Aliases for TIMP4 Gene
External Ids for TIMP4 Gene
Previous GeneCards Identifiers for TIMP4 Gene
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling. [provided by RefSeq, Jul 2008]
GeneCards Summary for TIMP4 Gene
TIMP4 (TIMP Metallopeptidase Inhibitor 4) is a Protein Coding gene. Diseases associated with TIMP4 include Corneal Neovascularization and Patella, Chondromalacia Of. Among its related pathways are Nanog in Mammalian ESC Pluripotency and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include protease binding and metalloendopeptidase inhibitor activity. An important paralog of this gene is TIMP2.
UniProtKB/Swiss-Prot Summary for TIMP4 Gene
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9.