This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endotheli... See more...

Aliases for TIE1 Gene

Aliases for TIE1 Gene

  • Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains 1 2 3 5
  • Tyrosine Kinase With Immunoglobulin And Epidermal Growth Factor Homology Domains 1 2 3
  • Tyrosine-Protein Kinase Receptor Tie-1 3 4
  • EC 2.7.10.1 4 50
  • JTK14 2 3
  • TIE 3 4
  • Tyrosine Kinase With Immunoglobulin-Like And EGF-Like Domains 1 2
  • EC 2.7.10.1'); 50
  • EC 2.7.10 50
  • TIE1 5

External Ids for TIE1 Gene

Previous HGNC Symbols for TIE1 Gene

  • TIE

Previous GeneCards Identifiers for TIE1 Gene

  • GC01P043437
  • GC01P043539
  • GC01P043766
  • GC01P041886

Summaries for TIE1 Gene

Entrez Gene Summary for TIE1 Gene

  • This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for TIE1 Gene

TIE1 (Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains 1) is a Protein Coding gene. Diseases associated with TIE1 include Angiosarcoma and Breast Angiosarcoma. Among its related pathways are Immune response IL-23 signaling pathway and Nanog in Mammalian ESC Pluripotency. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TEK.

UniProtKB/Swiss-Prot Summary for TIE1 Gene

  • Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TIE1 Gene

Genomics for TIE1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TIE1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J043300 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 250.7 +1.3 1347 3.4 RXRA ZNF585B HNF4A RAD21 ZNF16 NFIL3 EGR2 MAX ZBTB6 BCOR HSALNG0003082 TIE1 MED8 FOXJ3 ENSG00000237950 ARTN SZT2 DMAP1 HYI MPL
GH01J043266 Enhancer 0.8 Ensembl ENCODE dbSUPER 11.1 -33.3 -33265 1.6 RXRA HNF4A HHEX ZNF3 SP1 ZMYM3 CEBPB CFAP57 TIE1 SZT2 EBNA1BP2 TMEM125 lnc-EBNA1BP2-1 LOC105378685
GH01J043539 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 4.5 +246.5 246530 15.4 IKZF1 KLF9 CEBPA ZNF10 ATF3 POLR2A ZIC2 CHD4 YY1 MXD4 MED8 SZT2 KDM4A-AS1 ST3GAL3-AS1 PTPRF DMAP1 P3H1 PPIH KDM4A ST3GAL3
GH01J043323 Enhancer 0.4 dbSUPER 12.4 +23.4 23422 1.8 BATF ARID1B ATF3 SMARCA4 HSALNG0003085 TIE1 CDC20 ENSG00000234694 ELOVL1 MED8-AS1 MED8 SZT2 HSALNG0003084 RF00017-163
GH01J043293 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 2 -5.9 -5881 3.8 SP1 YY1 BCL11A CEBPB EP300 FOXA2 RXRA USF2 ASH2L BHLHE40 MED8 EBNA1BP2 MPL CDC20 ENSG00000234694 ELOVL1 MED8-AS1 SZT2 FAM183A ATP6V0B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TIE1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TIE1

Top Transcription factor binding sites by QIAGEN in the TIE1 gene promoter:
  • CUTL1
  • Egr-1
  • Elk-1
  • LCR-F1
  • POU2F1
  • POU2F1a
  • POU2F1b
  • POU2F1c
  • Spz1
  • STAT3

Genomic Locations for TIE1 Gene

Latest Assembly
chr1:43,300,954-43,323,108
(GRCh38/hg38)
Size:
22,155 bases
Orientation:
Plus strand

Previous Assembly
chr1:43,766,653-43,788,779
(GRCh37/hg19 by Entrez Gene)
Size:
22,127 bases
Orientation:
Plus strand

chr1:43,766,664-43,788,779
(GRCh37/hg19 by Ensembl)
Size:
22,116 bases
Orientation:
Plus strand

Genomic View for TIE1 Gene

Genes around TIE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIE1 Gene

Proteins for TIE1 Gene

  • Protein details for TIE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35590-TIE1_HUMAN
    Recommended name:
    Tyrosine-protein kinase receptor Tie-1
    Protein Accession:
    P35590
    Secondary Accessions:
    • B5A949
    • B5A950

    Protein attributes for TIE1 Gene

    Size:
    1138 amino acids
    Molecular mass:
    125090 Da
    Quaternary structure:
    • Heterodimer with TEK/TIE2.

