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This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, a... See more...
Aliases for TIMP1 Gene
Aliases for TIMP1 Gene
External Ids for TIMP1 Gene
- HGNC: 11820
- Entrez Gene: 7076
- Ensembl: ENSG00000102265
- OMIM: 305370
- UniProtKB: P01033
Previous HGNC Symbols for TIMP1 Gene
- TIMP
- CLGI
Previous GeneCards Identifiers for TIMP1 Gene
- GC0XP046244
- GC0XP045702
- GC0XP046487
- GC0XP046461
- GC0XP047197
- GC0XP047326
- GC0XP047441
- GC0XP045154
Summaries for TIMP1 Gene
-
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq, Jul 2008]
GeneCards Summary for TIMP1 Gene
TIMP1 (TIMP Metallopeptidase Inhibitor 1) is a Protein Coding gene. Diseases associated with TIMP1 include Oral Submucous Fibrosis and Lung Giant Cell Carcinoma. Among its related pathways are Matrix Metalloproteinases and p70S6K Signaling. Gene Ontology (GO) annotations related to this gene include cytokine activity and protease binding. An important paralog of this gene is TIMP2.
UniProtKB/Swiss-Prot Summary for TIMP1 Gene
-
Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors.
Additional gene information for TIMP1 Gene
- Monarch Initiative
- Search for TIMP1 at DataMed
- Search for TIMP1 at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TIMP1 Gene
Genomics for TIMP1 Gene
GeneHancer (GH) Regulatory Elements for TIMP1 Gene
Promoters and enhancers for TIMP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TIMP1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the TIMP1 gene promoter:
-
- AP-1
- Egr-1
- Egr-2
- Elk-1
- NF-kappaB1
- Nkx2-5
- Pax-5
- PPAR-gamma1
- Sox9
- Sp1
Genomic Locations for TIMP1 Gene
Genomic Locations for TIMP1 Gene
- chrX:47,582,291-47,586,791
- (GRCh38/hg38)
- Size:
- 4,501 bases
- Orientation:
- Plus strand
- chrX:47,441,690-47,446,190
- (GRCh37/hg19)
- Size:
- 4,501 bases
- Orientation:
- Plus strand
Genomic View for TIMP1 Gene
Genes around TIMP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xp11.3 by HGNC
- Xp11.3 by Entrez Gene
- Xp11.3 by Ensembl
TIMP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TIMP1 Gene
Proteins for TIMP1 Gene
-
Protein details for TIMP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P01033-TIMP1_HUMAN
- Recommended name:
- Metalloproteinase inhibitor 1
- Protein Accession:
- P01033
- Q14252
- Q9UCU1
Protein attributes for TIMP1 Gene
- Size:
- 207 amino acids
- Molecular mass:
- 23171 Da
- Quaternary structure:
-
- Interacts with MMP1, MMP3, MMP10 and MMP13, but has only very low affinity for MMP14. Interacts with CD63; identified in a complex with CD63 and ITGB1.
