The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known. [p... See more...

Aliases for TIGD3 Gene

Aliases for TIGD3 Gene

  • Tigger Transposable Element Derived 3 2 3 5
  • Tigger Transposable Element-Derived Protein 3 3 4
  • TIGD3 5

External Ids for TIGD3 Gene

Previous GeneCards Identifiers for TIGD3 Gene

  • GC11P067639
  • GC11P066803
  • GC11P065372
  • GC11P064897
  • GC11P064878
  • GC11P065122
  • GC11P061449

Summaries for TIGD3 Gene

Entrez Gene Summary for TIGD3 Gene

  • The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for TIGD3 Gene

TIGD3 (Tigger Transposable Element Derived 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is TIGD4.

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TIGD3 Gene

Genomics for TIGD3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TIGD3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TIGD3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TIGD3

Top Transcription factor binding sites by QIAGEN in the TIGD3 gene promoter:
  • C/EBPalpha
  • Egr-2
  • FOXF2
  • HOXA5
  • LCR-F1
  • Meis-1
  • Meis-1a
  • Meis-1b
  • RORalpha2
  • SEF-1 (1)

Genomic Locations for TIGD3 Gene

Latest Assembly
chr11:65,354,751-65,357,613
(GRCh38/hg38)
Size:
2,863 bases
Orientation:
Plus strand

Previous Assembly
chr11:65,122,222-65,125,084
(GRCh37/hg19 by Entrez Gene)
Size:
2,863 bases
Orientation:
Plus strand

chr11:65,122,238-65,125,084
(GRCh37/hg19 by Ensembl)
Size:
2,847 bases
Orientation:
Plus strand

Genomic View for TIGD3 Gene

Genes around TIGD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIGD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIGD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIGD3 Gene

Proteins for TIGD3 Gene

  • Protein details for TIGD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6B0B8-TIGD3_HUMAN
    Recommended name:
    Tigger transposable element-derived protein 3
    Protein Accession:
    Q6B0B8

    Protein attributes for TIGD3 Gene

    Size:
    471 amino acids
    Molecular mass:
    52027 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TIGD3 Gene

Post-translational modifications for TIGD3 Gene

No Post-translational modifications

Other Protein References for TIGD3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TIGD3 Gene

Domains & Families for TIGD3 Gene

Gene Families for TIGD3 Gene

Protein Domains for TIGD3 Gene

InterPro:
Blocks:
  • CENP-B protein
ProtoNet:

Suggested Antigen Peptide Sequences for TIGD3 Gene

GenScript: Design optimal peptide antigens:
  • Tigger transposable element-derived protein 3 (TIGD3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6B0B8

UniProtKB/Swiss-Prot:

TIGD3_HUMAN :
  • Belongs to the tigger transposable element derived protein family.
Family:
  • Belongs to the tigger transposable element derived protein family.
genes like me logo Genes that share domains with TIGD3: view

Function for TIGD3 Gene

Phenotypes From GWAS Catalog for TIGD3 Gene

Gene Ontology (GO) - Molecular Function for TIGD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IBA 21873635
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with TIGD3: view
genes like me logo Genes that share phenotypes with TIGD3: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TIGD3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TIGD3 Gene

Localization for TIGD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIGD3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TIGD3 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TIGD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with TIGD3: view

Pathways & Interactions for TIGD3 Gene

PathCards logo

SuperPathways for TIGD3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TIGD3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TIGD3 Gene

Drugs & Compounds for TIGD3 Gene

No Compound Related Data Available

Transcripts for TIGD3 Gene

mRNA/cDNA for TIGD3 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TIGD3

Alternative Splicing Database (ASD) splice patterns (SP) for TIGD3 Gene

No ASD Table

Relevant External Links for TIGD3 Gene

GeneLoc Exon Structure for
TIGD3

Expression for TIGD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TIGD3 Gene

mRNA differential expression in normal tissues according to GTEx for TIGD3 Gene

This gene is overexpressed in Whole Blood (x7.2), Testis (x5.8), Brain - Cerebellum (x5.1), and Brain - Cerebellar Hemisphere (x4.9).

Protein differential expression in normal tissues from HIPED for TIGD3 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TIGD3 Gene



Protein tissue co-expression partners for TIGD3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TIGD3

SOURCE GeneReport for Unigene cluster for TIGD3 Gene:

Hs.632121

Evidence on tissue expression from TISSUES for TIGD3 Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with TIGD3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TIGD3 Gene

Orthologs for TIGD3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TIGD3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TIGD3 30 31
  • 99.58 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TIGD3 30 31
  • 87.33 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TIGD3 30 31
  • 87.05 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Tigd3 30 17 31
  • 83.12 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tigd3 30
  • 82.41 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 20 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves TIGD3 31
  • 34 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TIGD3 31
  • 24 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tigd3 30
  • 45.28 (n)
Species where no ortholog for TIGD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for TIGD3 Gene

ENSEMBL:
Gene Tree for TIGD3 (if available)
TreeFam:
Gene Tree for TIGD3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TIGD3: view image

Paralogs for TIGD3 Gene

Paralogs for TIGD3 Gene

genes like me logo Genes that share paralogs with TIGD3: view

Variants for TIGD3 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TIGD3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TIGD3 Gene

Variant ID Type Subtype PubMed ID
esv2422285 CNV deletion 17116639
nsv482159 CNV gain 20164927
nsv526181 CNV gain 19592680
nsv832190 CNV loss 17160897

Variation tolerance for TIGD3 Gene

Residual Variation Intolerance Score: 11.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.25; 62.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TIGD3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TIGD3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TIGD3 Gene

Disorders for TIGD3 Gene

Additional Disease Information for TIGD3

No disorders were found for TIGD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIGD3 Gene

Publications for TIGD3 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  2. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  4. Putative CENP-B paralogues are not present at mammalian centromeres. (PMID: 22080934) Marshall OJ … Choo KH (Chromosoma 2012) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for TIGD3 Gene

Sources for TIGD3 Gene