    Three dimensional structures from OCA and Proteopedia for TIE1 Gene

    Alternative splice isoforms for TIE1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TIE1 Gene

Selected DME Specific Peptides for TIE1 Gene

P35590:
  • RDLAARN
  • NIINLLG
  • GNLLDFLRKSRVLETDPAFA
  • NCDDEVY
  • KIADFGLSRG
  • GECVCPPGF
  • KQFIHRDLAARN
  • AARNVLV
  • FTYAGID
  • KSDVWSFG
  • VSLGGTPYCGMTCAELYEKLP
  • EARKAYVNM
  • WMAIESL

Post-translational modifications for TIE1 Gene

  • Phosphorylated on tyrosine residues in response to ANGPT1, most likely by TEK/TIE2.
  • Glycosylation at Asn83, Asn161, Asn503, Asn596, and Asn709
  • Modification sites at PhosphoSitePlus

Other Protein References for TIE1 Gene

Domains & Families for TIE1 Gene

Gene Families for TIE1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TIE1 Gene

Suggested Antigen Peptide Sequences for TIE1 Gene

GenScript: Design optimal peptide antigens:
  • Soluble TIE1 variant 1 (B5A948_HUMAN)
  • Soluble TIE1 variant 4 (B5A951_HUMAN)
  • Soluble TIE1 variant 5 (B5A952_HUMAN)
  • Tie protein (Q6LD63_HUMAN)
  • Tyrosine-protein kinase receptor Tie-1 (TIE1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P35590

UniProtKB/Swiss-Prot:

TIE1_HUMAN :
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily.
genes like me logo Genes that share domains with TIE1: view

Function for TIE1 Gene

Molecular function for TIE1 Gene

UniProtKB/Swiss-Prot Function:
Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence={ECO:0000255|PROSITE-ProRule:PRU10028};.

Enzyme Numbers (IUBMB) for TIE1 Gene

Phenotypes From GWAS Catalog for TIE1 Gene

Gene Ontology (GO) - Molecular Function for TIE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA --
GO:0004714 transmembrane receptor protein tyrosine kinase activity TAS,IBA 21873635
GO:0005515 protein binding IPI 21982860
genes like me logo Genes that share ontologies with TIE1: view
genes like me logo Genes that share phenotypes with TIE1: view

Animal Models for TIE1 Gene

MGI Knock Outs for TIE1:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TIE1

Clone products for research

  • Addgene plasmids for TIE1

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TIE1 Gene

Localization for TIE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIE1 Gene

Cell membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TIE1 gene
Compartment Confidence
plasma membrane 4
extracellular 3
cytoskeleton 2
nucleus 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TIE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane TAS,IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043235 receptor complex IBA 21873635
genes like me logo Genes that share ontologies with TIE1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TIE1 Gene

Pathways & Interactions for TIE1 Gene

PathCards logo

SuperPathways for TIE1 Gene

SuperPathway Contained pathways
1 GPCR Pathway
.73
.73
.62
.59
.58
.58
.55
.38
2 ERK Signaling
.61
.61
.58
.51
.49
3 Nanog in Mammalian ESC Pluripotency
.61
.61
.59
.48
4 Actin Nucleation by ARP-WASP Complex
.66
.66
.41
5 Akt Signaling
.60
.60
.55
genes like me logo Genes that share pathways with TIE1: view

Pathways by source for TIE1 Gene

1 BioSystems pathway for TIE1 Gene
1 GeneGo (Thomson Reuters) pathway for TIE1 Gene
  • Development Angiopoietin - Tie2 signaling
32 Qiagen pathways for TIE1 Gene
  • 14-3-3 Induced Intracellular Signaling
  • Actin Nucleation and Branching
  • Actin Nucleation by ARP-WASP Complex
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
1 Cell Signaling Technology pathway for TIE1 Gene

SIGNOR curated interactions for TIE1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TIE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IBA 21873635
GO:0001568 blood vessel development IEA --
GO:0001570 vasculogenesis IEA --
GO:0001701 in utero embryonic development IEA --
GO:0001936 regulation of endothelial cell proliferation ISS --
genes like me logo Genes that share ontologies with TIE1: view

Drugs & Compounds for TIE1 Gene

(4) Drugs for TIE1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
ATP Investigational Nutra 0

(3) Additional Compounds for TIE1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
58-64-0
genes like me logo Genes that share compounds with TIE1: view

Transcripts for TIE1 Gene

mRNA/cDNA for TIE1 Gene

2 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TIE1

Clone products for research

  • Addgene plasmids for TIE1

Alternative Splicing Database (ASD) splice patterns (SP) for TIE1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: - - -
SP2:
SP3:
SP4: - -
SP5: -
SP6: -

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for TIE1 Gene

GeneLoc Exon Structure for
TIE1

Expression for TIE1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TIE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TIE1 Gene

This gene is overexpressed in Plasma (53.8) and Bone (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TIE1 Gene



Protein tissue co-expression partners for TIE1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TIE1

SOURCE GeneReport for Unigene cluster for TIE1 Gene:

Hs.78824

mRNA Expression by UniProt/SwissProt for TIE1 Gene:

P35590-TIE1_HUMAN
Tissue specificity: Specifically expressed in developing vascular endothelial cells.

