Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TICRR Gene

Aliases for TICRR Gene

  • TOPBP1 Interacting Checkpoint And Replication Regulator 2 3 5
  • TopBP1-Interacting Checkpoint And Replication Regulator 3 4
  • C15orf42 3 4
  • TopBP1-Interacting, Replication-Stimulating Protein 4
  • TOPBP1-Interacting Replication-Stimulating Protein 2
  • TopBP1-Interacting Replication-Stimulating Protein 3
  • Chromosome 15 Open Reading Frame 42 2
  • SLD3 Homolog (S. Cerevisiae) 2
  • Treslin 3
  • SLD3 3

External Ids for TICRR Gene

Previous HGNC Symbols for TICRR Gene

  • C15orf42

Previous GeneCards Identifiers for TICRR Gene

  • GC15P090119

Summaries for TICRR Gene

Entrez Gene Summary for TICRR Gene

  • Treslin is involved in the initiation of DNA replication (Kumagai et al., 2010 [PubMed 20116089]).[supplied by OMIM, Apr 2010]

GeneCards Summary for TICRR Gene

TICRR (TOPBP1 Interacting Checkpoint And Replication Regulator) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include chromatin binding.

UniProtKB/Swiss-Prot for TICRR Gene

  • Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation.

Additional gene information for TICRR Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TICRR Gene

Genomics for TICRR Gene

GeneHancer (GH) Regulatory Elements for TICRR Gene

Promoters and enhancers for TICRR Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I089574 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 561.7 +1.0 994 3.7 HDGF PKNOX1 SMAD1 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 YY1 POLR2B TICRR POLG LOC100631255 FANCI KIF7 GC15M089580 ENSG00000259713
GH15I089997 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.1 +426.7 426666 8.4 HDGF PKNOX1 CLOCK FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF710 FANCI NIFKP5 ENSG00000259212 ENSG00000259314 UNC45A POLG ENSG00000228998 PRC1 TICRR
GH15I089086 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.8 -484.3 -484252 9 CLOCK FEZF1 DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC MEF2D ABHD2 LOC102724566 POLG RNU7-195P ENSG00000261407 LOC100631255 FANCI TICRR HAPLN3 ISG20
GH15I090229 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.1 +656.9 656867 6.1 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 CIB1 PIR48569 GDPGP1 ENSG00000284626 ENSG00000259212 ENSG00000259314 UNC45A POLG FANCI TICRR
GH15I089892 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 10.1 +318.5 318469 2.3 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 AP3S2 POLG ENSG00000259314 LOC100631255 NIFKP5 FANCI ENSG00000259212 RPL36AP43 KIF7 ARPIN
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TICRR on UCSC Golden Path with GeneCards custom track

Genomic Locations for TICRR Gene

Genomic Locations for TICRR Gene
chr15:89,575,438-89,631,056
(GRCh38/hg38)
Size:
55,619 bases
Orientation:
Plus strand
chr15:90,118,713-90,174,287
(GRCh37/hg19)

Genomic View for TICRR Gene

Genes around TICRR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TICRR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TICRR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TICRR Gene

Proteins for TICRR Gene

  • Protein details for TICRR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z2Z1-TICRR_HUMAN
    Recommended name:
    Treslin
    Protein Accession:
    Q7Z2Z1
    Secondary Accessions:
    • B2RE07
    • B3KVV9
    • D3IUT4
    • Q8N4X8
    • Q8NCH6
    • Q9BU55

    Protein attributes for TICRR Gene

    Size:
    1910 amino acids
    Molecular mass:
    210857 Da
    Quaternary structure:
    • Interacts with TOPBP1 (via BRCT domains); interaction takes place in a CDK2-dependent manner (PubMed:20080954). Component of the replisome complex composed of at least DONSON, MCM2, MCM7, PCNA and TICRR (PubMed:28191891).
    SequenceCaution:
    • Sequence=BAC11165.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG38104.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG53921.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TICRR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TICRR Gene

Post-translational modifications for TICRR Gene

No Post-translational modifications

Other Protein References for TICRR Gene

No data available for DME Specific Peptides for TICRR Gene

Domains & Families for TICRR Gene

Gene Families for TICRR Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TICRR Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TICRR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z2Z1

UniProtKB/Swiss-Prot:

TICRR_HUMAN :
  • Belongs to the treslin family.
Family:
  • Belongs to the treslin family.
genes like me logo Genes that share domains with TICRR: view

Function for TICRR Gene

Molecular function for TICRR Gene

UniProtKB/Swiss-Prot Function:
Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation.

Phenotypes From GWAS Catalog for TICRR Gene

Gene Ontology (GO) - Molecular Function for TICRR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 20080954
GO:0005515 protein binding IPI 20080954
genes like me logo Genes that share ontologies with TICRR: view
genes like me logo Genes that share phenotypes with TICRR: view

Animal Model Products

CRISPR Products

miRNA for TICRR Gene

miRTarBase miRNAs that target TICRR

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TICRR Gene

Localization for TICRR Gene

Subcellular locations from UniProtKB/Swiss-Prot for TICRR Gene

Nucleus. Note=Associates with chromatin.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TICRR gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TICRR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 20080954
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with TICRR: view

