The mitochondrial protein encoded by this gene belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane, functioning as intermembrane space chaperones for the highly inso... See more...

Aliases for TIMM10 Gene

Aliases for TIMM10 Gene

  • Translocase Of Inner Mitochondrial Membrane 10 2 3 5
  • Mitochondrial Import Inner Membrane Translocase Subunit Tim10 3 4
  • TIM10 3 4
  • Translocase Of Inner Mitochondrial Membrane 10 (Yeast) Homolog 2
  • Translocase Of Inner Mitochondrial Membrane 10 Homolog (Yeast) 2
  • Translocase Of Inner Mitochondrial Membrane 10 Homolog 3
  • TIMM10A 3
  • TIM10A 3

External Ids for TIMM10 Gene

Previous GeneCards Identifiers for TIMM10 Gene

  • GC11M059689
  • GC11M058809
  • GC11M057546
  • GC11M057071
  • GC11M057052
  • GC11M057296
  • GC11M053644
  • GC11M057299
  • GC11M057531
  • GC11M057534
  • GC11M057777
  • GC11M058193
  • GC11M057537
  • GC11M057540
  • GC11M057543
  • GC11M057547
  • GC11M057552
  • GC11M057555
  • GC11M057558
  • GC11M057561

Summaries for TIMM10 Gene

Entrez Gene Summary for TIMM10 Gene

  • The mitochondrial protein encoded by this gene belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane, functioning as intermembrane space chaperones for the highly insoluble carrier proteins. [provided by RefSeq, Nov 2011]

GeneCards Summary for TIMM10 Gene

TIMM10 (Translocase Of Inner Mitochondrial Membrane 10) is a Protein Coding gene. Diseases associated with TIMM10 include Mitochondrial Metabolism Disease. Among its related pathways are Mitochondrial protein import and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and chaperone binding.

UniProtKB/Swiss-Prot Summary for TIMM10 Gene

  • Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.

Gene Wiki entry for TIMM10 Gene

Additional gene information for TIMM10 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TIMM10 Gene

Genomics for TIMM10 Gene

GeneHancer (GH) Regulatory Elements for TIMM10 Gene

Promoters and enhancers for TIMM10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J057529 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 750.6 +0.1 127 2.6 SIN3A ZNF24 ZBTB40 FOXA1 MLX RBPJ SMARCE1 POLR2A USF2 ATF1 TIMM10 lnc-SMTNL1-1 piR-46301 piR-47821 SSRP1 CLP1 ZDHHC5 PRG2 SLC43A3 SERPING1
GH11J057531 Promoter 0.7 Ensembl 763.4 +1.8 1802 0.4 HLF NFIB BCOR NFIC KDM1A ZMYM3 TIMM10 RN7SL605P piR-46301 piR-47821
GH11J057513 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 53.7 +15.8 15802 4 SMARCE1 USF2 HDAC2 NR2F6 MYC L3MBTL2 MAX MNT ZNF148 ELF3 SLC43A1 TIMM10 SMTNL1 RF00019-015
GH11J057496 Promoter/Enhancer 2.1 Ensembl ENCODE CraniofacialAtlas dbSUPER 49 +30.9 30874 6.7 FOXA1 LCORL RBPJ NR2F1 NR2F6 CREB1 MIXL1 NFYC HLF L3MBTL2 TIMM10 RPS4XP13 OR5AZ1P OR9Q2 OR5B1P OR5B15P BTBD18 RTN4RL2 RN7SKP259 MIR130A
GH11J057481 Promoter/Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas 44.8 +47.5 47474 2.7 MYC ETV6 RAD21 CTCF CREM KLF14 IKZF1 GLIS2 ZIC2 BACH1 TIMM10 RTN4RL2 RN7SKP259 SLC43A1 P2RX3 SSRP1 SLC43A3 ENSG00000254979 UBE2L6 HSALNG0084279
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TIMM10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TIMM10 gene promoter:
  • ATF
  • Evi-1
  • HEN1
  • ITF-2
  • Lmo2
  • Pax-6
  • RORalpha2
  • SRF
  • SRF (504 AA)
  • Tal-1beta

