This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternative... See more...

Aliases for TIAM2 Gene

Aliases for TIAM2 Gene

  • TIAM Rac1 Associated GEF 2 2 3 5
  • STEF 2 3 4
  • T-Lymphoma Invasion And Metastasis-Inducing Protein 2 3 4
  • SIF And TIAM1-Like Exchange Factor 3 4
  • TIAM-2 3 4
  • T-Cell Lymphoma Invasion And Metastasis 2 2
  • T Cell Lymphoma Invasion And Metastasis 2 3
  • Sif And Tiam1-Like Exchange Factor 2
  • KIAA2016 4
  • TIAM2 5

External Ids for TIAM2 Gene

Previous GeneCards Identifiers for TIAM2 Gene

  • GC06P155030
  • GC06P155364
  • GC06P155459
  • GC06P155479
  • GC06P155520
  • GC06U900794
  • GC06P152973
  • GC06P155153

Summaries for TIAM2 Gene

Entrez Gene Summary for TIAM2 Gene

  • This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for TIAM2 Gene

TIAM2 (TIAM Rac1 Associated GEF 2) is a Protein Coding gene. Diseases associated with TIAM2 include Lymphoma and Myasthenic Syndrome, Congenital, 6, Presynaptic. Among its related pathways are p75 NTR receptor-mediated signalling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is TIAM1.

UniProtKB/Swiss-Prot Summary for TIAM2 Gene

  • Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity). Activates specifically RAC1, but not CDC42 and RHOA.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TIAM2 Gene

Genomics for TIAM2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TIAM2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J155148 Promoter/Enhancer 0.9 EPDnew Ensembl ENCODE 250.1 +316.3 316304 2.4 SIN3A YY1 REST POU5F1 piR-61945-444 TIAM2 ENSG00000238963 RF00017-5384 RF00017-5383 CLDN20
GH06J155216 Promoter 0.3 EPDnew 250 +384.3 384250 0.1 TIAM2 RF00017-5383 piR-48749-040 CLDN20
GH06J155217 Promoter 0.3 EPDnew 250 +384.0 384011 0.1 TIAM2 RF00017-5383 piR-48749-040 CLDN20
GH06J154833 Enhancer 0.2 Ensembl 250.7 +0.8 804 0.2 TIAM2 NONHSAG045207.2 lnc-SCAF8-2 SCAF8 CLDN20
GH06J155220 Enhancer 1.2 FANTOM5 Ensembl ENCODE 26.7 +389.9 389903 6 BCLAF1 JUND BCL11A CEBPB TRIM22 EP300 IRF4 SMARCA5 FOSL2 NFE2 RF00017-5383 TIAM2 ENSG00000235381 TFB1M SCAF8 HSALNG0054499 CLDN20
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TIAM2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TIAM2

Top Transcription factor binding sites by QIAGEN in the TIAM2 gene promoter:
  • aMEF-2
  • AP-1
  • ATF-2
  • c-Jun
  • CUTL1
  • Evi-1
  • Nkx3-1 v1

Genomic Locations for TIAM2 Gene

Latest Assembly
chr6:154,832,697-155,257,723
(GRCh38/hg38)
Size:
425,027 bases
Orientation:
Plus strand

Previous Assembly
chr6:155,316,449-155,578,857
(GRCh37/hg19 by Entrez Gene)
Size:
262,409 bases
Orientation:
Plus strand

chr6:155,153,831-155,578,857
(GRCh37/hg19 by Ensembl)
Size:
425,027 bases
Orientation:
Plus strand

Genomic View for TIAM2 Gene

Genes around TIAM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIAM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIAM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIAM2 Gene

Proteins for TIAM2 Gene

  • Protein details for TIAM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVF5-TIAM2_HUMAN
    Recommended name:
    T-lymphoma invasion and metastasis-inducing protein 2
    Protein Accession:
    Q8IVF5
    Secondary Accessions:
    • B2RP56
    • C9JZV2
    • Q6NXN9
    • Q6ZUP9
    • Q9UFG6
    • Q9UKV9
    • Q9UKW0

    Protein attributes for TIAM2 Gene

    Size:
    1701 amino acids
    Molecular mass:
    190103 Da
    Quaternary structure:
    • Interacts with MAP1A, MAP1B, PARP1 and YWHAE. Interacts with CD44, PARD3 and MAPK8IP2 (By similarity).
    SequenceCaution:
    • Sequence=AAF05900.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAC23112.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAC86170.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for TIAM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TIAM2 Gene

