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Aliases for TIMP2 Gene

Aliases for TIMP2 Gene

  • TIMP Metallopeptidase Inhibitor 2 2 3 5
  • Tissue Inhibitor Of Metalloproteinases 2 3 4
  • CSC-21K 3 4
  • Tissue Inhibitor Of Metalloproteinase 2 2
  • Testicular Secretory Protein Li 57 3
  • Metalloproteinase Inhibitor 2 3
  • TIMP-2 4
  • DDC8 3

External Ids for TIMP2 Gene

Previous GeneCards Identifiers for TIMP2 Gene

  • GC17M076623
  • GC17M080115
  • GC17M077310
  • GC17M077446
  • GC17M074363
  • GC17M076850
  • GC17M072271

Summaries for TIMP2 Gene

Entrez Gene Summary for TIMP2 Gene

  • This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008]

GeneCards Summary for TIMP2 Gene

TIMP2 (TIMP Metallopeptidase Inhibitor 2) is a Protein Coding gene. Diseases associated with TIMP2 include Conjunctivochalasis and Lipodermatosclerosis. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and PAK Pathway. Gene Ontology (GO) annotations related to this gene include integrin binding and enzyme activator activity. An important paralog of this gene is TIMP4.

UniProtKB/Swiss-Prot for TIMP2 Gene

  • Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.

Gene Wiki entry for TIMP2 Gene

Additional gene information for TIMP2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIMP2 Gene

Genomics for TIMP2 Gene

GeneHancer (GH) Regulatory Elements for TIMP2 Gene

Promoters and enhancers for TIMP2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I078919 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 550.8 +2.2 2185 6.7 PKNOX1 ARID4B SIN3A TCF12 GLIS2 KLF7 ATF7 SP3 NCOA1 NFYC PIR33852 TIMP2 ENSG00000267491 CANT1 CEP295NL CYTH1
GH17I078878 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 13.8 +42.7 42675 9.2 PKNOX1 ARID4B SIN3A DMAP1 BRCA1 ZNF48 ETS1 ZNF766 GLIS2 ELK1 USP36 TIMP2 CYTH1 CANT1 ENGASE PIR59444 ENSG00000279339 CEP295NL
GH17I078875 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 13.7 +49.1 49149 2.4 SCRT1 KLF1 ZNF189 CEBPB ZFHX2 SCRT2 IKZF1 BCL6B PRDM10 ZNF600 TIMP2 USP36 PGS1 CANT1 CYTH1 PIR59444 GC17P078863 CEP295NL
GH17I078284 Enhancer 0.8 Ensembl ENCODE 5.6 +640.5 640457 1.6 ZNF10 MAX CEBPB CEBPG ZIC2 ZFHX2 POLR2A GLIS1 CEBPA MYC LINC01993 TIMP2 LOC105371912
GH17I078932 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 0.4 -9.3 -9296 4.5 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A ZNF2 SLC30A9 ZNF213 ZNF143 USP36 C1QTNF1 ENSG00000267491 CEP295NL CANT1 TIMP2 GC17P078963
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TIMP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TIMP2 gene promoter:

Genomic Locations for TIMP2 Gene

Genomic Locations for TIMP2 Gene
72,414 bases
Minus strand

Genomic View for TIMP2 Gene

Genes around TIMP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIMP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIMP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIMP2 Gene

Proteins for TIMP2 Gene

  • Protein details for TIMP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Metalloproteinase inhibitor 2
    Protein Accession:
    Secondary Accessions:
    • Q16121
    • Q93006
    • Q9UDF7

    Protein attributes for TIMP2 Gene

    220 amino acids
    Molecular mass:
    24399 Da
    Quaternary structure:
    • Interacts (via the C-terminal) with MMP2 (via the C-terminal PEX domain); the interaction inhibits the MMP2 activity.

    Three dimensional structures from OCA and Proteopedia for TIMP2 Gene

neXtProt entry for TIMP2 Gene

Post-translational modifications for TIMP2 Gene

  • The activity of TIMP2 is dependent on the presence of disulfide bonds.

