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Aliases for TIMM17A Gene

Aliases for TIMM17A Gene

  • Translocase Of Inner Mitochondrial Membrane 17A 2 3 5
  • Inner Membrane Preprotein Translocase Tim17a 3 4
  • TIM17A 3 4
  • TIM17 3 4
  • Translocase Of Inner Mitochondrial Membrane 17 Homolog A (Yeast) 2
  • Mitochondrial Import Inner Membrane Translocase Subunit Tim17-A 3
  • Translocase Of Inner Mitochondrial Membrane 17 Homolog A 3
  • Mitochondrial Inner Membrane Translocase 3
  • Preprotein Translocase 3
  • MIMT17 4
  • TIMM17 4

External Ids for TIMM17A Gene

Previous GeneCards Identifiers for TIMM17A Gene

  • GC01P199608
  • GC01P197358
  • GC01P198391
  • GC01P199212
  • GC01P198656
  • GC01P200192
  • GC01P173090

Summaries for TIMM17A Gene

GeneCards Summary for TIMM17A Gene

TIMM17A (Translocase Of Inner Mitochondrial Membrane 17A) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Mitochondrial protein import. Gene Ontology (GO) annotations related to this gene include P-P-bond-hydrolysis-driven protein transmembrane transporter activity. An important paralog of this gene is TIMM17B.

UniProtKB/Swiss-Prot for TIMM17A Gene

  • Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.

Gene Wiki entry for TIMM17A Gene

Additional gene information for TIMM17A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIMM17A Gene

Genomics for TIMM17A Gene

GeneHancer (GH) Regulatory Elements for TIMM17A Gene

Promoters and enhancers for TIMM17A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I201954 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 571.7 +0.0 30 2.5 MLX DMAP1 YBX1 IRF4 YY1 E2F8 ZNF143 ZNF548 SP3 NFYC TIMM17A RNPEP ENSG00000273478 KDM5B HNRNPA1P59 RPS27P8 IPO9 ELF3-AS1 IPO9-AS1 LMOD1
GH01I201828 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.1 -126.1 -126079 2.4 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B IPO9-AS1 IPO9 ENSG00000235121 RNPEP ENSG00000273478 LMOD1 SHISA4 TIMM17A RNU6-501P NAV1
GH01I201894 Enhancer 1.5 Ensembl ENCODE dbSUPER 11.6 -59.0 -59013 4.1 HDGF SMAD1 ARNT ARID4B SIN3A ZNF2 IRF4 ZNF213 E2F8 ZNF143 LMOD1 RNPEP ENSG00000273478 ELF3-AS1 TIMM17A RPS27P8 ENSG00000223774 GC01M201886
GH01I202103 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10 +151.5 151456 6.6 HDGF FOXA2 PKNOX1 CLOCK NEUROD1 ZBTB7B YY1 FOS DEK SP3 ELF3-AS1 ELF3 RNPEP ENSG00000273478 HNRNPA1P59 ENSG00000249007 RPS27P8 TIMM17A GPR37L1 PTPRVP
GH01I201911 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.1 -39.9 -39902 7.6 SMAD1 ATF1 FOXA2 FEZF1 ZNF766 GLIS2 GATA2 ATF7 FOS DEK SHISA4 LMOD1 IPO9-AS1 ENSG00000223774 SNORA70H RPL10P4 RNPEP TIMM17A IPO9 ENSG00000235121
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TIMM17A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TIMM17A gene promoter:

Genomic Locations for TIMM17A Gene

Genomic Locations for TIMM17A Gene
chr1:201,955,491-201,970,661
(GRCh38/hg38)
Size:
15,171 bases
Orientation:
Plus strand
chr1:201,924,619-201,939,789
(GRCh37/hg19)

Genomic View for TIMM17A Gene

Genes around TIMM17A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIMM17A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIMM17A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIMM17A Gene

Proteins for TIMM17A Gene

  • Protein details for TIMM17A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99595-TI17A_HUMAN
    Recommended name:
    Mitochondrial import inner membrane translocase subunit Tim17-A
    Protein Accession:
    Q99595
    Secondary Accessions:
    • B2RDM5
    • Q9BWF5

    Protein attributes for TIMM17A Gene

    Size:
    171 amino acids
    Molecular mass:
    18024 Da
    Quaternary structure:
    • Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50. The complex interacts with the TIMM44 component of the PAM complex and with DNAJC15.

neXtProt entry for TIMM17A Gene

Post-translational modifications for TIMM17A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TIMM17A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TIMM17A Gene

Domains & Families for TIMM17A Gene

Gene Families for TIMM17A Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for TIMM17A Gene

Graphical View of Domain Structure for InterPro Entry

Q99595

UniProtKB/Swiss-Prot:

TI17A_HUMAN :
  • Belongs to the Tim17/Tim22/Tim23 family.
Family:
  • Belongs to the Tim17/Tim22/Tim23 family.
genes like me logo Genes that share domains with TIMM17A: view

Function for TIMM17A Gene

Molecular function for TIMM17A Gene

UniProtKB/Swiss-Prot Function:
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.