Post-translational modifications for TIAM2 Gene

  • Phosphorylated on serine and threonine residues. Phosphorylated on Thr-1648 by Rho-kinase. Its phosphorylation by Rho-kinase inhibits its guanine nucleotide exchange activity, its interaction with MAP1A, MAP1B, PARP1 and YWHAE and reduces its ability to promote neurite growth (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TIAM2 Gene

Domains & Families for TIAM2 Gene

Gene Families for TIAM2 Gene

Protein Domains for TIAM2 Gene

InterPro:
Blocks:
  • Pleckstrin-like
  • DH domain
  • Protein kinase PKN/PRK1, effector

Suggested Antigen Peptide Sequences for TIAM2 Gene

GenScript: Design optimal peptide antigens:
  • T-cell lymphoma invasion and metastasis 2 (Q5VYA4_HUMAN)
  • SIF and TIAM1-like exchange factor (TIAM2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IVF5

UniProtKB/Swiss-Prot:

TIAM2_HUMAN :
  • The PH 1 domain and amino acids 621-782 (a region called TSS; otherwise known as CC-Ex) are necessary for membrane localization. The PH 1 and TSS domains are necessary for Rac1 activity. The PH 2 domain is engaged in the enhancement of the catalytic activity of the adjacent DH domain. The PH 1, TSS and DH domains are necessary to induce neurite-like structure (By similarity).
  • Belongs to the TIAM family.
Domain:
  • The PH 1 domain and amino acids 621-782 (a region called TSS; otherwise known as CC-Ex) are necessary for membrane localization. The PH 1 and TSS domains are necessary for Rac1 activity. The PH 2 domain is engaged in the enhancement of the catalytic activity of the adjacent DH domain. The PH 1, TSS and DH domains are necessary to induce neurite-like structure (By similarity).
Family:
  • Belongs to the TIAM family.
genes like me logo Genes that share domains with TIAM2: view

Function for TIAM2 Gene

Molecular function for TIAM2 Gene

UniProtKB/Swiss-Prot Function:
Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity). Activates specifically RAC1, but not CDC42 and RHOA.
GENATLAS Biochemistry:
murine T lymphoma invasion and metastasis inducing gene 2 (Tiam2) homolog,expressed in cerebrum,cerebellum and testis,involved in neural cell development with two alternatively spliced isoforms,long and short,lacking the EX and PDZ motifs

Phenotypes From GWAS Catalog for TIAM2 Gene

Gene Ontology (GO) - Molecular Function for TIAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity IEA --
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with TIAM2: view
genes like me logo Genes that share phenotypes with TIAM2: view

Animal Models for TIAM2 Gene

MGI Knock Outs for TIAM2:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TIAM2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TIAM2 Gene

Localization for TIAM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIAM2 Gene

Cytoplasm. Cell projection, lamellipodium. Cell projection, filopodium. Cell projection, growth cone. Cell projection, neuron projection. Perikaryon.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TIAM2 gene
Compartment Confidence
cytosol 5
extracellular 4
nucleus 4
plasma membrane 2
cytoskeleton 2
golgi apparatus 2
mitochondrion 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoli fibrillar center (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TIAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IBA 21873635
GO:0030027 lamellipodium IEA --
GO:0030175 filopodium IEA --
genes like me logo Genes that share ontologies with TIAM2: view

Pathways & Interactions for TIAM2 Gene

genes like me logo Genes that share pathways with TIAM2: view

SIGNOR curated interactions for TIAM2 Gene

Activates:

Gene Ontology (GO) - Biological Process for TIAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007264 small GTPase mediated signal transduction IEA,IBA 21873635
GO:0019216 regulation of lipid metabolic process TAS --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with TIAM2: view

Drugs & Compounds for TIAM2 Gene

(3) Drugs for TIAM2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with TIAM2: view

Transcripts for TIAM2 Gene

mRNA/cDNA for TIAM2 Gene

4 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
20 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TIAM2

Alternative Splicing Database (ASD) splice patterns (SP) for TIAM2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b · 20c ^
SP1: - - - - -
SP2: - - - - -
SP3: -
SP4: - - - - - - - - - - - -
SP5:
SP6:
SP7:
SP8:

ExUns: 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27a · 27b ^ 28 ^ 29 ^ 30a · 30b
SP1: -
SP2: -
SP3: - -
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for TIAM2 Gene

GeneLoc Exon Structure for
TIAM2

Expression for TIAM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TIAM2 Gene

Protein differential expression in normal tissues from HIPED for TIAM2 Gene

This gene is overexpressed in Frontal cortex (55.9) and Heart (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TIAM2 Gene



Protein tissue co-expression partners for TIAM2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TIAM2

SOURCE GeneReport for Unigene cluster for TIAM2 Gene:

Hs.586279

mRNA Expression by UniProt/SwissProt for TIAM2 Gene:

Q8IVF5-TIAM2_HUMAN
Tissue specificity: Expressed in the occipital, frontal and temporal lobes, cerebellum, putamen and testis.

