Aliases for TIMM23B Gene

Aliases for TIMM23B Gene

  • Translocase Of Inner Mitochondrial Membrane 23 Homolog B 2 3 5
  • Putative Mitochondrial Import Inner Membrane Translocase Subunit Tim23B 3 4
  • Translocase Of Inner Mitochondrial Membrane 23 Homolog B (Yeast) 2

External Ids for TIMM23B Gene

Previous GeneCards Identifiers for TIMM23B Gene

  • GC10U900492
  • GC10P051042
  • GC10P051371
  • GC10P051729

Summaries for TIMM23B Gene

GeneCards Summary for TIMM23B Gene

TIMM23B (Translocase Of Inner Mitochondrial Membrane 23 Homolog B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include P-P-bond-hydrolysis-driven protein transmembrane transporter activity. An important paralog of this gene is TIMM23.

UniProtKB/Swiss-Prot Summary for TIMM23B Gene

  • May participate in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. the PAM complex (By similarity).

Additional gene information for TIMM23B Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TIMM23B Gene

Genomics for TIMM23B Gene

GeneHancer (GH) Regulatory Elements for TIMM23B Gene

Promoters and enhancers for TIMM23B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J049940 Promoter 0.3 Ensembl 750.6 +0.1 68 4.2 TIMM23B TIMM23B-AGAP6 piR-39626-002 PARG
GH10J049931 Enhancer 0.5 dbSUPER 0.4 -9.0 -9006 3 SP7 HDAC1 ZSCAN5C ZNF366 KDM1A GFI1B TIMM23B piR-51819-005 PARG
GH10J049987 Enhancer 0.5 Ensembl 0.2 +45.1 45103 1.1 CBFA2T2 CREB1 CEBPB ZNF513 TAL1 CBFA2T3 ENSG00000285803 ENSG00000286029 piR-53124-006 RNA5SP317 AGAP6 TIMM23B TIMM23B-AGAP6
GH10J049937 Enhancer 0.2 Ensembl 0.6 -4.3 -4332 0.2 TIMM23B piR-51819-005 PARG
GH10J049988 Promoter 0.3 EPDnew 0.2 +46.6 46556 0.1 ENSG00000285803 ENSG00000286029 piR-53124-006 AGAP6 RNA5SP317 TIMM23B TIMM23B-AGAP6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TIMM23B on UCSC Golden Path with GeneCards custom track

Genomic Locations for TIMM23B Gene

Genomic Locations for TIMM23B Gene
46,807 bases
Plus strand
4,825 bases
Plus strand

Genomic View for TIMM23B Gene

Genes around TIMM23B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIMM23B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIMM23B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIMM23B Gene

Proteins for TIMM23B Gene

  • Protein details for TIMM23B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative mitochondrial import inner membrane translocase subunit Tim23B
    Protein Accession:
    Secondary Accessions:
    • Q5SRD2

    Protein attributes for TIMM23B Gene

    257 amino acids
    Molecular mass:
    28048 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TIMM23B Gene

Post-translational modifications for TIMM23B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TIMM23B Gene

No data available for DME Specific Peptides for TIMM23B Gene

Domains & Families for TIMM23B Gene

Gene Families for TIMM23B Gene

Protein Domains for TIMM23B Gene

Suggested Antigen Peptide Sequences for TIMM23B Gene

GenScript: Design optimal peptide antigens:
  • Putative mitochondrial import inner membrane translocase subunit Tim23B (TI23B_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Tim17/Tim22/Tim23 family.
  • Belongs to the Tim17/Tim22/Tim23 family.
genes like me logo Genes that share domains with TIMM23B: view

Function for TIMM23B Gene

Molecular function for TIMM23B Gene

UniProtKB/Swiss-Prot Function:
May participate in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. the PAM complex (By similarity).

Phenotypes From GWAS Catalog for TIMM23B Gene

Gene Ontology (GO) - Molecular Function for TIMM23B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0008320 protein transmembrane transporter activity IBA 21873635
GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with TIMM23B: view
genes like me logo Genes that share phenotypes with TIMM23B: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TIMM23B Gene

Localization for TIMM23B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIMM23B Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TIMM23B gene
Compartment Confidence
mitochondrion 3
lysosome 1

Gene Ontology (GO) - Cellular Components for TIMM23B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0005744 TIM23 mitochondrial import inner membrane translocase complex IBA 21873635
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TIMM23B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TIMM23B Gene

