Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TICAM1 Gene

Aliases for TICAM1 Gene

  • Toll Like Receptor Adaptor Molecule 1 2 3 5
  • TIR Domain-Containing Adapter Molecule 1 2 3 4
  • Toll-Interleukin-1 Receptor Domain-Containing Adapter Protein Inducing Interferon Beta 3 4
  • Proline-Rich, Vinculin And TIR Domain-Containing Protein B 3 4
  • TIR Domain-Containing Adapter Protein Inducing IFN-Beta 3 4
  • Putative NF-Kappa-B-Activating Protein 502H 3 4
  • MyD88-3 3 4
  • PRVTIRB 3 4
  • TICAM-1 3 4
  • TRIF 3 4
  • TIR Domain Containing Adaptor Inducing Interferon-Beta 3
  • Toll-Like Receptor Adaptor Molecule 1 2
  • IIAE6 3

External Ids for TICAM1 Gene

Previous GeneCards Identifiers for TICAM1 Gene

  • GC19M004767
  • GC19M004577

Summaries for TICAM1 Gene

Entrez Gene Summary for TICAM1 Gene

  • This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. [provided by RefSeq, Jan 2012]

GeneCards Summary for TICAM1 Gene

TICAM1 (Toll Like Receptor Adaptor Molecule 1) is a Protein Coding gene. Diseases associated with TICAM1 include Encephalopathy, Acute, Infection-Induced 6 and Herpes Simplex Encephalitis. Among its related pathways are Activated TLR4 signalling and Toll-like Receptor Signaling Pathway. Gene Ontology (GO) annotations related to this gene include protein kinase binding and obsolete signal transducer activity.

UniProtKB/Swiss-Prot for TICAM1 Gene

  • Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis (PubMed:12471095, PubMed:12539043, PubMed:14739303). Ligand binding to these receptors results in TRIF recruitment through its TIR domain (PubMed:12471095, PubMed:12539043, PubMed:14739303). Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively (PubMed:12471095, PubMed:12539043, PubMed:14739303). Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens (PubMed:25636800). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines (By similarity).

Additional gene information for TICAM1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TICAM1 Gene

Genomics for TICAM1 Gene

GeneHancer (GH) Regulatory Elements for TICAM1 Gene

Promoters and enhancers for TICAM1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J004828 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 607.8 +0.6 576 4.6 ZFX ZKSCAN8 ZNF148 NKRF MLLT1 CEBPG POLR2A ZNF687 ZSCAN21 SP7 TICAM1 GC19P004832 SAFB2 PLIN3 SAFB ARRDC5 FEM1A MIR7-3HG MIR7-3 SNRPEP4
GH19J004811 Enhancer 1.5 FANTOM5 ENCODE dbSUPER 29.7 +19.0 19030 2.4 CC2D1A CTCF MNT NKRF MLLT1 ZNF121 ZNF384 ZNF687 AHR CDC5L TICAM1 SEMA6B SNRPEP4 DUS3L PLIN3 YJU2 ENSG00000269604
GH19J004574 Enhancer 1.6 FANTOM5 ENCODE dbSUPER 27.4 +256.3 256259 2.5 SP1 CC2D1A CTCF ZNF148 MLLT1 GTF2F1 ZSCAN21 CDC5L ZBTB7A SP7 CACTIN YJU2 CACTIN-AS1 TICAM1 APBA3 DPP9-AS1 ENSG00000269807 ENSG00000267030 ENSG00000267769 SH3GL1
GH19J004837 Enhancer 1.2 FANTOM5 Ensembl ENCODE 28.4 -5.7 -5663 1.6 NKRF ZNF121 RELA CREM MLLT1 IKZF1 BACH1 IKZF2 LARP7 TRIM22 ENSG00000267484 TICAM1 SNRPEP4 SAFB DUS3L SEMA6B GC19P004832
GH19J004632 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE 15.3 +196.8 196809 4 CC2D1A ZFX CTCF CBFA2T2 ZNF148 ZNF121 GTF2F1 CDC5L SP7 TRIM24 TICAM1 SNRPEP4 SEMA6B YJU2 TNFAIP8L1 ANKRD24 SH3GL1 LOC100287614
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TICAM1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TICAM1 gene promoter:
  • ATF-2
  • CRE-BP1
  • E47
  • NF-kappaB
  • NF-kappaB1
  • Tal-1

