30 4
  • PART14 3
  • PARP-7 4

External Ids for TIPARP Gene

Previous GeneCards Identifiers for TIPARP Gene

  • GC03P157713
  • GC03P157875
  • GC03P156391
  • GC03P153788

Summaries for TIPARP Gene

Entrez Gene Summary for TIPARP Gene

  • This gene encodes a member of the poly(ADP-ribose) polymerase superfamily. Studies of the mouse ortholog have shown that the encoded protein catalyzes histone poly(ADP-ribosyl)ation and may be involved in T-cell function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

GeneCards Summary for TIPARP Gene

TIPARP (TCDD Inducible Poly(ADP-Ribose) Polymerase) is a Protein Coding gene. Diseases associated with TIPARP include Male Reproductive Organ Cancer. Gene Ontology (GO) annotations related to this gene include NAD+ ADP-ribosyltransferase activity and enhancer binding. An important paralog of this gene is PARP12.

UniProtKB/Swiss-Prot for TIPARP Gene

  • Poly [ADP-ribose] polymerase using NAD(+) as a substrate to transfer ADP-ribose onto glutamic acid residues of a protein acceptor; repeated rounds of ADP-ribosylation leads to the formation of poly(ADPribose) chains on the protein, thereby altering the function of the target protein. May play a role in the adaptive response to chemical exposure (TCDD) and thereby mediates certain effects of the chemicals (By similarity).

Gene Wiki entry for TIPARP Gene

Additional gene information for TIPARP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIPARP Gene

Genomics for TIPARP Gene

GeneHancer (GH) Regulatory Elements for TIPARP Gene

Promoters and enhancers for TIPARP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I156673 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 558.2 +7.3 7276 14.4 CLOCK FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF263 TIPARP CCNL1 LINC00886 LEKR1 SSR3 TIPARP-AS1 PIR33904 METTL15P1
GH03I157085 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE dbSUPER 11.6 +415.5 415458 6.2 HDGF PKNOX1 FOXA2 SMAD1 ARNT MLX ARID4B SIN3A FEZF1 DMAP1 LINC00881 CCNL1 TIPARP-AS1 TIPARP ENSG00000241770 KRT18P34 SSR3 KCNAB1-AS1 LINC02029 LINC00880
GH03I156642 Enhancer 1.3 FANTOM5 Ensembl ENCODE 18.1 -29.5 -29507 2.1 HDGF HDAC1 ATF1 BATF IRF4 ATF7 ETV6 BCLAF1 IKZF2 RUNX3 TIPARP TIPARP-AS1 LINC00886 LEKR1 GC03P156555
GH03I157124 Enhancer 2 VISTA FANTOM5 Ensembl ENCODE dbSUPER 11.1 +458.2 458213 13.5 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B FEZF1 DMAP1 ZNF2 GC03M157131 KRT18P34 CCNL1 LEKR1 LINC00880 ENSG00000241770 TIPARP SSR3 TIPARP-AS1
GH03I157064 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 15.1 +391.3 391309 0.4 HDGF BACH1 EBF1 IRF4 CTBP1 ATF7 IKZF2 ZNF687 TEAD2 DPF2 TIPARP LEKR1 CCNL1 LINC00886 LINC02029 RN7SKP177
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TIPARP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TIPARP gene promoter:

Genomic Locations for TIPARP Gene

Genomic Locations for TIPARP Gene
chr3:156,673,235-156,706,770
(GRCh38/hg38)
Size:
33,536 bases
Orientation:
Plus strand
chr3:156,391,024-156,424,559
(GRCh37/hg19)

Genomic View for TIPARP Gene

Genes around TIPARP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIPARP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIPARP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIPARP Gene

Proteins for TIPARP Gene

  • Protein details for TIPARP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z3E1-PARPT_HUMAN
    Recommended name:
    TCDD-inducible poly [ADP-ribose] polymerase
    Protein Accession:
    Q7Z3E1
    Secondary Accessions:
    • D3DNK6
    • Q68CY9
    • Q86VP4
    • Q9Y4P7

    Protein attributes for TIPARP Gene

    Size:
    657 amino acids
    Molecular mass:
    76227 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TIPARP Gene

Post-translational modifications for TIPARP Gene

No Post-translational modifications

No data available for DME Specific Peptides for TIPARP Gene

Domains & Families for TIPARP Gene

Gene Families for TIPARP Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for TIPARP Gene

Suggested Antigen Peptide Sequences for TIPARP Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TIPARP: view

No data available for UniProtKB/Swiss-Prot for TIPARP Gene

Function for TIPARP Gene

Molecular function for TIPARP Gene

UniProtKB/Swiss-Prot CatalyticActivity:
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
UniProtKB/Swiss-Prot Function:
Poly [ADP-ribose] polymerase using NAD(+) as a substrate to transfer ADP-ribose onto glutamic acid residues of a protein acceptor; repeated rounds of ADP-ribosylation leads to the formation of poly(ADPribose) chains on the protein, thereby altering the function of the target protein. May play a role in the adaptive response to chemical exposure (TCDD) and thereby mediates certain effects of the chemicals (By similarity).

