Aliases for TIMM23B Gene

Aliases for TIMM23B Gene

  • Translocase Of Inner Mitochondrial Membrane 23 Homolog B 2 3 5
  • Putative Mitochondrial Import Inner Membrane Translocase Subunit Tim23B 3 4
  • Translocase Of Inner Mitochondrial Membrane 23 Homolog B (Yeast) 2
  • BA592B15.7 2
  • TIMM23B 5

External Ids for TIMM23B Gene

Previous GeneCards Identifiers for TIMM23B Gene

  • GC10U900492
  • GC10P051042
  • GC10P051371
  • GC10P051729

Summaries for TIMM23B Gene

GeneCards Summary for TIMM23B Gene

TIMM23B (Translocase Of Inner Mitochondrial Membrane 23 Homolog B) is a Protein Coding gene. Diseases associated with TIMM23B include Mohr-Tranebjaerg Syndrome and 3-Methylglutaconic Aciduria, Type V. Gene Ontology (GO) annotations related to this gene include P-P-bond-hydrolysis-driven protein transmembrane transporter activity.

UniProtKB/Swiss-Prot Summary for TIMM23B Gene

  • May participate in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. the PAM complex (By similarity).

Additional gene information for TIMM23B Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TIMM23B Gene

Genomics for TIMM23B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TIMM23B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J049940 Promoter 0.3 Ensembl 600.7 +0.1 68 4.2 TIMM23B TIMM23B-AGAP6 piR-39626-002 PARG
GH10J049931 Enhancer 0.5 dbSUPER 0.4 -9.0 -9006 3 HDAC1 ZSCAN5C ATF4 ZNF366 ATF3 KDM1A MEIS2 GFI1B SP7 TIMM23B piR-51819-005 PARG OGDHL
GH10J049830 Enhancer 1.3 FANTOM5 Ensembl ENCODE CraniofacialAtlas 0.1 -107.9 -107880 10.7 GATAD2A TEAD4 SP1 CEBPA MNT ESR1 NFE2 ZNF316 FOXA2 MAFF lnc-OGDHL-1 AGAP6 SLC9A3P3 WASHC2A lnc-OGDHL-2 OGDHL TIMM23B PARG
GH10J049844 Enhancer 0.8 Ensembl ENCODE 0.2 -96.6 -96632 1.6 CEBPG CREB1 SOX13 CEBPB SP1 CTBP1 FOXA2 FOS ZNF217 JUND AGAP6 lnc-OGDHL-1 lnc-OGDHL-2 OGDHL TIMM23B PARG
GH10J049937 Enhancer 0.2 Ensembl 0.7 -4.3 -4332 0.2 TIMM23B piR-51819-005 PARG OGDHL
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TIMM23B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TIMM23B

Genomic Locations for TIMM23B Gene

Genomic Locations for TIMM23B Gene
chr10:49,942,033-49,974,850
(GRCh38/hg38)
Size:
32,818 bases
Orientation:
Plus strand
chr10:51,729,786-51,734,610
(GRCh37/hg19)
Size:
4,825 bases
Orientation:
Plus strand

Genomic View for TIMM23B Gene

Genes around TIMM23B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIMM23B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIMM23B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIMM23B Gene

Proteins for TIMM23B Gene

  • Protein details for TIMM23B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SRD1-TI23B_HUMAN
    Recommended name:
    Putative mitochondrial import inner membrane translocase subunit Tim23B
    Protein Accession:
    Q5SRD1
    Secondary Accessions:
    • Q5SRD2

    Protein attributes for TIMM23B Gene

    Size:
    257 amino acids
    Molecular mass:
    28048 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TIMM23B Gene

Post-translational modifications for TIMM23B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TIMM23B Gene

No data available for DME Specific Peptides for TIMM23B Gene

Domains & Families for TIMM23B Gene

Gene Families for TIMM23B Gene

Protein Domains for TIMM23B Gene

InterPro:
Blocks:
  • Mitochondrial import inner membrane translocase, subunit Tim17/22
ProtoNet:

Suggested Antigen Peptide Sequences for TIMM23B Gene

GenScript: Design optimal peptide antigens:
  • Putative mitochondrial import inner membrane translocase subunit Tim23B (TI23B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5SRD1

UniProtKB/Swiss-Prot:

TI23B_HUMAN :
  • Belongs to the Tim17/Tim22/Tim23 family.
Family:
  • Belongs to the Tim17/Tim22/Tim23 family.
genes like me logo Genes that share domains with TIMM23B: view

Function for TIMM23B Gene

Molecular function for TIMM23B Gene

UniProtKB/Swiss-Prot Function:
May participate in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. the PAM complex (By similarity).

