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Aliases for TICAM1 Gene

Aliases for TICAM1 Gene

  • Toll Like Receptor Adaptor Molecule 1 2 3 5
  • Toll-Interleukin-1 Receptor Domain-Containing Adapter Protein Inducing Interferon Beta 3 4
  • Proline-Rich, Vinculin And TIR Domain-Containing Protein B 3 4
  • TIR Domain-Containing Adapter Protein Inducing IFN-Beta 3 4
  • Putative NF-Kappa-B-Activating Protein 502H 3 4
  • TIR Domain-Containing Adapter Molecule 1 2 3
  • MyD88-3 3 4
  • PRVTIRB 3 4
  • TICAM-1 3 4
  • TRIF 3 4
  • TIR Domain Containing Adaptor Inducing Interferon-Beta 3
  • Toll-Like Receptor Adaptor Molecule 1 2
  • IIAE6 3

External Ids for TICAM1 Gene

Previous GeneCards Identifiers for TICAM1 Gene

  • GC19M004767
  • GC19M004577

Summaries for TICAM1 Gene

Entrez Gene Summary for TICAM1 Gene

  • This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. [provided by RefSeq, Jan 2012]

GeneCards Summary for TICAM1 Gene

TICAM1 (Toll Like Receptor Adaptor Molecule 1) is a Protein Coding gene. Diseases associated with TICAM1 include Herpes Simplex Encephalitis 4 and Herpes Simplex Encephalitis. Among its related pathways are Toll-like receptor signaling pathway and PI3K-Akt signaling pathway. Gene Ontology (GO) annotations related to this gene include protein kinase binding and signal transducer activity. An important paralog of this gene is TICAM2.

UniProtKB/Swiss-Prot for TICAM1 Gene

  • Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.

Additional gene information for TICAM1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TICAM1 Gene

Genomics for TICAM1 Gene

GeneHancer (GH) Regulatory Elements for TICAM1 Gene

Promoters and enhancers for TICAM1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I004828 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 557.9 +0.6 576 4.6 HDGF SMAD1 ARNT ARID4B SIN3A DMAP1 IRF4 YY1 SLC30A9 POLR2B TICAM1 GC19P004832 SAFB2 PLIN3 SAFB ARRDC5 FEM1A MIR7-3 MIR7-3HG SNRPEP4
GH19I004811 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 29.7 +17.4 17393 5.9 HDGF PKNOX1 SMAD1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B DUS3L CCDC94 TICAM1 SNRPEP4 SEMA6B ENSG00000267030 SAFB PLIN3 DPP9-AS1 ENSG00000267769
GH19I004574 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 27.4 +256.3 256259 2.5 HDGF PKNOX1 ARNT ARID4B FEZF1 ZNF2 ZBTB7B ZNF213 ZNF143 ZNF548 CACTIN CACTIN-AS1 APBA3 CCDC94 TICAM1 ENSG00000267030 DPP9-AS1 ENSG00000269807 ENSG00000267769 KDM4B
GH19I004721 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 16 +107.6 107639 4.5 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF548 SP3 NFYC ZFP41 DPP9 GC19P004749 GC19M004737 LOC105372250 TRG-TCC1-1 TRV-CAC3-1 PTPRS SAFB2 SAFB SNRPEP4
GH19I005679 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 15.9 -848.7 -848697 2.5 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A YBX1 DMAP1 ZNF2 HSD11B1L C19orf70 DUS3L SAFB KHSRP ENSG00000267571 KDM4B RANBP3 SAFB2 GTF2F1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TICAM1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TICAM1 gene promoter:

Genomic Locations for TICAM1 Gene

Genomic Locations for TICAM1 Gene
chr19:4,815,924-4,831,742
(GRCh38/hg38)
Size:
15,819 bases
Orientation:
Minus strand
chr19:4,815,938-4,831,737
(GRCh37/hg19)

Genomic View for TICAM1 Gene

Genes around TICAM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TICAM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TICAM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TICAM1 Gene

Proteins for TICAM1 Gene

  • Protein details for TICAM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUC6-TCAM1_HUMAN
    Recommended name:
    TIR domain-containing adapter molecule 1
    Protein Accession:
    Q8IUC6
    Secondary Accessions:
    • B3Y691
    • O75532
    • Q86XP8
    • Q96GA0

