The protein encoded by this gene is similar in sequence to tubulointerstitial nephritis antigen, a secreted glycoprotein that is recognized by antibodies in some types of immune-related tubulointerstitial nephritis. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011] See more...

Aliases for TINAGL1 Gene

Aliases for TINAGL1 Gene

  • Tubulointerstitial Nephritis Antigen Like 1 2 3 5
  • Tubulointerstitial Nephritis Antigen-Related Protein 3 4
  • Tubulointerstitial Nephritis Antigen-Like 3 4
  • Glucocorticoid-Inducible Protein 5 3 4
  • TIN Ag-Related Protein 3 4
  • TINAG-Like 1 2 3
  • Lipocalin 7 2 3
  • TIN-Ag-RP 3 4
  • OLRG-2 3 4
  • LCN7 3 4
  • Oxidized LDL-Responsive Gene 2 Protein 4
  • Oxidized-LDL Responsive Gene 2 3
  • Androgen-Regulated Gene 1 3
  • Androgen Regulated Gene 1 2
  • TINAGRP 3
  • LIECG3 3
  • P3ECSL 3
  • TINAGL 4
  • OLRG2 4
  • ARG1 3
  • GIS5 4

External Ids for TINAGL1 Gene

Previous HGNC Symbols for TINAGL1 Gene

  • LCN7

Previous GeneCards Identifiers for TINAGL1 Gene

  • GC01P031712
  • GC01P031814
  • GC01P032042
  • GC01P030159

Summaries for TINAGL1 Gene

Entrez Gene Summary for TINAGL1 Gene

  • The protein encoded by this gene is similar in sequence to tubulointerstitial nephritis antigen, a secreted glycoprotein that is recognized by antibodies in some types of immune-related tubulointerstitial nephritis. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for TINAGL1 Gene

TINAGL1 (Tubulointerstitial Nephritis Antigen Like 1) is a Protein Coding gene. Diseases associated with TINAGL1 include Taylor's Syndrome. Gene Ontology (GO) annotations related to this gene include cysteine-type peptidase activity and scavenger receptor activity. An important paralog of this gene is TINAG.

UniProtKB/Swiss-Prot Summary for TINAGL1 Gene

  • May be implicated in the adrenocortical zonation and in mechanisms for repressing the CYP11B1 gene expression in adrenocortical cells. This is a non catalytic peptidase C1 family protein (By similarity).

Gene Wiki entry for TINAGL1 Gene

Additional gene information for TINAGL1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TINAGL1 Gene

Genomics for TINAGL1 Gene

GeneHancer (GH) Regulatory Elements for TINAGL1 Gene

Promoters and enhancers for TINAGL1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TINAGL1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TINAGL1

Top Transcription factor binding sites by QIAGEN in the TINAGL1 gene promoter:
  • E4BP4
  • FOXF2
  • FOXO4
  • GATA-2
  • HTF
  • RORalpha1
  • STAT3
  • STAT5A
  • TGIF
  • ZIC2

Genomic Locations for TINAGL1 Gene

Genomic Locations for TINAGL1 Gene
chr1:31,576,384-31,587,686
(GRCh38/hg38)
Size:
11,303 bases
Orientation:
Plus strand
chr1:32,042,086-32,053,288
(GRCh37/hg19)
Size:
11,203 bases
Orientation:
Plus strand

Genomic View for TINAGL1 Gene

Genes around TINAGL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TINAGL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TINAGL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TINAGL1 Gene

Proteins for TINAGL1 Gene

  • Protein details for TINAGL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZM7-TINAL_HUMAN
    Recommended name:
    Tubulointerstitial nephritis antigen-like
    Protein Accession:
    Q9GZM7
    Secondary Accessions:
    • A8K9Q5
    • B4DPK6
    • D3DPN8
    • Q8TEJ9
    • Q8WZ23
    • Q96GZ4
    • Q96JW3

    Protein attributes for TINAGL1 Gene

    Size:
    467 amino acids
    Molecular mass:
    52387 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH09048.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55403.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TINAGL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TINAGL1 Gene

Post-translational modifications for TINAGL1 Gene

  • Glycosylated.
  • Glycosylation at Asn78 and Asn161
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • TINAL_HUMAN (1864)