Genomic Locations for TIMM10 Gene

Genomic Locations for TIMM10 Gene
chr11:57,528,463-57,530,803
(GRCh38/hg38)
Size:
2,341 bases
Orientation:
Minus strand
chr11:57,295,936-57,298,276
(GRCh37/hg19)
Size:
2,341 bases
Orientation:
Minus strand

Genomic View for TIMM10 Gene

Genes around TIMM10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIMM10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIMM10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIMM10 Gene

Proteins for TIMM10 Gene

  • Protein details for TIMM10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62072-TIM10_HUMAN
    Recommended name:
    Mitochondrial import inner membrane translocase subunit Tim10
    Protein Accession:
    P62072
    Secondary Accessions:
    • A8K136
    • Q9WV99
    • Q9WVA0
    • Q9Y5J8

    Protein attributes for TIMM10 Gene

    Size:
    90 amino acids
    Molecular mass:
    10333 Da
    Quaternary structure:
    • Heterohexamer; composed of 3 copies of TIMM9 and 3 copies of TIMM10/TIM10A, named soluble 70 kDa complex. The complex forms a 6-bladed alpha-propeller structure and associates with the TIMM22 component of the TIM22 complex. Interacts with multi-pass transmembrane proteins in transit. Also forms a complex composed of TIMM9, TIMM10/TIM10A and FXC1/TIM10B.

    Three dimensional structures from OCA and Proteopedia for TIMM10 Gene

neXtProt entry for TIMM10 Gene

Post-translational modifications for TIMM10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TIMM10 Gene

No data available for DME Specific Peptides for TIMM10 Gene

Domains & Families for TIMM10 Gene

Gene Families for TIMM10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TIMM10 Gene

Suggested Antigen Peptide Sequences for TIMM10 Gene

GenScript: Design optimal peptide antigens:
  • Mitochondrial import inner membrane translocase subunit Tim10 (TIM10_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P62072

UniProtKB/Swiss-Prot:

TIM10_HUMAN :
  • The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM10 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (Probable).
  • Belongs to the small Tim family.
Domain:
  • The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM10 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (Probable).
Family:
  • Belongs to the small Tim family.
genes like me logo Genes that share domains with TIMM10: view

Function for TIMM10 Gene

Molecular function for TIMM10 Gene

UniProtKB/Swiss-Prot Function:
Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
GENATLAS Biochemistry:
translocase of inner mitochondrial membrane 10 (yeast) homolog,expressed in cardiac,skeletal muscle and pancreas,S cerevisiae Tim10p,and essential for escorting a class of multimembrane-spanning proteins

Phenotypes From GWAS Catalog for TIMM10 Gene

Gene Ontology (GO) - Molecular Function for TIMM10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14726512
GO:0008270 zinc ion binding TAS 10552927
GO:0008565 protein transporter activity IEA --
GO:0042803 protein homodimerization activity IPI 16387659
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TIMM10: view
genes like me logo Genes that share phenotypes with TIMM10: view

Animal Model Products

CRISPR Products

miRNA for TIMM10 Gene

miRTarBase miRNAs that target TIMM10

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TIMM10 Gene

Localization for TIMM10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIMM10 Gene

Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TIMM10 gene
Compartment Confidence
mitochondrion 5
extracellular 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TIMM10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IDA --
GO:0005743 mitochondrial inner membrane TAS,IDA --
GO:0005744 TIM23 mitochondrial import inner membrane translocase complex TAS 10552927
GO:0005758 mitochondrial intermembrane space TAS 14726512
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TIMM10: view

Pathways & Interactions for TIMM10 Gene

PathCards logo

SuperPathways for TIMM10 Gene

genes like me logo Genes that share pathways with TIMM10: view

Pathways by source for TIMM10 Gene

2 Reactome pathways for TIMM10 Gene

Gene Ontology (GO) - Biological Process for TIMM10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006626 protein targeting to mitochondrion TAS 10552927
GO:0007605 sensory perception of sound TAS 10552927
GO:0015031 protein transport IEA --
GO:0045039 protein import into mitochondrial inner membrane ISS 14726512
GO:0072321 chaperone-mediated protein transport IDA 16387659
genes like me logo Genes that share ontologies with TIMM10: view

