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Aliases for TIGD5 Gene

Aliases for TIGD5 Gene

  • Tigger Transposable Element Derived 5 2 3 5

External Ids for TIGD5 Gene

Previous GeneCards Identifiers for TIGD5 Gene

  • GC08P142725
  • GC08P144908
  • GC08P144454
  • GC08P144785
  • GC08P144751
  • GC08P144680
  • GC08P139914

Summaries for TIGD5 Gene

Entrez Gene Summary for TIGD5 Gene

  • The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for TIGD5 Gene

TIGD5 (Tigger Transposable Element Derived 5) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is JRKL.

Additional gene information for TIGD5 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIGD5 Gene

Genomics for TIGD5 Gene

GeneHancer (GH) Regulatory Elements for TIGD5 Gene

Promoters and enhancers for TIGD5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I143595 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 561.7 +0.1 97 5.1 HDGF PKNOX1 CLOCK SMAD1 ARNT ZFP64 ARID4B NEUROD1 SIN3A DMAP1 EEF1D TIGD5 PIR45575 NAPRT CPSF1 ZNF623 VPS28 JRK LOC105375803 GPAA1
GH08I143460 Enhancer 1.3 Ensembl ENCODE dbSUPER 31.6 -135.6 -135583 3.6 HDGF PKNOX1 ZNF493 ZNF213 ZNF207 ATF7 RUNX3 ZNF202 JUNB REST ZNF623 CPSF1 VPS28 SLC52A2 JRK GPAA1 ADCK5 TIGD5 ZNF707 ZNF696
GH08I143968 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 11.7 +376.4 376405 11 HDGF CLOCK FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 PLEC ZNF623 ZNF7 ZNF251 LRRC14 ZNF16 CPSF1 GPAA1 WDR97 ZNF707
GH08I144455 Enhancer 1.3 Ensembl ENCODE 19.2 +858.6 858611 1.6 HDGF HNRNPUL1 PKNOX1 FOXA2 ARNT ZFP64 SIN3A ZNF2 POLR2B ZNF766 ZNF251 ZNF623 ZNF7 LRRC14 ZNF250 ZNF16 CPSF1 VPS28 ZNF517 ZNF34
GH08I144094 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.7 +498.7 498735 4.7 HDGF PKNOX1 CLOCK ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 POLR2B CYC1 WDR97 ZNF7 CPSF1 ZNF250 ZNF251 LRRC14 LOC105375803 VPS28 ADCK5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TIGD5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TIGD5 gene promoter:

Genomic Locations for TIGD5 Gene

Genomic Locations for TIGD5 Gene
5,390 bases
Plus strand

Genomic View for TIGD5 Gene

Genes around TIGD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIGD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIGD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIGD5 Gene

Proteins for TIGD5 Gene

  • Protein details for TIGD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tigger transposable element-derived protein 5
    Protein Accession:
    Secondary Accessions:
    • E7EWS2
    • Q6NT83
    • Q8N5A1
    • Q96JW8

    Protein attributes for TIGD5 Gene

    642 amino acids
    Molecular mass:
    69222 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH32632.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB55398.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD97303.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TIGD5 Gene


neXtProt entry for TIGD5 Gene

Post-translational modifications for TIGD5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TIGD5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TIGD5 Gene

Domains & Families for TIGD5 Gene

Suggested Antigen Peptide Sequences for TIGD5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tigger transposable element derived protein family.
  • Belongs to the tigger transposable element derived protein family.
genes like me logo Genes that share domains with TIGD5: view

Function for TIGD5 Gene

Phenotypes From GWAS Catalog for TIGD5 Gene

Gene Ontology (GO) - Molecular Function for TIGD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with TIGD5: view

Phenotypes for TIGD5 Gene

genes like me logo Genes that share phenotypes with TIGD5: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TIGD5 Gene

Localization for TIGD5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIGD5 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TIGD5 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TIGD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TIGD5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TIGD5 Gene

Pathways & Interactions for TIGD5 Gene

SuperPathways for TIGD5 Gene

No Data Available

Interacting Proteins for TIGD5 Gene

Gene Ontology (GO) - Biological Process for TIGD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TIGD5: view

No data available for Pathways by source and SIGNOR curated interactions for TIGD5 Gene

Drugs & Compounds for TIGD5 Gene

No Compound Related Data Available

Transcripts for TIGD5 Gene

mRNA/cDNA for TIGD5 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(43) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TIGD5 Gene

Tigger transposable element derived 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIGD5 Gene

No ASD Table

Relevant External Links for TIGD5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TIGD5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TIGD5 Gene

Protein differential expression in normal tissues from HIPED for TIGD5 Gene

This gene is overexpressed in Kidney (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TIGD5 Gene

Protein tissue co-expression partners for TIGD5 Gene

NURSA nuclear receptor signaling pathways regulating expression of TIGD5 Gene:


SOURCE GeneReport for Unigene cluster for TIGD5 Gene:


Evidence on tissue expression from TISSUES for TIGD5 Gene

  • Kidney(4.1)
  • Skin(4)
genes like me logo Genes that share expression patterns with TIGD5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TIGD5 Gene

Orthologs for TIGD5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TIGD5 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia TIGD5 33 34
  • 88.95 (n)
(Bos Taurus)
Mammalia TIGD5 33 34
  • 87.34 (n)
(Mus musculus)
Mammalia Tigd5 33 16
  • 81.53 (n)
(Ornithorhynchus anatinus)
Mammalia TIGD5 34
  • 80 (a)
(Rattus norvegicus)
Mammalia Tigd5 33
  • 79.39 (n)
(Monodelphis domestica)
Mammalia TIGD5 34
  • 73 (a)
(Gallus gallus)
Aves TIGD5 33 34
  • 68.5 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 21 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tigd5 33
  • 64.48 (n)
Species where no ortholog for TIGD5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TIGD5 Gene

Gene Tree for TIGD5 (if available)
Gene Tree for TIGD5 (if available)

Paralogs for TIGD5 Gene

Paralogs for TIGD5 Gene

(1) SIMAP similar genes for TIGD5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TIGD5: view

Variants for TIGD5 Gene

Sequence variations from dbSNP and Humsavar for TIGD5 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000551410 -- 143,597,910(+) C/A coding_sequence_variant, missense_variant
rs1001156173 -- 143,598,513(+) A/C/G coding_sequence_variant, missense_variant
rs1001505088 -- 143,595,932(+) C/T upstream_transcript_variant
rs1001598335 -- 143,596,177(+) T/A upstream_transcript_variant
rs1001790227 -- 143,598,779(+) G/A coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for TIGD5 Gene

Variant ID Type Subtype PubMed ID
dgv12410n54 CNV loss 21841781
dgv12418n54 CNV loss 21841781
dgv12419n54 CNV loss 21841781
dgv12420n54 CNV gain 21841781
dgv12421n54 CNV gain 21841781
dgv12422n54 CNV gain 21841781
dgv12423n54 CNV gain+loss 21841781
dgv12424n54 CNV gain+loss 21841781
dgv12425n54 CNV loss 21841781
dgv12426n54 CNV loss 21841781
dgv7336n100 CNV gain 25217958
esv26007 CNV loss 19812545
nsv1161809 CNV deletion 26073780
nsv1161810 CNV deletion 26073780
nsv466004 CNV loss 19166990
nsv470247 CNV loss 18288195
nsv516210 CNV loss 19592680
nsv612774 CNV loss 21841781
nsv612777 CNV gain 21841781
nsv612793 CNV loss 21841781
nsv612813 CNV loss 21841781
nsv612819 CNV gain 21841781
nsv612820 CNV loss 21841781
nsv612822 CNV gain 21841781
nsv612845 CNV gain 21841781
nsv612847 CNV loss 21841781
nsv612849 CNV loss 21841781
nsv612850 CNV loss 21841781
nsv824771 CNV gain 20364138
nsv831488 CNV loss 17160897
nsv950013 CNV deletion 24416366

Variation tolerance for TIGD5 Gene

Gene Damage Index Score: 1.92; 35.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TIGD5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIGD5 Gene

Disorders for TIGD5 Gene

Additional Disease Information for TIGD5

No disorders were found for TIGD5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIGD5 Gene

Publications for TIGD5 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for TIGD5 Gene

Sources for TIGD5 Gene

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