Protein Expression for TIMP1 Gene
Post-translational modifications for TIMP1 Gene
Other Protein References for TIMP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- RayBiotech Rabbit Anti-Human TIMP1
- NSJ Bioreagents TIMP1 Antibody
- Atlas Antibodies Anti-TIMP1 Antibody
-
Creative Biolabs
- Recombinant Anti-Human TIMP1 Antibody
- Recombinant Anti-Human TIMP1 Antibody Fab Fragment
- Afuco™ Anti-Human TIMP1 ADCC Therapeutic Antibody, ADCC Enhanced
- Anti-Human TIMP1 Therapeutic Antibody
- Anti-Human TIMP-1 Therapeutic Antibody Fab Fragment (MS-BW-27)
- Anti-Human TIMP-1 Therapeutic Antibody (MS-BW-3 )
- Anti-Human TIMP-1 Therapeutic Antibody (MS-BW-1)
- Hi-Affi™ Recombinant Rabbit Anti-TIMP1 Monoclonal Antibody (DS3575AB)
- Recombinant Mouse anti-Human TIMP1 Monoclonal antibody (203E2)
- Anti-Human TIMP-1 Therapeutic Antibody Fab Fragment (MS-BW-3 )
- Hi-Affi™ Recombinant Rabbit Anti-TIMP1 Monoclonal Antibody (SI552DS)
- Recombinant Human Anti-TIMP1 Antibody Fab Fragment (HuCAL)
- Anti-Human TIMP-1 Therapeutic Antibody Fab Fragment (MS-BW-1)
- Anti-Human TIMP-1 Therapeutic Antibody (MS-BW-27)
- Recombinant Human Anti-TIMP1 Antibody (HuCAL)
- Anti-Human TIMP-1 Therapeutic Antibody (MS-BW-28)
- Anti-Human TIMP-1 Therapeutic Antibody Fab Fragment (MS-BW-28)
- BioLegend TIMP-1 Antibody (635302) and TIMP-1 Antibody (676002)
-
Custom Antibody ServicesOriGene Antibodies for TIMP1
- Novus Biologicals Antibodies for TIMP1
-
Abcam antibodies for TIMP1
- Invitrogen Antibodies for TIMP1 (AFLGC-TIMP1)
-
Santa Cruz Biotechnology (SCBT) Antibodies for TIMP1
- Sino Biological Antibodies for TIMP1
Protein Products
- G Biosciences Human TIMP-1/Metalloproteinase inhibitor 1, Lyophilized
- Atlas Antibodies PrEST Antigen TIMP1
-
Creative Biomart
- Recombinant Human metallopeptidase inhibitor 1, His-tagged
- Recombinant Human TIMP Metallopeptidase Inhibitor 1 (TIMP1-1688H)
- Recombinant Human TIMP Metallopeptidase Inhibitor 1 (TIMP1-2886H)
- Recombinant Human TIMP1
- Recombinant Human TIMP Metallopeptidase Inhibitor 1 (TIMP1-5140H)
- Recombinant Human TIMP Metallopeptidase Inhibitor 1, His-tagged
- Recombinant Human TIMP1, His-tagged (TIMP1-30304TH)
- Recombinant Human TIMP1, MBP-tagged
- Native Human TIMP1
- Native Human TIMP-1
- Recombinant Human TIMP1, None tagged
- Recombinant Human TIMP1 cell lysate
- Recombinant Human TIMP1, His-tagged (TIMP1-77H)
- Recombinant Human TIMP1, MIgG2a Fc-tagged
- Recombinant Human TIMP1, His tagged
- Recombinant Human TIMP1, HIgG1 Fc-tagged
- Recombinant Human TIMP1 Protein, Fc-tagged
- Recombinant Human TIMP1 Protein, His-tagged
- Creative Diagnostics TIMP1 peptide
-
OriGene Purified Proteins for TIMP1
- Search Origene for MassSpec and Protein Over-expression Lysates for TIMP1
- Origene Custom Protein Services for TIMP1
- Sino Biological Recombinant Proteins for TIMP1
- Sino Biological Cell Lysates for TIMP1
- ProSpec Recombinant Proteins for TIMP1
-
Abcam proteins for TIMP1
Assay Products
- RayBiotech Human TIMP-1 ELISA and Human TIMP-1 ELISA (For Lysates)
- Novus Biologicals ELISA Kits for TIMP1
-
Abcam assays for TIMP1
- Sino Biological Assays for TIMP1
No data available for DME Specific Peptides for TIMP1 Gene
Domains & Families for TIMP1 Gene
Gene Families for TIMP1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Candidate cardiovascular disease genes
- Plasma proteins
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for TIMP1 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for TIMP1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ60276, weakly similar to Metalloproteinase inhibitor 1 (B4DJK3_HUMAN)
- Tissue inhibitor of metalloproteinase 1 (Q58P21_HUMAN)
- TIMP metallopeptidase inhibitor 1 (Q5H9A8_HUMAN)
- cDNA, FLJ92204, Homo sapiens tissue inhibitor of metalloproteinase 1 (erythroidpotentiating activity, collagenase inhibitor) (TIMP1), mRNA (Q6FGX5_HUMAN)
- Tissue inhibitor of metalloproteinases 1 (TIMP1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P01033- Family:
-
- Belongs to the protease inhibitor I35 (TIMP) family.
