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This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq, Jul 2008]
TIMP1 (TIMP Metallopeptidase Inhibitor 1) is a Protein Coding gene. Diseases associated with TIMP1 include Oral Submucous Fibrosis and Lung Giant Cell Carcinoma. Among its related pathways are G-protein signaling Ras family GTPases in kinase cascades (scheme) and Degradation of the extracellular matrix. Gene Ontology (GO) annotations related to this gene include cytokine activity and protease binding. An important paralog of this gene is TIMP2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002020 | protease binding | IEA,IBA | 21873635 |
GO:0004857 | enzyme inhibitor activity | IEA | -- |
GO:0005125 | cytokine activity | IDA | 3839290 |
GO:0005515 | protein binding | IEA,IPI | 2251898 |
GO:0008083 | growth factor activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA,TAS | -- |
GO:0005581 | collagen trimer | IEA | -- |
GO:0005604 | basement membrane | IEA | -- |
GO:0005615 | extracellular space | IBA,IDA | 3903517 |
GO:0005788 | endoplasmic reticulum lumen | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
|
Rac1 Pathway
.65
Glioma Invasiveness
.64
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
Nuclear Receptor Activation by Vitamin-A
.57
|
2 | GPCR Pathway |
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
|
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
|
3 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
MAPK Signaling
.58
|
Molecular Mechanisms of Cancer
.51
ILK Signaling
.49
|
4 | Nanog in Mammalian ESC Pluripotency |
GSK3 Signaling
.62
Nanog in Mammalian ESC Pluripotency
.62
|
14-3-3 Induced Intracellular Signaling
.59
eNOS Signaling
.48
|
5 | CREB Pathway |
CREB Pathway
.68
IP3 Pathway
.68
|
Activation of PKC through GPCR
.63
Intracellular Calcium Signaling
.50
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001775 | cell activation | IEA | -- |
GO:0002248 | connective tissue replacement involved in inflammatory response wound healing | IEA | -- |
GO:0002576 | platelet degranulation | TAS | -- |
GO:0007568 | aging | IEA | -- |
GO:0008284 | positive regulation of cell proliferation | IDA | 3839290 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
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This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Cow (Bos Taurus) |
Mammalia | TIMP1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | TIMP1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Timp1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Timp1 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | TIMP1 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | TIMP1 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.7905 30 |
|
Disorder | Aliases | PubMed IDs |
---|---|---|
oral submucous fibrosis |
|
|
lung giant cell carcinoma |
|
|
gingivitis |
|
|
conjunctivochalasis |
|
|
gingival overgrowth |
|