Other Protein References for TIMP2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TIMP2 (TIMP2)
  • Abcam antibodies for TIMP2

No data available for DME Specific Peptides for TIMP2 Gene

Domains & Families for TIMP2 Gene

Gene Families for TIMP2 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Candidate cardiovascular disease genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for TIMP2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protease inhibitor I35 (TIMP) family.
  • Belongs to the protease inhibitor I35 (TIMP) family.
genes like me logo Genes that share domains with TIMP2: view

Function for TIMP2 Gene

Molecular function for TIMP2 Gene

GENATLAS Biochemistry:
matrix metalloproteinase,tissue inhibitor 2,with two alternatively spliced forms may be associated with SYN4,involved in the invasive phenotype of acute myelogenous leukemia
UniProtKB/Swiss-Prot Function:
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.
UniProtKB/Swiss-Prot Induction:
Down-regulated by TGFB1.

Phenotypes From GWAS Catalog for TIMP2 Gene

Gene Ontology (GO) - Molecular Function for TIMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 9573338
GO:0004857 enzyme inhibitor activity IEA --
GO:0005178 integrin binding IEA --
GO:0005515 protein binding IPI 24112707
GO:0008191 metalloendopeptidase inhibitor activity IDA,IEA 9573338
genes like me logo Genes that share ontologies with TIMP2: view
genes like me logo Genes that share phenotypes with TIMP2: view

Animal Models for TIMP2 Gene

MGI Knock Outs for TIMP2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TIMP2 Gene

Localization for TIMP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIMP2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TIMP2 gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 2
nucleus 2
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TIMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS,IEA --
GO:0005578 proteinaceous extracellular matrix IBA --
GO:0005615 extracellular space IEA,IBA --
GO:0009986 cell surface IEA --
GO:0030426 growth cone IEA --
genes like me logo Genes that share ontologies with TIMP2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TIMP2 Gene

Pathways & Interactions for TIMP2 Gene

genes like me logo Genes that share pathways with TIMP2: view

Gene Ontology (GO) - Biological Process for TIMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007417 central nervous system development IEA --
GO:0007568 aging IEA --
GO:0008285 negative regulation of cell proliferation IEA --
GO:0009725 response to hormone IBA --
GO:0010466 negative regulation of peptidase activity IEA --
genes like me logo Genes that share ontologies with TIMP2: view

No data available for SIGNOR curated interactions for TIMP2 Gene

Drugs & Compounds for TIMP2 Gene

(49) Drugs for TIMP2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(39) Additional Compounds for TIMP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TIMP2: view

Transcripts for TIMP2 Gene

Unigene Clusters for TIMP2 Gene

TIMP metallopeptidase inhibitor 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIMP2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d
SP1: - - - - -
SP2: -
SP4: -
SP5: - - -

Relevant External Links for TIMP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TIMP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TIMP2 Gene

mRNA differential expression in normal tissues according to GTEx for TIMP2 Gene

This gene is overexpressed in Artery - Aorta (x4.1).

Protein differential expression in normal tissues from HIPED for TIMP2 Gene

This gene is overexpressed in Amniocyte (39.0) and Serum (14.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TIMP2 Gene

Protein tissue co-expression partners for TIMP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TIMP2 Gene:


SOURCE GeneReport for Unigene cluster for TIMP2 Gene:


Evidence on tissue expression from TISSUES for TIMP2 Gene

  • Skin(4.9)
  • Nervous system(4.7)
  • Lung(4.3)
  • Eye(4.1)
  • Heart(4.1)
  • Pancreas(3.9)
  • Muscle(3.3)
  • Kidney(3.1)
  • Blood(3)
  • Bone(2.9)
  • Gall bladder(2.8)
  • Liver(2.8)
  • Lymph node(2.8)
  • Intestine(2.7)
  • Spleen(2.4)
  • Stomach(2.2)
  • Thyroid gland(2.1)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with TIMP2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TIMP2 Gene

