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Aliases for TIMP4 Gene

Aliases for TIMP4 Gene

  • TIMP Metallopeptidase Inhibitor 4 2 3 5
  • Tissue Inhibitor Of Metalloproteinases 4 3 4
  • Tissue Inhibitor Of Metalloproteinase 4 2 3
  • TIMP-4 3 4
  • Metalloproteinase Inhibitor 4 3

External Ids for TIMP4 Gene

Previous GeneCards Identifiers for TIMP4 Gene

  • GC03M012123
  • GC03M012038
  • GC03M012169

Summaries for TIMP4 Gene

Entrez Gene Summary for TIMP4 Gene

  • This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling. [provided by RefSeq, Jul 2008]

GeneCards Summary for TIMP4 Gene

TIMP4 (TIMP Metallopeptidase Inhibitor 4) is a Protein Coding gene. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and PAK Pathway. Gene Ontology (GO) annotations related to this gene include protease binding and metalloendopeptidase inhibitor activity. An important paralog of this gene is TIMP2.

UniProtKB/Swiss-Prot for TIMP4 Gene

  • Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9.

Gene Wiki entry for TIMP4 Gene

Additional gene information for TIMP4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIMP4 Gene

Genomics for TIMP4 Gene

GeneHancer (GH) Regulatory Elements for TIMP4 Gene

Promoters and enhancers for TIMP4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I012158 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 556.8 +0.4 392 1.9 MXI1 RFX1 MAX SIN3A MCM5 CEBPB CEBPG ZIC2 SMARCB1 SP1 TIMP4 ENSG00000271716 PPARG GC03M012148 SYN2
GH03I012461 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 16 -303.4 -303362 2.9 ELF3 FOXA2 MLX ARID4B ZNF48 RAD21 RARA YY1 SLC30A9 SCRT2 TIMP4 TSEN2 MKRN2 SYN2 PPARG GC03P012458 GC03P012338
GH03I012191 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.8 -34.5 -34528 3.9 ATF1 IRF4 YY1 GTF3C2 ZNF766 ZNF143 ATF7 FOS RUNX3 DEK SYN2 PPARG TAMM41 TSEN2 TIMP4 VGLL4 ENSG00000271716 RAF1 PIR34150 GC03P012190
GH03I012482 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 9.5 -324.8 -324785 3.4 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B TSEN2 VGLL4 TAMM41 RPL32 TIMP4 SYN2 MKRN2 NUP210 GC03P012458 GC03P012338
GH03I012292 Enhancer 0.9 Ensembl ENCODE dbSUPER 18.3 -134.8 -134755 3 ZFHX2 ZNF146 PRDM6 PRDM10 FOSL2 FOS EGR2 SYN2 TIMP4 PPARG ENSG00000225026
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TIMP4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TIMP4 gene promoter:

Genomic Locations for TIMP4 Gene

Genomic Locations for TIMP4 Gene
6,301 bases
Minus strand

Genomic View for TIMP4 Gene

Genes around TIMP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIMP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIMP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIMP4 Gene

Proteins for TIMP4 Gene

  • Protein details for TIMP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Metalloproteinase inhibitor 4
    Protein Accession:
    Secondary Accessions:
    • B2R7K6

    Protein attributes for TIMP4 Gene

    224 amino acids
    Molecular mass:
    25503 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TIMP4 Gene

Post-translational modifications for TIMP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TIMP4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TIMP4 Gene

Domains & Families for TIMP4 Gene

Gene Families for TIMP4 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for TIMP4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protease inhibitor I35 (TIMP) family.
  • Belongs to the protease inhibitor I35 (TIMP) family.
genes like me logo Genes that share domains with TIMP4: view

Function for TIMP4 Gene

Molecular function for TIMP4 Gene

GENATLAS Biochemistry:
matrix metalloproteinase,tissue inhibitor 4,abundantly expressed only in adult heart maybe embedded in intron V of SYN2
UniProtKB/Swiss-Prot Function:
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9.

Phenotypes From GWAS Catalog for TIMP4 Gene

Gene Ontology (GO) - Molecular Function for TIMP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IBA --
GO:0004857 enzyme inhibitor activity IEA --
GO:0008191 metalloendopeptidase inhibitor activity NAS,IBA 8939999
GO:0030414 peptidase inhibitor activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TIMP4: view
genes like me logo Genes that share phenotypes with TIMP4: view

Animal Models for TIMP4 Gene

MGI Knock Outs for TIMP4:

Animal Model Products

  • Taconic Biosciences Mouse Models for TIMP4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TIMP4 Gene

Localization for TIMP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIMP4 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TIMP4 gene
Compartment Confidence
extracellular 5
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TIMP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005578 proteinaceous extracellular matrix IBA --
GO:0005615 extracellular space IBA,IEA --
GO:0030017 sarcomere IEA --
genes like me logo Genes that share ontologies with TIMP4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TIMP4 Gene

Pathways & Interactions for TIMP4 Gene

genes like me logo Genes that share pathways with TIMP4: view

Gene Ontology (GO) - Biological Process for TIMP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007219 Notch signaling pathway IEA --
GO:0007417 central nervous system development IEA --
GO:0008150 biological_process ND --
GO:0009725 response to hormone IBA,IEA --
GO:0010466 negative regulation of peptidase activity IEA --
genes like me logo Genes that share ontologies with TIMP4: view

No data available for SIGNOR curated interactions for TIMP4 Gene

Drugs & Compounds for TIMP4 Gene

(2) Drugs for TIMP4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for TIMP4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TIMP4: view

Transcripts for TIMP4 Gene

mRNA/cDNA for TIMP4 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(50) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TIMP4 Gene

TIMP metallopeptidase inhibitor 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIMP4 Gene

No ASD Table

Relevant External Links for TIMP4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TIMP4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TIMP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TIMP4 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x10.6), Adipose - Subcutaneous (x7.2), and Breast - Mammary Tissue (x4.7).

