Aliases for TIPARP Gene
External Ids for TIPARP Gene
Previous GeneCards Identifiers for TIPARP Gene
This gene encodes a member of the poly(ADP-ribose) polymerase superfamily. Studies of the mouse ortholog have shown that the encoded protein catalyzes histone poly(ADP-ribosyl)ation and may be involved in T-cell function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
GeneCards Summary for TIPARP Gene
TIPARP (TCDD Inducible Poly(ADP-Ribose) Polymerase) is a Protein Coding gene. Diseases associated with TIPARP include Male Reproductive Organ Cancer. Gene Ontology (GO) annotations related to this gene include NAD+ ADP-ribosyltransferase activity and enhancer binding. An important paralog of this gene is PARP12.
UniProtKB/Swiss-Prot for TIPARP Gene
Poly [ADP-ribose] polymerase using NAD(+) as a substrate to transfer ADP-ribose onto glutamic acid residues of a protein acceptor; repeated rounds of ADP-ribosylation leads to the formation of poly(ADPribose) chains on the protein, thereby altering the function of the target protein. May play a role in the adaptive response to chemical exposure (TCDD) and thereby mediates certain effects of the chemicals (By similarity).