Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TIFAB Gene

Aliases for TIFAB Gene

  • TIFA Inhibitor 2 3 5
  • TRAF-Interacting Protein With Forkhead-Associated Domain, Family Member B 2 3
  • TIFA-Like Protein 3 4
  • TRAF-Interacting Protein With FHA Domain-Containing Protein B 3
  • TIFA-Related Protein TIFAB 3

External Ids for TIFAB Gene

Previous GeneCards Identifiers for TIFAB Gene

  • GC05U900526
  • GC05M134813
  • GC05M129972

Summaries for TIFAB Gene

Entrez Gene Summary for TIFAB Gene

  • TIFAB associates with TIFA (MIM 609028) and inhibits TIFA-mediated activation of NF-kappa-B (NFKB1; MIM 164011) (Matsumura et al., 2004 [PubMed 15047173]).[supplied by OMIM, Mar 2009]

GeneCards Summary for TIFAB Gene

TIFAB (TIFA Inhibitor) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TIFAB Gene

  • Inhibits TIFA-mediated TRAF6 activation possibly by inducing a conformational change in TIFA.

Additional gene information for TIFAB Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIFAB Gene

Genomics for TIFAB Gene

GeneHancer (GH) Regulatory Elements for TIFAB Gene

Promoters and enhancers for TIFAB Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J135450 Promoter/Enhancer 0.7 EPDnew Ensembl 659.2 +0.7 698 1.8 TIFAB ENSG00000249639
GH05J135455 Enhancer 1.5 FANTOM5 Ensembl ENCODE 12.2 -4.2 -4248 2.1 PKNOX1 ATF1 ZNF2 IRF4 ZNF48 YY1 TCF12 ZNF766 CBX5 ZNF143 TIFAB DDX46 ENSG00000250167 CXCL14 JADE2 H2AFY ENSG00000249639 NEUROG1
GH05J135488 Enhancer 1.3 Ensembl ENCODE dbSUPER 5.9 -37.4 -37446 2.2 FOXA2 SIN3A ZNF48 GLIS2 ZNF213 KLF7 SP3 SP5 NFYC NFIL3 NEUROG1 ENSG00000250167 CXCL14 TIFAB ENSG00000249639 JADE2 ENSG00000270021
GH05J135493 Enhancer 1 Ensembl ENCODE dbSUPER 6.5 -41.5 -41453 1.6 JUN CEBPB EP300 ZNF335 FOSL1 JUND ZBTB48 STAT3 FOS FOSL2 TIFAB NEUROG1
GH05J135482 Enhancer 1.2 ENCODE dbSUPER 0.3 -30.0 -29970 0.6 HDGF FOXA2 MLX ARID4B DMAP1 GLI4 ZNF48 ETS1 GATA2 ZNF416 SMAD5 DDX46 ENSG00000250167 NEUROG1 CXCL14 TGFBI C5orf66 ENSG00000254239 TIFAB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TIFAB on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TIFAB gene promoter:
  • TBP
  • POU3F1
  • SRF (504 AA)
  • SRF
  • Brachyury
  • IRF-2
  • c-Myb
  • AP-4
  • AREB6
  • RREB-1

Genomic Locations for TIFAB Gene

Genomic Locations for TIFAB Gene
8,182 bases
Minus strand
8,182 bases
Minus strand

Genomic View for TIFAB Gene

Genes around TIFAB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIFAB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIFAB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIFAB Gene

Proteins for TIFAB Gene

  • Protein details for TIFAB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TRAF-interacting protein with FHA domain-containing protein B
    Protein Accession:
    Secondary Accessions:
    • Q5H8A9

    Protein attributes for TIFAB Gene

    161 amino acids
    Molecular mass:
    17888 Da
    Quaternary structure:
    • Interacts with TIFA.
    • Sequence=BAC85138.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TIFAB Gene

Post-translational modifications for TIFAB Gene

No Post-translational modifications

Other Protein References for TIFAB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TIFAB Gene

Domains & Families for TIFAB Gene

Gene Families for TIFAB Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TIFAB Gene


Suggested Antigen Peptide Sequences for TIFAB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TIFAB: view

No data available for UniProtKB/Swiss-Prot for TIFAB Gene

Function for TIFAB Gene

Molecular function for TIFAB Gene

UniProtKB/Swiss-Prot Function:
Inhibits TIFA-mediated TRAF6 activation possibly by inducing a conformational change in TIFA.
genes like me logo Genes that share phenotypes with TIFAB: view

Animal Models for TIFAB Gene

MGI Knock Outs for TIFAB:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TIFAB