Phenotypes From GWAS Catalog for TIMM23B Gene

Gene Ontology (GO) - Molecular Function for TIMM23B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0008320 protein transmembrane transporter activity IBA 21873635
GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with TIMM23B: view
genes like me logo Genes that share phenotypes with TIMM23B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TIMM23B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TIMM23B Gene

Localization for TIMM23B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIMM23B Gene

Mitochondrion inner membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TIMM23B gene
Compartment Confidence
mitochondrion 4
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for TIMM23B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005744 TIM23 mitochondrial import inner membrane translocase complex IBA 21873635
GO:0031305 integral component of mitochondrial inner membrane IBA 21873635
genes like me logo Genes that share ontologies with TIMM23B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TIMM23B Gene

Pathways & Interactions for TIMM23B Gene

PathCards logo

SuperPathways for TIMM23B Gene

No Data Available

Interacting Proteins for TIMM23B Gene

Gene Ontology (GO) - Biological Process for TIMM23B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0030150 protein import into mitochondrial matrix IBA 21873635
genes like me logo Genes that share ontologies with TIMM23B: view

No data available for Pathways by source and SIGNOR curated interactions for TIMM23B Gene

Drugs & Compounds for TIMM23B Gene

No Compound Related Data Available

Transcripts for TIMM23B Gene

mRNA/cDNA for TIMM23B Gene

3 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TIMM23B

Alternative Splicing Database (ASD) splice patterns (SP) for TIMM23B Gene

No ASD Table

Relevant External Links for TIMM23B Gene

GeneLoc Exon Structure for
TIMM23B

Expression for TIMM23B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TIMM23B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

Protein differential expression in normal tissues from HIPED for TIMM23B Gene

This gene is overexpressed in Nasal epithelium (35.8), Bone (16.8), Pancreas (9.2), and Lung (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TIMM23B Gene



Protein tissue co-expression partners for TIMM23B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TIMM23B

genes like me logo Genes that share expression patterns with TIMM23B: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TIMM23B Gene

Orthologs for TIMM23B Gene

This gene was present in the common ancestor of animals.

Orthologs for TIMM23B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TIMM23B 30
  • 97.87 (n)
TIMM23 31
  • 82 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 96 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 94 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia TIMM23 31
  • 82 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Timm23 31
  • 79 (a)
ManyToMany
Gm10273 31
  • 79 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 73 (a)
OneToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 75 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 73 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii LOC100535463 30
  • 72.11 (n)
timm23 31
  • 63 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG40042 31
  • 36 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea timm-23 31
  • 18 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.5979 31
  • 23 (a)
OneToMany
Species where no ortholog for TIMM23B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for TIMM23B Gene

ENSEMBL:
Gene Tree for TIMM23B (if available)
TreeFam:
Gene Tree for TIMM23B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TIMM23B: view image

Paralogs for TIMM23B Gene

(11) SIMAP similar genes for TIMM23B Gene using alignment to 5 proteins:

  • TI23B_HUMAN
  • E7EP42_HUMAN
  • M0QZG8_HUMAN
  • M0R0T5_HUMAN
  • S4R2X5_HUMAN
genes like me logo Genes that share paralogs with TIMM23B: view

No data available for Paralogs for TIMM23B Gene

Variants for TIMM23B Gene

Additional dbSNP identifiers (rs#s) for TIMM23B Gene

Structural Variations from Database of Genomic Variants (DGV) for TIMM23B Gene

Variant ID Type Subtype PubMed ID
esv26750 CNV loss 19812545
nsv1143639 CNV deletion 24896259
nsv8655 CNV loss 18304495
nsv947999 CNV duplication 23825009

Additional Variant Information for TIMM23B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TIMM23B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for TIMM23B Gene

Disorders for TIMM23B Gene

MalaCards: The human disease database

(3) MalaCards diseases for TIMM23B Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with TIMM23B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TIMM23B Gene

Publications for TIMM23B Gene

  1. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4
  2. PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling. (PMID: 31091453) Shami Shah A … Baskin JM (Cell reports 2019) 3
  3. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3
  4. Mapping the Genetic Landscape of Human Cells. (PMID: 30033366) Horlbeck MA … Gilbert LA (Cell 2018) 3
  5. Delineating WWOX Protein Interactome by Tandem Affinity Purification-Mass Spectrometry: Identification of Top Interactors and Key Metabolic Pathways Involved. (PMID: 30619736) Hussain T … Aldaz CM (Frontiers in oncology 2018) 3

Products for TIMM23B Gene

Sources for TIMM23B Gene