Function for TIMP1 Gene
Molecular function for TIMP1 Gene
- UniProtKB/Swiss-Prot Function:
- Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors.
- GENATLAS Biochemistry:
- matrix metalloproteinase,tissue inhibitor 1 (erythroid potentiating activity),involved in the regulation of bone modeling and remodeling in normal developing human bone,involved in the invasive phenotype of acute myelogenous leukemia,demonstrating polymorphic X-chromosome inactivation
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002020 | protease binding | IEA,IBA | 21873635 |
| GO:0004857 | enzyme inhibitor activity | IEA | -- |
| GO:0005125 | cytokine activity | IDA | 3839290 |
| GO:0005515 | protein binding | IEA,IPI | 2251898 |
| GO:0008083 | growth factor activity | IEA | -- |
Phenotypes for TIMP1 Gene
- MGI mutant phenotypes for TIMP1:
-
inferred from 2 alleles
- cardiovascular system phenotype
- respiratory system phenotype
- limbs/digits/tail phenotype
- homeostasis/metabolism phenotype
- neoplasm
- endocrine/exocrine gland phenotype
- mortality/aging
- reproductive system phenotype
- skeleton phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for TIMP1:
Animal Models for TIMP1 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for TIMP1
CRISPR Products
-
OriGene CRISPR knockouts for TIMP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TIMP1
- genomics-online: gRNA clones - Search for available TIMP1 gRNA products
- Overview of 166 available TIMP1 gene related products
- Applied Biological Materials (abm): CRISPR Clones for TIMP1 - Select products 50% OFF >
- * TIMP1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * TIMP1 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for TIMP1
miRNA for TIMP1 Gene
- miRTarBase miRNAs that target TIMP1
-
- hsa-mir-519a-3p (MIRT006638)
- hsa-mir-26b-5p (MIRT028755)
- hsa-mir-181a-5p (MIRT052992)
- hsa-mir-1293 (MIRT437506)
- hsa-mir-377-3p (MIRT731726)
- hsa-mir-19a-5p (MIRT733941)
- hsa-mir-96-5p (MIRT733942)
- hsa-mir-1292-5p (MIRT737141)
- hsa-mir-205-3p (MIRT738846)
- hsa-mir-3138 (MIRT740162)
- hsa-mir-363-5p (MIRT741852)
- hsa-mir-4289 (MIRT743745)
- hsa-mir-4426 (MIRT744293)
- hsa-mir-4471 (MIRT744956)
- hsa-mir-4481 (MIRT745129)
- hsa-mir-4647 (MIRT746452)
- hsa-mir-4662b (MIRT746706)
- hsa-mir-4745-5p (MIRT748200)
- hsa-mir-6745 (MIRT754479)
- hsa-mir-6871-5p (MIRT758035)
- hsa-mir-8059 (MIRT760039)
- hsa-mir-8071 (MIRT760104)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for TIMP1
- Browse OriGene Inhibitory RNA Products For TIMP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TIMP1
- genomics-online: shRNA clones - Search for available TIMP1 shRNA products
- Overview of 166 available TIMP1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for TIMP1
- Addgene plasmids for TIMP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TIMP1
- genomics-online: cdna clones - Search for available TIMP1 CDNA products
- Overview of 166 available TIMP1 gene related products
- orf clones - Search for available TIMP1 ORF products
- Overview of 166 available TIMP1 gene related products
- Applied Biological Materials (abm): Clones for TIMP1 - Select products 50% OFF >
- * TIMP1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * TIMP1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Cell Line Products
-
Horizon Cell Lines for TIMP1
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TIMP1 Gene
Localization for TIMP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TIMP1 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| endoplasmic reticulum | 4 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| nucleus | 2 |