Pathways & Interactions for TICRR Gene

SuperPathways for TICRR Gene

No Data Available

Interacting Proteins for TICRR Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000268138%0d%0a9606.ENSP00000260810%0d%0a9606.ENSP00000274026%0d%0a
Selected Interacting proteins: ENSP00000268138 Q7Z2Z1-TICRR_HUMAN for TICRR Gene via STRING IID

Gene Ontology (GO) - Biological Process for TICRR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000075 cell cycle checkpoint ISS --
GO:0001731 formation of translation preinitiation complex ISS --
GO:0006260 DNA replication IEA,ISS --
GO:0006281 DNA repair ISS --
GO:0006974 cellular response to DNA damage stimulus IEA --
genes like me logo Genes that share ontologies with TICRR: view

No data available for Pathways by source and SIGNOR curated interactions for TICRR Gene

Drugs & Compounds for TICRR Gene

No Compound Related Data Available

Transcripts for TICRR Gene

Unigene Clusters for TICRR Gene

TOPBP1-interacting checkpoint and replication regulator:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TICRR Gene

No ASD Table

Relevant External Links for TICRR Gene

GeneLoc Exon Structure for
TICRR
ECgene alternative splicing isoforms for
TICRR

Expression for TICRR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TICRR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TICRR Gene

This gene is overexpressed in Esophagus - Mucosa (x7.0).

Protein differential expression in normal tissues from HIPED for TICRR Gene

This gene is overexpressed in Plasma (36.2), Tlymphocyte (23.6), and Peripheral blood mononuclear cells (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TICRR Gene



Protein tissue co-expression partners for TICRR Gene

NURSA nuclear receptor signaling pathways regulating expression of TICRR Gene:

TICRR

SOURCE GeneReport for Unigene cluster for TICRR Gene:

Hs.441708

Evidence on tissue expression from TISSUES for TICRR Gene

  • Lung(4)
  • Muscle(4)
genes like me logo Genes that share expression patterns with TICRR: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TICRR Gene

Orthologs for TICRR Gene

This gene was present in the common ancestor of chordates.

Orthologs for TICRR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TICRR 33 34
  • 98.13 (n)
dog
(Canis familiaris)
Mammalia TICRR 33 34
  • 82 (n)
cow
(Bos Taurus)
Mammalia TICRR 33 34
  • 80.81 (n)
mouse
(Mus musculus)
Mammalia Ticrr 33 16 34
  • 77.74 (n)
rat
(Rattus norvegicus)
Mammalia Ticrr 33
  • 77.55 (n)
oppossum
(Monodelphis domestica)
Mammalia TICRR 34
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TICRR 34
  • 36 (a)
OneToOne
chicken
(Gallus gallus)
Aves C10H15ORF42 33
  • 60.03 (n)
TICRR 34
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TICRR 34
  • 37 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ticrr 33
  • 53.76 (n)
Species where no ortholog for TICRR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TICRR Gene

ENSEMBL:
Gene Tree for TICRR (if available)
TreeFam:
Gene Tree for TICRR (if available)

Paralogs for TICRR Gene

No data available for Paralogs for TICRR Gene

Variants for TICRR Gene

Sequence variations from dbSNP and Humsavar for TICRR Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1054435 benign, Acrocallosal syndrome, Schinzel type 89,628,075(+) A/G downstream_transcript_variant
rs113145397 likely-benign, Acrocallosal syndrome, Schinzel type 89,627,989(+) TTTTTTTTT/TTTTTTTTTT 3_prime_UTR_variant
rs137993810 conflicting-interpretations-of-pathogenicity, uncertain-significance, not specified, Acrocallosal syndrome, Schinzel type 89,628,452(+) C/G downstream_transcript_variant
rs141028210 conflicting-interpretations-of-pathogenicity, uncertain-significance, not specified, Acrocallosal syndrome, Schinzel type 89,628,491(+) A/T downstream_transcript_variant
rs147387691 uncertain-significance, Acrocallosal syndrome, Schinzel type 89,628,382(+) C/G/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TICRR Gene

Variant ID Type Subtype PubMed ID
nsv521260 CNV loss 19592680
nsv1659 CNV deletion 18451855
nsv1160317 CNV duplication 26073780
nsv1038140 CNV gain 25217958
esv3892721 CNV gain 25118596
esv3637198 CNV loss 21293372
esv34025 CNV loss 18971310
esv2750005 CNV deletion 23290073

Variation tolerance for TICRR Gene

Residual Variation Intolerance Score: 97.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 20.43; 99.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TICRR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TICRR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TICRR Gene

Disorders for TICRR Gene

Additional Disease Information for TICRR

No disorders were found for TICRR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TICRR Gene

Publications for TICRR Gene

  1. A vertebrate gene, ticrr, is an essential checkpoint and replication regulator. (PMID: 20080954) Sansam CL … Lees JA (Genes & development 2010) 2 3 4 58
  2. Treslin collaborates with TopBP1 in triggering the initiation of DNA replication. (PMID: 20116089) Kumagai A … Dunphy WG (Cell 2010) 2 3 4 58
  3. Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism. (PMID: 28191891) Reynolds JJ … Stewart GS (Nature genetics 2017) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Cyclin-dependent kinase regulates the length of S phase through TICRR/TRESLIN phosphorylation. (PMID: 25737283) Sansam CG … Sansam CL (Genes & development 2015) 3 58

Products for TICRR Gene

Sources for TICRR Gene

Content
Loading form....