Aliases for TIFA Gene
Aliases for TIFA Gene
External Ids for TIFA Gene
- HGNC: 19075
- Entrez Gene: 92610
- Ensembl: ENSG00000145365
- OMIM: 609028
- UniProtKB: Q96CG3
Previous GeneCards Identifiers for TIFA Gene
- GC04M113555
- GC04M113416
- GC04M113196
- GC04M108928
Summaries for TIFA Gene
GeneCards Summary for TIFA Gene
TIFA (TRAF Interacting Protein With Forkhead Associated Domain) is a Protein Coding gene. Among its related pathways are Diseases associated with the TLR signaling cascade.
UniProtKB/Swiss-Prot for TIFA Gene
-
Adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the downstream activation of NF-kappa-B and AP-1 pathways. Induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIFA Gene
Genomics for TIFA Gene
GeneHancer (GH) Regulatory Elements for TIFA Gene
Promoters and enhancers for TIFA Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around TIFA on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for TIFA Gene
Genomic Locations for TIFA Gene
- chr4:112,274,542-112,285,903
- (GRCh38/hg38)
- Size:
- 11,362 bases
- Orientation:
- Minus strand
- chr4:113,195,698-113,207,059
- (GRCh37/hg19)
Genomic View for TIFA Gene
Genes around TIFA on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q25 by Ensembl
- 4q25 by Entrez Gene
- 4q25 by HGNC
TIFA Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TIFA Gene
Proteins for TIFA Gene
-
Protein details for TIFA Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96CG3-TIFA_HUMAN
- Recommended name:
- TRAF-interacting protein with FHA domain-containing protein A
- Protein Accession:
- Q96CG3
Protein attributes for TIFA Gene
- Size:
- 184 amino acids
- Molecular mass:
- 21445 Da
- Quaternary structure:
-
- Homotrimer. Interacts with IRAK1, TIFAB, ZCCHC11, TRAF2 and TRAF6. Binding to TIFAB inhibits TRAF6 activation possibly by inducing a conformational change in TIFA. Binding to ZCCHC11 suppresses the TRAF6-dependent activation of NF-kappa-B.
Protein Expression for TIFA Gene
Post-translational modifications for TIFA Gene
Other Protein References for TIFA Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for TIFA
- Novus Biologicals Antibodies for TIFA
- Invitrogen Antibodies for TIFA
- Search GeneTex for Antibodies for TIFA
Protein Products
-
OriGene Purified Proteins for TIFA
- Search Origene for MassSpec and Protein Over-expression Lysates for TIFA
- Origene Custom Protein Services for TIFA
- ProSpec Recombinant Proteins for TIFA
- Search GeneTex for Proteins for TIFA
-
Abcam proteins for TIFA
Assay Products
- antibodies-online: Search results for available TIFA related products ranked by validation data
No data available for DME Specific Peptides for TIFA Gene
Domains & Families for TIFA Gene
Gene Families for TIFA Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for TIFA Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for TIFA Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for TIFA Gene
Function for TIFA Gene
Molecular function for TIFA Gene
- UniProtKB/Swiss-Prot Function:
- Adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the downstream activation of NF-kappa-B and AP-1 pathways. Induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 11798190 |
Phenotypes for TIFA Gene
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for TIFA gene
-
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CRISPR Products
-
OriGene CRISPR knockouts for TIFA
- genomics-online: gRNA clones - Search results for 101 available TIFA gene related products
- Overview of 101 available TIFA gene related products
- Applied Biological Materials CRISPR for TIFA
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TIFA
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miRNA for TIFA Gene
- miRTarBase miRNAs that target TIFA
-
- hsa-mir-215-5p (MIRT024752)
- hsa-mir-192-5p (MIRT026675)
- hsa-mir-1273e (MIRT456652)
- hsa-mir-921 (MIRT456653)
- hsa-mir-142-3p (MIRT456654)
- hsa-mir-6073 (MIRT456655)
- hsa-mir-650 (MIRT456656)
- hsa-mir-3612 (MIRT456657)
- hsa-mir-2467-3p (MIRT456658)
- hsa-mir-6086 (MIRT456659)
- hsa-mir-377-5p (MIRT456660)
- hsa-mir-4537 (MIRT456661)
- hsa-mir-1827 (MIRT456662)
- hsa-mir-219b-3p (MIRT456663)
- hsa-mir-4257 (MIRT456664)
- hsa-mir-1247-3p (MIRT456665)
- hsa-mir-3174 (MIRT456666)
- hsa-mir-6511a-5p (MIRT456667)
- hsa-mir-1910-3p (MIRT456668)
- hsa-mir-302f (MIRT456669)
- hsa-mir-4649-3p (MIRT746489)
- hsa-mir-4722-5p (MIRT747630)
- hsa-mir-4768-3p (MIRT748638)
- hsa-mir-6808-5p (MIRT756609)
- hsa-mir-6893-5p (MIRT758754)
- hsa-mir-940 (MIRT760850)
miRNA Products
- Search ViGene Biosciences for TIFA
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TIFA
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- genomics-online: shRNA clones - Search results for 101 available TIFA gene related products
- Overview of 101 available TIFA gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TIFA gene
Clone Products
- Sino Biological Human cDNA Clone for TIFA
- VectorBuilder custom plasmid, inducible vectors for TIFA
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TIFA
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for TIFA
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for TIFA
-
ViGene Biosciences adenoviral particle packaged cDNA for TIFA gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TIFA gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TIFA gene
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TIFA Gene
Localization for TIFA Gene
| Compartment | Confidence |
|---|---|
| nucleus | 3 |
| cytosol | 3 |
| extracellular | 1 |
- Cytosol (2)
- Nucleoli (2)
- Nucleus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for TIFA Gene
Pathways & Interactions for TIFA Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Diseases associated with the TLR signaling cascade | ||
Pathways by source for TIFA Gene
2 BioSystems pathways for TIFA Gene
Interacting Proteins for TIFA Gene
Selected Interacting proteins:
Q96CG3-TIFA_HUMAN
ENSP00000354911
for TIFA Gene via
IID
MINT
STRING
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007249 | I-kappaB kinase/NF-kappaB signaling | IEA | -- |
No data available for SIGNOR curated interactions for TIFA Gene
Transcripts for TIFA Gene