Enzyme Numbers (IUBMB) for TIPARP Gene

Phenotypes From GWAS Catalog for TIPARP Gene

Gene Ontology (GO) - Molecular Function for TIPARP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003950 NAD+ ADP-ribosyltransferase activity IDA 23275542
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0035326 enhancer binding IDA 23275542
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TIPARP: view
genes like me logo Genes that share phenotypes with TIPARP: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TIPARP Gene

Localization for TIPARP Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TIPARP gene
Compartment Confidence
nucleus 5
cytoskeleton 3
plasma membrane 1
extracellular 1
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TIPARP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 23275542
genes like me logo Genes that share ontologies with TIPARP: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TIPARP Gene

Pathways & Interactions for TIPARP Gene

SuperPathways for TIPARP Gene

No Data Available

Interacting Proteins for TIPARP Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000295924%0d%0a9606.ENSP00000278616%0d%0a
Selected Interacting proteins: ENSP00000295924 Q7Z3E1-PARPT_HUMAN for TIPARP Gene via STRING IID

Gene Ontology (GO) - Biological Process for TIPARP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001570 vasculogenesis IEA --
GO:0001822 kidney development IEA --
GO:0006471 protein ADP-ribosylation IEA --
GO:0006807 nitrogen compound metabolic process IEA --
GO:0008209 androgen metabolic process IEA --
genes like me logo Genes that share ontologies with TIPARP: view

No data available for Pathways by source and SIGNOR curated interactions for TIPARP Gene

Drugs & Compounds for TIPARP Gene

(2) Drugs for TIPARP Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotinamide Approved, Investigational Nutra 942,946
NAD Pharma Full agonist, Agonist 0
genes like me logo Genes that share compounds with TIPARP: view

Transcripts for TIPARP Gene

mRNA/cDNA for TIPARP Gene

Unigene Clusters for TIPARP Gene

TCDD-inducible poly(ADP-ribose) polymerase:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIPARP Gene

No ASD Table

Relevant External Links for TIPARP Gene

GeneLoc Exon Structure for
TIPARP
ECgene alternative splicing isoforms for
TIPARP

Expression for TIPARP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TIPARP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of TIPARP Gene:

TIPARP

SOURCE GeneReport for Unigene cluster for TIPARP Gene:

Hs.744050

Evidence on tissue expression from TISSUES for TIPARP Gene

  • Nervous system(4.8)
  • Spleen(2.6)
  • Lung(2.4)
  • Lymph node(2.2)
  • Bone marrow(2)
  • Liver(2)
genes like me logo Genes that share expression patterns with TIPARP: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TIPARP Gene

Orthologs for TIPARP Gene

This gene was present in the common ancestor of chordates.

Orthologs for TIPARP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TIPARP 33 34
  • 99.64 (n)
dog
(Canis familiaris)
Mammalia TIPARP 33 34
  • 94.06 (n)
cow
(Bos Taurus)
Mammalia TIPARP 33 34
  • 92.99 (n)
mouse
(Mus musculus)
Mammalia Tiparp 33 16 34
  • 90.55 (n)
rat
(Rattus norvegicus)
Mammalia Tiparp 33
  • 90.24 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TIPARP 34
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TIPARP 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves TIPARP 33 34
  • 72.7 (n)
lizard
(Anolis carolinensis)
Reptilia TIPARP 34
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tiparp 33
  • 65.18 (n)
Str.10375 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.9867 33
zebrafish
(Danio rerio)
Actinopterygii tiparp 33 34
  • 60.04 (n)
Species where no ortholog for TIPARP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TIPARP Gene

ENSEMBL:
Gene Tree for TIPARP (if available)
TreeFam:
Gene Tree for TIPARP (if available)

Paralogs for TIPARP Gene

Paralogs for TIPARP Gene

(2) SIMAP similar genes for TIPARP Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TIPARP: view

Variants for TIPARP Gene

Sequence variations from dbSNP and Humsavar for TIPARP Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000078051 -- 156,692,874(+) T/C intron_variant
rs1000186877 -- 156,677,234(+) G/A intron_variant
rs1000187550 -- 156,685,471(+) G/T intron_variant
rs1000201034 -- 156,681,100(+) A/G intron_variant
rs1000521073 -- 156,676,060(+) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TIPARP Gene

Variant ID Type Subtype PubMed ID
nsv954498 CNV duplication 24416366

Variation tolerance for TIPARP Gene

Residual Variation Intolerance Score: 14.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.43; 28.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TIPARP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TIPARP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIPARP Gene

Disorders for TIPARP Gene

MalaCards: The human disease database

(1) MalaCards diseases for TIPARP Gene - From: DISEASES

Disorder Aliases PubMed IDs
male reproductive organ cancer
  • male genital cancer
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TIPARP

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TIPARP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TIPARP Gene

Publications for TIPARP Gene

  1. Identification and characterization of human TIPARP gene within the CCNL amplicon at human chromosome 3q25.31. (PMID: 12851707) Katoh M … Katoh M (International journal of oncology 2003) 2 3 4 22 58
  2. A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24. (PMID: 20852632) Goode EL … Ovarian Cancer Association Consortium (OCAC) (Nature genetics 2010) 3 44 58
  3. A human intervention study with foods containing natural Ah-receptor agonists does not significantly show AhR-mediated effects as measured in blood cells and urine. (PMID: 18762178) de Waard PW … de Kok TM (Chemico-biological interactions 2008) 3 22 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. TCDD-inducible poly-ADP-ribose polymerase (TIPARP/PARP7) mono-ADP-ribosylates and co-activates liver X receptors. (PMID: 26814197) Bindesbøll C … Matthews J (The Biochemical journal 2016) 3 58

Products for TIPARP Gene

Sources for TIPARP Gene

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