| golgi apparatus | 2 |
| mitochondrion | 1 |
| cytosol | 1 |
| lysosome | 1 |
- Golgi apparatus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA,TAS | -- |
| GO:0005581 | collagen trimer | IEA | -- |
| GO:0005604 | basement membrane | IEA | -- |
| GO:0005615 | extracellular space | IDA,IBA | 3903517 |
| GO:0005788 | endoplasmic reticulum lumen | TAS | -- |
Pathways & Interactions for TIMP1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
|
Rac1 Pathway
.65
Glioma Invasiveness
.64
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
Nuclear Receptor Activation by Vitamin-A
.57
|
| 2 | GPCR Pathway |
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
|
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
|
| 3 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
MAPK Signaling
.58
|
Molecular Mechanisms of Cancer
.51
ILK Signaling
.49
|
| 4 | Nanog in Mammalian ESC Pluripotency |
GSK3 Signaling
.61
Nanog in Mammalian ESC Pluripotency
.61
|
14-3-3 Induced Intracellular Signaling
.59
eNOS Signaling
.48
|
| 5 | CREB Pathway |
CREB Pathway
.68
IP3 Pathway
.68
|
Activation of PKC through GPCR
.63
Intracellular Calcium Signaling
.50
|
Pathways by source for TIMP1 Gene
5 BioSystems pathways for TIMP1 Gene
12 Reactome pathways for TIMP1 Gene
1 KEGG pathway for TIMP1 Gene
5 GeneGo (Thomson Reuters) pathways for TIMP1 Gene
56 Qiagen pathways for TIMP1 Gene
- 14-3-3 Induced Intracellular Signaling
- Actin-Based Motility by Rho Family GTPases
- Activation of cAMP-Dependent PKA
- Activation of PKA through GPCR
- Activation of PKC through GPCR
1 Cell Signaling Technology pathway for TIMP1 Gene
Interacting Proteins for TIMP1 Gene
Selected Interacting proteins:
P01033-TIMP1_HUMAN
ENSP00000218388
for TIMP1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for TIMP1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001775 | cell activation | IEA | -- |
| GO:0002248 | connective tissue replacement involved in inflammatory response wound healing | IEA | -- |
| GO:0002576 | platelet degranulation | TAS | -- |
| GO:0007568 | aging | IEA | -- |
| GO:0008284 | positive regulation of cell proliferation | IDA | 3839290 |
Drugs & Compounds for TIMP1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
- G Biosciences Human TIMP-1/Metalloproteinase inhibitor 1, Lyophilized
- Atlas Antibodies PrEST Antigen TIMP1
-
Creative Biomart
- Recombinant Human metallopeptidase inhibitor 1, His-tagged
- Recombinant Human TIMP Metallopeptidase Inhibitor 1 (TIMP1-1688H)
- Recombinant Human TIMP Metallopeptidase Inhibitor 1 (TIMP1-2886H)
- Recombinant Human TIMP1
- Recombinant Human TIMP Metallopeptidase Inhibitor 1 (TIMP1-5140H)
- Recombinant Human TIMP Metallopeptidase Inhibitor 1, His-tagged
- Recombinant Human TIMP1, His-tagged (TIMP1-30304TH)
- Recombinant Human TIMP1, MBP-tagged
- Native Human TIMP1
- Native Human TIMP-1
- Recombinant Human TIMP1, None tagged
- Recombinant Human TIMP1 cell lysate
- Recombinant Human TIMP1, His-tagged (TIMP1-77H)
- Recombinant Human TIMP1, MIgG2a Fc-tagged
- Recombinant Human TIMP1, His tagged
- Recombinant Human TIMP1, HIgG1 Fc-tagged
- Recombinant Human TIMP1 Protein, Fc-tagged
- Recombinant Human TIMP1 Protein, His-tagged
- Creative Diagnostics TIMP1 peptide
Transcripts for TIMP1 Gene
mRNA/cDNA for TIMP1 Gene
- (1) REFSEQ mRNAs :
- (18) Additional mRNA sequences :
- (1070) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000218388 769 bps (ENST00000218388.8)
- ENST00000377017 626 bps (ENST00000377017.5)
- ENST00000441738 341 bps (ENST00000441738.1)
- ENST00000445623 595 bps (ENST00000445623.1)
- ENST00000456754 1095 bps (ENST00000456754.6)