Orthologs for TIMP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TIMP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TIMP2 33 34
  • 99.24 (n)
(Canis familiaris)
Mammalia TIMP2 33 34
  • 92.27 (n)
(Mus musculus)
Mammalia Timp2 33 16 34
  • 91.97 (n)
(Rattus norvegicus)
Mammalia Timp2 33
  • 91.97 (n)
(Bos Taurus)
Mammalia TIMP2 33 34
  • 91.67 (n)
(Monodelphis domestica)
Mammalia TIMP2 34
  • 79 (a)
(Gallus gallus)
Aves TIMP2 33 34
  • 79.63 (n)
(Anolis carolinensis)
Reptilia TIMP2 34
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia timp2 33
  • 77.16 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.26350 33
(Danio rerio)
Actinopterygii timp2a 33 34
  • 75.8 (n)
timp2b 34
  • 50 (a)
timp2 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4143 33
Species where no ortholog for TIMP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TIMP2 Gene

Gene Tree for TIMP2 (if available)
Gene Tree for TIMP2 (if available)

Paralogs for TIMP2 Gene

Paralogs for TIMP2 Gene

(4) SIMAP similar genes for TIMP2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TIMP2: view

Variants for TIMP2 Gene

Sequence variations from dbSNP and Humsavar for TIMP2 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000001586 -- 78,918,553(-) T/C/G intron_variant
rs1000021645 -- 78,903,335(-) A/G intron_variant
rs1000052083 -- 78,926,947(-) C/T upstream_transcript_variant
rs1000056290 -- 78,924,200(-) G/A intron_variant
rs1000058962 -- 78,923,218(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TIMP2 Gene

Variant ID Type Subtype PubMed ID
nsv952377 CNV deletion 24416366
nsv952376 CNV deletion 24416366
nsv576101 CNV gain 21841781
nsv457917 CNV gain 19166990
nsv1134680 CNV deletion 24896259
nsv1118771 CNV deletion 24896259
nsv1112717 CNV deletion 24896259
nsv1070850 CNV deletion 25765185
nsv1066843 CNV gain 25217958
nsv1057193 CNV gain 25217958
esv3554834 CNV deletion 23714750
esv2667094 CNV deletion 23128226
esv2031325 CNV deletion 18987734

Variation tolerance for TIMP2 Gene

Residual Variation Intolerance Score: 56.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.43; 9.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TIMP2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIMP2 Gene

Disorders for TIMP2 Gene

MalaCards: The human disease database

(34) MalaCards diseases for TIMP2 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • acute lipodermatosclerosis
gallbladder cancer
  • gallbladder ca
inguinal hernia
  • hernia inguinal
  • fibrocytic tumor
- elite association - COSMIC cancer census association via MalaCards
Search TIMP2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TIMP2

Genetic Association Database
Human Genome Epidemiology Navigator
Tumor Gene Database
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TIMP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TIMP2 Gene

Publications for TIMP2 Gene

  1. Gene polymorphisms related to angiogenesis, inflammation and thrombosis that influence risk for oral cancer. (PMID: 18674955) Vairaktaris E … Patsouris E (Oral oncology 2009) 3 22 44 58
  2. TIMP-2 gene polymorphism is associated with intracerebral hemorrhage. (PMID: 19844095) Reuter B … Fatar M (Cerebrovascular diseases (Basel, Switzerland) 2009) 3 22 44 58
  3. Host single nucleotide polymorphisms of MMP-9 -1562/TIMP-1 372 have gender differences in the risk of gastric intestinal metaplasia after Helicobacter pylori infection. (PMID: 19889076) Hung KH … Sheu BS (Helicobacter 2009) 3 22 44 58
  4. Tissue inhibitor of metalloproteinases-2 (TIMP-2) mRNA expression in tumor cell lines and human tumor tissues. (PMID: 2380196) Stetler-Stevenson WG … Liotta LA (The Journal of biological chemistry 1990) 3 4 22 58
  5. Matrix metalloproteinase-10/TIMP-2 structure and analyses define conserved core interactions and diverse exosite interactions in MMP/TIMP complexes. (PMID: 24073280) Batra J … Radisky ES (PloS one 2013) 3 4 58

Products for TIMP2 Gene

Sources for TIMP2 Gene

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