Aliases for TIMP2 Gene
Aliases for TIMP2 Gene
External Ids for TIMP2 Gene
- HGNC: 11821
- Entrez Gene: 7077
- Ensembl: ENSG00000035862
- OMIM: 188825
- UniProtKB: P16035
Previous GeneCards Identifiers for TIMP2 Gene
- GC17M076623
- GC17M080115
- GC17M077310
- GC17M077446
- GC17M074363
- GC17M076850
- GC17M072271
Summaries for TIMP2 Gene
-
This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008]
GeneCards Summary for TIMP2 Gene
TIMP2 (TIMP Metallopeptidase Inhibitor 2) is a Protein Coding gene. Diseases associated with TIMP2 include Conjunctivochalasis and Lipodermatosclerosis. Among its related pathways are ERK Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include integrin binding and enzyme activator activity. An important paralog of this gene is TIMP4.
UniProtKB/Swiss-Prot for TIMP2 Gene
-
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.
Additional gene information for TIMP2 Gene
- Monarch Initiative
- Search for TIMP2 at DataMed
- Search for TIMP2 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIMP2 Gene
Genomics for TIMP2 Gene
GeneHancer (GH) Regulatory Elements for TIMP2 Gene
Promoters and enhancers for TIMP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around TIMP2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the TIMP2 gene promoter:
-
- AP-2alpha isoform 4
- AP-2alpha isoform 3
- AP-2alpha isoform 2
- AP-2alpha
- AP-2alphaA
- AP-1
- p53
- Sp1
- ATF
Regulatory Element Products
Genomic Locations for TIMP2 Gene
Genomic Locations for TIMP2 Gene
- chr17:78,852,977-78,925,390
- (GRCh38/hg38)
- Size:
- 72,414 bases
- Orientation:
- Minus strand
- chr17:76,849,059-76,921,472
- (GRCh37/hg19)
- Size:
- 72,414 bases
- Orientation:
- Minus strand
Genomic View for TIMP2 Gene
Genes around TIMP2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25.3 by Entrez Gene
- 17q25.3 by HGNC
- 17q25.3 by Ensembl
TIMP2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TIMP2 Gene
Proteins for TIMP2 Gene
-
Protein details for TIMP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P16035-TIMP2_HUMAN
- Recommended name:
- Metalloproteinase inhibitor 2
- Protein Accession:
- P16035
- Q16121
- Q93006
- Q9UDF7
Protein attributes for TIMP2 Gene
- Size:
- 220 amino acids
- Molecular mass:
- 24399 Da
- Quaternary structure:
-
- Interacts (via the C-terminal) with MMP2 (via the C-terminal PEX domain); the interaction inhibits the MMP2 activity.
Protein Expression for TIMP2 Gene
Post-translational modifications for TIMP2 Gene
- The activity of TIMP2 is dependent on the presence of disulfide bonds.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for TIMP2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for TIMP2 (TIMP-2)
-
Custom Antibody ServicesOriGene Antibodies for TIMP2
- AM05382PU-N
- AM31016PU-N
- AM31017PU-N
- AP06355PU-N
- AP23358PU-N
- AP31205PU-N
- BP861
- TA313021
- TA322881
- TA325939
- TA325940
- TA327073
- TA327966
- TA353511
- TA354126
- TA504017
- CF504017
- TA504018
- CF504018
- TA504042
- CF504042
- TA504043
- CF504043
- TA504044
- CF504044
- TA504191
- CF504191
- TA504312
- CF504312
- TA600235
- TA600236
- TA600237
- TA600238
- TA700235
- TA700236
- TA700237
- TA700238
- TA700242
- TA700243
- Novus Biologicals Antibodies for TIMP2
-
Abcam antibodies for TIMP2
- Invitrogen Antibodies for TIMP2
- antibodies-online: Search results for 328 available TIMP2 Antibodies ranked by validation data
- Compare Top TIMP2 Antibodies
-
Recommended
- 233 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 10 LMNX Antibodies (anti-human)
- 9 IHC (p) Antibodies (anti-human)
- 8 FACS Antibodies (anti-human)
- 4 IF Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 2 IP Antibodies (anti-human)
- 104 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 6 FACS Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- 2 IP Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- 110 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 8 FACS Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 2 IP Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- GeneTex TIMP2 Antibody for TIMP2
