Aliases for TIA1 Gene
External Ids for TIA1 Gene
Previous GeneCards Identifiers for TIA1 Gene
The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms has been found for this gene. [provided by RefSeq, May 2017]
GeneCards Summary for TIA1 Gene
TIA1 (TIA1 Cytotoxic Granule Associated RNA Binding Protein) is a Protein Coding gene. Diseases associated with TIA1 include Welander Distal Myopathy and Amyotrophic Lateral Sclerosis 26 With Or Without Frontotemporal Dementia. Among its related pathways are Signaling by GPCR and IL-10 Pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is TIAL1.
UniProtKB/Swiss-Prot Summary for TIA1 Gene
Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.