    Protein attributes for TICAM1 Gene

    Size:
    712 amino acids
    Molecular mass:
    76422 Da
    Quaternary structure:
    • Homodimer (Probable). Interacts with AZI2, IRF3 and IRF7. Interacts with TICAM2 in TLR4 recruitment. Interaction with PIAS4 inhibits the TICAM1-induced NF-kappa-B, IRF and IFNB1 activation. Interacts with IKBKB and IKBKE. Interaction with SARM1 blocks TICAM1-dependent transcription factor activation. Interacts with TRAF3 (By similarity). Interacts with TBK1, TRAF6 and RIPK1 and these interactions are enhanced in the presence of WDFY1 (PubMed:25736436). Interacts with TRAFD1 (By similarity). Interacts with UBQLN1 (via UBA domain). Interacts with TLR4 in response to LPS in a WDFY1-dependent manner (By similarity). Interacts with WDFY1 in response to poly(I:C) (By similarity). Interacts (via the TIR domain) with TLR3 in response to poly(I:C) and this interaction is enhanced in the presence of WDFY1 (PubMed:25736436). Interacts with TRIM56 (PubMed:22948160).
    SequenceCaution:
    • Sequence=AAO85488.1; Type=Frameshift; Positions=141, 148, 161; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TICAM1 Gene

neXtProt entry for TICAM1 Gene

Post-translational modifications for TICAM1 Gene

Other Protein References for TICAM1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for TICAM1
  • Santa Cruz Biotechnology (SCBT) Antibodies for TICAM1

No data available for DME Specific Peptides for TICAM1 Gene

Domains & Families for TICAM1 Gene

Gene Families for TICAM1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for TICAM1 Gene

Suggested Antigen Peptide Sequences for TICAM1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IUC6

UniProtKB/Swiss-Prot:

TCAM1_HUMAN :
  • The N-terminal region is essential for activation of the IFNB promoter activity.
Domain:
  • The N-terminal region is essential for activation of the IFNB promoter activity.
  • The N-terminal domain (TRIF-NTD) is globular and consists of two alpha-helical subdomains connected by a 14-residue linker. It shares structural similarity with IFIT family members N-terminal regions.
genes like me logo Genes that share domains with TICAM1: view

Function for TICAM1 Gene

Molecular function for TICAM1 Gene

UniProtKB/Swiss-Prot Function:
Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.

Phenotypes From GWAS Catalog for TICAM1 Gene

Gene Ontology (GO) - Molecular Function for TICAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity HMP,IEA 12761501
GO:0005515 protein binding IPI 14982987
GO:0019901 protein kinase binding IPI 14530355
genes like me logo Genes that share ontologies with TICAM1: view
genes like me logo Genes that share phenotypes with TICAM1: view

Animal Models for TICAM1 Gene

MGI Knock Outs for TICAM1:

miRNA for TICAM1 Gene

miRTarBase miRNAs that target TICAM1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TICAM1 Gene

Localization for TICAM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TICAM1 Gene

Cytoplasmic vesicle, autophagosome. Note=Colocalizes with UBQLN1 in the autophagosome. {ECO:0000269 PubMed:21695056}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TICAM1 gene
Compartment Confidence
cytosol 5
endosome 5
plasma membrane 3
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TICAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005776 autophagosome IEA --
GO:0005829 cytosol TAS --
GO:0010008 endosome membrane TAS --
GO:0031410 cytoplasmic vesicle IEA --
GO:0097342 ripoptosome IDA 21737330
genes like me logo Genes that share ontologies with TICAM1: view

Pathways & Interactions for TICAM1 Gene

SuperPathways for TICAM1 Gene

genes like me logo Genes that share pathways with TICAM1: view

SIGNOR curated interactions for TICAM1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for TICAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002281 macrophage activation involved in immune response IEA --
GO:0002376 immune system process IEA --
GO:0002756 MyD88-independent toll-like receptor signaling pathway IEA,TAS --
GO:0006915 apoptotic process IEA --
GO:0006954 inflammatory response IEA --
genes like me logo Genes that share ontologies with TICAM1: view

Drugs & Compounds for TICAM1 Gene

(1) Drugs for TICAM1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for TICAM1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TICAM1: view

Transcripts for TICAM1 Gene

mRNA/cDNA for TICAM1 Gene

Unigene Clusters for TICAM1 Gene

Toll-like receptor adaptor molecule 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TICAM1 Gene

No ASD Table

Relevant External Links for TICAM1 Gene

GeneLoc Exon Structure for
TICAM1
ECgene alternative splicing isoforms for
TICAM1

Expression for TICAM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TICAM1 Gene

mRNA differential expression in normal tissues according to GTEx for TICAM1 Gene

This gene is overexpressed in Esophagus - Mucosa (x4.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TICAM1 Gene



NURSA nuclear receptor signaling pathways regulating expression of TICAM1 Gene:

TICAM1

SOURCE GeneReport for Unigene cluster for TICAM1 Gene:

Hs.29344

mRNA Expression by UniProt/SwissProt for TICAM1 Gene:

Q8IUC6-TCAM1_HUMAN
Tissue specificity: Ubiquitously expressed but with higher levels in liver.

Evidence on tissue expression from TISSUES for TICAM1 Gene

  • Lung(4.2)
  • Nervous system(4.1)
  • Spleen(2.3)
  • Lymph node(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TICAM1 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • immune
  • nervous
Regions:
Head and neck:
  • brain
  • head
General:
  • blood
  • white blood cell
genes like me logo Genes that share expression patterns with TICAM1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Protein tissue co-expression partners for TICAM1 Gene

Orthologs for TICAM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TICAM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TICAM1 33 34
  • 98.31 (n)
cow
(Bos Taurus)
Mammalia TICAM1 33 34
  • 77.27 (n)
dog
(Canis familiaris)
Mammalia TICAM1 33 34
  • 76.97 (n)
mouse
(Mus musculus)
Mammalia Ticam1 33 16 34
  • 66.47 (n)
rat
(Rattus norvegicus)
Mammalia Ticam1 33
  • 66.37 (n)
oppossum
(Monodelphis domestica)
Mammalia TICAM1 34
  • 42 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TICAM1 34
  • 40 (a)
OneToOne
chicken
(Gallus gallus)
Aves TICAM1 34
  • 30 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TICAM1 34
  • 28 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ticam1 34 34
  • 25 (a)
OneToMany
Species where no ortholog for TICAM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TICAM1 Gene

ENSEMBL:
Gene Tree for TICAM1 (if available)
TreeFam:
Gene Tree for TICAM1 (if available)

Paralogs for TICAM1 Gene

Paralogs for TICAM1 Gene

genes like me logo Genes that share paralogs with TICAM1: view

Variants for TICAM1 Gene

Sequence variations from dbSNP and Humsavar for TICAM1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs141687483 uncertain-significance, Herpes simplex encephalitis, susceptibility to, 4 4,818,109(-) G/T coding_sequence_variant, missense_variant
rs143679494 likely-benign, Herpes simplex encephalitis, susceptibility to, 4 4,816,676(-) C/A/T coding_sequence_variant, missense_variant
rs145148929 likely-benign, Herpes simplex encephalitis, susceptibility to, 4 4,817,899(-) G/A coding_sequence_variant, missense_variant
rs146550489 risk-factor, uncertain-significance, Herpes simplex encephalitis, susceptibility to, 4, Herpes simplex encephalitis 4 (HSE4) [MIM:614850] 4,817,821(-) G/A coding_sequence_variant, missense_variant
rs151272128 likely-benign, Herpes simplex encephalitis, susceptibility to, 4 4,817,645(-) C/A/G/T coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for TICAM1 Gene

Variant ID Type Subtype PubMed ID
nsv1062709 CNV loss 25217958
nsv470117 CNV loss 18288195

Variation tolerance for TICAM1 Gene

Residual Variation Intolerance Score: 93.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.89; 79.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TICAM1 Gene

Human Gene Mutation Database (HGMD)
TICAM1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TICAM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TICAM1 Gene

Disorders for TICAM1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for TICAM1 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
herpes simplex encephalitis 4
  • herpes simplex encephalitis, susceptibility to, 4
herpes simplex encephalitis
  • herpes simplex meningo-encephalitis
herpes simplex
  • herpesvirus hominis disease
encephalitis
pertussis
  • bordetella infection
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

TCAM1_HUMAN
  • Herpes simplex encephalitis 4 (HSE4) [MIM:614850]: A rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. HSE is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome. {ECO:0000269 PubMed:22105173}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Additional Disease Information for TICAM1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TICAM1: view

No data available for Genatlas for TICAM1 Gene

Publications for TICAM1 Gene

  1. Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling. (PMID: 12471095) Yamamoto M … Akira S (Journal of immunology (Baltimore, Md. : 1950) 2002) 2 3 4 22 58
  2. The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling. (PMID: 16964262) Carty M … Bowie AG (Nature immunology 2006) 3 4 22 58
  3. Cutting Edge: NF-kappaB-activating kinase-associated protein 1 participates in TLR3/Toll-IL-1 homology domain-containing adapter molecule-1-mediated IFN regulatory factor 3 activation. (PMID: 15611223) Sasai M … Seya T (Journal of immunology (Baltimore, Md. : 1950) 2005) 3 4 22 58
  4. Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways. (PMID: 14739303) Han KJ … Shu HB (The Journal of biological chemistry 2004) 3 4 22 58
  5. Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta. (PMID: 14982987) Jiang Z … Li X (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 22 58

Products for TICAM1 Gene

Sources for TICAM1 Gene

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