-
Santa Cruz Biotechnology (SCBT) Antibodies for TIMP2
Protein Products
- R&D Systems Proteins and Enzymes for TIMP2 (TIMP-2)
- Search Origene for MassSpec and Protein Over-expression Lysates for TIMP2
- Origene Custom Protein Services for TIMP2
- Sino Biological Recombinant Proteins for TIMP2
- Sino Biological Cell Lysates for TIMP2
- ProSpec Recombinant Proteins for TIMP2
- GeneTex Proteins for TIMP2
-
Abcam proteins for TIMP2
Assay Products
- R&D Systems ELISAs, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for TIMP2 (TIMP-2)
- Novus Biologicals ELISA Kits for TIMP2
- antibodies-online: Search results for 105 available TIMP2 Elisa Kits ranked by validation data
- Compare Top TIMP2 Elisa Kits
-
Recommended
- 1 Cat (Feline) ELISA Kit
- 4 Chicken ELISA Kits
- 7 Cow (Bovine) ELISA Kits
- 6 Dog (Canine) ELISA Kits
- 1 Fish ELISA Kit
- 3 Guinea Pig ELISA Kits
- 6 Horse (Equine) ELISA Kits
- 34 Human ELISA Kits
- 19 Mouse (Murine) ELISA Kits
- 7 Pig (Porcine) ELISA Kits
- 4 Rabbit ELISA Kits
- 19 Rat (Rattus) ELISA Kits
- 1 Rhesus Monkey ELISA Kit
- 2 Wild boar (Sus scrofa) ELISA Kits
- 1 Zebrafish ELISA Kit
-
Abcam assays for TIMP2
No data available for DME Specific Peptides for TIMP2 Gene
Domains & Families for TIMP2 Gene
Gene Families for TIMP2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Candidate cardiovascular disease genes
- Plasma proteins
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for TIMP2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for TIMP2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P16035- Family:
-
- Belongs to the protease inhibitor I35 (TIMP) family.
Function for TIMP2 Gene
Molecular function for TIMP2 Gene
- UniProtKB/Swiss-Prot Function:
- Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.
- UniProtKB/Swiss-Prot Induction:
- Down-regulated by TGFB1.
- GENATLAS Biochemistry:
- matrix metalloproteinase,tissue inhibitor 2,with two alternatively spliced forms may be associated with SYN4,involved in the invasive phenotype of acute myelogenous leukemia
Phenotypes From GWAS Catalog for TIMP2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002020 | protease binding | IPI | 9573338 |
| GO:0004857 | enzyme inhibitor activity | IEA | -- |
| GO:0005178 | integrin binding | IEA | -- |
| GO:0005515 | protein binding | IPI,IEA | 24112707 |
| GO:0008191 | metalloendopeptidase inhibitor activity | IEA,IDA | 9573338 |
Phenotypes for TIMP2 Gene
- MGI mutant phenotypes for TIMP2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for TIMP2:
-
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Increased cell death HMECs cells
- Negative genetic interaction between BLM-/- and BLM+/+
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Reduced mammosphere formation
- Decreased shRNA abundance
- Decreased cell migration
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
Animal Model Products
-
Taconic Biosciences Mouse Models for TIMP2
- Cyagen custom Knockout/knockin (KOKI) mouse models for TIMP2
-
CRISPR Products
-
OriGene CRISPR knockouts for TIMP2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TIMP2
- genomics-online: gRNA clones - Search results for available TIMP2 gene related products
- Applied Biological Materials CRISPR for TIMP2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TIMP2
- GenScript: Design CRISPR guide RNA sequences for TIMP2
miRNA for TIMP2 Gene
- miRTarBase miRNAs that target TIMP2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TIMP2
- Browse OriGene Inhibitory RNA Products For TIMP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TIMP2
- genomics-online: shRNA clones - Search results for available TIMP2 gene related products
Clone Products
- Sino Biological Human cDNA Clone for TIMP2
