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Aliases for TIGAR Gene

Aliases for TIGAR Gene

  • TP53 Induced Glycolysis Regulatory Phosphatase 2 3 5
  • TP53-Induced Glycolysis And Apoptosis Regulator 2 3 4
  • Fructose-2,6-Bisphosphatase TIGAR 3 4
  • C12orf5 3 4
  • TP53-Induced Glycolysis Regulatory Phosphatase 4
  • Probable Fructose-2,6-Bisphosphatase TIGAR 3
  • Fructose-2,6-Bisphosphate 2-Phosphatase 3
  • Chromosome 12 Open Reading Frame 5 2
  • Transactivated By NS3TP2 Protein 3
  • EC 3.1.3.46 4
  • FR2BP 3

External Ids for TIGAR Gene

Previous HGNC Symbols for TIGAR Gene

  • C12orf5

Previous GeneCards Identifiers for TIGAR Gene

  • GC12P004323
  • GC12P004588
  • GC12P005882
  • GC12P004693
  • GC12P004857
  • GC12P005013
  • GC12P005175
  • GC12P005327
  • GC12P005489
  • GC12P005647
  • GC12P005780

Summaries for TIGAR Gene

Entrez Gene Summary for TIGAR Gene

  • This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region. [provided by RefSeq, Jul 2008]

GeneCards Summary for TIGAR Gene

TIGAR (TP53 Induced Glycolysis Regulatory Phosphatase) is a Protein Coding gene. Diseases associated with TIGAR include Hypoxia. Among its related pathways are DNA Damage and Apoptosis and Autophagy. Gene Ontology (GO) annotations related to this gene include phosphatase activity and fructose-2,6-bisphosphate 2-phosphatase activity.

UniProtKB/Swiss-Prot for TIGAR Gene

  • Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate (PubMed:19015259). Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6-bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production (PubMed:16839880, PubMed:22887998). Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death (PubMed:16839880, PubMed:19713938, PubMed:23726973, PubMed:22887998, PubMed:23817040). Plays a role in promoting protection against cell death during hypoxia by decreasing mitochondria ROS levels in a HK2-dependent manner through a mechanism that is independent of its fructose-bisphosphatase activity (PubMed:23185017). In response to cardiac damage stress, mediates p53-induced inhibition of myocyte mitophagy through ROS levels reduction and the subsequent inactivation of BNIP3. Reduced mitophagy results in an enhanced apoptotic myocyte cell death, and exacerbates cardiac damage (By similarity). Plays a role in adult intestinal regeneration; contributes to the growth, proliferation and survival of intestinal crypts following tissue ablation (PubMed:23726973). Plays a neuroprotective role against ischemic brain damage by enhancing PPP flux and preserving mitochondria functions (By similarity). Protects glioma cells from hypoxia- and ROS-induced cell death by inhibiting glycolysis and activating mitochondrial energy metabolism and oxygen consumption in a TKTL1-dependent and p53/TP53-independent manner (PubMed:22887998). Plays a role in cancer cell survival by promoting DNA repair through activating PPP flux in a CDK5-ATM-dependent signaling pathway during hypoxia and/or genome stress-induced DNA damage responses (PubMed:25928429). Involved in intestinal tumor progression (PubMed:23726973).

Gene Wiki entry for TIGAR Gene

Additional gene information for TIGAR Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIGAR Gene

Genomics for TIGAR Gene

GeneHancer (GH) Regulatory Elements for TIGAR Gene

Promoters and enhancers for TIGAR Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J004320 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 609.3 +14.4 14438 4.4 SP1 ELF3 MNT CBFA2T2 NKRF POLR2A MLLT1 MYC NCOA6 YY1 TIGAR ENSG00000213970 RPS15P7 ENSG00000285901
GH12J004306 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 600.7 +0.0 44 2.7 CTCF ZSCAN21 YY1 RAD21 CREB1 GLIS2 ZBTB33 ZNF600 ZIC2 GATAD2A TIGAR ENSG00000213970 ENSG00000285901
GH12J004305 Enhancer 0.5 Ensembl dbSUPER 600.7 -2.0 -1962 0.4 POLR2A TIGAR FGF23 PIR44232 ENSG00000285901
GH12J004568 Promoter/Enhancer 1.1 Ensembl ENCODE 5.3 +260.7 260738 3 SP1 IKZF1 IKZF2 DPF2 ELF1 NR2F1 NBN BHLHE40 AKAP3 C12orf4 RAD51AP1 ENSG00000256748 NDUFA9 TIGAR DYRK4
GH12J004505 Enhancer 1 Ensembl ENCODE 5.2 +199.1 199138 3 ELF3 SP1 CREM ZNF644 ZBED1 HMG20B CEBPA GATAD2A RXRB ATF7 FGF6 FGF23 RAD51AP1 C12orf4 TIGAR
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TIGAR on UCSC Golden Path with GeneCards custom track

Genomic Locations for TIGAR Gene

Genomic Locations for TIGAR Gene
chr12:4,307,763-4,360,028
(GRCh38/hg38)
Size:
52,266 bases
Orientation:
Plus strand
chr12:4,430,359-4,469,194
(GRCh37/hg19)
Size:
38,836 bases
Orientation:
Plus strand

Genomic View for TIGAR Gene

Genes around TIGAR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIGAR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIGAR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIGAR Gene

Proteins for TIGAR Gene

  • Protein details for TIGAR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQ88-TIGAR_HUMAN
    Recommended name:
    Fructose-2,6-bisphosphatase TIGAR
    Protein Accession:
    Q9NQ88
    Secondary Accessions:
    • B2R840

    Protein attributes for TIGAR Gene

    Size:
    270 amino acids
    Molecular mass:
    30063 Da
    Quaternary structure:
    • Interacts with HK2; the interaction increases hexokinase HK2 activity in a hypoxia- and HIF1A-dependent manner, resulting in the regulation of mitochondrial membrane potential, thus increasing NADPH production and decreasing intracellular ROS levels (PubMed:23185017).

    Three dimensional structures from OCA and Proteopedia for TIGAR Gene

neXtProt entry for TIGAR Gene

Post-translational modifications for TIGAR Gene

  • Ubiquitination at posLast=3737
  • Modification sites at PhosphoSitePlus

Other Protein References for TIGAR Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TIGAR Gene

Domains & Families for TIGAR Gene

Gene Families for TIGAR Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for TIGAR Gene

GenScript: Design optimal peptide antigens:
  • TP53-induced glycolysis and apoptosis regulator (TIGAR_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NQ88

UniProtKB/Swiss-Prot:

TIGAR_HUMAN :
  • Belongs to the phosphoglycerate mutase family.
Family:
  • Belongs to the phosphoglycerate mutase family.
genes like me logo Genes that share domains with TIGAR: view

Function for TIGAR Gene

Molecular function for TIGAR Gene

UniProtKB/Swiss-Prot Function:
Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate (PubMed:19015259). Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6-bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production (PubMed:16839880, PubMed:22887998). Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death (PubMed:16839880, PubMed:19713938, PubMed:23726973, PubMed:22887998, PubMed:23817040). Plays a role in promoting protection against cell death during hypoxia by decreasing mitochondria ROS levels in a HK2-dependent manner through a mechanism that is independent of its fructose-bisphosphatase activity (PubMed:23185017). In response to cardiac damage stress, mediates p53-induced inhibition of myocyte mitophagy through ROS levels reduction and the subsequent inactivation of BNIP3. Reduced mitophagy results in an enhanced apoptotic myocyte cell death, and exacerbates cardiac damage (By similarity). Plays a role in adult intestinal regeneration; contributes to the growth, proliferation and survival of intestinal crypts following tissue ablation (PubMed:23726973). Plays a neuroprotective role against ischemic brain damage by enhancing PPP flux and preserving mitochondria functions (By similarity). Protects glioma cells from hypoxia- and ROS-induced cell death by inhibiting glycolysis and activating mitochondrial energy metabolism and oxygen consumption in a TKTL1-dependent and p53/TP53-independent manner (PubMed:22887998). Plays a role in cancer cell survival by promoting DNA repair through activating PPP flux in a CDK5-ATM-dependent signaling pathway during hypoxia and/or genome stress-induced DNA damage responses (PubMed:25928429). Involved in intestinal tumor progression (PubMed:23726973).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=beta-D-fructose 2,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate; Xref=Rhea:RHEA:17289, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57634, ChEBI:CHEBI:58579; EC=3.1.3.46; Evidence=. ;.
UniProtKB/Swiss-Prot Induction:
Up-regulated by p53/TP53 (at protein level) (PubMed:16839880). Rapidly up-regulated by p53/TP53 (PubMed:16140933, PubMed:16839880, PubMed:19713938). Up-regulated in glioma cell line in a p53/TP53-independent manner (PubMed:22887998).