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TIFAB Gene

Localization for TIFAB Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TIFAB gene
Compartment Confidence
lysosome 1

Gene Ontology (GO) - Cellular Components for TIFAB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with TIFAB: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for TIFAB Gene

Pathways & Interactions for TIFAB Gene

SuperPathways for TIFAB Gene

No Data Available

Interacting Proteins for TIFAB Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q6ZNK6-TIFAB_HUMAN ENSP00000440509 for TIFAB Gene via IID STRING

Gene Ontology (GO) - Biological Process for TIFAB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007249 I-kappaB kinase/NF-kappaB signaling IEA --
GO:0007356 thorax and anterior abdomen determination IGI 23419067
GO:0021559 trigeminal nerve development IGI 23419067
GO:0021650 vestibulocochlear nerve formation IGI 23419067
GO:0030432 peristalsis IGI 23419067
genes like me logo Genes that share ontologies with TIFAB: view

No data available for Pathways by source and SIGNOR curated interactions for TIFAB Gene

Drugs & Compounds for TIFAB Gene

No Compound Related Data Available

Transcripts for TIFAB Gene

mRNA/cDNA for TIFAB Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TIFAB Gene

TRAF-interacting protein with forkhead-associated domain, family member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TIFAB

Alternative Splicing Database (ASD) splice patterns (SP) for TIFAB Gene

No ASD Table

Relevant External Links for TIFAB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TIFAB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TIFAB Gene

Protein differential expression in normal tissues from HIPED for TIFAB Gene

This gene is overexpressed in Monocytes (41.3) and Tlymphocyte (27.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TIFAB Gene

Protein tissue co-expression partners for TIFAB Gene

NURSA nuclear receptor signaling pathways regulating expression of TIFAB Gene:


SOURCE GeneReport for Unigene cluster for TIFAB Gene:

genes like me logo Genes that share expression patterns with TIFAB: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TIFAB Gene

Orthologs for TIFAB Gene

This gene was present in the common ancestor of mammals.

Orthologs for TIFAB Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TIFAB 34 33
  • 99.38 (n)
(Canis familiaris)
Mammalia TIFAB 34 33
  • 84.6 (n)
(Rattus norvegicus)
Mammalia Tifab 33
  • 81.86 (n)
(Bos Taurus)
Mammalia TIFAB 34 33
  • 81.57 (n)
(Mus musculus)
Mammalia Tifab 16 34 33
  • 80.95 (n)
(Monodelphis domestica)
Mammalia TIFAB 34
  • 50 (a)
(Ornithorhynchus anatinus)
Mammalia TIFAB 34
  • 47 (a)
Species where no ortholog for TIFAB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TIFAB Gene

Gene Tree for TIFAB (if available)
Gene Tree for TIFAB (if available)
Evolutionary constrained regions (ECRs) for TIFAB: view image

Paralogs for TIFAB Gene

No data available for Paralogs for TIFAB Gene

Variants for TIFAB Gene

Sequence variations from dbSNP and Humsavar for TIFAB Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000088351 -- 135,452,813(-) A/C upstream_transcript_variant
rs1000846504 -- 135,451,284(-) C/T intron_variant
rs1001330660 -- 135,450,704(-) T/C intron_variant
rs1001431619 -- 135,450,536(-) G/A intron_variant
rs1002032453 -- 135,449,350(-) T/G 3_prime_UTR_variant

Variation tolerance for TIFAB Gene

Residual Variation Intolerance Score: 74.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.74; 15.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TIFAB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TIFAB Gene

Disorders for TIFAB Gene

Additional Disease Information for TIFAB

No disorders were found for TIFAB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIFAB Gene

Publications for TIFAB Gene

  1. TIFAB inhibits TIFA, TRAF-interacting protein with a forkhead-associated domain. (PMID: 15047173) Matsumura T … Inoue J (Biochemical and biophysical research communications 2004) 2 3 4 22 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor-TRAF6 signaling. (PMID: 26458771) Varney ME … Starczynowski DT (The Journal of experimental medicine 2015) 3 58
  4. A boy with homozygous microdeletion of NEUROG1 presents with a congenital cranial dysinnervation disorder [Moebius syndrome variant]. (PMID: 23419067) Schröder JC … Bartsch O (Behavioral and brain functions : BBF 2013) 3 58
  5. TRAF-interacting protein with a forkhead-associated domain B (TIFAB) is a negative regulator of the TRAF6-induced cellular functions. (PMID: 19470519) Matsumura T … Inoue J (Journal of biochemistry 2009) 22 58

Products for TIFAB Gene

Sources for TIFAB Gene

Loading form....