Aliases for TIAL1 Gene
External Ids for TIAL1 Gene
Previous GeneCards Identifiers for TIAL1 Gene
The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing. [provided by RefSeq, Jul 2008]
GeneCards Summary for TIAL1 Gene
TIAL1 (TIA1 Cytotoxic Granule Associated RNA Binding Protein Like 1) is a Protein Coding gene. Diseases associated with TIAL1 include Salpingitis Isthmica Nodosa and Ulcerative Blepharitis. Among its related pathways are Signaling by GPCR and Signaling by FGFR2. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is TIA1.
UniProtKB/Swiss-Prot Summary for TIAL1 Gene
RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.