- VectorBuilder custom plasmid, inducible vectors for TIMP2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TIMP2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TIMP2
- genomics-online: cdna clones - Search results for available TIMP2 gene related products
- orf clones - Search results for available TIMP2 gene related products
- Applied Biological Materials Clones for TIMP2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for TIMP2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TIMP2 Gene
Localization for TIMP2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TIMP2 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| nucleus | 2 |
| cytosol | 2 |
| mitochondrion | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA,TAS | -- |
| GO:0005615 | extracellular space | IEA,IBA | -- |
| GO:0009986 | cell surface | IEA | -- |
| GO:0030426 | growth cone | IEA | -- |
| GO:0031012 | extracellular matrix | HDA | 23979707 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for TIMP2 Gene
Pathways & Interactions for TIMP2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptotic Pathways in Synovial Fibroblasts |
.74
.66
|
.65
.61
.60
.57
|
| 2 | GPCR Pathway |
.73
.62
|
.55
|
| 3 | ERK Signaling |
.61
.58
|
.49
|
| 4 | Nanog in Mammalian ESC Pluripotency |
.61
|
.48
|
| 5 | CREB Pathway |
.68
.68
|
|
Pathways by source for TIMP2 Gene
3 BioSystems pathways for TIMP2 Gene
6 Reactome pathways for TIMP2 Gene
2 GeneGo (Thomson Reuters) pathways for TIMP2 Gene
55 Qiagen pathways for TIMP2 Gene
1 Cell Signaling Technology pathway for TIMP2 Gene
Interacting Proteins for TIMP2 Gene
Selected Interacting proteins:
P16035-TIMP2_HUMAN
ENSP00000262768
for TIMP2 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for TIMP2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007417 | central nervous system development | IEA | -- |
| GO:0007568 | aging | IEA | -- |
| GO:0008285 | negative regulation of cell proliferation | IEA | -- |
| GO:0009725 | response to hormone | IBA | -- |
| GO:0010033 | response to organic substance | IBA | -- |
No data available for SIGNOR curated interactions for TIMP2 Gene
Transcripts for TIMP2 Gene
mRNA/cDNA for TIMP2 Gene
- (1) REFSEQ mRNAs :
- (14) Additional mRNA sequences :
- (869) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000585421 3345 bps (uc060kwu.1)
- ENST00000536189 3415 bps (uc010wty.2)
- ENST00000262768 3652 bps (uc002jwf.4)
- ENST00000586057 3389 bps (uc002jwe.4)
- ENST00000592761 2433 bps (uc060kww.1)
Unigene Clusters for TIMP2 Gene
- TIMP metallopeptidase inhibitor 2:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for TIMP2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TIMP2
- genomics-online: gRNA clones - Search results for available TIMP2 gene related products
- Applied Biological Materials CRISPR for TIMP2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TIMP2
- GenScript: Design CRISPR guide RNA sequences for TIMP2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TIMP2
- Browse OriGene Inhibitory RNA Products For TIMP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TIMP2
- genomics-online: shRNA clones - Search results for available TIMP2 gene related products
Clone Products
- Sino Biological Human cDNA Clone for TIMP2
- VectorBuilder custom plasmid, inducible vectors for TIMP2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TIMP2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TIMP2
- genomics-online: cdna clones - Search results for available TIMP2 gene related products
- orf clones - Search results for available TIMP2 gene related products
- Applied Biological Materials Clones for TIMP2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||
| SP5: | - | - | - |
Expression for TIMP2 Gene
mRNA differential expression in normal tissues according to GTEx for TIMP2 Gene
This gene is overexpressed in Artery - Aorta (x4.1).
This gene is overexpressed in Amniocyte (39.0) and Serum (14.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TIMP2 Gene
NURSA nuclear receptor signaling pathways regulating expression of TIMP2 Gene:
TIMP2SOURCE GeneReport for Unigene cluster for TIMP2 Gene:
Hs.633514Evidence on tissue expression from TISSUES for TIMP2 Gene
- Skin(4.9)
- Nervous system(4.7)
- Lung(4.3)
- Eye(4.1)
- Heart(4.1)
- Pancreas(3.9)
- Muscle(3.3)
- Kidney(3.1)
- Blood(3)
- Bone(2.9)
- Gall bladder(2.8)
- Intestine(2.8)
- Liver(2.8)
- Lymph node(2.8)
- Spleen(2.4)
- Stomach(2.2)
- Thyroid gland(2.1)
- Adrenal gland(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for TIMP2
-
OriGene qPCR primer pairs for TIMP2
- genomics-online: primer clones - Search results for available TIMP2 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TIMP2 Gene
Orthologs for TIMP2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TIMP2 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | TIMP2 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Timp2 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Timp2 33 |
|
||
| cow (Bos Taurus) |
Mammalia | TIMP2 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | TIMP2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | TIMP2 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | TIMP2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | timp2 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.26350 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | timp2a 34 33 |
|
OneToMany | |
| timp2b 34 |
|
OneToMany | |||
| timp2 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.4143 33 |
|
- Species where no ortholog for TIMP2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for TIMP2 Gene
- ENSEMBL:
- Gene Tree for TIMP2 (if available)
- TreeFam:
- Gene Tree for TIMP2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TIMP2: view image
Paralogs for TIMP2 Gene
Variants for TIMP2 Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000001586 | -- | 78,918,553(-) | T/C/G | intron_variant | |
| rs1000021645 | -- | 78,903,335(-) | A/G | intron_variant | |
| rs1000052083 | -- | 78,926,947(-) | C/T | upstream_transcript_variant | |
| rs1000056290 | -- | 78,924,200(-) | G/A | intron_variant | |
| rs1000058962 | -- | 78,923,218(-) | G/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2031325 | CNV | deletion | 18987734 |
| esv2667094 | CNV | deletion | 23128226 |
| esv3554834 | CNV | deletion | 23714750 |
| nsv1057193 | CNV | gain | 25217958 |
| nsv1066843 | CNV | gain | 25217958 |
| nsv1070850 | CNV | deletion | 25765185 |
| nsv1112717 | CNV | deletion | 24896259 |
| nsv1118771 | CNV | deletion | 24896259 |
| nsv1134680 | CNV | deletion | 24896259 |
| nsv457917 | CNV | gain | 19166990 |
| nsv576101 | CNV | gain | 21841781 |
| nsv952376 | CNV | deletion | 24416366 |
| nsv952377 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
56.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.43;
9.51% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TIMP2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIMP2 Gene
Disorders for TIMP2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| conjunctivochalasis |
|
|
| lipodermatosclerosis |
|
|
| inguinal hernia |
|
|
| fibrosarcoma |
|
|
| sorsby fundus dystrophy |
|
|
Search TIMP2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TIMP2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Tumor Gene Database
- (TGDB)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for TIMP2 Gene
Publications for TIMP2 Gene
- Host single nucleotide polymorphisms of MMP-9 -1562/TIMP-1 372 have gender differences in the risk of gastric intestinal metaplasia after Helicobacter pylori infection. (PMID: 19889076) Hung KH … Sheu BS (Helicobacter 2009) 3 22 44 58
- Gene polymorphisms related to angiogenesis, inflammation and thrombosis that influence risk for oral cancer. (PMID: 18674955) Vairaktaris E … Patsouris E (Oral oncology 2009) 3 22 44 58
- TIMP-2 gene polymorphism is associated with intracerebral hemorrhage. (PMID: 19844095) Reuter B … Fatar M (Cerebrovascular diseases (Basel, Switzerland) 2009) 3 22 44 58
- Tissue inhibitor of metalloproteinases-2 (TIMP-2) mRNA expression in tumor cell lines and human tumor tissues. (PMID: 2380196) Stetler-Stevenson WG … Liotta LA (The Journal of biological chemistry 1990) 3 4 22 58
- Matrix metalloproteinase-10/TIMP-2 structure and analyses define conserved core interactions and diverse exosite interactions in MMP/TIMP complexes. (PMID: 24073280) Batra J … Radisky ES (PloS one 2013) 3 4 58
Products for TIMP2 Gene
- R&D Systems Antibodies for TIMP2 (TIMP-2)
- R&D Systems Proteins and Enzymes for TIMP2 (TIMP-2)
- R&D Systems ELISAs, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for TIMP2 (TIMP-2)
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
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- Custom Antibody ServicesOriGene Antibodies for TIMP2
