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Aliases for TIGD3 Gene

Aliases for TIGD3 Gene

  • Tigger Transposable Element Derived 3 2 3 5

External Ids for TIGD3 Gene

Previous GeneCards Identifiers for TIGD3 Gene

  • GC11P067639
  • GC11P066803
  • GC11P065372
  • GC11P064897
  • GC11P064878
  • GC11P065122
  • GC11P061449

Summaries for TIGD3 Gene

Entrez Gene Summary for TIGD3 Gene

  • The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for TIGD3 Gene

TIGD3 (Tigger Transposable Element Derived 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is TIGD4.

Additional gene information for TIGD3 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIGD3 Gene

Genomics for TIGD3 Gene

GeneHancer (GH) Regulatory Elements for TIGD3 Gene

Promoters and enhancers for TIGD3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I065353 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 0.0 -46 2.6 HDGF ARNT ARID4B SIN3A ZNF48 YY1 TCF12 POLR2B GLIS2 ARID2 TIGD3 LOC728975 MEN1 DPF2
GH11I065567 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.3 +218.9 218907 12 MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 SSSCA1 EHBP1L1 FAM89B PCNX3 SF1 EIF1AD POLA2 LOC105369352 NEAT1 ZFPL1
GH11I065636 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.4 +285.9 285915 8.2 HDGF PKNOX1 SMAD1 ZFP64 ARID4B SIN3A YBX1 POLR2B ZNF207 ZNF143 SIPA1 EIF1AD RBM14 SF1 ZFPL1 RBM4 PCNX3 POLA2 SART1 MUS81
GH11I065414 Promoter/Enhancer 2.4 FANTOM5 Ensembl ENCODE dbSUPER 9.6 +69.4 69414 18.8 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 NEAT1 ENSG00000277599 ENSG00000278050 ENSG00000278144 GC11P065529 SF1 ZFPL1 EIF1AD POLA2 PCNX3
GH11I065438 Enhancer 1.4 Ensembl ENCODE dbSUPER 11.2 +89.5 89464 10.7 PKNOX1 CLOCK SMAD1 IRF4 YY1 TCF12 ZNF121 POLR2B GLIS2 E2F8 ENSG00000275948 GC11P065523 GC11P065530 GC11P065531 MIR612 NEAT1 SF1 RELA VPS51 EIF1AD
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TIGD3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TIGD3 gene promoter:

Genomic Locations for TIGD3 Gene

Genomic Locations for TIGD3 Gene
chr11:65,354,767-65,357,613
(GRCh38/hg38)
Size:
2,847 bases
Orientation:
Plus strand
chr11:65,122,238-65,125,084
(GRCh37/hg19)

Genomic View for TIGD3 Gene

Genes around TIGD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIGD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIGD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIGD3 Gene

Proteins for TIGD3 Gene

  • Protein details for TIGD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6B0B8-TIGD3_HUMAN
    Recommended name:
    Tigger transposable element-derived protein 3
    Protein Accession:
    Q6B0B8

    Protein attributes for TIGD3 Gene

    Size:
    471 amino acids
    Molecular mass:
    52027 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TIGD3 Gene

Post-translational modifications for TIGD3 Gene

No Post-translational modifications

Other Protein References for TIGD3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TIGD3 Gene

Domains & Families for TIGD3 Gene

Protein Domains for TIGD3 Gene

Suggested Antigen Peptide Sequences for TIGD3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6B0B8

UniProtKB/Swiss-Prot:

TIGD3_HUMAN :
  • Belongs to the tigger transposable element derived protein family.
Family:
  • Belongs to the tigger transposable element derived protein family.
genes like me logo Genes that share domains with TIGD3: view

Function for TIGD3 Gene

Phenotypes From GWAS Catalog for TIGD3 Gene

Gene Ontology (GO) - Molecular Function for TIGD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with TIGD3: view
genes like me logo Genes that share phenotypes with TIGD3: view

miRNA for TIGD3 Gene

miRTarBase miRNAs that target TIGD3

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TIGD3 Gene

Localization for TIGD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIGD3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TIGD3 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TIGD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TIGD3: view

