Aliases for TIMP2 Gene
External Ids for TIMP2 Gene
Previous GeneCards Identifiers for TIMP2 Gene
This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008]
GeneCards Summary for TIMP2 Gene
TIMP2 (TIMP Metallopeptidase Inhibitor 2) is a Protein Coding gene. Diseases associated with TIMP2 include Conjunctivochalasis and Mixed Cell Uveal Melanoma. Among its related pathways are Matrix Metalloproteinases and p70S6K Signaling. Gene Ontology (GO) annotations related to this gene include integrin binding and enzyme activator activity. An important paralog of this gene is TIMP4.
UniProtKB/Swiss-Prot Summary for TIMP2 Gene
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.