This gene produces a spliced long non-coding RNA that binds RNAs. This transcript interacts with staufen-1 protein to regulate the stability of mRNAs for genes involved in the differentiation of epidermal tissue. Variation in this gene may be associated with cancer progression. [provided by RefSeq, Aug 2017] See more...

Aliases for TINCR Gene

Subcategory (RNA class) for TINCR Gene

lncRNA

Number of RNA Genes sources:

3 / 14

Aliases for TINCR Gene

  • TINCR Ubiquitin Domain Containing 2 3 5
  • Tissue Differentiation-Inducing Non-Protein Coding RNA 2 3
  • Long Intergenic Non-Protein Coding RNA 36 2 3
  • Placenta-Specific 2 (Non-Protein Coding) 2 3
  • Terminal Differentiation-Induced NcRNA 2 3
  • TINCR Ubiquitin Domain-Containing 13
  • Non-Protein Coding RNA 36 2
  • Placenta-Specific 2 2
  • Onco-LncRNA-16 3
  • HSALNG0123468 167
  • NONHSAG024566 92
  • HSALNG0123467 167
  • Lnc-TINCR-1 168
  • NCRNA00036 3
  • LINC00036 3
  • PLAC2 3

External Ids for TINCR Gene

Previous HGNC Symbols for TINCR Gene

  • PLAC2

Summaries for TINCR Gene

Entrez Gene Summary for TINCR Gene

  • This gene produces a spliced long non-coding RNA that binds RNAs. This transcript interacts with staufen-1 protein to regulate the stability of mRNAs for genes involved in the differentiation of epidermal tissue. Variation in this gene may be associated with cancer progression. [provided by RefSeq, Aug 2017]

GeneCards Summary for TINCR Gene

TINCR (TINCR Ubiquitin Domain Containing) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with TINCR include Pulmonary Disease, Chronic Obstructive and Esophagus Squamous Cell Carcinoma.

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TINCR Gene

Genomics for TINCR Gene

GeneHancer (GH) Regulatory Elements for TINCR Gene

Promoters and enhancers for TINCR Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J005567 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 500.4 +10.4 10448 1.4 ZFX CTCF ZIC2 CLOCK ZBTB26 KLF7 ZBTB7A PHF8 EZH2 ZNF777 TINCR LONP1 piR-57460-331 lnc-SAFB-1 RF00017-2764
GH19J005577 Promoter/Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas 500.7 +0.4 364 1 FOXK2 ZNF217 CTCF CLOCK GABPA REST KLF4 RAD21 ZBTB7A MYC SNRPEP4 TINCR lnc-SAFB2-3 piR-42491-110 RPL36 DUS3L RANBP3 LONP1 lnc-SAFB-1 RF00017-2764
GH19J005580 Enhancer 0.7 Ensembl CraniofacialAtlas 500.7 -1.9 -1946 1 ZIC2 ZNF423 SCRT1 GLIS1 PRDM10 ZBTB8A ZNF121 SCRT2 TINCR piR-42491-110 RPL36 LONP1 lnc-TINCR-3 lnc-SAFB-1 RF00017-2764
GH19J005559 Enhancer 0.5 Ensembl 8.2 +17.9 17948 1.6 NRF1 ZIC2 PBX2 PKNOX1 ZBTB7A GLIS1 LONP1 TINCR lnc-SAFB-1 piR-57460-331 RF00017-2764
GH19J005563 Enhancer 0.9 Ensembl ENCODE 0.4 +14.2 14154 2.3 ZNF623 RFX1 HINFP ZNF341 SIN3A KLF9 CTCF FOS SMARCA5 ELF1 KHSRP LONP1 RPL36 SNRPEP4 DUS3L RANBP3 lnc-SAFB-1 piR-57460-331 TINCR RF00017-2764
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TINCR on UCSC Golden Path with GeneCards custom track

Genomic Locations for TINCR Gene

Genomic Locations for TINCR Gene
chr19:5,558,136-5,578,349
(GRCh38/hg38)
Size:
20,214 bases
Orientation:
Minus strand
chr19:5,558,178-5,568,045
(GRCh37/hg19)
Size:
9,868 bases
Orientation:
Minus strand

Genomic View for TINCR Gene

Genes around TINCR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TINCR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TINCR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TINCR Gene

Proteins for TINCR Gene

  • Protein details for TINCR Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A1B0GTR7-A0A1B0GTR7_HUMAN
    Recommended name:
    TINCR ubiquitin domain-containing
    Protein Accession:
    A0A1B0GTR7

    Protein attributes for TINCR Gene

    Size:
    56 amino acids
    Molecular mass:
    6469 Da
    Quaternary structure:
    No Data Available
  • Protein details for TINCR Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A1B0GVN0-A0A1B0GVN0_HUMAN
    Recommended name:
    TINCR ubiquitin domain-containing
    Protein Accession:
    A0A1B0GVN0

