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Aliases for TIGD2 Gene

Aliases for TIGD2 Gene

  • Tigger Transposable Element Derived 2 2 3 5
  • Tigger Transposable Element-Derived Protein 2 3
  • Epididymis Luminal Protein 106 3
  • HEL106 3

External Ids for TIGD2 Gene

Previous GeneCards Identifiers for TIGD2 Gene

  • GC04U990144
  • GC04P090335
  • GC04P090492
  • GC04P090391
  • GC04P090252
  • GC04P090033
  • GC04P085785

Summaries for TIGD2 Gene

Entrez Gene Summary for TIGD2 Gene

  • The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for TIGD2 Gene

TIGD2 (Tigger Transposable Element Derived 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is JRKL.

Additional gene information for TIGD2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIGD2 Gene

Genomics for TIGD2 Gene

GeneHancer (GH) Regulatory Elements for TIGD2 Gene

Promoters and enhancers for TIGD2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I089110 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 555.7 +0.9 908 3.7 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF207 TIGD2 FAM13A ENSG00000270720 GC04P089101
GH04I089055 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 16.3 -54.7 -54670 2.5 PKNOX1 ATF1 ARNT SIN3A YY1 POLR2B ARID2 ATF7 NCOA1 GTF2B FAM13A TIGD2 GC04P089101 GC04M088970
GH04I088818 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 10.7 -290.0 -289961 6.4 HDGF PKNOX1 SMAD1 FOXA2 MLX ARNT ARID4B SIN3A YY1 POLR2B FAM13A TIGD2 PIR43353 LOC105377327
GH04I088997 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.3 -111.5 -111485 5.5 PKNOX1 ATF1 FOXA2 FEZF1 ELK1 ATF7 REST TSHZ1 ZNF592 MEF2D FAM13A FAM13A-AS1 TIGD2 NAP1L5 SNCA GC04M088970 GC04P089101
GH04I089020 Enhancer 0.8 ENCODE dbSUPER 14.9 -89.5 -89485 2.1 NR2F1 MZF1 DPF2 ZBTB40 BATF E4F1 ATF2 SMARCA4 ZNF512 ZFP36 TIGD2 FAM13A-AS1 FAM13A NAP1L5 GC04M088970 GC04P089101
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TIGD2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TIGD2 gene promoter:

Genomic Locations for TIGD2 Gene

Genomic Locations for TIGD2 Gene
3,402 bases
Plus strand

Genomic View for TIGD2 Gene

Genes around TIGD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIGD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIGD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIGD2 Gene

Proteins for TIGD2 Gene

  • Protein details for TIGD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tigger transposable element-derived protein 2
    Protein Accession:

    Protein attributes for TIGD2 Gene

    525 amino acids
    Molecular mass:
    59623 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TIGD2 Gene

Post-translational modifications for TIGD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TIGD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TIGD2 Gene

Domains & Families for TIGD2 Gene

Suggested Antigen Peptide Sequences for TIGD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tigger transposable element derived protein family.
  • Belongs to the tigger transposable element derived protein family.
genes like me logo Genes that share domains with TIGD2: view

Function for TIGD2 Gene

Phenotypes From GWAS Catalog for TIGD2 Gene

Gene Ontology (GO) - Molecular Function for TIGD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with TIGD2: view
genes like me logo Genes that share phenotypes with TIGD2: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TIGD2 Gene

Localization for TIGD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIGD2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TIGD2 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TIGD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TIGD2: view

Pathways & Interactions for TIGD2 Gene

SuperPathways for TIGD2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TIGD2 Gene


No data available for Pathways by source and SIGNOR curated interactions for TIGD2 Gene

Drugs & Compounds for TIGD2 Gene

No Compound Related Data Available

Transcripts for TIGD2 Gene

mRNA/cDNA for TIGD2 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(27) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TIGD2 Gene

Tigger transposable element derived 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIGD2 Gene

No ASD Table

Relevant External Links for TIGD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TIGD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TIGD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TIGD2 Gene

This gene is overexpressed in Liver (x6.7).

Protein differential expression in normal tissues from HIPED for TIGD2 Gene

This gene is overexpressed in Frontal cortex (37.5) and NK cells (14.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TIGD2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TIGD2 Gene:


SOURCE GeneReport for Unigene cluster for TIGD2 Gene:

genes like me logo Genes that share expression patterns with TIGD2: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TIGD2 Gene

Orthologs for TIGD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TIGD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia TIGD2 33 34
  • 93.14 (n)
(Bos Taurus)
Mammalia TIGD2 33 34
  • 92.57 (n)
(Mus musculus)
Mammalia Tigd2 33 16 34
  • 86.77 (n)
(Rattus norvegicus)
Mammalia LOC100912924 33
  • 86.7 (n)
(Monodelphis domestica)
Mammalia TIGD2 34
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 61 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 43 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003894 33
  • 48.22 (n)
Species where no ortholog for TIGD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TIGD2 Gene

Gene Tree for TIGD2 (if available)
Gene Tree for TIGD2 (if available)

Paralogs for TIGD2 Gene

Paralogs for TIGD2 Gene

(5) SIMAP similar genes for TIGD2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TIGD2: view

Variants for TIGD2 Gene

Sequence variations from dbSNP and Humsavar for TIGD2 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000129223 -- 89,114,390(+) A/G coding_sequence_variant, synonymous_variant
rs1001897578 -- 89,111,219(+) C/G upstream_transcript_variant
rs1002330820 -- 89,111,299(+) G/A upstream_transcript_variant
rs1002615263 -- 89,111,783(+) G/A upstream_transcript_variant
rs1002798352 -- 89,111,391(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TIGD2 Gene

Variant ID Type Subtype PubMed ID
esv3569577 CNV loss 25503493
nsv461576 CNV gain 19166990
nsv470051 CNV gain 18288195
nsv594806 CNV gain 21841781

Variation tolerance for TIGD2 Gene

Residual Variation Intolerance Score: 14.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.34; 76.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TIGD2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIGD2 Gene

Disorders for TIGD2 Gene

Additional Disease Information for TIGD2

No disorders were found for TIGD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIGD2 Gene

Publications for TIGD2 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58
  3. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PMID: 16712791) Wang AG … Kim NS (Biochemical and biophysical research communications 2006) 3 58
  4. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y … Sugano S (Genome research 2004) 3 58
  5. Tiggers and DNA transposon fossils in the human genome. (PMID: 8643651) Smit AF … Riggs AD (Proceedings of the National Academy of Sciences of the United States of America 1996) 3 58

Products for TIGD2 Gene

Sources for TIGD2 Gene

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