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Aliases for TIGD4 Gene

Aliases for TIGD4 Gene

  • Tigger Transposable Element Derived 4 2 3 5

External Ids for TIGD4 Gene

Previous GeneCards Identifiers for TIGD4 Gene

  • GC04M154542
  • GC04M154079
  • GC04M154268
  • GC04M154048
  • GC04M153909
  • GC04M153690
  • GC04M149416

Summaries for TIGD4 Gene

Entrez Gene Summary for TIGD4 Gene

  • The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for TIGD4 Gene

TIGD4 (Tigger Transposable Element Derived 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and chromatin binding. An important paralog of this gene is CENPB.

Additional gene information for TIGD4 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIGD4 Gene

Genomics for TIGD4 Gene

GeneHancer (GH) Regulatory Elements for TIGD4 Gene

Promoters and enhancers for TIGD4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I152778 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 -0.2 -157 2.6 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B E2F8 ARFIP1 TIGD4 GC04M152775 GC04M152797
GH04I153218 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.9 -441.6 -441621 6.4 FOXA2 SIN3A FEZF1 DMAP1 GLI4 ZNF2 ZNF48 YY1 GLIS2 ZNF213 TRIM2 ARFIP1 MIR4453HG RNU6-1196P ENSG00000201786 TIGD4 MND1 RNF175 LOC105377496 GC04M153170
GH04I153485 Enhancer 1.4 Ensembl ENCODE dbSUPER 11 -709.5 -709478 7.9 HDGF PKNOX1 CLOCK SMAD1 ARNT FEZF1 ZNF2 IRF4 FOS JUNB TMEM131L TIGD4 MND1 PIR44013
GH04I153114 Enhancer 1.1 FANTOM5 Ensembl ENCODE 2.8 -336.3 -336280 3.7 CTCF USF1 JUN DACH1 EBF1 SP1 FOSL1 JUND ZNF585B FOSL2 TRIM2 MIR4453HG TMEM131L TIGD4 GC04P153070 GC04P153071
GH04I153247 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 1.7 -469.6 -469634 3 SIN3A BMI1 ZNF335 GLIS2 EGR1 SCRT2 RUNX3 EGR2 SP3 ZNF398 GC04M153247 LOC105377496 TRIM2 MND1 TMEM131L TIGD4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TIGD4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TIGD4 gene promoter:

Genomic Locations for TIGD4 Gene

Genomic Locations for TIGD4 Gene
10,436 bases
Minus strand

Genomic View for TIGD4 Gene

Genes around TIGD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIGD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIGD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIGD4 Gene

Proteins for TIGD4 Gene

  • Protein details for TIGD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tigger transposable element-derived protein 4
    Protein Accession:
    Secondary Accessions:
    • Q96LP5

    Protein attributes for TIGD4 Gene

    512 amino acids
    Molecular mass:
    57468 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB71642.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for TIGD4 Gene

Post-translational modifications for TIGD4 Gene

No Post-translational modifications

Other Protein References for TIGD4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TIGD4 Gene

Domains & Families for TIGD4 Gene

Suggested Antigen Peptide Sequences for TIGD4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tigger transposable element derived protein family.
  • Belongs to the tigger transposable element derived protein family.
genes like me logo Genes that share domains with TIGD4: view

Function for TIGD4 Gene

Phenotypes From GWAS Catalog for TIGD4 Gene

Gene Ontology (GO) - Molecular Function for TIGD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with TIGD4: view
genes like me logo Genes that share phenotypes with TIGD4: view

miRNA for TIGD4 Gene

miRTarBase miRNAs that target TIGD4

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TIGD4 Gene

Localization for TIGD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIGD4 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TIGD4 gene
Compartment Confidence
nucleus 5
cytosol 3
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TIGD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TIGD4: view

Pathways & Interactions for TIGD4 Gene

SuperPathways for TIGD4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TIGD4 Gene


No data available for Pathways by source and SIGNOR curated interactions for TIGD4 Gene

Drugs & Compounds for TIGD4 Gene

No Compound Related Data Available

Transcripts for TIGD4 Gene

mRNA/cDNA for TIGD4 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TIGD4 Gene

Tigger transposable element derived 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIGD4 Gene

No ASD Table

Relevant External Links for TIGD4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TIGD4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TIGD4 Gene

mRNA differential expression in normal tissues according to GTEx for TIGD4 Gene

This gene is overexpressed in Testis (x8.8).

Protein differential expression in normal tissues from HIPED for TIGD4 Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TIGD4 Gene

Protein tissue co-expression partners for TIGD4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TIGD4 Gene:


SOURCE GeneReport for Unigene cluster for TIGD4 Gene:

genes like me logo Genes that share expression patterns with TIGD4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TIGD4 Gene

Orthologs for TIGD4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TIGD4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TIGD4 33 34
  • 99.48 (n)
(Canis familiaris)
Mammalia TIGD4 33 34
  • 91.83 (n)
(Bos Taurus)
Mammalia TIGD4 33 34
  • 89.65 (n)
(Rattus norvegicus)
Mammalia LOC102550932 33
  • 84.24 (n)
(Mus musculus)
Mammalia Tigd4 33 16 34
  • 84.11 (n)
(Monodelphis domestica)
Mammalia TIGD4 34
  • 78 (a)
(Anolis carolinensis)
Reptilia TIGD4 34
  • 65 (a)
Species where no ortholog for TIGD4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TIGD4 Gene

Gene Tree for TIGD4 (if available)
Gene Tree for TIGD4 (if available)

Paralogs for TIGD4 Gene

Paralogs for TIGD4 Gene

(1) SIMAP similar genes for TIGD4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TIGD4: view

Variants for TIGD4 Gene

Sequence variations from dbSNP and Humsavar for TIGD4 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000168153 -- 152,779,905(-) T/C upstream_transcript_variant
rs10002433 -- 152,772,068(-) G/A intron_variant
rs1000496773 -- 152,769,176(-) A/C 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs1000583628 -- 152,778,378(-) T/C intron_variant
rs10008780 -- 152,774,102(-) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TIGD4 Gene

Variant ID Type Subtype PubMed ID
esv2763399 CNV gain 21179565
nsv516652 CNV loss 19592680
nsv522511 CNV loss 19592680

Variation tolerance for TIGD4 Gene

Residual Variation Intolerance Score: 77.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.43; 54.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TIGD4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIGD4 Gene

Disorders for TIGD4 Gene

Additional Disease Information for TIGD4

No disorders were found for TIGD4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIGD4 Gene

Publications for TIGD4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T … Hayashizaki Y (Cell 2010) 3 58

Products for TIGD4 Gene

Sources for TIGD4 Gene

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