Enzyme Numbers (IUBMB) for TIGAR Gene

Phenotypes From GWAS Catalog for TIGAR Gene

Gene Ontology (GO) - Molecular Function for TIGAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0004083 bisphosphoglycerate 2-phosphatase activity IDA 19015259
GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity IDA,EXP 19015259
GO:0005515 protein binding IPI 23185017
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with TIGAR: view
genes like me logo Genes that share phenotypes with TIGAR: view

Animal Models for TIGAR Gene

MGI Knock Outs for TIGAR:

Animal Model Products

  • Taconic Biosciences Mouse Models for TIGAR

CRISPR Products

miRNA for TIGAR Gene

miRTarBase miRNAs that target TIGAR

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TIGAR

Clone Products

  • Applied Biological Materials (abm): Clones for TIGAR - Now 50% OFF >
  • * TIGAR as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * TIGAR tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TIGAR Gene

Localization for TIGAR Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIGAR Gene

Cytoplasm. Nucleus. Mitochondrion. Note=Translocated to the mitochondria during hypoxia in a HIF1A-dependent manner (PubMed:23185017). Colocalizes with HK2 in the mitochondria during hypoxia (PubMed:23185017). Translocated to the nucleus during hypoxia and/or genome stress-induced DNA damage responses in cancer cells (PubMed:25928429). Translocation to the mitochondria is enhanced in ischemic cortex after reperfusion and/or during oxygen and glucose deprivation (OGD)/reoxygenation insult in primary neurons (By similarity). {ECO:0000250 UniProtKB:Q8BZA9, ECO:0000269 PubMed:23185017, ECO:0000269 PubMed:25928429}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TIGAR gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 4
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TIGAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005634 nucleus IDA,IEA 25928429
GO:0005737 cytoplasm IDA,IEA 23185017
GO:0005739 mitochondrion IEA --
GO:0005741 mitochondrial outer membrane IDA 23185017
genes like me logo Genes that share ontologies with TIGAR: view

Pathways & Interactions for TIGAR Gene

genes like me logo Genes that share pathways with TIGAR: view

Gene Ontology (GO) - Biological Process for TIGAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002931 response to ischemia ISS --
GO:0006003 fructose 2,6-bisphosphate metabolic process IEA,IDA 19015259
GO:0006914 autophagy IEA --
GO:0006915 apoptotic process IEA --
GO:0006974 cellular response to DNA damage stimulus IDA 25928429
genes like me logo Genes that share ontologies with TIGAR: view

No data available for SIGNOR curated interactions for TIGAR Gene

Drugs & Compounds for TIGAR Gene

(2) Drugs for TIGAR Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(3) Additional Compounds for TIGAR Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Beta-D-Fructose 6-phosphate
  • 6-O-phosphono-beta-D-Fructofuranose
  • FRUCTOSE-6-phosphATE
  • 6-O-phosphono-b-D-Fructofuranose
  • 6-O-phosphono-β-D-fructofuranose
  • b-D-Fructose 6-phosphate
D-Fructose 2,6-bisphosphate
  • 2,6-Di-O-phosphono-beta-D-fructofuranose
  • 2,6-Di-O-phosphono-b-D-fructofuranose
  • 2,6-Di-O-phosphono-β-D-fructofuranose
  • D-Fructose 2,6-bisphosphoric acid
  • b-D-Fructose 2,6-bisphosphate
Fructose 6-phosphate
  • D-Fructose 6-phosphate
  • D-Fructose 6-phosphoric acid
  • Fructose-6-phosphate
  • Neuberg ester
  • Fructose 6-phosphoric acid
643-13-0
genes like me logo Genes that share compounds with TIGAR: view

Transcripts for TIGAR Gene

mRNA/cDNA for TIGAR Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TIGAR

Clone Products

  • Applied Biological Materials (abm): Clones for TIGAR - Now 50% OFF >
  • * TIGAR as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * TIGAR tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for TIGAR Gene

No ASD Table

Relevant External Links for TIGAR Gene

GeneLoc Exon Structure for
TIGAR
ECgene alternative splicing isoforms for
TIGAR

Expression for TIGAR Gene

Protein differential expression in normal tissues from HIPED for TIGAR Gene

This gene is overexpressed in Heart (18.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TIGAR Gene



Protein tissue co-expression partners for TIGAR Gene

NURSA nuclear receptor signaling pathways regulating expression of TIGAR Gene:

TIGAR

mRNA Expression by UniProt/SwissProt for TIGAR Gene:

Q9NQ88-TIGAR_HUMAN
Tissue specificity: Expressed in the brain (PubMed:22887998). Expressed in breast tumors (PubMed:21820150). Expressed in glioblastomas (PubMed:22887998).