- AM05382PU-N
- AM31016PU-N
- AM31017PU-N
- AP06355PU-N
- AP23358PU-N
- AP31205PU-N
- BP861
- TA313021
- TA322881
- TA325939
- TA325940
- TA327073
- TA327966
- TA353511
- TA354126
- TA504017
- CF504017
- TA504018
- CF504018
- TA504042
- CF504042
- TA504043
- CF504043
- TA504044
- CF504044
- TA504191
- CF504191
- TA504312
- CF504312
- TA600235
- TA600236
- TA600237
- TA600238
- TA700235
- TA700236
- TA700237
- TA700238
- TA700242
- TA700243
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for TIMP2
- Origene Custom Protein Services for TIMP2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TIMP2
- Browse OriGene Inhibitory RNA Products For TIMP2
- OriGene qPCR primer pairs and template standards for TIMP2
- OriGene qPCR primer pairs for TIMP2
- OriGene CRISPR knockouts for TIMP2
- OriGene ORF clones in human for TIMP2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For TIMP2
- GenScript: Next-day shipping of latest version cDNA ORF clones for TIMP2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for TIMP2
- GenScript Custom Assay Services for TIMP2
- GenScript Custom overexpressing Cell Line Services for TIMP2
- GenScript: Design CRISPR guide RNA sequences for TIMP2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for TIMP2
- Sino Biological Human cDNA Clone for TIMP2
- Sino Biological Recombinant Proteins for TIMP2
- Sino Biological Cell Lysates for TIMP2
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for TIMP2
- Novus Biologicals proteins and lysates for TIMP2
- Novus Biologicals ELISA Kits for TIMP2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for TIMP2
- Abcam proteins for TIMP2
- Abcam assays for TIMP2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
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- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for TIMP2
- Taconic Biosciences Mouse Models for TIMP2
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for TIMP2
- Cyagen custom Knockout/knockin (KOKI) mouse models for TIMP2
- VectorBuilder custom plasmid, inducible vectors for TIMP2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TIMP2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 328 available TIMP2 Antibodies ranked by validation data
- Compare Top TIMP2 Antibodies
- Recommended
- 233 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 10 LMNX Antibodies (anti-human)
- 9 IHC (p) Antibodies (anti-human)
- 8 FACS Antibodies (anti-human)
- 4 IF Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 2 IP Antibodies (anti-human)
- 104 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 6 FACS Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- 2 IP Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- 110 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 8 FACS Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 2 IP Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- antibodies-online: Search results for 105 available TIMP2 Elisa Kits ranked by validation data
- Compare Top TIMP2 Elisa Kits
- Recommended
- 1 Cat (Feline) ELISA Kit
- 4 Chicken ELISA Kits
- 7 Cow (Bovine) ELISA Kits
- 6 Dog (Canine) ELISA Kits
- 1 Fish ELISA Kit
- 3 Guinea Pig ELISA Kits
- 6 Horse (Equine) ELISA Kits
- 34 Human ELISA Kits
- 19 Mouse (Murine) ELISA Kits
- 7 Pig (Porcine) ELISA Kits
- 4 Rabbit ELISA Kits
- 19 Rat (Rattus) ELISA Kits
- 1 Rhesus Monkey ELISA Kit
- 2 Wild boar (Sus scrofa) ELISA Kits
- 1 Zebrafish ELISA Kit
- antibodies-online: Search results for 46 available TIMP2 Proteins ranked by validation data
- Compare Top TIMP2 Proteins
- GeneTex TIMP2 Antibody for TIMP2
- GeneTex Proteins for TIMP2
- Santa Cruz Biotechnology (SCBT) Antibodies for TIMP2
- Search Santa Cruz Biotechnology (SCBT) for TIMP2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TIMP2
- Horizon Cell Lines for TIMP2
- genomics-online: cdna clones - Search results for available TIMP2 gene related products
- orf clones - Search results for available TIMP2 gene related products
- genomics-online: gRNA clones - Search results for available TIMP2 gene related products
- genomics-online: primer clones - Search results for available TIMP2 gene related products
- genomics-online: shRNA clones - Search results for available TIMP2 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TIMP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TIMP2
- GeneCopoeia miRNA 3'UTR Target clone products for TIMP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TIMP2
Sources for TIMP2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
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- (123) CDC
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- (125) NCBI Bookshelf
- (126) ClinVar
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- (128) ViGene Biosciences
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- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt