The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have... See more...

Aliases for TIAL1 Gene

Aliases for TIAL1 Gene

  • TIA1 Cytotoxic Granule Associated RNA Binding Protein Like 1 2 3 5
  • Nucleolysin TIAR 3 4
  • TIA1 Related 2 3
  • TIAR 2 3
  • TIA1 Cytotoxic Granule-Associated RNA-Binding Protein-Like 1 2
  • Aging-Associated Gene 7 Protein 3
  • T-Cluster Binding Protein 3
  • TIA-1-Related Nucleolysin 3
  • TIA-1-Related Protein 4
  • TIAL1 5
  • TCBP 3

External Ids for TIAL1 Gene

Previous GeneCards Identifiers for TIAL1 Gene

  • GC10M120253
  • GC10M120578
  • GC10M121466
  • GC10M120999
  • GC10M121324
  • GC10M114963

Summaries for TIAL1 Gene

Entrez Gene Summary for TIAL1 Gene

  • The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing. [provided by RefSeq, Jul 2008]

GeneCards Summary for TIAL1 Gene

TIAL1 (TIA1 Cytotoxic Granule Associated RNA Binding Protein Like 1) is a Protein Coding gene. Diseases associated with TIAL1 include Salpingitis Isthmica Nodosa and Ulcerative Blepharitis. Among its related pathways are Signaling by GPCR and Signaling by FGFR2. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is TIA1.

UniProtKB/Swiss-Prot Summary for TIAL1 Gene

  • RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.

Gene Wiki entry for TIAL1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TIAL1 Gene

Genomics for TIAL1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TIAL1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TIAL1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TIAL1

Top Transcription factor binding sites by QIAGEN in the TIAL1 gene promoter:
  • c-Myb
  • C/EBPalpha
  • CHOP-10
  • FOXJ2 (long isoform)
  • GR
  • GR-alpha
  • GR-beta
  • Meis-1
  • Meis-1a
  • Meis-1b

Genomic Locations for TIAL1 Gene

Latest Assembly
chr10:119,571,802-119,598,841
(GRCh38/hg38)
Size:
27,040 bases
Orientation:
Minus strand

Previous Assembly
chr10:121,332,977-121,356,476
(GRCh37/hg19 by Entrez Gene)
Size:
23,500 bases
Orientation:
Minus strand

chr10:121,334,199-121,356,541
(GRCh37/hg19 by Ensembl)
Size:
22,343 bases
Orientation:
Minus strand

Genomic View for TIAL1 Gene

Genes around TIAL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIAL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIAL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIAL1 Gene

Proteins for TIAL1 Gene

  • Protein details for TIAL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01085-TIAR_HUMAN
    Recommended name:
    Nucleolysin TIAR
    Protein Accession:
    Q01085
    Secondary Accessions:
    • A8K3T0
    • A8K4L9

    Protein attributes for TIAL1 Gene

    Size:
    375 amino acids
    Molecular mass:
    41591 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for TIAL1 Gene

    Alternative splice isoforms for TIAL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TIAL1 Gene

Post-translational modifications for TIAL1 Gene

  • Phosphorylated by MAPK14 following DNA damage, releasing TIAR from GADD45A mRNA.
  • Ubiquitination at Lys122 and Lys203
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TIAL1 Gene

Domains & Families for TIAL1 Gene

Gene Families for TIAL1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TIAL1 Gene

InterPro:
Blocks:
  • RNA-binding region RNP-1 (RNA recognition motif)

Suggested Antigen Peptide Sequences for TIAL1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ75459 (A8K4L9_HUMAN)
  • TIA1 cytotoxic granule-associated RNA binding protein-like 1, isoform CRA_a (O15187_HUMAN)
  • TIA-1-related protein (TIAR_HUMAN)
genes like me logo Genes that share domains with TIAL1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TIAL1 Gene

Function for TIAL1 Gene

Molecular function for TIAL1 Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.

Phenotypes From GWAS Catalog for TIAL1 Gene

Gene Ontology (GO) - Molecular Function for TIAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding IEA,HDA 22658674
GO:0005515 protein binding IPI --
genes like me logo Genes that share ontologies with TIAL1: view
genes like me logo Genes that share phenotypes with TIAL1: view

Animal Models for TIAL1 Gene

MGI Knock Outs for TIAL1:
  • Tial1 Tial1<tm1b(EUCOMM)Wtsi>
  • Tial1 Tial1<tm1Mst>

miRNA for TIAL1 Gene

miRTarBase miRNAs that target TIAL1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TIAL1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TIAL1 Gene

Localization for TIAL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIAL1 Gene

Cytoplasm. Nucleus. Cytoplasmic granule. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granules (By similarity). Cytoplasmic granules of cytolytic T-lymphocytes. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TIAL1 gene
Compartment Confidence
nucleus 5
lysosome 4
cytosol 3
extracellular 2
cytoskeleton 2
endoplasmic reticulum 2
plasma membrane 1
mitochondrion 1
peroxisome 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TIAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,ISS --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm ISS --
GO:0005764 lysosome TAS 1326761
GO:0010494 cytoplasmic stress granule ISS --
genes like me logo Genes that share ontologies with TIAL1: view

Pathways & Interactions for TIAL1 Gene

genes like me logo Genes that share pathways with TIAL1: view

Pathways by source for TIAL1 Gene

SIGNOR curated interactions for TIAL1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for TIAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II TAS 9207209
GO:0006915 apoptotic process TAS,IEA --
GO:0006952 defense response TAS 1326761
GO:0008543 fibroblast growth factor receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with TIAL1: view

Drugs & Compounds for TIAL1 Gene

(3) Drugs for TIAL1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for TIAL1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TIAL1: view

Transcripts for TIAL1 Gene

mRNA/cDNA for TIAL1 Gene

8 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TIAL1

Alternative Splicing Database (ASD) splice patterns (SP) for TIAL1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - -
SP6: - -
SP7: -
SP8: - -
SP9: -
SP10:
SP11:
SP12:

ExUns: 16a · 16b · 16c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for TIAL1 Gene

GeneLoc Exon Structure for
TIAL1

Expression for TIAL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TIAL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TIAL1 Gene

This gene is overexpressed in Bone (10.5) and Peripheral blood mononuclear cells (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TIAL1 Gene



Protein tissue co-expression partners for TIAL1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TIAL1

SOURCE GeneReport for Unigene cluster for TIAL1 Gene:

Hs.501203

Evidence on tissue expression from TISSUES for TIAL1 Gene

  • Lung(4.5)
  • Nervous system(3.7)
  • Skin(2.6)
  • Kidney(2.6)
  • Blood(2.5)
  • Intestine(2.5)
  • Stomach(2.4)
  • Muscle(2.3)
  • Lymph node(2.3)
  • Bone marrow(2.3)
  • Spleen(2.2)
  • Heart(2.2)
  • Liver(2.2)
  • Thyroid gland(2.1)
genes like me logo Genes that share expression patterns with TIAL1: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TIAL1 Gene

Orthologs for TIAL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TIAL1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TIAL1 29 30
  • 99.74 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TIAL1 30
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia TIAL1 29 30
  • 97.28 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TIAL1 29 30
  • 95.56 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TIAL1 30
  • 95 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tial1 29
  • 94.98 (n)
Mouse
(Mus musculus)
Mammalia Tial1 29 16 30
  • 94.81 (n)
OneToOne
Chicken
(Gallus gallus)
Aves TIAR 30
  • 98 (a)
OneToOne
TIA1 29
  • 87.89 (n)
Lizard
(Anolis carolinensis)
Reptilia TIAL1 30
  • 92 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia tial1-A-prov 29
Zebrafish
(Danio rerio)
Actinopterygii tial1 29 30
  • 76.4 (n)
OneToOne
zgc66130 29
Fruit Fly
(Drosophila melanogaster)
Insecta CG4787 31
  • 62 (a)
Rox8 29 30
  • 55.84 (n)
ManyToMany
CG34354 30
  • 30 (a)
ManyToMany
CG34362 30
  • 20 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002335 29
  • 54.47 (n)
Worm
(Caenorhabditis elegans)
Secernentea C18A3.5a 31
  • 51 (a)
C07A4.1 31
  • 46 (a)
C18A3.5b 31
  • 44 (a)
Y46G5A.13 31
  • 44 (a)
tiar-1 30
  • 39 (a)
ManyToMany
tiar-2 30
  • 34 (a)
ManyToMany
tiar-3 30
  • 26 (a)
ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PUB1 30
  • 26 (a)
OneToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons UBP1B 29
  • 52.01 (n)
Rice
(Oryza sativa)
Liliopsida Os11g0620100 29
  • 53.14 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.8430 30
  • 48 (a)
ManyToMany
-- 30
  • 30 (a)
ManyToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.5046 29
Species where no ortholog for TIAL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for TIAL1 Gene

ENSEMBL:
Gene Tree for TIAL1 (if available)
TreeFam:
Gene Tree for TIAL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TIAL1: view image
Alliance of Genome Resources:
Additional Orthologs for TIAL1

Paralogs for TIAL1 Gene

(22) SIMAP similar genes for TIAL1 Gene using alignment to 6 proteins:

  • TIAR_HUMAN
  • A6NKZ9_HUMAN
  • E7ETC0_HUMAN
  • E7ETJ9_HUMAN
  • O15187_HUMAN
  • Q49AS9_HUMAN

Pseudogenes.org Pseudogenes for TIAL1 Gene

genes like me logo Genes that share paralogs with TIAL1: view

Variants for TIAL1 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TIAL1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TIAL1 Gene

Variant ID Type Subtype PubMed ID
nsv1044497 CNV gain 25217958
nsv552215 CNV loss 21841781

Variation tolerance for TIAL1 Gene

Residual Variation Intolerance Score: 27.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.14; 3.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TIAL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TIAL1
Leiden Open Variation Database (LOVD)
TIAL1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TIAL1 Gene

Disorders for TIAL1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TIAL1 Gene - From: COP and GCD

- elite association - COSMIC cancer census association via MalaCards
Search TIAL1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TIAL1

genes like me logo Genes that share disorders with TIAL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TIAL1 Gene

Publications for TIAL1 Gene

  1. Identification and functional characterization of a TIA-1-related nucleolysin. (PMID: 1326761) Kawakami A … Anderson P (Proceedings of the National Academy of Sciences of the United States of America 1992) 2 3 4 22
  2. DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization. (PMID: 20932473) Reinhardt HC … Yaffe MB (Molecular cell 2010) 3 4
  3. A systematic analysis of intronic sequences downstream of 5' splice sites reveals a widespread role for U-rich motifs and TIA1/TIAL1 proteins in alternative splicing regulation. (PMID: 18456862) Aznarez I … Blencowe BJ (Genome research 2008) 3 22
  4. Competitive binding of AUF1 and TIAR to MYC mRNA controls its translation. (PMID: 17486099) Liao B … Brewer G (Nature structural & molecular biology 2007) 3 22
  5. Elucidation of a C-rich signature motif in target mRNAs of RNA-binding protein TIAR. (PMID: 17682065) Kim HS … Wilce JA (Molecular and cellular biology 2007) 3 22

Products for TIAL1 Gene

Sources for TIAL1 Gene