Genomic Locations for TICAM1 Gene

Genomic Locations for TICAM1 Gene
chr19:4,815,924-4,831,742
(GRCh38/hg38)
Size:
15,819 bases
Orientation:
Minus strand
chr19:4,815,938-4,831,737
(GRCh37/hg19)
Size:
15,800 bases
Orientation:
Minus strand

Genomic View for TICAM1 Gene

Genes around TICAM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TICAM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TICAM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TICAM1 Gene

Proteins for TICAM1 Gene

  • Protein details for TICAM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUC6-TCAM1_HUMAN
    Recommended name:
    TIR domain-containing adapter molecule 1
    Protein Accession:
    Q8IUC6
    Secondary Accessions:
    • B3Y691
    • O75532
    • Q86XP8
    • Q96GA0

    Protein attributes for TICAM1 Gene

    Size:
    712 amino acids
    Molecular mass:
    76422 Da
    Quaternary structure:
    • Homodimer (PubMed:12539043). Found in a multi-helicase-TICAM1 complex at least composed of DHX36, DDX1, DDX21 and TICAM1; this complex exists in resting cells with or without poly(I:C) RNA ligand stimulation. Interacts (via TIR domain) with DDX21 (via C-terminus). Interacts (via TIR domain) with DHX36 (via C-terminus) (By similarity). Interacts with AZI2 and IRF7 (PubMed:12471095, PubMed:15611223). Interacts with TICAM2 in TLR4 recruitment (PubMed:12721283, PubMed:25736436). Interaction with PIAS4 inhibits the TICAM1-induced NF-kappa-B, IRF and IFNB1 activation (PubMed:15251447). Interacts with IKBKB and IKBKE. Interaction with SARM1 blocks TICAM1-dependent transcription factor activation (PubMed:16964262). Interacts with TRAF3 (By similarity). Interacts (when phosphorylated) with IRF3; following activation and phosphorylation on the pLxIS motif by TBK1, recruits IRF3 (PubMed:12471095, PubMed:14739303, PubMed:25636800, PubMed:27302953). Interacts with TBK1, TRAF6 and RIPK1 and these interactions are enhanced in the presence of WDFY1 (PubMed:14982987, PubMed:25736436). Interacts with TRAFD1 (By similarity). Interacts with UBQLN1 (via UBA domain) (PubMed:21695056). Interacts with TLR4 in response to LPS in a WDFY1-dependent manner (By similarity). Interacts with WDFY1 in response to poly(I:C) (By similarity). Interacts (via the TIR domain) with TLR3 in response to poly(I:C) and this interaction is enhanced in the presence of WDFY1 (PubMed:25736436). Interacts with TRIM56 (PubMed:22948160). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines (By similarity). Interacts (via the TIR domain) with TLR5 (PubMed:20855887).
    • (Microbial infection) Interacts with Seneca Valley virus protease 3C; this interaction allows the cleavage of TICAM1/TRIF and subsequent suppression of host innate immunity.
    SequenceCaution:
    • Sequence=AAO85488.1; Type=Frameshift; Positions=141, 148, 161; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TICAM1 Gene

neXtProt entry for TICAM1 Gene

Post-translational modifications for TICAM1 Gene

  • Phosphorylated by TBK1 (PubMed:14530355, PubMed:25636800). Following activation, phosphorylated by TBK1 at Ser-210 in the pLxIS motif (PubMed:25636800). The phosphorylated pLxIS motif constitutes an IRF3-binding motif, leading to recruitment of the transcription factor IRF3 to induce type-I interferons and other cytokines (PubMed:25636800, PubMed:27302953).
  • Polyubiquitinated by TRIM38 with 'Lys-48'-linked chains, leading to proteasomal degradation.
  • (Microbial infection) Cleaved and degraded by hepatitis A virus (HAV) protein 3CD allowing the virus to disrupt host TLR3 signaling.
  • (Microbial infection) Cleaved by Seneca Valley virus protease 3C allowing the virus to disrupt host TLR3 signaling.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TICAM1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TICAM1 Gene

Domains & Families for TICAM1 Gene

Gene Families for TICAM1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for TICAM1 Gene

Suggested Antigen Peptide Sequences for TICAM1 Gene

GenScript: Design optimal peptide antigens:
  • Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta (TCAM1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IUC6

UniProtKB/Swiss-Prot:

TCAM1_HUMAN :
  • The pLxIS motif constitutes an IRF3-binding motif: following phosphorylation by TBK1, the phosphorylated pLxIS motif of TICAM1 recruits IRF3 (PubMed:25636800). IRF3 is then phosphorylated and activated by TBK1 to induce type-I interferons and other cytokines (PubMed:25636800).
Domain:
  • The pLxIS motif constitutes an IRF3-binding motif: following phosphorylation by TBK1, the phosphorylated pLxIS motif of TICAM1 recruits IRF3 (PubMed:25636800). IRF3 is then phosphorylated and activated by TBK1 to induce type-I interferons and other cytokines (PubMed:25636800).
  • The N-terminal region is essential for activation of the IFNB promoter activity.
  • The N-terminal domain (TRIF-NTD) is globular and consists of two alpha-helical subdomains connected by a 14-residue linker. It shares structural similarity with IFIT family members N-terminal regions.
genes like me logo Genes that share domains with TICAM1: view

Function for TICAM1 Gene

Molecular function for TICAM1 Gene

UniProtKB/Swiss-Prot Function:
Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis (PubMed:12471095, PubMed:12539043, PubMed:14739303). Ligand binding to these receptors results in TRIF recruitment through its TIR domain (PubMed:12471095, PubMed:12539043, PubMed:14739303). Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively (PubMed:12471095, PubMed:12539043, PubMed:14739303). Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens (PubMed:25636800). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines (By similarity).

Phenotypes From GWAS Catalog for TICAM1 Gene

Gene Ontology (GO) - Molecular Function for TICAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14982987
GO:0019901 protein kinase binding IPI 14530355
genes like me logo Genes that share ontologies with TICAM1: view
genes like me logo Genes that share phenotypes with TICAM1: view

Animal Models for TICAM1 Gene

MGI Knock Outs for TICAM1:

Animal Model Products

CRISPR Products

miRNA for TICAM1 Gene

miRTarBase miRNAs that target TICAM1

Clone Products

  • Applied Biological Materials (abm): Clones for TICAM1 - Now 50% OFF >
  • * TICAM1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * TICAM1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TICAM1 Gene

Localization for TICAM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TICAM1 Gene

Cytoplasmic vesicle, autophagosome. Cytoplasm, cytosol. Mitochondrion. Note=Colocalizes with UBQLN1 in the autophagosome (PubMed:21695056). Colocalizes in the cytosol with DDX1, DDX21 and DHX36. Colocalizes in the mitochondria with DDX1 and poly(I:C) RNA ligand. The multi-helicase-TICAM1 complex may translocate to the mitochondria upon poly(I:C) RNA ligand stimulation (By similarity). {ECO:0000250 UniProtKB:Q80UF7, ECO:0000269 PubMed:21695056}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TICAM1 gene
Compartment Confidence
cytosol 5
mitochondrion 4
endosome 4
plasma membrane 3
nucleus 2
extracellular 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TICAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion ISS --
GO:0005776 autophagosome IEA --
GO:0005829 cytosol TAS --
GO:0010008 endosome membrane TAS --
genes like me logo Genes that share ontologies with TICAM1: view

Pathways & Interactions for TICAM1 Gene

PathCards logo

SuperPathways for TICAM1 Gene

genes like me logo Genes that share pathways with TICAM1: view

SIGNOR curated interactions for TICAM1 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for TICAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002281 macrophage activation involved in immune response IEA --
GO:0002376 immune system process IEA --
GO:0002735 positive regulation of myeloid dendritic cell cytokine production ISS,IEA --
GO:0002756 MyD88-independent toll-like receptor signaling pathway IEA,TAS --
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with TICAM1: view

Drugs & Compounds for TICAM1 Gene

(1) Drugs for TICAM1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for TICAM1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TICAM1: view

Transcripts for TICAM1 Gene

mRNA/cDNA for TICAM1 Gene

(2) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(106) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for TICAM1 Gene

Toll-like receptor adaptor molecule 1:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for TICAM1 - Now 50% OFF >
  • * TICAM1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * TICAM1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for TICAM1 Gene

No ASD Table

Relevant External Links for TICAM1 Gene

GeneLoc Exon Structure for
TICAM1
ECgene alternative splicing isoforms for
TICAM1

Expression for TICAM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TICAM1 Gene

mRNA differential expression in normal tissues according to GTEx for TICAM1 Gene

This gene is overexpressed in Esophagus - Mucosa (x4.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TICAM1 Gene



NURSA nuclear receptor signaling pathways regulating expression of TICAM1 Gene:

TICAM1

SOURCE GeneReport for Unigene cluster for TICAM1 Gene:

Hs.29344

mRNA Expression by UniProt/SwissProt for TICAM1 Gene:

Q8IUC6-TCAM1_HUMAN
Tissue specificity: Ubiquitously expressed but with higher levels in liver.