Evidence on tissue expression from TISSUES for TIE1 Gene

  • Lung(4.6)
  • Nervous system(4)
  • Heart(3)
  • Muscle(2.6)
  • Blood(2.3)
  • Kidney(2.2)
  • Spleen(2.1)
  • Eye(2.1)
  • Intestine(2)
genes like me logo Genes that share expression patterns with TIE1: view

Primer products for research

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TIE1 Gene

Orthologs for TIE1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TIE1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TIE1 29 30
  • 99.56 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TIE1 29 30
  • 89.9 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TIE1 29 30
  • 89.69 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tie1 29
  • 87.88 (n)
Mouse
(Mus musculus)
Mammalia Tie1 29 16 30
  • 87.76 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TIE1 30
  • 80 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TIE1 30
  • 70 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TIE1 29 30
  • 68.52 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TIE1 30
  • 63 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tie1 29
  • 60.88 (n)
Zebrafish
(Danio rerio)
Actinopterygii tie1 29 30
  • 59.45 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Tie 30
  • 17 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea ver-3 30
  • 14 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 38 (a)
OneToMany
Species where no ortholog for TIE1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TIE1 Gene

ENSEMBL:
Gene Tree for TIE1 (if available)
TreeFam:
Gene Tree for TIE1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TIE1: view image
Alliance of Genome Resources:
Additional Orthologs for TIE1

Paralogs for TIE1 Gene

genes like me logo Genes that share paralogs with TIE1: view

Variants for TIE1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TIE1 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs142835682 Benign: not provided 43,313,863(+) C/T
NM_005424.5(TIE1):c.2304C>T (p.Ser768=)
SYNONYMOUS
rs201801618 Benign: not provided 43,305,342(+) C/T
NM_005424.5(TIE1):c.483C>T (p.Asn161=)
SYNONYMOUS
rs34084603 Benign: not provided 43,306,994(+) G/A
NM_005424.5(TIE1):c.639G>A (p.Arg213=)
SYNONYMOUS
rs35033063 Benign: not provided 43,307,215(+) C/T
NM_005424.5(TIE1):c.714C>T (p.His238=)
SYNONYMOUS
rs34993202 -- p.Arg1109His

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TIE1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TIE1 Gene

Variant ID Type Subtype PubMed ID
esv2747574 CNV deletion 23290073
nsv546128 CNV loss 21841781
nsv829693 CNV loss 17160897

Variation tolerance for TIE1 Gene

Residual Variation Intolerance Score: 3.76% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.72; 46.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TIE1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TIE1
Leiden Open Variation Database (LOVD)
TIE1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIE1 Gene

Disorders for TIE1 Gene

MalaCards: The human disease database

(13) MalaCards diseases for TIE1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
angiosarcoma
  • hemangiosarcoma
breast angiosarcoma
  • hemangiosarcoma of the breast
malignant renovascular hypertension
  • secondary malignant renovascular hypertension
cerebral cavernous malformations
  • ccm
arteriovenous malformation
  • arteriovenous hemangioma
- elite association - COSMIC cancer census association via MalaCards
Search TIE1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TIE1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with TIE1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TIE1 Gene

Publications for TIE1 Gene

  1. Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis. (PMID: 18593464) Jin P … Paleolog EM (Arthritis research & therapy 2008) 3 4 22
  2. A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains. (PMID: 1312667) Partanen J … Alitalo K (Molecular and cellular biology 1992) 2 3 4
  3. Tie1-Tie2 interactions mediate functional differences between angiopoietin ligands. (PMID: 20227369) Seegar TC … Barton WA (Molecular cell 2010) 3 4
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 40
  5. Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease. (PMID: 20346360) Roberts KE … Pulmonary Vascular Complications of Liver Disease Study Group (Gastroenterology 2010) 3 40

Products for TIE1 Gene

  • Addgene plasmids for TIE1

Sources for TIE1 Gene