Evidence on tissue expression from TISSUES for TIAM2 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with TIAM2: view

Primer products for research

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TIAM2 Gene

Orthologs for TIAM2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TIAM2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TIAM2 29 30
  • 99.37 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 93 (a)
OneToMany
-- 30
  • 78 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia TIAM2 29 30
  • 85.39 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia LOC100362710 29
  • 84.1 (n)
Dog
(Canis familiaris)
Mammalia TIAM2 29 30
  • 83.99 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Tiam2 29 16 30
  • 83.76 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TIAM2 30
  • 82 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TIAM2 29
  • 74 (n)
Lizard
(Anolis carolinensis)
Reptilia TIAM2 30
  • 71 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii tiam2 29
  • 58.19 (n)
tiam2a 30
  • 52 (a)
OneToMany
TIAM2 (1 of 2) 30
  • 52 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta sif 30 31
  • 20 (a)
OneToMany
Species where no ortholog for TIAM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TIAM2 Gene

ENSEMBL:
Gene Tree for TIAM2 (if available)
TreeFam:
Gene Tree for TIAM2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TIAM2: view image
Alliance of Genome Resources:
Additional Orthologs for TIAM2

Paralogs for TIAM2 Gene

(2) SIMAP similar genes for TIAM2 Gene using alignment to 10 proteins:

  • TIAM2_HUMAN
  • E9PKT1_HUMAN
  • E9PMZ8_HUMAN
  • F5H1M3_HUMAN
  • F5H6R0_HUMAN
  • F5H6W6_HUMAN
  • F5H8H5_HUMAN
  • H0YGV1_HUMAN
  • H7C5V6_HUMAN
  • H7C602_HUMAN
genes like me logo Genes that share paralogs with TIAM2: view

Variants for TIAM2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TIAM2 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
778273 Benign: not provided 155,240,626(+) T/.
NM_012454.3(TIAM2):c.3265C>T (p.Pro1089Ser)
MISSENSE_VARIANT,NO_SEQUENCE_ALTERATION
rs114808212 Benign: not provided 155,129,244(+) G/C
NM_012454.3(TIAM2):c.21G>C (p.Gln7His)
MISSENSE
rs114815467 Benign: not provided 155,130,342(+) G/T
NM_012454.3(TIAM2):c.1119G>T (p.Lys373Asn)
MISSENSE
rs138915668 Likely Benign: not provided 155,179,410(+) T/C
NM_012454.3(TIAM2):c.2661T>C (p.Asn887=)
SYNONYMOUS
rs144697464 Benign: not provided 155,137,431(+) C/T
NM_012454.3(TIAM2):c.1449C>T (p.Ala483=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TIAM2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TIAM2 Gene

Variant ID Type Subtype PubMed ID
esv3328575 CNV duplication 20981092
esv3400314 CNV insertion 20981092
esv5639 OTHER inversion 19470904
esv9372 CNV gain 19470904
nsv1025003 CNV gain 25217958
nsv525690 CNV loss 19592680
nsv526576 CNV loss 19592680
nsv5552 CNV deletion 18451855

Variation tolerance for TIAM2 Gene

Residual Variation Intolerance Score: 85.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.12; 96.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TIAM2 Gene

Human Gene Mutation Database (HGMD)
TIAM2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TIAM2
Leiden Open Variation Database (LOVD)
TIAM2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIAM2 Gene

Disorders for TIAM2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TIAM2 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
lymphoma
  • lymphoid cancer
myasthenic syndrome, congenital, 6, presynaptic
  • cms6
congenital myasthenic syndrome
  • congenital myasthenic syndromes
- elite association - COSMIC cancer census association via MalaCards
Search TIAM2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TIAM2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with TIAM2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TIAM2 Gene

Publications for TIAM2 Gene

  1. Cloning and characterization of T-cell lymphoma invasion and metastasis 2 (TIAM2), a novel guanine nucleotide exchange factor related to TIAM1. (PMID: 10512681) Chiu CY … Duhl DM (Genomics 1999) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
  3. The PHCCEx domain of Tiam1/2 is a novel protein- and membrane-binding module. (PMID: 19893486) Terawaki S … Hakoshima T (The EMBO journal 2010) 2 3
  4. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. (PMID: 30021884) Fasci D … Heck AJR (Molecular & cellular proteomics : MCP 2018) 3
  5. STEF/TIAM2-mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap. (PMID: 29844364) Woroniuk A … Malliri A (Nature communications 2018) 3

Products for TIAM2 Gene

Sources for TIAM2 Gene