The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known. [p... See more...

Aliases for TIGD2 Gene

Aliases for TIGD2 Gene

  • Tigger Transposable Element Derived 2 2 3 5
  • Tigger Transposable Element-Derived Protein 2 3 4
  • Epididymis Luminal Protein 106 3
  • HEL106 3
  • TIGD2 5

External Ids for TIGD2 Gene

Previous GeneCards Identifiers for TIGD2 Gene

  • GC04U990144
  • GC04P090335
  • GC04P090492
  • GC04P090391
  • GC04P090252
  • GC04P090033
  • GC04P085785

Summaries for TIGD2 Gene

Entrez Gene Summary for TIGD2 Gene

  • The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for TIGD2 Gene

TIGD2 (Tigger Transposable Element Derived 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is JRKL.

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TIGD2 Gene

Genomics for TIGD2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TIGD2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J089110 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 255.6 +1.2 1161 3.9 TBP ZBTB10 SP1 MXD4 CEBPA MNT SMAD5 ETS1 ZFP64 ZNF217 TIGD2 ENSG00000270720 FAM13A lnc-TIGD2-2 HSALNG0035778 GPRIN3
GH04J089109 Enhancer 0.2 CraniofacialAtlas 250.7 -1.1 -1119 0.4 ENSG00000270720 FAM13A TIGD2 lnc-TIGD2-2 piR-31199-269 NAP1L5
GH04J089055 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 17.2 -54.7 -54739 3.3 TBP SIX5 MNT IKZF1 SMAD5 ETS1 SIX4 BHLHE40 ARNT RAD51 FAM13A TIGD2 piR-31199-269 NAP1L5
GH04J088818 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.7 -289.6 -289630 6.4 TBP CEBPA NR2C1 MNT IKZF1 SMAD5 IRF2 HES1 MBD2 CTCF FAM13A TIGD2 lnc-NAP1L5-3 piR-31937-158 NAP1L5
GH04J088997 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10.3 -111.2 -111154 5.5 FEZF1 CEBPA IKZF1 HOMEZ CEBPB ELK1 ZNF395 REST VEZF1 GABPA FAM13A FAM13A-AS1 TIGD2 NAP1L5 SNCA HSALNG0035775 lnc-NAP1L5-4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TIGD2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TIGD2

Top Transcription factor binding sites by QIAGEN in the TIGD2 gene promoter:
  • aMEF-2
  • AML1a
  • C/EBPalpha
  • C/EBPbeta
  • Egr-3
  • FOXD3
  • HSF2
  • MEF-2A
  • RSRFC4

Genomic Locations for TIGD2 Gene

Latest Assembly
chr4:89,111,169-89,114,901
(GRCh38/hg38)
Size:
3,733 bases
Orientation:
Plus strand

Previous Assembly
chr4:90,032,320-90,036,052
(GRCh37/hg19 by Entrez Gene)
Size:
3,733 bases
Orientation:
Plus strand

chr4:90,033,968-90,036,050
(GRCh37/hg19 by Ensembl)
Size:
2,083 bases
Orientation:
Plus strand

Genomic View for TIGD2 Gene

Genes around TIGD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIGD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIGD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIGD2 Gene

Proteins for TIGD2 Gene

  • Protein details for TIGD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4W5G0-TIGD2_HUMAN
    Recommended name:
    Tigger transposable element-derived protein 2
    Protein Accession:
    Q4W5G0

    Protein attributes for TIGD2 Gene

    Size:
    525 amino acids
    Molecular mass:
    59623 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TIGD2 Gene

Post-translational modifications for TIGD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TIGD2 Gene

No data available for DME Specific Peptides for TIGD2 Gene

Domains & Families for TIGD2 Gene

Gene Families for TIGD2 Gene

Protein Domains for TIGD2 Gene

InterPro:
Blocks:
  • CENP-B protein
  • CENP-B, N-terminal DNA-binding
ProtoNet:

Suggested Antigen Peptide Sequences for TIGD2 Gene

GenScript: Design optimal peptide antigens:
  • Tigger transposable element-derived protein 2 (TIGD2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q4W5G0

UniProtKB/Swiss-Prot:

TIGD2_HUMAN :
  • Belongs to the tigger transposable element derived protein family.
Family:
  • Belongs to the tigger transposable element derived protein family.
genes like me logo Genes that share domains with TIGD2: view

Function for TIGD2 Gene

Phenotypes From GWAS Catalog for TIGD2 Gene

Gene Ontology (GO) - Molecular Function for TIGD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IBA 21873635
genes like me logo Genes that share ontologies with TIGD2: view
genes like me logo Genes that share phenotypes with TIGD2: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TIGD2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TIGD2 Gene

Localization for TIGD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIGD2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TIGD2 gene
Compartment Confidence
nucleus 4
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TIGD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with TIGD2: view

Pathways & Interactions for TIGD2 Gene

PathCards logo

SuperPathways for TIGD2 Gene

No Data Available

Interacting Proteins for TIGD2 Gene

Gene Ontology (GO) - Biological Process for TIGD2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TIGD2 Gene

Drugs & Compounds for TIGD2 Gene

No Compound Related Data Available

Transcripts for TIGD2 Gene

mRNA/cDNA for TIGD2 Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TIGD2

Alternative Splicing Database (ASD) splice patterns (SP) for TIGD2 Gene

No ASD Table

Relevant External Links for TIGD2 Gene

GeneLoc Exon Structure for
TIGD2

Expression for TIGD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TIGD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TIGD2 Gene

This gene is overexpressed in Liver (x6.7).

Protein differential expression in normal tissues from HIPED for TIGD2 Gene

This gene is overexpressed in Frontal cortex (37.5) and NK cells (14.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TIGD2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TIGD2

SOURCE GeneReport for Unigene cluster for TIGD2 Gene:

Hs.58924
genes like me logo Genes that share expression patterns with TIGD2: view

Primer products for research

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TIGD2 Gene

Orthologs for TIGD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TIGD2 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia TIGD2 30 31
  • 93.14 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TIGD2 30 31
  • 92.57 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Tigd2 30 17 31
  • 86.77 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia LOC100912924 30
  • 86.7 (n)
Oppossum
(Monodelphis domestica)
Mammalia TIGD2 31
  • 82 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 61 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 43 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003894 30
  • 48.22 (n)
Species where no ortholog for TIGD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for TIGD2 Gene

ENSEMBL:
Gene Tree for TIGD2 (if available)
TreeFam:
Gene Tree for TIGD2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TIGD2: view image

Paralogs for TIGD2 Gene

Paralogs for TIGD2 Gene

(5) SIMAP similar genes for TIGD2 Gene using alignment to 1 proteins:

  • TIGD2_HUMAN
genes like me logo Genes that share paralogs with TIGD2: view

Variants for TIGD2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TIGD2 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs2280099 - p.His475Arg

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TIGD2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TIGD2 Gene

Variant ID Type Subtype PubMed ID
esv3569577 CNV loss 25503493
nsv461576 CNV gain 19166990
nsv470051 CNV gain 18288195
nsv594806 CNV gain 21841781

Variation tolerance for TIGD2 Gene

Residual Variation Intolerance Score: 14.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.34; 76.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TIGD2 Gene

Human Gene Mutation Database (HGMD)
TIGD2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TIGD2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIGD2 Gene

Disorders for TIGD2 Gene

Additional Disease Information for TIGD2

Genetic Association Database
(GAD)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for TIGD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIGD2 Gene

Publications for TIGD2 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4
  2. H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids. (PMID: 30804502) Nakamura K … Groth A (Nature cell biology 2019) 3
  3. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. (PMID: 29987050) Xiao T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2018) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for TIGD2 Gene

Sources for TIGD2 Gene