Aliases for TIFA Gene
External Ids for TIFA Gene
Previous GeneCards Identifiers for TIFA Gene
GeneCards Summary for TIFA Gene
TIFA (TRAF Interacting Protein With Forkhead Associated Domain) is a Protein Coding gene. Among its related pathways are Diseases associated with the TLR signaling cascade.
UniProtKB/Swiss-Prot for TIFA Gene
Adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the downstream activation of NF-kappa-B and AP-1 pathways. Induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism.