TIAM1 Gene (Protein Coding)

T Cell Lymphoma Invasion And Metastasis 1

GC21M031118
GIFtS:
46
This gene encodes a RAC1-specific guanine nucleotide exchange factor (GEF). GEFs mediate the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP). The binding of GTP induces a conformational change in RAC1 that allows downstream effectors to bind and transduce a signal. This gene thus regulates RAC1 signaling pathways that affect cell shape, migration, adhes... See more...

Aliases for TIAM1 Gene

Aliases for TIAM1 Gene

  • T Cell Lymphoma Invasion And Metastasis 1 2 3 5
  • T-Lymphoma Invasion And Metastasis-Inducing Protein 1 3 4
  • TIAM-1 3 4
  • Human T-Lymphoma Invasion And Metastasis Inducing TIAM1 Protein 3
  • T-Cell Lymphoma Invasion And Metastasis 1 2

External Ids for TIAM1 Gene

Previous GeneCards Identifiers for TIAM1 Gene

  • GC21M029069
  • GC21M031411
  • GC21M031412
  • GC21M031414
  • GC21M032361
  • GC21M017900
  • GC21M032490

Summaries for TIAM1 Gene

Entrez Gene Summary for TIAM1 Gene

  • This gene encodes a RAC1-specific guanine nucleotide exchange factor (GEF). GEFs mediate the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP). The binding of GTP induces a conformational change in RAC1 that allows downstream effectors to bind and transduce a signal. This gene thus regulates RAC1 signaling pathways that affect cell shape, migration, adhesion, growth, survival, and polarity, as well as influencing actin cytoskeletal formation, endocytosis, and membrane trafficking. This gene thus plays an important role in cell invasion, metastasis, and carcinogenesis. In addition to RAC1, the encoded protein activates additional Rho-like GTPases such as CDC42, RAC2, RAC3 and RHOA. This gene encodes multiple protein isoforms that experience a diverse array of intramolecular, protein-protein, and phosphorylation interactions as well as phosphoinositide binding. Both the longer and shorter isoforms have C-terminal Dbl homology (DH) and pleckstrin homology (PH) domains while only the longer isoforms of this gene have the N-terminal myristoylation site and the downstream N-terminal PH domain, ras-binding domain (RBD), and PSD-95/DlgA/ZO-1 (PDZ) domain. [provided by RefSeq, Jul 2017]

GeneCards Summary for TIAM1 Gene

TIAM1 (T Cell Lymphoma Invasion And Metastasis 1) is a Protein Coding gene. Diseases associated with TIAM1 include Lymphoma and Colorectal Cancer. Among its related pathways are Tight junction and CCR5 Pathway in Macrophages. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is TIAM2.

UniProtKB/Swiss-Prot Summary for TIAM1 Gene

  • Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Required for normal cell adhesion and cell migration.

Gene Wiki entry for TIAM1 Gene

Additional gene information for TIAM1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TIAM1 Gene

Genomics for TIAM1 Gene

GeneHancer (GH) Regulatory Elements for TIAM1 Gene

Promoters and enhancers for TIAM1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH21J031559 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE CraniofacialAtlas 763.2 +0.9 907 3.9 SP1 CTCF ZBTB6 TCF7L2 CTBP1 ZNF362 ZNF121 HDGF MNT ZNF280D TIAM1 LOC150051 MIS18A SCAF4 RF00017-3684
GH21J031407 Enhancer 1.1 FANTOM5 Ensembl ENCODE 16.8 +150.4 150376 4.4 ZNF362 ZFP41 ZNF121 MLLT1 PRDM1 IKZF1 IKZF2 ZSCAN4 PKNOX1 ZNF239 MIS18A ENSG00000238390 SCAF4 TIAM1 URB1 MIS18A-AS1 LOC150051 KR153194-114 LOC100129168
GH21J031529 Enhancer 0.9 Ensembl ENCODE 18.2 +29.0 28976 3.2 GATA3 TCF7L2 ZNF217 ZNF362 NCOA3 SP7 PRDM1 ZNF680 ZIC2 ZBTB8A TIAM1 LOC150051 MIS18A-AS1 piR-41306-166 ENSG00000237325
GH21J031180 Promoter/Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +375.9 375920 7.5 ZBTB40 CTCF RAD21 ZNF121 ZNF384 SMC3 PRDM4 LOC150051 TIAM1 RF00017-3683 piR-48820-061
GH21J031525 Enhancer 0.8 Ensembl ENCODE 16.5 +32.9 32878 2.2 ZNF362 SP7 GLIS2 ZIC2 PRDM10 CTBP1 ZEB2 ZNF629 PATZ1 ZBTB10 TIAM1 LOC150051 piR-41306-166 ENSG00000237325
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TIAM1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TIAM1 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • GATA-1
  • GATA-3
  • HOXA5
  • SRF
  • SRF (504 AA)

Genomic Locations for TIAM1 Gene

Genomic Locations for TIAM1 Gene
chr21:31,118,416-31,559,977
(GRCh38/hg38)
Size:
441,562 bases
Orientation:
Minus strand
chr21:32,490,734-32,932,290
(GRCh37/hg19)
Size:
441,557 bases
Orientation:
Minus strand

Genomic View for TIAM1 Gene

Genes around TIAM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIAM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIAM1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TIAM1 Gene

Proteins for TIAM1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for TIAM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13009-TIAM1_HUMAN
    Recommended name:
    T-lymphoma invasion and metastasis-inducing protein 1
    Protein Accession:
    Q13009
    Secondary Accessions:
    • B7ZLR6
    • F5GZ53
    • Q17RT7

    Protein attributes for TIAM1 Gene

    Size:
    1591 amino acids
    Molecular mass:
    177508 Da
    Quaternary structure:
    • Component of the Par polarity complex, composed of at least phosphorylated PRKCZ, PARD3 and TIAM1. Interacts with NTRK2; mediates the activation of RAC1 by BDNF. Interacts with MAPK8IP2 and CD44 (By similarity). Interacts with BAIAP2. Interacts with EPHA8; regulates clathrin-mediated endocytosis of EPHA8. Interacts with PARD3. Interacts (via PDZ domain) with CNTNAP4, SDC1 and SDC3 (via C-terminus).

    Three dimensional structures from OCA and Proteopedia for TIAM1 Gene

    Alternative splice isoforms for TIAM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TIAM1 Gene

Protein Expression for TIAM1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for TIAM1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TIAM1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TIAM1 Gene

Domains & Families for TIAM1 Gene

Gene Families for TIAM1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for TIAM1 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TIAM1 Gene

GenScript: Design optimal peptide antigens:
  • TIAM1 protein (B7ZLR6_HUMAN)
  • T-lymphoma invasion and metastasis-inducing protein 1 (TIAM1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q13009

UniProtKB/Swiss-Prot:

TIAM1_HUMAN :
  • The first PH domain mediates interaction with membranes enriched in phosphoinositides.
  • Belongs to the TIAM family.
Domain:
  • The first PH domain mediates interaction with membranes enriched in phosphoinositides.
Family:
  • Belongs to the TIAM family.
genes like me logo Genes that share domains with TIAM1: view

Function for TIAM1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for TIAM1 Gene

UniProtKB/Swiss-Prot Function:
Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Required for normal cell adhesion and cell migration.
GENATLAS Biochemistry:
murine T lymphoma invasion and metastasis inducing gene 1 (Tiam1) homolog,overexpressed in bone marrow of Down syndrome children during the acute phase of AML (M7),involved in neural cell development

Phenotypes From GWAS Catalog for TIAM1 Gene

Gene Ontology (GO) - Molecular Function for TIAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity EXP 15721239
GO:0005089 Rho guanyl-nucleotide exchange factor activity TAS 10835422
GO:0005515 protein binding IPI 17440041
GO:0008017 microtubule binding IEA --
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with TIAM1: view
genes like me logo Genes that share phenotypes with TIAM1: view

Animal Models for TIAM1 Gene

MGI Knock Outs for TIAM1:
  • Tiam1 Tiam1<tm1Jgc>
  • Tiam1 Tiam1<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for TIAM1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TIAM1 Gene

Localization for TIAM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIAM1 Gene