Protein differential expression in normal tissues from HIPED for TIMP4 Gene

This gene is overexpressed in Milk (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TIMP4 Gene

Protein tissue co-expression partners for TIMP4 Gene

NURSA nuclear receptor signaling pathways regulating expression of TIMP4 Gene:


SOURCE GeneReport for Unigene cluster for TIMP4 Gene:


mRNA Expression by UniProt/SwissProt for TIMP4 Gene:

Tissue specificity: Abundant in heart and present at low levels in many other tissues.

Evidence on tissue expression from TISSUES for TIMP4 Gene

  • Heart(4.6)
  • Nervous system(4.6)
  • Muscle(2.9)
genes like me logo Genes that share expression patterns with TIMP4: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TIMP4 Gene

Orthologs for TIMP4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TIMP4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TIMP4 33 34
  • 98.96 (n)
(Canis familiaris)
Mammalia TIMP4 33 34
  • 91.07 (n)
(Bos Taurus)
Mammalia TIMP4 33 34
  • 89.43 (n)
(Rattus norvegicus)
Mammalia Timp4 33
  • 87.8 (n)
(Mus musculus)
Mammalia Timp4 33 16 34
  • 87.65 (n)
(Monodelphis domestica)
Mammalia TIMP4 34
  • 69 (a)
(Gallus gallus)
Aves TIMP4 33 34
  • 76.05 (n)
(Anolis carolinensis)
Reptilia TIMP4 34
  • 68 (a)
(Danio rerio)
Actinopterygii TIMP4 34
  • 37 (a)
Species where no ortholog for TIMP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TIMP4 Gene

Gene Tree for TIMP4 (if available)
Gene Tree for TIMP4 (if available)

Paralogs for TIMP4 Gene

Paralogs for TIMP4 Gene

(3) SIMAP similar genes for TIMP4 Gene using alignment to 1 proteins: Pseudogenes for TIMP4 Gene

genes like me logo Genes that share paralogs with TIMP4: view

Variants for TIMP4 Gene

Sequence variations from dbSNP and Humsavar for TIMP4 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000388727 -- 12,158,340(-) T/C intron_variant
rs1000457963 -- 12,152,763(-) A/C downstream_transcript_variant
rs1000751587 -- 12,158,557(-) C/G intron_variant
rs1001365306 -- 12,157,314(-) C/T intron_variant
rs1001795055 -- 12,156,961(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TIMP4 Gene

Variant ID Type Subtype PubMed ID
dgv763e201 CNV deletion 23290073
dgv850e199 CNV deletion 23128226
esv1007552 CNV deletion 20482838
esv1015927 CNV deletion 17803354
esv2193425 CNV deletion 18987734
esv2724931 CNV deletion 23290073
esv2724932 CNV deletion 23290073
esv3030297 CNV deletion 24192839
esv3561484 CNV deletion 23714750
nsv1073205 CNV deletion 25765185
nsv1112379 CNV deletion 24896259
nsv1139090 CNV deletion 24896259
nsv1147269 CNV deletion 26484159
nsv236830 CNV deletion 16902084
nsv7351 OTHER inversion 18451855

Variation tolerance for TIMP4 Gene

Residual Variation Intolerance Score: 20.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.53; 11.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TIMP4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIMP4 Gene

Disorders for TIMP4 Gene

Additional Disease Information for TIMP4

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TIMP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIMP4 Gene

Publications for TIMP4 Gene

  1. Cloning of the human tissue inhibitor of metalloproteinase-4 gene (TIMP4) and localization of the TIMP4 and Timp4 genes to human chromosome 3p25 and mouse chromosome 6, respectively. (PMID: 9693046) Olson TM … Apte SS (Genomics 1998) 2 3 4 22 58
  2. Molecular cloning and characterization of human tissue inhibitor of metalloproteinase 4. (PMID: 8939999) Greene J … Shi YE (The Journal of biological chemistry 1996) 2 3 4 22 58
  3. Promoter polymorphism (rs3755724, -55C/T) of tissue inhibitor of metalloproteinase 4 (TIMP4) as a risk factor for Kawasaki disease with coronary artery lesions in a Korean population. (PMID: 19048177) Ban JY … Chung JH (Pediatric cardiology 2009) 3 22 44 58
  4. Polymorphisms of MMP-3 and TIMP-4 genes affect angiographic coronary plaque progression in non-diabetic and type 2 diabetic patients. (PMID: 19376102) Chen QJ … Shen WF (Clinica chimica acta; international journal of clinical chemistry 2009) 3 22 44 58
  5. Association of TIMP-4 gene polymorphism with the risk of osteoarthritis in the Korean population. (PMID: 18301898) Lee HJ … Kim S (Rheumatology international 2008) 3 22 44 58

Products for TIMP4 Gene

Sources for TIMP4 Gene

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