Other Protein References for TINAGL1 Gene

Assay Products

  • Boster Bio ELISA Kits for TINAGL1
  • Signalway ELISA kits for TINAGL1

No data available for DME Specific Peptides for TINAGL1 Gene

Domains & Families for TINAGL1 Gene

Gene Families for TINAGL1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for TINAGL1 Gene

Blocks:
  • Papain cysteine protease (C1) family signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TINAGL1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ54963, highly similar to Tubulointerstitial nephritis antigen-like (B4DNS5_HUMAN)
  • cDNA FLJ55020, highly similar to Tubulointerstitial nephritis antigen-like (B4DPK6_HUMAN)
  • cDNA FLJ53214, highly similar to Tubulointerstitial nephritis antigen-like (B4DVG5_HUMAN)
  • Tubulointerstitial nephritis antigen-related protein (TINAL_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9GZM7

UniProtKB/Swiss-Prot:

TINAL_HUMAN :
  • Belongs to the peptidase C1 family.
Family:
  • Belongs to the peptidase C1 family.
genes like me logo Genes that share domains with TINAGL1: view

Function for TINAGL1 Gene

Molecular function for TINAGL1 Gene

UniProtKB/Swiss-Prot Function:
May be implicated in the adrenocortical zonation and in mechanisms for repressing the CYP11B1 gene expression in adrenocortical cells. This is a non catalytic peptidase C1 family protein (By similarity).

Phenotypes From GWAS Catalog for TINAGL1 Gene

Gene Ontology (GO) - Molecular Function for TINAGL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005044 scavenger receptor activity IEA --
GO:0005201 extracellular matrix structural constituent RCA,NAS 20551380
GO:0005515 protein binding IPI 25416956
GO:0008234 NOT cysteine-type peptidase activity IEA,IDA 11170462
GO:0030247 polysaccharide binding IEA --
genes like me logo Genes that share ontologies with TINAGL1: view
genes like me logo Genes that share phenotypes with TINAGL1: view

Animal Models for TINAGL1 Gene

MGI Knock Outs for TINAGL1:

Animal Model Products

  • Taconic Biosciences Mouse Models for TINAGL1

CRISPR Products

miRNA for TINAGL1 Gene

miRTarBase miRNAs that target TINAGL1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TINAGL1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TINAGL1 Gene

Localization for TINAGL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TINAGL1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TINAGL1 gene
Compartment Confidence
extracellular 5
lysosome 3
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TINAGL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 11170462
GO:0005615 extracellular space IBA,ISS 22261194
GO:0005737 cytoplasm IEA --
GO:0062023 colocalizes_with collagen-containing extracellular matrix HDA 20551380
GO:0070062 extracellular exosome HDA 19199708
genes like me logo Genes that share ontologies with TINAGL1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TINAGL1 Gene

Pathways & Interactions for TINAGL1 Gene

PathCards logo

SuperPathways for TINAGL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TINAGL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 NOT proteolysis IEA,IDA 11170462
GO:0006897 endocytosis IEA --
GO:0006955 immune response IEA --
GO:0007155 cell adhesion IBA 21873635
GO:0016197 endosomal transport TAS 10799322
genes like me logo Genes that share ontologies with TINAGL1: view

No data available for Pathways by source and SIGNOR curated interactions for TINAGL1 Gene

Drugs & Compounds for TINAGL1 Gene

(2) Drugs for TINAGL1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TINAGL1: view

Transcripts for TINAGL1 Gene

mRNA/cDNA for TINAGL1 Gene

3 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TINAGL1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TINAGL1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - -
SP4: -
SP5: - -
SP6: - - - -
SP7: - - - - - - -
SP8: - - - - -
SP9: - - - - -
SP10:
SP11: - -

Relevant External Links for TINAGL1 Gene

GeneLoc Exon Structure for
TINAGL1

Expression for TINAGL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TINAGL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TINAGL1 Gene

This gene is overexpressed in Artery - Aorta (x4.1).

