Aliases for TICRR Gene
External Ids for TICRR Gene
Previous HGNC Symbols for TICRR Gene
Previous GeneCards Identifiers for TICRR Gene
Treslin is involved in the initiation of DNA replication (Kumagai et al., 2010 [PubMed 20116089]).[supplied by OMIM, Apr 2010]
GeneCards Summary for TICRR Gene
TICRR (TOPBP1 Interacting Checkpoint And Replication Regulator) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include chromatin binding.
UniProtKB/Swiss-Prot for TICRR Gene
Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation.