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Aliases for TIGD7 Gene

Aliases for TIGD7 Gene

  • Tigger Transposable Element Derived 7 2 3 5
  • Tigger Transposable Element-Derived Protein 7 3
  • Sancho 3

External Ids for TIGD7 Gene

Previous GeneCards Identifiers for TIGD7 Gene

  • GC16M003361
  • GC16M003349
  • GC16M003288
  • GC16M003340

Summaries for TIGD7 Gene

Entrez Gene Summary for TIGD7 Gene

  • The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for TIGD7 Gene

TIGD7 (Tigger Transposable Element Derived 7) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is JRKL.

Additional gene information for TIGD7 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIGD7 Gene

Genomics for TIGD7 Gene

GeneHancer (GH) Regulatory Elements for TIGD7 Gene

Promoters and enhancers for TIGD7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J003304 Promoter/Enhancer 1.5 Ensembl ENCODE 650.7 +0.4 423 2.2 HDGF PKNOX1 SMAD1 SIN3A ZNF2 YY1 POLR2B ZNF766 CBX5 E2F8 ZNF75A TIGD7 GC16P003602 ZNF263 CREBBP ENSG00000261938 ZNF597 AMDHD2 SRRM2 LOC105371055
GH16J003281 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 27.5 +22.1 22147 3.6 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF263 ZNF75A TIGD7 CLUAP1 ZNF213-AS1 MTCO1P28 FLYWCH1 MTND1P8 ZSCAN32 MMP25
GH16J004270 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 18.5 -967.0 -966986 4.5 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 TFAP4 GC16P004274 ZNF75A ZNF500 CREBBP ANKS3 ENSG00000261938 TIGD7 ENSG00000261789 LOC105371067
GH16J003400 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 22.7 -95.5 -95490 2.4 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B ZSCAN32 ZNF174 ZNF597 ZNF200 TIGD7 ZNF75A CREBBP CLUAP1 MTCO1P28 AMDHD2
GH16J002750 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 19.5 +552.7 552657 4.7 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 SRRM2 GC16P003532 SRRM2-AS1 ZNF75A ZNF263 TSC2 ERVK13-1 ZNF213-AS1 E4F1 ENSG00000261938
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TIGD7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TIGD7 gene promoter:

Genomic Locations for TIGD7 Gene

Genomic Locations for TIGD7 Gene
chr16:3,298,808-3,305,729
(GRCh38/hg38)
Size:
6,922 bases
Orientation:
Minus strand
chr16:3,348,808-3,355,729
(GRCh37/hg19)

Genomic View for TIGD7 Gene

Genes around TIGD7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIGD7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIGD7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIGD7 Gene

Proteins for TIGD7 Gene

  • Protein details for TIGD7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NT04-TIGD7_HUMAN
    Recommended name:
    Tigger transposable element-derived protein 7
    Protein Accession:
    Q6NT04
    Secondary Accessions:
    • Q9BXZ0

    Protein attributes for TIGD7 Gene

    Size:
    549 amino acids
    Molecular mass:
    63236 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TIGD7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TIGD7 Gene

Post-translational modifications for TIGD7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TIGD7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TIGD7 Gene

Domains & Families for TIGD7 Gene

Suggested Antigen Peptide Sequences for TIGD7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6NT04

UniProtKB/Swiss-Prot:

TIGD7_HUMAN :
  • Belongs to the tigger transposable element derived protein family.
Family:
  • Belongs to the tigger transposable element derived protein family.
genes like me logo Genes that share domains with TIGD7: view

Function for TIGD7 Gene

Phenotypes From GWAS Catalog for TIGD7 Gene

Gene Ontology (GO) - Molecular Function for TIGD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TIGD7: view

Phenotypes for TIGD7 Gene

genes like me logo Genes that share phenotypes with TIGD7: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TIGD7 Gene

Localization for TIGD7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIGD7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TIGD7 gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TIGD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TIGD7: view

Pathways & Interactions for TIGD7 Gene

SuperPathways for TIGD7 Gene

No Data Available

Interacting Proteins for TIGD7 Gene

Gene Ontology (GO) - Biological Process for TIGD7 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TIGD7 Gene

Drugs & Compounds for TIGD7 Gene

No Compound Related Data Available

Transcripts for TIGD7 Gene

mRNA/cDNA for TIGD7 Gene

(39) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TIGD7 Gene

Tigger transposable element derived 7:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIGD7 Gene

No ASD Table

Relevant External Links for TIGD7 Gene

GeneLoc Exon Structure for
TIGD7
ECgene alternative splicing isoforms for
TIGD7

Expression for TIGD7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TIGD7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TIGD7 Gene

This gene is overexpressed in Plasma (25.0), Gallbladder (18.6), and Colon (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TIGD7 Gene



Protein tissue co-expression partners for TIGD7 Gene

NURSA nuclear receptor signaling pathways regulating expression of TIGD7 Gene:

TIGD7

SOURCE GeneReport for Unigene cluster for TIGD7 Gene:

Hs.161287

mRNA Expression by UniProt/SwissProt for TIGD7 Gene:

Q6NT04-TIGD7_HUMAN
Tissue specificity: Expressed in all tissues tested. Higher expression in testis and ovary.

Evidence on tissue expression from TISSUES for TIGD7 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with TIGD7: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TIGD7 Gene

Orthologs for TIGD7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TIGD7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TIGD7 34 33
  • 99.76 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TIGD7 34 33
  • 89.88 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TIGD7 34 33
  • 88.89 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TIGD7 34
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TIGD7 34
  • 60 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Jrk 34
  • 24 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 23 (a)
ManyToMany
Species where no ortholog for TIGD7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TIGD7 Gene

ENSEMBL:
Gene Tree for TIGD7 (if available)
TreeFam:
Gene Tree for TIGD7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TIGD7: view image

Paralogs for TIGD7 Gene

Paralogs for TIGD7 Gene

(2) SIMAP similar genes for TIGD7 Gene using alignment to 2 proteins:

  • TIGD7_HUMAN
  • I3L2A8_HUMAN

Pseudogenes.org Pseudogenes for TIGD7 Gene

genes like me logo Genes that share paralogs with TIGD7: view

Variants for TIGD7 Gene

Sequence variations from dbSNP and Humsavar for TIGD7 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000154979 -- 3,302,955(-) A/G intron_variant
rs1000289238 -- 3,303,924(-) C/G intron_variant
rs1001048991 -- 3,305,394(-) G/A 5_prime_UTR_variant
rs1001143115 -- 3,305,180(-) C/T intron_variant
rs1001281880 -- 3,304,413(-) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TIGD7 Gene

Variant ID Type Subtype PubMed ID
nsv1036149 CNV gain 25217958
nsv1044147 CNV loss 25217958

Variation tolerance for TIGD7 Gene

Residual Variation Intolerance Score: 79.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.97; 36.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TIGD7 Gene

Human Gene Mutation Database (HGMD)
TIGD7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TIGD7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIGD7 Gene

Disorders for TIGD7 Gene

Additional Disease Information for TIGD7

No disorders were found for TIGD7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIGD7 Gene

Publications for TIGD7 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Isolation and characterization of a Jerky and JRK/JH8 like gene, tigger transposable element derived 7, TIGD7. (PMID: 15487591) Dou T … Mao Y (Biochemical genetics 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for TIGD7 Gene

Sources for TIGD7 Gene

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