Aliases for TICAM1 Gene
- Toll Like Receptor Adaptor Molecule 1 2 3 5
- TIR Domain-Containing Adapter Molecule 1 2 3 4
- PRVTIRB 2 3 4
- TICAM-1 2 3 4
- TRIF 2 3 4
- Toll-Interleukin-1 Receptor Domain-Containing Adapter Protein Inducing Interferon Beta 3 4
- Proline-Rich, Vinculin And TIR Domain-Containing Protein B 3 4
- TIR Domain-Containing Adapter Protein Inducing IFN-Beta 3 4
External Ids for TICAM1 Gene
Previous GeneCards Identifiers for TICAM1 Gene
This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. Mutations in this gene are associated with encephalopathy, acute, infection-induced. [provided by RefSeq, Jul 2020]
GeneCards Summary for TICAM1 Gene
TICAM1 (Toll Like Receptor Adaptor Molecule 1) is a Protein Coding gene. Diseases associated with TICAM1 include Encephalopathy, Acute, Infection-Induced 6 and Herpes Simplex Encephalitis. Among its related pathways are IKK complex recruitment mediated by RIP1 and Toll-Like receptor Signaling Pathways. Gene Ontology (GO) annotations related to this gene include protein kinase binding and obsolete signal transducer activity.
UniProtKB/Swiss-Prot Summary for TICAM1 Gene
Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis (PubMed:12471095, PubMed:12539043, PubMed:14739303, PubMed:28747347). Ligand binding to these receptors results in TRIF recruitment through its TIR domain (PubMed:12471095, PubMed:12539043, PubMed:14739303). Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively (PubMed:12471095, PubMed:12539043, PubMed:14739303). Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens (PubMed:25636800). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines (By similarity).