CRISPR Products
-
OriGene CRISPR knockouts for TIMP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TIMP1
- genomics-online: gRNA clones - Search for available TIMP1 gRNA products
- Overview of 166 available TIMP1 gene related products
- Applied Biological Materials (abm): CRISPR Clones for TIMP1 - Select products 50% OFF >
- * TIMP1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * TIMP1 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for TIMP1
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for TIMP1
- Browse OriGene Inhibitory RNA Products For TIMP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TIMP1
- genomics-online: shRNA clones - Search for available TIMP1 shRNA products
- Overview of 166 available TIMP1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for TIMP1
- Addgene plasmids for TIMP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TIMP1
- genomics-online: cdna clones - Search for available TIMP1 CDNA products
- Overview of 166 available TIMP1 gene related products
- orf clones - Search for available TIMP1 ORF products
- Overview of 166 available TIMP1 gene related products
- Applied Biological Materials (abm): Clones for TIMP1 - Select products 50% OFF >
- * TIMP1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * TIMP1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Expression for TIMP1 Gene
mRNA differential expression in normal tissues according to GTEx for TIMP1 Gene
This gene is overexpressed in Artery - Coronary (x5.4) and Artery - Aorta (x4.1).
This gene is overexpressed in Amniocyte (19.1), Vitreous humor (12.2), Islet of Langerhans (6.3), and Milk (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TIMP1 Gene
NURSA nuclear receptor signaling pathways regulating expression of TIMP1 Gene:
TIMP1SOURCE GeneReport for Unigene cluster for TIMP1 Gene:
Hs.522632mRNA Expression by UniProt/SwissProt for TIMP1 Gene:
P01033-TIMP1_HUMAN
Tissue specificity:
Detected in rheumatoid synovial fluid (at protein level).
Evidence on tissue expression from TISSUES for TIMP1 Gene
- Lung(4.9)
- Blood(4.7)
- Bone marrow(4.5)
- Pancreas(4.4)
- Saliva(4.3)
- Skin(4.2)
- Heart(4)
- Nervous system(4)
- Bone(3.9)
- Eye(3.7)
- Liver(3.7)
- Intestine(3.6)
- Muscle(3.6)
- Kidney(3.3)
- Lymph node(3)
- Spleen(3)
- Gall bladder(2.7)
- Stomach(2.4)
- Adrenal gland(2.3)
- Thyroid gland(2.3)
Primer Products
-
OriGene qPCR primer pairs for TIMP1
-
OriGene qPCR primer pairs and template standards for TIMP1
- genomics-online: primer clones - Search for available TIMP1 Primer products
- Overview of 166 available TIMP1 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for TIMP1 Gene
Orthologs for TIMP1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | TIMP1 33 32 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | TIMP1 33 32 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Timp1 17 33 32 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Timp1 32 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | TIMP1 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | TIMP1 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | -- 33 |
|
OneToMany | |
| -- 33 |
|
OneToMany | |||
| -- 33 |
|
OneToMany | |||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.7905 32 |
|
- Species where no ortholog for TIMP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for TIMP1 Gene
- ENSEMBL:
- Gene Tree for TIMP1 (if available)
- TreeFam:
- Gene Tree for TIMP1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TIMP1: view image
Paralogs for TIMP1 Gene
Variants for TIMP1 Gene
