This gene produces a spliced long non-coding RNA that binds RNAs. This transcript interacts with staufen-1 protein to regulate the stability of mRNAs for genes involved in the differentiation of epidermal tissue. Variation in this gene may be associated with cancer progression. [provided by RefSeq, Aug 2017] See more...

Aliases for TINCR Gene

Subcategory (RNA class) for TINCR Gene

lncRNA

Number of RNA Genes sources:

3 / 17

Aliases for TINCR Gene

  • TINCR Ubiquitin Domain Containing 2 3 5
  • Tissue Differentiation-Inducing Non-Protein Coding RNA 2 3
  • Long Intergenic Non-Protein Coding RNA 36 2 3
  • Placenta-Specific 2 (Non-Protein Coding) 2 3
  • Terminal Differentiation-Induced NcRNA 2 3
  • Onco-LncRNA-16 2 3
  • NCRNA00036 2 3
  • LINC00036 2 3
  • TINCR Ubiquitin Domain-Containing 13
  • Non-Protein Coding RNA 36 2
  • Placenta-Specific 2 2
  • NONHSAG024566.2 91
  • HSALNG0123468 164
  • HSALNG0123467 164
  • Lnc-TINCR-1 165
  • FLJ90734 2
  • PLAC2 3
  • TINCR 5

External Ids for TINCR Gene

Previous HGNC Symbols for TINCR Gene

  • PLAC2

Summaries for TINCR Gene

Entrez Gene Summary for TINCR Gene

  • This gene produces a spliced long non-coding RNA that binds RNAs. This transcript interacts with staufen-1 protein to regulate the stability of mRNAs for genes involved in the differentiation of epidermal tissue. Variation in this gene may be associated with cancer progression. [provided by RefSeq, Aug 2017]

GeneCards Summary for TINCR Gene

TINCR (TINCR Ubiquitin Domain Containing) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with TINCR include Pulmonary Disease, Chronic Obstructive and Esophagus Squamous Cell Carcinoma.

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TINCR Gene

Genomics for TINCR Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TINCR Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J005567 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 600.4 +10.4 10448 1.4 KDM1A ZIC2 CEBPA CTCF ZFX KLF7 ZNF157 ZNF444 ZBTB26 ZNF777 TINCR DUS3L KHSRP LONP1 SNRPEP4 SAFB ENSG00000267571 GTF2F1 piR-57460-331 lnc-SAFB-1
GH19J005577 Promoter/Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas 600.7 +0.4 364 1 CREB1 CTCF ZNF692 TARDBP FOXA1 ZNF143 PATZ1 REST RAD21 IRF2 TINCR SNRPEP4 lnc-SAFB2-3 piR-42491-110 RPL36 DUS3L RANBP3 LONP1 lnc-SAFB-1 SAFB
GH19J005580 Enhancer 0.7 Ensembl CraniofacialAtlas 600.7 -1.9 -1946 1 PRDM10 ZIC2 SCRT2 ZNF423 SCRT1 GLIS1 ZNF121 ZBTB8A TINCR piR-42491-110 RPL36 LONP1 lnc-TINCR-3 lnc-SAFB-1 SAFB ZNRF4 RF00017-2766
GH19J005559 Enhancer 0.4 Ensembl 8.2 +17.9 17948 1.6 ZIC2 PKNOX1 NRF1 GLIS1 LONP1 TINCR lnc-SAFB-1 piR-57460-331 SAFB ZNRF4 RF00017-2766
GH19J005563 Enhancer 0.9 Ensembl ENCODE 0.4 +14.2 14154 2.3 CREB1 CTCF ZNF629 KDM1A RFX1 PATZ1 BRD9 ZNF747 ZNF341 CEBPB KHSRP LONP1 RPL36 SNRPEP4 DUS3L RANBP3 piR-57460-331 lnc-SAFB-1 TINCR SAFB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TINCR on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for TINCR Gene

Genomic Locations for TINCR Gene
chr19:5,558,136-5,578,349
(GRCh38/hg38)
Size:
20,214 bases
Orientation:
Minus strand
chr19:5,558,178-5,568,045
(GRCh37/hg19)
Size:
9,868 bases
Orientation:
Minus strand

Genomic View for TINCR Gene

Genes around TINCR on UCSC Golden Path with GeneCards custom track
TINCR in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
TINCR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TINCR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TINCR Gene

Proteins for TINCR Gene

  • Protein details for TINCR Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A2R8Y7D0-A0A2R8Y7D0_HUMAN
    Recommended name:
    TINCR ubiquitin domain-containing
    Protein Accession:
    A0A2R8Y7D0

    Protein attributes for TINCR Gene

    Size:
    120 amino acids
    Molecular mass:
    13788 Da
    Quaternary structure:
    No Data Available
  • Protein details for TINCR Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A1B0GTR7-A0A1B0GTR7_HUMAN
    Recommended name:
    TINCR ubiquitin domain-containing
    Protein Accession:
    A0A1B0GTR7

