Aliases for TICAM2 Gene
- TIRAP3 3 4
- Toll/Interleukin-1 Receptor (TIR) Domain-Containing Adapter Protein 3
- Toll/Interleukin-1 Receptor Domain-Containing Protein 4
- Toll-Like Receptor Adaptor Molecule 2 2
- NF-Kappa-B-Activating Protein 502 3
- TRIF-Related Adaptor Molecule 3
- TRIF-Related Adapter Molecule 4
- Cytoplasmic Adaptor 3
- TICAM2 5
External Ids for TICAM2 Gene
Previous GeneCards Identifiers for TICAM2 Gene
TIRP is a Toll/interleukin-1 receptor (IL1R; MIM 147810) (TIR) domain-containing adaptor protein involved in Toll receptor signaling (see TLR4; MIM 603030).[supplied by OMIM, Apr 2004]
GeneCards Summary for TICAM2 Gene
TICAM2 (Toll Like Receptor Adaptor Molecule 2) is a Protein Coding gene. Among its related pathways are Activated TLR4 signalling and IKK complex recruitment mediated by RIP1. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and phospholipid binding.
UniProtKB/Swiss-Prot Summary for TICAM2 Gene
Functions as sorting adapter in different signaling pathways to facilitate downstream signaling leading to type I interferon induction (PubMed:16603631, PubMed:16757566, PubMed:25385819, PubMed:25825441). In TLR4 signaling, physically bridges TLR4 and TICAM1 and functionally transmits signal to TICAM1 in early endosomes after endocytosis of TLR4. In TLR2 signaling, physically bridges TLR2 and MYD88 and is required for the TLR2-dependent movement of MYD88 to endosomes following ligand engagement (PubMed:25385819). Involved in IL-18 signaling and is proposed to function as a sorting adapter for MYD88 in IL-18 signaling during adaptive immune response (PubMed:22685567). Forms a complex with RAB11FIP2 that is recruited to the phagosomes to promote the activation of the actin-regulatory GTPases RAC1 and CDC42 and subsequent phagocytosis of Gram-negative bacteria (PubMed:30883606).
[Isoform 2]: Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1 thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late endosomes.