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This gene encodes an adapter protein involved in adaptive and innate immunity. This protein includes a forkhead-associated (FHA) domain that specifically binds to phosphorylated serine and threonine residues. In response to bacterial infection, the encoded host cell protein undergoes an intermolecular interaction between the FHA domain and a phosphorylated threonine that leads to protein oligomerization and stimulation of the NF-kappa B and other downstream signaling pathways. This protein exhibits reduced expression in hepatocellular carcinoma and may suppress hepatocellular carcinoma progression. This protein may also play a role in the DNA damage response. [provided by RefSeq, Jun 2018]
TIFA (TRAF Interacting Protein With Forkhead Associated Domain) is a Protein Coding gene. Diseases associated with TIFA include Hepatocellular Carcinoma. Among its related pathways are Diseases associated with the TLR signaling cascade and Shigellosis. An important paralog of this gene is TIFAB.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 11798190 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IBA,IDA | 22566686 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Diseases associated with the TLR signaling cascade | ||
2 | Shigellosis | ||
3 | Toll-like Receptor Signaling Pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002376 | immune system process | IEA | -- |
GO:0002753 | cytoplasmic pattern recognition receptor signaling pathway | IDA | 26068852 |
GO:0007249 | I-kappaB kinase/NF-kappaB signaling | IBA | 21873635 |
GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | IBA,IDA | 26068852 |
GO:0045087 | innate immune response | IBA,IDA | 26068852 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TIFA 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | TIFA 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Tifa 30 |
|
||
Cow (Bos Taurus) |
Mammalia | TIFA 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Tifa 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | TIFA 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Chicken (Gallus gallus) |
Aves | TIFA 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | TIFA 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tifa 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | LOC560548 30 |
|
||
TIFA 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 04 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs6834237 | - | p.Thr19Met |
Disorder | Aliases | PubMed IDs |
---|---|---|
hepatocellular carcinoma |
|
|