mRNA/cDNA for TIFA Gene
- (1) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (125) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TIFA Gene
CRISPR Products
-
OriGene CRISPR knockouts for TIFA
- genomics-online: gRNA clones - Search results for 101 available TIFA gene related products
- Overview of 101 available TIFA gene related products
- Applied Biological Materials CRISPR for TIFA
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TIFA
- GenScript: Design CRISPR guide RNA sequences for TIFA
miRNA Products
- Search ViGene Biosciences for TIFA
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TIFA
- Browse OriGene Inhibitory RNA Products For TIFA
- genomics-online: shRNA clones - Search results for 101 available TIFA gene related products
- Overview of 101 available TIFA gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TIFA gene
Clone Products
- Sino Biological Human cDNA Clone for TIFA
- VectorBuilder custom plasmid, inducible vectors for TIFA
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TIFA
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for TIFA
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for TIFA Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
- Gut Tube (Gastrointestinal Tract)
- Brain (Nervous System)
This gene is overexpressed in Spleen (22.9), Blymphocyte (11.5), Fetal gut (10.1), Salivary gland (9.1), Skin (8.7), and Lymph node (6.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TIFA Gene
NURSA nuclear receptor signaling pathways regulating expression of TIFA Gene:
TIFASOURCE GeneReport for Unigene cluster for TIFA Gene:
Hs.310640Primer Products
-
OriGene qPCR primer pairs for TIFA
-
OriGene qPCR primer pairs and template standards for TIFA
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TIFA Gene
Orthologs for TIFA Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TIFA 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | TIFA 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Tifa 33 |
|
||
| cow (Bos Taurus) |
Mammalia | TIFA 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Tifa 33 16 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | TIFA 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| chicken (Gallus gallus) |
Aves | TIFA 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | TIFA 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | tifa 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC560548 33 |
|
||
| TIFA 34 |
|
OneToOne |
- Species where no ortholog for TIFA was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for TIFA Gene
No data available for Paralogs for TIFA Gene
Variants for TIFA Gene
| SNP ID | Clin | Chr 04 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs10000620 | -- | 112,282,048(-) | A/G | intron_variant | |
| rs10000700 | -- | 112,282,115(-) | A/G | intron_variant | |
| rs1000091899 | -- | 112,286,880(-) | G/C | upstream_transcript_variant | |
| rs10003654 | -- | 112,282,997(-) | A/G | intron_variant | |
| rs10008828 | -- | 112,283,940(-) | T/C | intron_variant |
Residual Variation Intolerance Score:
75.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.30;
41.10% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TIFA Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TIFA
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TIFA Gene
Disorders for TIFA Gene
Additional Disease Information for TIFA
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for TIFA Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIFA Gene
Publications for TIFA Gene
- TIFA activates IkappaB kinase (IKK) by promoting oligomerization and ubiquitination of TRAF6. (PMID: 15492226) Ea CK … Chen ZJ (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 22 58
- A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PMID: 20332099) Kalsi G … Riley BP (Human molecular genetics 2010) 3 44 58
- A novel Zinc finger protein, ZCCHC11, interacts with TIFA and modulates TLR signaling. (PMID: 16643855) Minoda Y … Yoshimura A (Biochemical and biophysical research communications 2006) 3 4 58
- TIFAB inhibits TIFA, TRAF-interacting protein with a forkhead-associated domain. (PMID: 15047173) Matsumura T … Inoue J (Biochemical and biophysical research communications 2004) 3 4 58
- Identification of TIFA as an adapter protein that links tumor necrosis factor receptor-associated factor 6 (TRAF6) to interleukin-1 (IL-1) receptor-associated kinase-1 (IRAK-1) in IL-1 receptor signaling. (PMID: 12566447) Takatsuna H … Inoue J (The Journal of biological chemistry 2003) 3 4 58
Products for TIFA Gene
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- Custom Antibody ServicesOriGene Antibodies for TIFA
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- Cloud-Clone Corp. disease models service
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- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for TIFA
- VectorBuilder custom plasmid, inducible vectors for TIFA
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TIFA
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 39 available TIFA Antibodies ranked by validation data
- Compare Top TIFA Antibodies
- antibodies-online: Search results for available TIFA related products ranked by validation data
- antibodies-online: Search results for 8 available TIFA Proteins ranked by validation data
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- Quality Products:
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- ViGene Biosciences adenoviral particle packaged cDNA for TIFA gene
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- Overview of 101 available TIFA gene related products
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- genomics-online: gRNA clones - Search results for 101 available TIFA gene related products
- Overview of 101 available TIFA gene related products
- genomics-online: primer clones - Search results for 101 available TIFA gene related products
- Overview of 101 available TIFA gene related products
- genomics-online: shRNA clones - Search results for 101 available TIFA gene related products
- Overview of 101 available TIFA gene related products
Sources for TIFA Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
