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This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008]
TIMP2 (TIMP Metallopeptidase Inhibitor 2) is a Protein Coding gene. Diseases associated with TIMP2 include Conjunctivochalasis and Fibrosarcoma. Among its related pathways are ERK Signaling and Nanog in Mammalian ESC Pluripotency. Gene Ontology (GO) annotations related to this gene include integrin binding and enzyme activator activity. An important paralog of this gene is TIMP4.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002020 | protease binding | IPI | 9573338 |
GO:0004857 | enzyme inhibitor activity | IEA | -- |
GO:0005178 | integrin binding | IEA | -- |
GO:0005515 | protein binding | IEA,IPI | 12032297 |
GO:0008191 | metalloendopeptidase inhibitor activity | IEA,IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA,TAS | -- |
GO:0005615 | extracellular space | IEA,IBA | 21873635 |
GO:0009986 | cell surface | IEA | -- |
GO:0030426 | growth cone | IEA | -- |
GO:0031012 | extracellular matrix | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
|
Rac1 Pathway
.65
Glioma Invasiveness
.64
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
Nuclear Receptor Activation by Vitamin-A
.57
|
2 | GPCR Pathway |
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
|
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
|
3 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
MAPK Signaling
.58
|
Molecular Mechanisms of Cancer
.51
ILK Signaling
.49
|
4 | Nanog in Mammalian ESC Pluripotency |
GSK3 Signaling
.61
Nanog in Mammalian ESC Pluripotency
.61
|
14-3-3 Induced Intracellular Signaling
.59
eNOS Signaling
.48
|
5 | CREB Pathway |
CREB Pathway
.68
IP3 Pathway
.68
|
Activation of PKC through GPCR
.63
Intracellular Calcium Signaling
.50
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007417 | central nervous system development | IEA | -- |
GO:0007568 | aging | IEA | -- |
GO:0008285 | negative regulation of cell proliferation | IEA | -- |
GO:0009725 | response to hormone | IBA | 21873635 |
GO:0010033 | response to organic substance | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | ||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||
SP5: | - | - | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TIMP2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | TIMP2 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Timp2 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Timp2 30 |
|
||
Cow (Bos Taurus) |
Mammalia | TIMP2 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | TIMP2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | TIMP2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | TIMP2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | timp2 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.26350 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | timp2a 30 31 |
|
OneToMany | |
timp2b 31 |
|
OneToMany | |||
timp2 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.4143 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2031325 | CNV | deletion | 18987734 |
esv2667094 | CNV | deletion | 23128226 |
esv3554834 | CNV | deletion | 23714750 |
nsv1057193 | CNV | gain | 25217958 |
nsv1066843 | CNV | gain | 25217958 |
nsv1070850 | CNV | deletion | 25765185 |
nsv1112717 | CNV | deletion | 24896259 |
nsv1118771 | CNV | deletion | 24896259 |
nsv1134680 | CNV | deletion | 24896259 |
nsv457917 | CNV | gain | 19166990 |
nsv576101 | CNV | gain | 21841781 |
nsv952376 | CNV | deletion | 24416366 |
nsv952377 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
conjunctivochalasis |
|
|
fibrosarcoma |
|
|
preterm premature rupture of the membranes |
|
|
gingival hypertrophy |
|
|
pulmonary emphysema |
|
|