    Protein attributes for TINCR Gene

    Size:
    87 amino acids
    Molecular mass:
    10124 Da
    Quaternary structure:
    No Data Available
  • Protein details for TINCR Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A2R8Y7D0-A0A2R8Y7D0_HUMAN
    Recommended name:
    TINCR ubiquitin domain-containing
    Protein Accession:
    A0A2R8Y7D0

    Protein attributes for TINCR Gene

    Size:
    120 amino acids
    Molecular mass:
    13788 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TINCR Gene

Post-translational modifications for TINCR Gene

No Post-translational modifications

Other Protein References for TINCR Gene

No data available for DME Specific Peptides for TINCR Gene

Domains & Families for TINCR Gene

Gene Families for TINCR Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TINCR Gene

Suggested Antigen Peptide Sequences for TINCR Gene

GenScript: Design optimal peptide antigens:
  • Placenta-specific protein 2 (PLAC2_HUMAN)
genes like me logo Genes that share domains with TINCR: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TINCR Gene

Function for TINCR Gene

Phenotypes From GWAS Catalog for TINCR Gene

genes like me logo Genes that share phenotypes with TINCR: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TINCR

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TINCR Gene

Localization for TINCR Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TINCR gene
Compartment Confidence
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for TINCR Gene

Pathways & Interactions for TINCR Gene

PathCards logo

SuperPathways for TINCR Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for TINCR Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for TINCR Gene

Drugs & Compounds for TINCR Gene

No Compound Related Data Available

Transcripts for TINCR Gene

mRNA/cDNA for TINCR Gene

13 RNACentral transcripts :
2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
3 NONCODE transcripts :
3 LncBook transcripts :
11 LNCipedia transcripts :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TINCR

Alternative Splicing Database (ASD) splice patterns (SP) for TINCR Gene

No ASD Table

Relevant External Links for TINCR Gene

GeneLoc Exon Structure for
TINCR

Expression for TINCR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TINCR Gene

mRNA differential expression in normal tissues according to GTEx for TINCR Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x14.2), Skin - Not Sun Exposed (Suprapubic) (x12.8), and Esophagus - Mucosa (x5.0).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TINCR

SOURCE GeneReport for Unigene cluster for TINCR Gene:

Hs.515575
genes like me logo Genes that share expression patterns with TINCR: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TINCR Gene

Orthologs for TINCR Gene

Evolution for TINCR Gene

ENSEMBL:
Gene Tree for TINCR (if available)
TreeFam:
Gene Tree for TINCR (if available)

No data available for Orthologs for TINCR Gene

Paralogs for TINCR Gene

No data available for Paralogs for TINCR Gene

Variants for TINCR Gene

Additional dbSNP identifiers (rs#s) for TINCR Gene

Structural Variations from Database of Genomic Variants (DGV) for TINCR Gene

Variant ID Type Subtype PubMed ID
esv3643529 CNV gain 21293372
nsv1062851 CNV gain 25217958

Additional Variant Information for TINCR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TINCR

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for TINCR Gene

Disorders for TINCR Gene

MalaCards: The human disease database

(7) MalaCards diseases for TINCR Gene - From: LncRNADisease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
pulmonary disease, chronic obstructive
  • copd
esophagus squamous cell carcinoma
  • scc of esophagus
squamous cell carcinoma
  • epidermoid carcinoma
bladder cancer
  • bladder cancer, somatic
gastric cancer
  • gastric cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search TINCR in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TINCR

genes like me logo Genes that share disorders with TINCR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TINCR Gene

Publications for TINCR Gene

  1. TINCR, staufen1, and cellular differentiation. (PMID: 24019000) Kretz M (RNA biology 2013) 2 3 54
  2. Control of somatic tissue differentiation by the long non-coding RNA TINCR. (PMID: 23201690) Kretz M … Khavari PA (Nature 2013) 2 3 54
  3. LncRNA TINCR/microRNA-107/CD36 regulates cell proliferation and apoptosis in colorectal cancer via PPAR signaling pathway based on bioinformatics analysis. (PMID: 30521471) Zhang X … Zhang L (Biological chemistry 2019) 3 54
  4. LincRNA TINCR facilitates excessive proliferation and inflammation in post-burn skin fibroblasts by directly binding with SND1 protein and inducing SND1-mediated TGF-β1 expression. (PMID: 30642630) Qin G … Zeng W (Biochemical and biophysical research communications 2019) 3 54
  5. lncRNA PLAC2 activated by H3K27 acetylation promotes cell proliferation and invasion via the activation of Wnt/β‑catenin pathway in oral squamous cell carcinoma. (PMID: 30720068) Chen F … Wang R (International journal of oncology 2019) 3 54

Products for TINCR Gene

Sources for TINCR Gene