Pathways & Interactions for TIMM23B Gene

PathCards logo

SuperPathways for TIMM23B Gene

No Data Available

Gene Ontology (GO) - Biological Process for TIMM23B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA --
GO:0008150 biological_process ND --
GO:0015031 protein transport IEA --
GO:0030150 protein import into mitochondrial matrix IBA 21873635
genes like me logo Genes that share ontologies with TIMM23B: view

No data available for Pathways by source and SIGNOR curated interactions for TIMM23B Gene

Drugs & Compounds for TIMM23B Gene

No Compound Related Data Available

Transcripts for TIMM23B Gene

mRNA/cDNA for TIMM23B Gene

(3) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIMM23B Gene

No ASD Table

Relevant External Links for TIMM23B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TIMM23B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TIMM23B Gene

Protein differential expression in normal tissues from HIPED for TIMM23B Gene

This gene is overexpressed in Nasal epithelium (35.8), Bone (16.8), Pancreas (9.2), and Lung (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TIMM23B Gene

Protein tissue co-expression partners for TIMM23B Gene

NURSA nuclear receptor signaling pathways regulating expression of TIMM23B Gene:


Evidence on tissue expression from TISSUES for TIMM23B Gene

  • Nervous system(3.8)
genes like me logo Genes that share expression patterns with TIMM23B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TIMM23B Gene

Orthologs for TIMM23B Gene

This gene was present in the common ancestor of animals.

Orthologs for TIMM23B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TIMM23B 32
  • 97.87 (n)
TIMM23 33
  • 82 (a)
(Canis familiaris)
Mammalia -- 33
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 94 (a)
(Bos Taurus)
Mammalia TIMM23 33
  • 82 (a)
(Mus musculus)
Mammalia Timm23 33
  • 79 (a)
Gm10273 33
  • 79 (a)
(Monodelphis domestica)
Mammalia -- 33
  • 73 (a)
(Gallus gallus)
Aves -- 33
  • 75 (a)
(Anolis carolinensis)
Reptilia -- 33
  • 73 (a)
(Danio rerio)
Actinopterygii LOC100535463 32
  • 72.11 (n)
timm23 33
  • 63 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG40042 33
  • 36 (a)
(Caenorhabditis elegans)
Secernentea timm-23 33
  • 18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5979 33
  • 23 (a)
Species where no ortholog for TIMM23B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TIMM23B Gene

Gene Tree for TIMM23B (if available)
Gene Tree for TIMM23B (if available)
Evolutionary constrained regions (ECRs) for TIMM23B: view image

Paralogs for TIMM23B Gene

Paralogs for TIMM23B Gene

(11) SIMAP similar genes for TIMM23B Gene using alignment to 5 proteins:

  • E7EP42_HUMAN
  • M0R0T5_HUMAN
  • S4R2X5_HUMAN
genes like me logo Genes that share paralogs with TIMM23B: view

Variants for TIMM23B Gene

Sequence variations from dbSNP and Humsavar for TIMM23B Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1046730 -- 49,974,396(+) C/G/T 3_prime_UTR_variant, non_coding_transcript_variant
rs1046739 -- 49,974,477(+) C/T 3_prime_UTR_variant, non_coding_transcript_variant
rs1046740 -- 49,974,486(+) A/G 3_prime_UTR_variant, non_coding_transcript_variant
rs1046741 -- 49,974,487(+) A/T 3_prime_UTR_variant, non_coding_transcript_variant
rs1046746 -- 49,974,532(+) C/G 3_prime_UTR_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TIMM23B Gene

Variant ID Type Subtype PubMed ID
esv26750 CNV loss 19812545
nsv1143639 CNV deletion 24896259
nsv8655 CNV loss 18304495
nsv947999 CNV duplication 23825009

Additional Variant Information for TIMM23B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for TIMM23B Gene

Disorders for TIMM23B Gene

Additional Disease Information for TIMM23B

No disorders were found for TIMM23B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIMM23B Gene

Publications for TIMM23B Gene

  1. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 56
  2. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3 56
  3. Mapping the Genetic Landscape of Human Cells. (PMID: 30033366) Horlbeck MA … Gilbert LA (Cell 2018) 3 56
  4. Delineating WWOX Protein Interactome by Tandem Affinity Purification-Mass Spectrometry: Identification of Top Interactors and Key Metabolic Pathways Involved. (PMID: 30619736) Hussain T … Aldaz CM (Frontiers in oncology 2018) 3 56
  5. Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair. (PMID: 29229926) Lu H … Bohr VA (Nature communications 2017) 3 56

Products for TIMM23B Gene

Sources for TIMM23B Gene