| SNP ID | Clin | Chr 0X pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000082751 | -- | 47,586,417(+) | C/G | 3_prime_UTR_variant, intron_variant | |
| rs1001077846 | -- | 47,583,198(+) | AATAAT/AAT | intron_variant | |
| rs1001096299 | -- | 47,581,904(+) | C/T | upstream_transcript_variant | |
| rs1001206339 | -- | 47,585,416(+) | G/A | coding_sequence_variant, intron_variant, missense_variant | |
| rs1002150296 | -- | 47,583,793(+) | T/G | intron_variant |
Residual Variation Intolerance Score:
96.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.29;
76.48% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TIMP1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TIMP1 Gene
Disorders for TIMP1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| oral submucous fibrosis |
|
|
| lung giant cell carcinoma |
|
|
| sorsby fundus dystrophy |
|
|
| gingival overgrowth |
|
|
| conjunctivochalasis |
|
Search TIMP1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TIMP1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Tumor Gene Database
- (TGDB)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for TIMP1 Gene
Publications for TIMP1 Gene
- Identification of CD63 as a tissue inhibitor of metalloproteinase-1 interacting cell surface protein. (PMID: 16917503) Jung KK … Kim HR (The EMBO journal 2006) 3 4 23 56
- Genetic polymorphisms and cerebrospinal fluid levels of tissue inhibitor of metalloproteinases 1 in sporadic Alzheimer's disease. (PMID: 12218659) Wollmer MA … Nitsch RM (Psychiatric genetics 2002) 3 23 43 56
- NMR structure of tissue inhibitor of metalloproteinases-1 implicates localized induced fit in recognition of matrix metalloproteinases. (PMID: 10623524) Wu B … Van Doren SR (Journal of molecular biology 2000) 3 4 23 56
- TIMP-1 modulates chemotaxis of human neural stem cells through CD63 and integrin signalling. (PMID: 24635319) Lee SY … Lee MA (The Biochemical journal 2014) 3 4 56
- Timp1 interacts with beta-1 integrin and CD63 along melanoma genesis and confers anoikis resistance by activating PI3-K signaling pathway independently of Akt phosphorylation. (PMID: 23522389) Toricelli M … Jasiulionis MG (Molecular cancer 2013) 3 4 56
ExternalLinks
Products for TIMP1 Gene
- View all 34 R&D Systems TIMP1 (TIMP-1) Products
- View all 2 R&D Systems TIMP1 (TIMP-1) Proteins and Enzymes
- View all 19 R&D Systems TIMP1 (TIMP-1) Primary Antibodies
- View all 4 R&D Systems TIMP1 (TIMP-1) ELISAs
- View all 2 R&D Systems TIMP1 (TIMP-1) Luminex Assays
- View all 6 R&D Systems TIMP1 (TIMP-1) Proteome Profiler Antibody Arrays
- View all R&D Systems TIMP1 (TIMP-1) ELISpot and FluoroSpot Kits
- Learn more about R&D Systems custom TIMP1 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for TIMP1
- Custom Assay Services
- OriGene Purified Proteins for TIMP1
- Search Origene for MassSpec and Protein Over-expression Lysates for TIMP1
- Origene Custom Protein Services for TIMP1
- Origene sirna, shrna, and RNAi products in human, mouse, rat for TIMP1
- Browse OriGene Inhibitory RNA Products For TIMP1
- OriGene qPCR primer pairs for TIMP1
- OriGene qPCR primer pairs and template standards for TIMP1
- OriGene CRISPR knockouts for TIMP1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For TIMP1
- Sino Biological Human cDNA Clone for TIMP1
- Sino Biological Recombinant Proteins for TIMP1
- Sino Biological Cell Lysates for TIMP1
- Sino Biological Antibodies for TIMP1
- Sino Biological Assays for TIMP1
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for TIMP1
- Novus Biologicals proteins and lysates for TIMP1
- Novus Biologicals ELISA Kits for TIMP1
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for TIMP1