Phenotypes From GWAS Catalog for TIMM17A Gene

Gene Ontology (GO) - Molecular Function for TIMM17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with TIMM17A: view
genes like me logo Genes that share phenotypes with TIMM17A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TIMM17A Gene

Localization for TIMM17A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIMM17A Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TIMM17A gene
Compartment Confidence
mitochondrion 5
nucleus 4
plasma membrane 2
endoplasmic reticulum 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (4)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TIMM17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IEA,IDA --
GO:0005743 mitochondrial inner membrane IDA 20053669
GO:0005744 mitochondrial inner membrane presequence translocase complex IDA 10339406
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TIMM17A: view

Pathways & Interactions for TIMM17A Gene

genes like me logo Genes that share pathways with TIMM17A: view

Pathways by source for TIMM17A Gene

2 Reactome pathways for TIMM17A Gene

Gene Ontology (GO) - Biological Process for TIMM17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006626 protein targeting to mitochondrion TAS 10339406
GO:0006810 transport IEA --
GO:0006886 intracellular protein transport IEA --
GO:0015031 protein transport IEA --
GO:0030150 protein import into mitochondrial matrix IBA --
genes like me logo Genes that share ontologies with TIMM17A: view

No data available for SIGNOR curated interactions for TIMM17A Gene

Drugs & Compounds for TIMM17A Gene

(1) Drugs for TIMM17A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TIMM17A: view

Transcripts for TIMM17A Gene

Unigene Clusters for TIMM17A Gene

Translocase of inner mitochondrial membrane 17 homolog A (yeast):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIMM17A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP1:
SP2: -
SP3: - -

Relevant External Links for TIMM17A Gene

GeneLoc Exon Structure for
TIMM17A
ECgene alternative splicing isoforms for
TIMM17A

Expression for TIMM17A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TIMM17A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TIMM17A Gene

This gene is overexpressed in Fetal Brain (37.3), Stomach (21.8), and Placenta (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TIMM17A Gene



Protein tissue co-expression partners for TIMM17A Gene

NURSA nuclear receptor signaling pathways regulating expression of TIMM17A Gene:

TIMM17A

SOURCE GeneReport for Unigene cluster for TIMM17A Gene:

Hs.20716

Evidence on tissue expression from TISSUES for TIMM17A Gene

  • Nervous system(4.8)
  • Lung(4.5)
  • Bone marrow(4.3)
  • Muscle(4.3)
  • Kidney(2.9)
  • Liver(2.5)
genes like me logo Genes that share expression patterns with TIMM17A: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TIMM17A Gene

Orthologs for TIMM17A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TIMM17A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TIMM17A 33 34
  • 98.83 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TIMM17A 34
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TIMM17A 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TIMM17A 33 34
  • 95.13 (n)
rat
(Rattus norvegicus)
Mammalia Timm17a 33
  • 90.06 (n)
mouse
(Mus musculus)
Mammalia Timm17a 33 16 34
  • 89.08 (n)
cow
(Bos Taurus)
Mammalia TIMM17A 33 34
  • 87.13 (n)
chicken
(Gallus gallus)
Aves TIMM17A 33 34
  • 79.92 (n)
lizard
(Anolis carolinensis)
Reptilia TIMM17A 34
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia timm17a 33
  • 72.85 (n)
Str.10877 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.30296 33
zebrafish
(Danio rerio)
Actinopterygii timm17a 33 34
  • 77.31 (n)
fruit fly
(Drosophila melanogaster)
Insecta Tim17b1 35 34
  • 65 (a)
Tim17b 34
  • 65 (a)
ManyToMany
Tim17a1 35 34
  • 59 (a)
Tim17b2 35 34
  • 59 (a)
CG1724 35 34
  • 57 (a)
Tim17a2 35 34
  • 57 (a)
worm
(Caenorhabditis elegans)
Secernentea E04A4.5 35 34
  • 50 (a)
D2096.1 34
  • 26 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TIM17 34
  • 47 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os03g0415500 33
  • 54.64 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4827 34
  • 51 (a)
OneToMany
Species where no ortholog for TIMM17A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TIMM17A Gene

ENSEMBL:
Gene Tree for TIMM17A (if available)
TreeFam:
Gene Tree for TIMM17A (if available)

Paralogs for TIMM17A Gene

Paralogs for TIMM17A Gene

(2) SIMAP similar genes for TIMM17A Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for TIMM17A Gene

genes like me logo Genes that share paralogs with TIMM17A: view

Variants for TIMM17A Gene

Sequence variations from dbSNP and Humsavar for TIMM17A Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000131923 -- 201,953,550(+) G/A upstream_transcript_variant
rs1000185883 -- 201,960,545(+) G/T intron_variant
rs1000295142 -- 201,966,719(+) G/A intron_variant
rs1000328603 -- 201,964,969(+) T/A intron_variant
rs1000398304 -- 201,964,816(+) T/A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TIMM17A Gene

Variant ID Type Subtype PubMed ID
nsv1121787 CNV deletion 24896259
nsv161136 CNV deletion 16902084
nsv478856 CNV novel sequence insertion 20440878
nsv946576 CNV duplication 23825009

Variation tolerance for TIMM17A Gene

Residual Variation Intolerance Score: 55.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.62; 65.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TIMM17A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TIMM17A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIMM17A Gene

Disorders for TIMM17A Gene

Additional Disease Information for TIMM17A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TIMM17A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIMM17A Gene

Publications for TIMM17A Gene

  1. Genetic and structural characterization of the human mitochondrial inner membrane translocase. (PMID: 10339406) Bauer MF … Hofmann S (Journal of molecular biology 1999) 2 3 4 22 58
  2. The preprotein translocase of the inner mitochondrial membrane: evolutionary conservation of targeting and assembly of Tim17. (PMID: 8893850) Bömer U … Maarse AC (Journal of molecular biology 1996) 2 3 4 22 58
  3. Methylation-controlled J-protein MCJ acts in the import of proteins into human mitochondria. (PMID: 23263864) Schusdziarra C … Hell K (Human molecular genetics 2013) 3 4 58
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for TIMM17A Gene

Sources for TIMM17A Gene

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