Protein differential expression in normal tissues from HIPED for TINAGL1 Gene

This gene is overexpressed in Gallbladder (14.9), Adipocyte (6.3), and Rectum (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TINAGL1 Gene



Protein tissue co-expression partners for TINAGL1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TINAGL1

SOURCE GeneReport for Unigene cluster for TINAGL1 Gene:

Hs.199368

mRNA Expression by UniProt/SwissProt for TINAGL1 Gene:

Q9GZM7-TINAL_HUMAN
Tissue specificity: Highly expressed in aorta, heart, placenta, kidney and a colorectal adenocarcinoma cell line. Moderately expressed in skeletal muscle, pancreas, lung, lymph nodes, adrenal gland, bone marrow and thyroid. Weakly expressed in colon, small intestine, ovary, spleen, testis and prostate. Predominantly found in vascular smooth muscle cells, but also in cardiac and skeletal muscle cells as well as kidney.

Evidence on tissue expression from TISSUES for TINAGL1 Gene

  • Kidney(4.6)
  • Muscle(4.4)
  • Intestine(4.2)
  • Liver(4.2)
  • Pancreas(4.2)
genes like me logo Genes that share expression patterns with TINAGL1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TINAGL1 Gene

Orthologs for TINAGL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TINAGL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TINAGL1 31 30
  • 97.43 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TINAGL1 31 30
  • 91.42 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TINAGL1 31 30
  • 88.76 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tinagl1 30
  • 85.72 (n)
mouse
(Mus musculus)
Mammalia Tinagl1 17 31 30
  • 85.2 (n)
oppossum
(Monodelphis domestica)
Mammalia TINAGL1 31
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TINAGL1 31
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves TINAGL1 31 30
  • 72.84 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TINAGL1 31
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tinagl1 30
  • 65.38 (n)
zebrafish
(Danio rerio)
Actinopterygii tinagl1 31 30
  • 65.24 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Swim 31 30
  • 54.85 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007684 30
  • 52.85 (n)
worm
(Caenorhabditis elegans)
Secernentea F26E4.3 31 30
  • 49.22 (n)
OneToMany
Species where no ortholog for TINAGL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TINAGL1 Gene

ENSEMBL:
Gene Tree for TINAGL1 (if available)
TreeFam:
Gene Tree for TINAGL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TINAGL1: view image

Paralogs for TINAGL1 Gene

Paralogs for TINAGL1 Gene

(1) SIMAP similar genes for TINAGL1 Gene using alignment to 3 proteins:

  • TINAL_HUMAN
  • B4DNS5_HUMAN
  • E7EUP2_HUMAN
genes like me logo Genes that share paralogs with TINAGL1: view

Variants for TINAGL1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TINAGL1 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
749342 Likely Benign: not provided 31,577,232(+) C/T SYNONYMOUS_VARIANT
rs17497479 - p.Ala69Ser

Additional dbSNP identifiers (rs#s) for TINAGL1 Gene

Structural Variations from Database of Genomic Variants (DGV) for TINAGL1 Gene

Variant ID Type Subtype PubMed ID
dgv16e201 CNV deletion 23290073
dgv17e201 CNV deletion 23290073
esv1695245 CNV deletion 17803354
esv2746419 CNV deletion 23290073
esv2746441 CNV deletion 23290073
esv2746452 CNV deletion 23290073
esv2758930 CNV loss 17122850
nsv10062 CNV gain+loss 18304495
nsv1011229 CNV loss 25217958
nsv950384 CNV deletion 24416366

Variation tolerance for TINAGL1 Gene

Residual Variation Intolerance Score: 23.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.65; 31.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TINAGL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TINAGL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TINAGL1 Gene

Disorders for TINAGL1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TINAGL1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
taylor's syndrome
  • congestion-fibrosis syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TINAGL1

genes like me logo Genes that share disorders with TINAGL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TINAGL1 Gene

Publications for TINAGL1 Gene

  1. TIN-ag-RP, a novel catalytically inactive cathepsin B-related protein with EGF domains, is predominantly expressed in vascular smooth muscle cells. (PMID: 11170462) Wex T … Brömme D (Biochemistry 2001) 2 3 4 23 54
  2. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  5. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D … Gu J (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 54

Products for TINAGL1 Gene

Sources for TINAGL1 Gene