- Abcam proteins for TIMP1
- Abcam assays for TIMP1
- Find your target
- Browse Primary Antibodies
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- ProSpec Recombinant Proteins for TIMP1
- Taconic Biosciences Mouse Models for TIMP1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for TIMP1 (AFLGC-TIMP1)
- Addgene plasmids for TIMP1
- antibodies-online: Show 81 available TIMP1 Antibodies ranked by validation data
- Compare Top TIMP1 Antibodies
- antibodies-online: Show 148 available TIMP1 Elisa Kits ranked by validation data
- Compare Top TIMP1 Elisa Kits
- Quality Products:
- antibodies-online: Show 64 available TIMP1 Proteins ranked by validation data
- Compare Top TIMP1 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for TIMP1
- Search Santa Cruz Biotechnology (SCBT) for TIMP1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TIMP1
- Horizon Cell Lines for TIMP1
- genomics-online: cdna clones - Search for available TIMP1 CDNA products
- Overview of 166 available TIMP1 gene related products
- orf clones - Search for available TIMP1 ORF products
- Overview of 166 available TIMP1 gene related products
- genomics-online: gRNA clones - Search for available TIMP1 gRNA products
- Overview of 166 available TIMP1 gene related products
- genomics-online: primer clones - Search for available TIMP1 Primer products
- Overview of 166 available TIMP1 gene related products
- genomics-online: shRNA clones - Search for available TIMP1 shRNA products
- Overview of 166 available TIMP1 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TIMP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TIMP1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for TIMP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TIMP1
Sources for TIMP1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
- (39) DGV
- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
- (82) BioSystems
- (83) MaxQB
- (84) IUPHAR
- (85) BioGPS
- (86) Illumina
- (87) COMPARTMENTS
- (88) HOMER
- (89) PaxDb
- (90) ApexBio
- (91) Addgene
- (92) antibodies-online
- (93) CYP
- (94) NONCODE
- (95) TreeFam
- (96) PathCards
- (97) GeneReviews
- (98) GeneTex
- (99) Taconic Biosciences
- (100) GTEx
- (101) ProteomicsDB
- (102) SCBT
- (103) DGIdb
- (104) ClinicalTrials
- (105) RVIS
- (106) SIGNOR
- (107) diseasecard
- (108) NIH Rare Diseases
- (109) Orphanet
- (110) UMLS
- (111) GTR
- (112) Disease Ontology
- (113) Genetics Home Reference
- (114) MeSH
- (115) MedlinePlus
- (116) CDC
- (117) NINDS
- (118) NCBI Bookshelf
- (119) ClinVar
- (120) Gene Damage Index
- (121) HPO
- (122) UDN
- (123) VISTA
- (124) FANTOM5
- (125) ENCODE
- (126) ProSci
- (127) Horizon
- (128) NURSA
- (129) IID
- (130) VectorBuilder
- (131) SNPedia
- (132) BRCA Exchange
- (133) CIViC
- (134) ProteoGenix
- (135) dbSUPER
- (136) TISSUES
- (137) Gene ORGANizer
- (138) abm
- (139) Human Protein Atlas
- (140) GWAS Catalog
- (141) Monarch Initiative
- (142) DataMed
- (143) HumanCyc
- (144) genomics-online
- (145) UCNEbase
- (146) EPDnew
- (147) Applied Biosystems
- (148) GlyConnect
- (149) Aminode
- (150) GeneCopoeia
- (151) GPS-Prot
- (152) RNACentral
- (153) LncRNADisease
- (154) LOVD
- (155) miR2Disease
- (156) DiseaseEnhancer
- (157) Boster Bio
- (158) Biorbyt
- (159) Biocompare
- (160) Mastermind
- (161) CTD^2 Dashboard
- (162) CraniofacialAtlas
- (163) GeneImprint
- (164) Synthego
- (165) Bio Basic
- (166) ENA
- (167) GtRNAdb
- (168) LncBase
- (169) LncBook
- (170) LNCipedia
- (171) LncRNAdb
- (172) Modomics
- (173) PDBe
- (174) Rfam
- (175) SILVA
- (176) snOPY
- (177) SRPDB
- (178) GENCODE
- (179) TarBase
- (180) MyBioSource