    Protein attributes for TINCR Gene

    Size:
    56 amino acids
    Molecular mass:
    6469 Da
    Quaternary structure:
    No Data Available
  • Protein details for TINCR Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A1B0GVN0-A0A1B0GVN0_HUMAN
    Recommended name:
    TINCR ubiquitin domain-containing
    Protein Accession:
    A0A1B0GVN0

    Protein attributes for TINCR Gene

    Size:
    87 amino acids
    Molecular mass:
    10124 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TINCR Gene

Post-translational modifications for TINCR Gene

No Post-translational modifications

Other Protein References for TINCR Gene

No data available for DME Specific Peptides for TINCR Gene

Domains & Families for TINCR Gene

Gene Families for TINCR Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TINCR Gene

Suggested Antigen Peptide Sequences for TINCR Gene

GenScript: Design optimal peptide antigens:
  • Placenta-specific protein 2 (PLAC2_HUMAN)
genes like me logo Genes that share domains with TINCR: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TINCR Gene

Function for TINCR Gene

Phenotypes From GWAS Catalog for TINCR Gene

Gene Ontology (GO) - Molecular Function for TINCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with TINCR: view
genes like me logo Genes that share phenotypes with TINCR: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TINCR

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TINCR Gene

Localization for TINCR Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TINCR gene
Compartment Confidence
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for TINCR Gene

Pathways & Interactions for TINCR Gene

PathCards logo

SuperPathways for TINCR Gene

No Data Available

Gene Ontology (GO) - Biological Process for TINCR Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for TINCR Gene

Drugs & Compounds for TINCR Gene

No Compound Related Data Available

Transcripts for TINCR Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for TINCR Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000403BBA_9606 lncRNA 3733 2

RefSeq: NR_027064,

LNCipedia: lnc-TINCR-1:1,

URS000034D1BD_9606 lncRNA 402 3

LncBook: HSALNT0254965,

LNCipedia: lnc-TINCR-1:8,

NONCODE: NONHSAT060693.2,

URS00008B85D3_9606 lncRNA 1856 2

LNCipedia: lnc-TINCR-1:9,

NONCODE: NONHSAT060692.2,

URS000025AB36_9606 lncRNA 583 2

LncBook: HSALNT0254964,

LNCipedia: lnc-TINCR-1:10,

URS0000D6D9EB_9606 lncRNA 4421 1

LNCipedia: lnc-TINCR-1:4,

TINCR in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for TINCR Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TINCR

Alternative Splicing Database (ASD) splice patterns (SP) for TINCR Gene

No ASD Table

Relevant External Links for TINCR Gene

GeneLoc Exon Structure for
TINCR

Expression for TINCR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TINCR Gene

mRNA differential expression in normal tissues according to GTEx for TINCR Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x14.2), Skin - Not Sun Exposed (Suprapubic) (x12.8), and Esophagus - Mucosa (x5.0).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TINCR

SOURCE GeneReport for Unigene cluster for TINCR Gene:

Hs.515575
genes like me logo Genes that share expression patterns with TINCR: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TINCR Gene

Orthologs for TINCR Gene

Evolution for TINCR Gene

ENSEMBL:
Gene Tree for TINCR (if available)
TreeFam:
Gene Tree for TINCR (if available)

No data available for Orthologs for TINCR Gene

Paralogs for TINCR Gene

No data available for Paralogs for TINCR Gene

Variants for TINCR Gene

Additional dbSNP identifiers (rs#s) for TINCR Gene

Structural Variations from Database of Genomic Variants (DGV) for TINCR Gene

Variant ID Type Subtype PubMed ID
esv3643529 CNV gain 21293372
nsv1062851 CNV gain 25217958

Additional Variant Information for TINCR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TINCR

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for TINCR Gene

Disorders for TINCR Gene

MalaCards: The human disease database

(8) MalaCards diseases for TINCR Gene - From: LncRNADisease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
pulmonary disease, chronic obstructive
  • copd
esophagus squamous cell carcinoma
  • oesophagus squamous cell carcinoma
squamous cell carcinoma
  • epidermoid carcinoma
gastric cancer
  • gastric cancer, somatic
bladder cancer
  • bladder cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search TINCR in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with TINCR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TINCR Gene

Publications for TINCR Gene

  1. TINCR, staufen1, and cellular differentiation. (PMID: 24019000) Kretz M (RNA biology 2013) 2 3
  2. Control of somatic tissue differentiation by the long non-coding RNA TINCR. (PMID: 23201690) Kretz M … Khavari PA (Nature 2013) 2 3
  3. lncRNA TINCR sponges miR-214-5p to upregulate ROCK1 in hepatocellular carcinoma. (PMID: 31900116) Hu M … Ye L (BMC medical genetics 2020) 3
  4. LncRNA terminal differentiation-induced ncRNA (TINCR) sponges miR-302 to upregulate cyclin D1 in cervical squamous cell carcinoma (CSCC). (PMID: 31388923) Hou A … Zhou X (Human cell 2019) 3
  5. LncRNA TINCR/microRNA-107/CD36 regulates cell proliferation and apoptosis in colorectal cancer via PPAR signaling pathway based on bioinformatics analysis. (PMID: 30521471) Zhang X … Zhang L (Biological chemistry 2019) 3

Products for TINCR Gene

Sources for TINCR Gene