Evidence on tissue expression from TISSUES for TICAM1 Gene

  • Lung(4.2)
  • Nervous system(4.1)
  • Spleen(2.3)
  • Lymph node(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TICAM1 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • immune
  • nervous
Regions:
Head and neck:
  • brain
  • head
General:
  • blood
  • white blood cell
genes like me logo Genes that share expression patterns with TICAM1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Protein tissue co-expression partners for TICAM1 Gene

Orthologs for TICAM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TICAM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TICAM1 34 35
  • 98.31 (n)
cow
(Bos Taurus)
Mammalia TICAM1 34 35
  • 77.27 (n)
dog
(Canis familiaris)
Mammalia TICAM1 34 35
  • 76.97 (n)
mouse
(Mus musculus)
Mammalia Ticam1 34 35 17
  • 66.47 (n)
rat
(Rattus norvegicus)
Mammalia Ticam1 34
  • 66.37 (n)
oppossum
(Monodelphis domestica)
Mammalia TICAM1 35
  • 42 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TICAM1 35
  • 40 (a)
OneToOne
chicken
(Gallus gallus)
Aves TICAM1 35
  • 30 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TICAM1 35
  • 28 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ticam1 35 35
  • 25 (a)
OneToMany
Species where no ortholog for TICAM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TICAM1 Gene

ENSEMBL:
Gene Tree for TICAM1 (if available)
TreeFam:
Gene Tree for TICAM1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TICAM1: view image

Paralogs for TICAM1 Gene

No data available for Paralogs for TICAM1 Gene

Variants for TICAM1 Gene

Sequence variations from dbSNP and Humsavar for TICAM1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs11466719 benign, Herpes simplex encephalitis, susceptibility to, 4, - 4,818,155(-) G/A/T coding_sequence_variant, missense_variant
rs11466720 benign, Herpes simplex encephalitis, susceptibility to, 4 4,818,072(-) C/A/T coding_sequence_variant, synonymous_variant
rs11466723 benign, Herpes simplex encephalitis, susceptibility to, 4 4,816,575(-) C/T coding_sequence_variant, synonymous_variant
rs1332617784 likely-benign, Herpes simplex encephalitis, susceptibility to, 4 4,816,623(-) C/T coding_sequence_variant, synonymous_variant
rs140568066 uncertain-significance, Herpes simplex encephalitis, susceptibility to, 4 4,817,114(-) G/A coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for TICAM1 Gene

Variant ID Type Subtype PubMed ID
nsv1062709 CNV loss 25217958
nsv470117 CNV loss 18288195

Variation tolerance for TICAM1 Gene

Residual Variation Intolerance Score: 93.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.89; 79.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TICAM1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TICAM1
Human Gene Mutation Database (HGMD)
TICAM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TICAM1 Gene

Disorders for TICAM1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for TICAM1 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
encephalopathy, acute, infection-induced 6
  • encephalopathy, acute, infection-induced , susceptibility to, 6
herpes simplex encephalitis
  • herpes simplex meningo-encephalitis
hepatitis a
  • viral hepatitis a
herpes simplex
  • herpesvirus hominis disease
encephalitis
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

TCAM1_HUMAN
  • Encephalopathy, acute, infection-induced, Herpes-specific, 6 (IIAE6) [MIM:614850]: A rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. It is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome. {ECO:0000269 PubMed:22105173}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Additional Disease Information for TICAM1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TICAM1: view

No data available for Genatlas for TICAM1 Gene

Publications for TICAM1 Gene

  1. Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling. (PMID: 12471095) Yamamoto M … Akira S (Journal of immunology (Baltimore, Md. : 1950) 2002) 2 3 4 23 58
  2. The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling. (PMID: 16964262) Carty M … Bowie AG (Nature immunology 2006) 3 4 23 58
  3. Cutting Edge: NF-kappaB-activating kinase-associated protein 1 participates in TLR3/Toll-IL-1 homology domain-containing adapter molecule-1-mediated IFN regulatory factor 3 activation. (PMID: 15611223) Sasai M … Seya T (Journal of immunology (Baltimore, Md. : 1950) 2005) 3 4 23 58
  4. Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways. (PMID: 14739303) Han KJ … Shu HB (The Journal of biological chemistry 2004) 3 4 23 58
  5. Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta. (PMID: 14982987) Jiang Z … Li X (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 23 58

Products for TICAM1 Gene

Sources for TICAM1 Gene

Content
Loading form....