Cell junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Detected at the boundary between cells with actin-rich protrusions (By similarity). Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TIAM1 gene
Compartment Confidence
plasma membrane 5
nucleus 4
cytosol 4
cytoskeleton 3
extracellular 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (4)
  • Nucleus (3)
  • Cytokinetic bridge (2)
  • Cytosol (2)
  • Nuclear membrane (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TIAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA,TAS --
GO:0005874 microtubule IEA --
GO:0005886 plasma membrane IDA 23109420
genes like me logo Genes that share ontologies with TIAM1: view

Pathways & Interactions for TIAM1 Gene

genes like me logo Genes that share pathways with TIAM1: view

SIGNOR curated interactions for TIAM1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for TIAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003300 cardiac muscle hypertrophy IEA --
GO:0006915 apoptotic process IEA --
GO:0007160 cell-matrix adhesion IMP 20361982
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with TIAM1: view

Drugs & Compounds for TIAM1 Gene

Products:

  1. Drug

(3) Drugs for TIAM1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(9) Additional Compounds for TIAM1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TIAM1: view

Transcripts for TIAM1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for TIAM1 Gene

(12) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(163) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for TIAM1

Alternative Splicing Database (ASD) splice patterns (SP) for TIAM1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - - - - -
SP2: - - - - - - -
SP3:
SP4:
SP5:

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for TIAM1 Gene

GeneLoc Exon Structure for
TIAM1
ECgene alternative splicing isoforms for
TIAM1

Expression for TIAM1 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TIAM1 Gene

mRNA expression in normal human tissues for TIAM1 Gene
mRNA expression by GTEx for TIAM1 GenemRNA expression by BioGPS for TIAM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TIAM1 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x14.6) and Brain - Cerebellum (x10.3).

Protein differential expression in normal tissues from HIPED for TIAM1 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (52.5) and Plasma (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TIAM1 Gene



NURSA nuclear receptor signaling pathways regulating expression of TIAM1 Gene:

TIAM1

SOURCE GeneReport for Unigene cluster for TIAM1 Gene:

Hs.517228

mRNA Expression by UniProt/SwissProt for TIAM1 Gene:

Q13009-TIAM1_HUMAN
Tissue specificity: Found in virtually all analyzed tumor cell lines including B- and T-lymphomas, neuroblastomas, melanomas and carcinomas.

Evidence on tissue expression from TISSUES for TIAM1 Gene

  • Nervous system(4.8)
  • Lymph node(2.1)
genes like me logo Genes that share expression patterns with TIAM1: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TIAM1 Gene

Orthologs for TIAM1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TIAM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia TIAM1 33 32
  • 99.69 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia TIAM1 33 32
  • 91.31 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia TIAM1 33 32
  • 90.49 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Tiam1 17 33 32
  • 89.38 (n)
rat
(Rattus norvegicus)
 Mammalia Tiam1 32
  • 88.87 (n)
oppossum
(Monodelphis domestica)
 Mammalia TIAM1 33
  • 86 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia TIAM1 33
  • 76 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves TIAM1 33 32
  • 79.32 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia TIAM1 33
  • 84 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia tiam1 32
  • 72.57 (n)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.25648 32
zebrafish
(Danio rerio)
 Actinopterygii LOC100330358 32
  • 65.03 (n)
TIAM1 (1 of 3) 33
  • 64 (a)
 OneToMany
tiam1a 33
  • 62 (a)
 OneToMany
TIAM1 (3 of 3) 33
  • 17 (a)
 OneToMany
fruit fly
(Drosophila melanogaster)
 Insecta sif 33 34
  • 19 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 33
  • 24 (a)
 ManyToMany
Species where no ortholog for TIAM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TIAM1 Gene

ENSEMBL:
Gene Tree for TIAM1 (if available)
TreeFam:
Gene Tree for TIAM1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TIAM1: view image

Paralogs for TIAM1 Gene

Paralogs for TIAM1 Gene

(2) SIMAP similar genes for TIAM1 Gene using alignment to 5 proteins:

  • TIAM1_HUMAN
  • B7ZLR6_HUMAN
  • C9JMB5_HUMAN
  • F5GZ53_HUMAN
  • H7C079_HUMAN
genes like me logo Genes that share paralogs with TIAM1: view

Variants for TIAM1 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for TIAM1 Gene

SNP ID Clin Chr 21 pos Variation AA Info Type
rs1192824496 A colorectal cancer sample 31,217,663(-) G/A coding_sequence_variant, genic_upstream_transcript_variant, missense_variant
rs1319513413 A colorectal cancer sample 31,130,242(-) G/A coding_sequence_variant, missense_variant
rs760788922 uncertain-significance, not provided 31,251,762(-) T/C/G coding_sequence_variant, genic_upstream_transcript_variant, missense_variant
rs1000000483 -- 31,540,856(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000010790 -- 31,274,075(-) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TIAM1 Gene

Variant ID Type Subtype PubMed ID
dgv2379n106 CNV deletion 24896259
dgv811e214 CNV gain 21293372
esv1536810 CNV deletion 17803354
esv2659845 CNV deletion 23128226
esv2668093 CNV deletion 23128226
esv2671245 CNV deletion 23128226
esv2723329 CNV deletion 23290073
esv2723330 CNV deletion 23290073
esv2723331 CNV deletion 23290073
esv2762107 CNV gain 21179565
esv32755 CNV gain 17666407
esv3435719 CNV insertion 20981092
esv3575385 CNV gain 25503493
esv3646851 CNV loss 21293372
esv3646854 CNV loss 21293372
esv3646858 CNV loss 21293372
esv3646860 CNV loss 21293372
esv3646861 CNV loss 21293372
esv3646863 CNV gain 21293372
esv3646864 CNV loss 21293372
esv3646865 CNV loss 21293372
nsv1061254 CNV gain 25217958
nsv1067151 CNV gain 25217958
nsv1073124 CNV deletion 25765185
nsv1116916 CNV deletion 24896259
nsv1123551 CNV deletion 24896259
nsv1127892 CNV deletion 24896259
nsv1136622 CNV deletion 24896259
nsv1152605 CNV insertion 26484159
nsv459238 CNV gain 19166990
nsv519899 CNV gain 19592680
nsv525026 CNV loss 19592680
nsv587362 CNV gain 21841781
nsv587363 CNV gain 21841781
nsv587364 CNV gain 21841781
nsv819990 CNV loss 19587683
nsv828862 CNV loss 20364138
nsv828863 CNV loss 20364138
nsv953353 CNV deletion 24416366

Variation tolerance for TIAM1 Gene

Residual Variation Intolerance Score: 11.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.44; 96.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TIAM1 Gene

Human Gene Mutation Database (HGMD)
TIAM1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TIAM1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIAM1 Gene

Disorders for TIAM1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for TIAM1 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lymphoma
  • lymphoid cancer
colorectal cancer
  • crc
wolf-hirschhorn syndrome
  • whs
amyotrophic lateral sclerosis 1
  • als1
- elite association - COSMIC cancer census association via MalaCards
Search TIAM1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TIAM1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TIAM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TIAM1 Gene

Publications for TIAM1 Gene

  1. The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesion. (PMID: 20361982) Shepherd TR … Fuentes EJ (Journal of molecular biology 2010) 3 4 23 56
  2. Tiam1-IRSp53 complex formation directs specificity of rac-mediated actin cytoskeleton regulation. (PMID: 15899863) Connolly BA … Buchsbaum RJ (Molecular and cellular biology 2005) 3 4 23 56
  3. The RacGEF Tiam1 inhibits migration and invasion of metastatic melanoma via a novel adhesive mechanism. (PMID: 15340013) Uhlenbrock K … Ahmadian MR (Journal of cell science 2004) 2 3 23 56
  4. Localization of a human homolog of the mouse Tiam-1 gene to chromosome 21q22.1. (PMID: 8595894) Chen H … Antonarakis SE (Genomics 1995) 2 3 23 56
  5. Sequence of the human invasion-inducing TIAM1 gene, its conservation in evolution and its expression in tumor cell lines of different tissue origin. (PMID: 7731688) Habets GG … Collard JG (Oncogene 1995) 3 4 23 56

ExternalLinks

View latest publications for TIAM1 gene in Mastermind

Products for TIAM1 Gene

  • Addgene plasmids for TIAM1

Sources for TIAM1 Gene