Pathways & Interactions for TIGD3 Gene

SuperPathways for TIGD3 Gene

No Data Available

Interacting Proteins for TIGD3 Gene

Gene Ontology (GO) - Biological Process for TIGD3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TIGD3 Gene

Drugs & Compounds for TIGD3 Gene

No Compound Related Data Available

Transcripts for TIGD3 Gene

mRNA/cDNA for TIGD3 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(28) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TIGD3 Gene

Tigger transposable element derived 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIGD3 Gene

No ASD Table

Relevant External Links for TIGD3 Gene

GeneLoc Exon Structure for
TIGD3
ECgene alternative splicing isoforms for
TIGD3

Expression for TIGD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TIGD3 Gene

mRNA differential expression in normal tissues according to GTEx for TIGD3 Gene

This gene is overexpressed in Whole Blood (x7.2), Testis (x5.8), Brain - Cerebellum (x5.1), and Brain - Cerebellar Hemisphere (x4.9).

Protein differential expression in normal tissues from HIPED for TIGD3 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TIGD3 Gene



Protein tissue co-expression partners for TIGD3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TIGD3 Gene:

TIGD3

SOURCE GeneReport for Unigene cluster for TIGD3 Gene:

Hs.632121

Evidence on tissue expression from TISSUES for TIGD3 Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with TIGD3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TIGD3 Gene

Orthologs for TIGD3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TIGD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TIGD3 33 34
  • 99.58 (n)
dog
(Canis familiaris)
Mammalia TIGD3 33 34
  • 87.33 (n)
cow
(Bos Taurus)
Mammalia TIGD3 33 34
  • 87.05 (n)
mouse
(Mus musculus)
Mammalia Tigd3 33 16 34
  • 83.12 (n)
rat
(Rattus norvegicus)
Mammalia Tigd3 33
  • 82.41 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 20 (a)
ManyToMany
chicken
(Gallus gallus)
Aves TIGD3 34
  • 34 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TIGD3 34
  • 24 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tigd3 33
  • 45.28 (n)
Species where no ortholog for TIGD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TIGD3 Gene

ENSEMBL:
Gene Tree for TIGD3 (if available)
TreeFam:
Gene Tree for TIGD3 (if available)

Paralogs for TIGD3 Gene

Paralogs for TIGD3 Gene

genes like me logo Genes that share paralogs with TIGD3: view

Variants for TIGD3 Gene

Sequence variations from dbSNP and Humsavar for TIGD3 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000392770 -- 65,354,482(+) G/C upstream_transcript_variant
rs1000446606 -- 65,354,578(+) CCC/CC upstream_transcript_variant
rs1001239360 -- 65,355,626(+) G/A/C intron_variant
rs1001503323 -- 65,354,838(+) G/C 5_prime_UTR_variant
rs1001607208 -- 65,355,826(+) G/A coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for TIGD3 Gene

Variant ID Type Subtype PubMed ID
esv2422285 CNV deletion 17116639
nsv482159 CNV gain 20164927
nsv526181 CNV gain 19592680
nsv832190 CNV loss 17160897

Variation tolerance for TIGD3 Gene

Residual Variation Intolerance Score: 11.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.25; 62.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TIGD3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TIGD3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIGD3 Gene

Disorders for TIGD3 Gene

Additional Disease Information for TIGD3

No disorders were found for TIGD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIGD3 Gene

Publications for TIGD3 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. Putative CENP-B paralogues are not present at mammalian centromeres. (PMID: 22080934) Marshall OJ … Choo KH (Chromosoma 2012) 3 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  5. A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus. (PMID: 9253601) Guru SC … Chandrasekharappa SC (Genome research 1997) 3 58

Products for TIGD3 Gene

Sources for TIGD3 Gene

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