Evidence on tissue expression from TISSUES for TIGAR Gene

  • Nervous system(2.6)
genes like me logo Genes that share expression patterns with TIGAR: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TIGAR Gene

Orthologs for TIGAR Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TIGAR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C12H12orf5 34
  • 99.51 (n)
C12orf5 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C27H12orf5 34
  • 86.86 (n)
C12orf5 35
  • 84 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C5H12orf5 34
  • 83.4 (n)
TIGAR 35
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 9630033F20Rik 35 34
  • 75.56 (n)
OneToOne
Tigar 17
rat
(Rattus norvegicus)
Mammalia RGD1308005 34
  • 75.17 (n)
oppossum
(Monodelphis domestica)
Mammalia C12orf5 35
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C12orf5 35
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1H12ORF5 34
  • 67.18 (n)
C12orf5 35
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c12orf5 34
  • 58.77 (n)
zebrafish
(Danio rerio)
Actinopterygii C4H12orf5 (1 of 2) 35
  • 39 (a)
OneToMany
C25H12orf5 (2 of 2) 35
  • 38 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 35
  • 27 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 32 (a)
OneToOne
Species where no ortholog for TIGAR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TIGAR Gene

ENSEMBL:
Gene Tree for TIGAR (if available)
TreeFam:
Gene Tree for TIGAR (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TIGAR: view image

Paralogs for TIGAR Gene

No data available for Paralogs for TIGAR Gene

Variants for TIGAR Gene

Sequence variations from dbSNP and Humsavar for TIGAR Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000015167 -- 4,330,761(+) G/A intron_variant
rs1000062195 -- 4,347,395(+) T/C intron_variant
rs1000132103 -- 4,346,305(+) T/A intron_variant
rs1000163282 -- 4,330,396(+) A/T intron_variant
rs1000201912 -- 4,325,678(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TIGAR Gene

Variant ID Type Subtype PubMed ID
esv275025 CNV gain+loss 21479260
nsv1040098 CNV gain 25217958
nsv468985 CNV loss 19166990
nsv483060 CNV loss 15286789
nsv519278 CNV loss 19592680
nsv523578 CNV loss 19592680
nsv528492 CNV loss 19592680
nsv557122 CNV loss 21841781
nsv557123 CNV gain 21841781
nsv832317 CNV gain 17160897

Variation tolerance for TIGAR Gene

Residual Variation Intolerance Score: 51.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TIGAR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TIGAR

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIGAR Gene

Disorders for TIGAR Gene

MalaCards: The human disease database

(1) MalaCards diseases for TIGAR Gene - From: GeneCards

Disorder Aliases PubMed IDs
hypoxia
- elite association - COSMIC cancer census association via MalaCards
Search TIGAR in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TIGAR

genes like me logo Genes that share disorders with TIGAR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TIGAR Gene

Publications for TIGAR Gene

  1. Modulation of intracellular ROS levels by TIGAR controls autophagy. (PMID: 19713938) Bensaad K … Vousden KH (The EMBO journal 2009) 2 3 4 58
  2. TIGAR regulates DNA damage and repair through pentosephosphate pathway and Cdk5-ATM pathway. (PMID: 25928429) Yu HP … Qin ZH (Scientific reports 2015) 3 4 58
  3. TIGAR is required for efficient intestinal regeneration and tumorigenesis. (PMID: 23726973) Cheung EC … Vousden KH (Developmental cell 2013) 3 4 58
  4. Knockdown of TIGAR by RNA interference induces apoptosis and autophagy in HepG2 hepatocellular carcinoma cells. (PMID: 23817040) Ye L … Ge S (Biochemical and biophysical research communications 2013) 3 4 58
  5. Regulatory role of p53 in cancer metabolism via SCO2 and TIGAR in human breast cancer. (PMID: 21820150) Won KY … Lee DK (Human pathology 2012) 3 4 58

Products for TIGAR Gene

Sources for TIGAR Gene

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