No data available for SIGNOR curated interactions for TIMM10 Gene

Drugs & Compounds for TIMM10 Gene

No Compound Related Data Available

Transcripts for TIMM10 Gene

mRNA/cDNA for TIMM10 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(183) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIMM10 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
SP1: -
SP2:

Relevant External Links for TIMM10 Gene

GeneLoc Exon Structure for
TIMM10
ECgene alternative splicing isoforms for
TIMM10

Expression for TIMM10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TIMM10 Gene

Protein differential expression in normal tissues from HIPED for TIMM10 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (23.1), Pancreas (10.9), and Bone (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TIMM10 Gene



Protein tissue co-expression partners for TIMM10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TIMM10 Gene:

TIMM10

SOURCE GeneReport for Unigene cluster for TIMM10 Gene:

Hs.235750

mRNA Expression by UniProt/SwissProt for TIMM10 Gene:

P62072-TIM10_HUMAN
Tissue specificity: Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle.

Evidence on tissue expression from TISSUES for TIMM10 Gene

  • Liver(4.3)
  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with TIMM10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TIMM10 Gene

Orthologs for TIMM10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TIMM10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TIMM10 33 32
  • 100 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TIMM10 33
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TIMM10 33 32
  • 94.44 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Timm10 17 33 32
  • 92.59 (n)
cow
(Bos Taurus)
Mammalia TIMM10 33 32
  • 92.59 (n)
OneToMany
-- 33
  • 78 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Timm10 32
  • 92.59 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TIMM10 33
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves TIMM10 33 32
  • 78.89 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TIMM10 33
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia timm10 32
  • 77.52 (n)
MGC76115 32
African clawed frog
(Xenopus laevis)
Amphibia Xl.23815 32
zebrafish
(Danio rerio)
Actinopterygii timm10 33 32
  • 73.11 (n)
OneToOne
Dr.28317 32
fruit fly
(Drosophila melanogaster)
Insecta Tim10 33 32
  • 70.18 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010679 32
  • 67.98 (n)
worm
(Caenorhabditis elegans)
Secernentea tin-10 33 32
  • 63.11 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TIM10 35 33
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5364 33
  • 57 (a)
OneToOne
Cin.1154 32
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1154 32
Species where no ortholog for TIMM10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TIMM10 Gene

ENSEMBL:
Gene Tree for TIMM10 (if available)
TreeFam:
Gene Tree for TIMM10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TIMM10: view image

Paralogs for TIMM10 Gene

(1) SIMAP similar genes for TIMM10 Gene using alignment to 1 proteins:

  • TIM10_HUMAN
genes like me logo Genes that share paralogs with TIMM10: view

No data available for Paralogs for TIMM10 Gene

Variants for TIMM10 Gene

Sequence variations from dbSNP and Humsavar for TIMM10 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000223759 -- 57,537,355(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000312783 -- 57,528,079(-) T/G downstream_transcript_variant
rs1000339548 -- 57,528,119(-) G/A downstream_transcript_variant
rs1000588555 -- 57,535,744(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000620995 -- 57,529,715(-) G/A intron_variant

Variation tolerance for TIMM10 Gene

Residual Variation Intolerance Score: 48.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.11; 2.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TIMM10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TIMM10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TIMM10 Gene

Disorders for TIMM10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TIMM10 Gene - From: DISEASES

Disorder Aliases PubMed IDs
mitochondrial metabolism disease
  • mitochondrial diseases
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TIMM10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TIMM10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TIMM10 Gene

Publications for TIMM10 Gene

  1. The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom. (PMID: 10611480) Bauer MF … Hofmann S (FEBS letters 1999) 3 4 23 56
  2. The human family of Deafness/Dystonia peptide (DDP) related mitochondrial import proteins. (PMID: 10552927) Jin H … Vetrie DL (Genomics 1999) 2 3 4 56
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 43 56
  4. Crystal structure of the mitochondrial chaperone TIM9.10 reveals a six-bladed alpha-propeller. (PMID: 16387659) Webb CT … Gulbis JM (Molecular cell 2006) 3 4 56
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56

Products for TIMM10 Gene

Sources for TIMM10 Gene