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The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms has been found for this gene. [provided by RefSeq, May 2017]
TIA1 (TIA1 Cytotoxic Granule Associated RNA Binding Protein) is a Protein Coding gene. Diseases associated with TIA1 include Welander Distal Myopathy and Peripheral T-Cell Lymphoma. Among its related pathways are Signaling by GPCR and Signaling by FGFR2. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is TIAL1.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH02J070246 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE CraniofacialAtlas | 610.5 | +1.1 | 1092 | 4.6 | HNRNPL GATAD2A TEAD4 PRDM10 REST ZNF512 LEF1 SOX13 IKZF1 POLR2A | TIA1 C2orf42 lnc-C2orf42-4 TRG-CCC2-1 FAM136A MPHOSPH10 CLEC4F PCBP1-AS1 GMCL1 TEX261 | |
GH02J070236 | Promoter | 0.3 | EPDnew | 600.4 | +12.7 | 12700 | 0.1 | TIA1 lnc-SNRPG-1 C2orf42 lnc-C2orf42-4 PCBP1 | ||
GH02J070227 | Promoter | 0.3 | EPDnew | 600.4 | +21.0 | 21040 | 0.1 | lnc-SNRPG-1 TIA1 MXD1 SNRNP27 lnc-PCYOX1-4 C2orf42 lnc-C2orf42-4 PCBP1 | ||
GH02J070225 | Promoter | 0.3 | EPDnew | 600.4 | +23.4 | 23363 | 0.1 | TIA1 SNRNP27 MXD1 lnc-SNRPG-1 lnc-PCYOX1-4 C2orf42 lnc-C2orf42-4 PCBP1 | ||
GH02J070224 | Promoter | 0.3 | EPDnew | 600.4 | +24.2 | 24189 | 0.1 | TIA1 SNRNP27 MXD1 lnc-SNRPG-1 lnc-PCYOX1-4 C2orf42 lnc-C2orf42-4 PCBP1 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003723 | RNA binding | IEA,HDA | 22658674 |
GO:0005515 | protein binding | IPI | 7544399 |
GO:0008143 | poly(A) binding | TAS | 1934064 |
GO:0035925 | mRNA 3'-UTR AU-rich region binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | IDA | 24965446 |
GO:0005829 | cytosol | IDA | -- |
GO:0010494 | cytoplasmic stress granule | ISS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by FGFR2 | ||
2 | Apoptosis and Autophagy | ||
3 | Translational Control | ||
4 | IL-10 Pathway |
IL-10 Pathway
-
|
|
5 | HIV Transcription Elongation |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006915 | apoptotic process | TAS,IEA | -- |
GO:0008543 | fibroblast growth factor receptor signaling pathway | TAS | -- |
GO:0017148 | negative regulation of translation | IEA | -- |
GO:0042036 | negative regulation of cytokine biosynthetic process | IEA | -- |
GO:0048024 | regulation of mRNA splicing, via spliceosome | IDA | 11106748 |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12a | · |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP11: |
ExUns: | 12b | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · | 15b | · | 15c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||
SP2: | - | ||||||||||||
SP3: | |||||||||||||
SP4: | |||||||||||||
SP5: | |||||||||||||
SP6: | |||||||||||||
SP7: | - | ||||||||||||
SP8: | |||||||||||||
SP9: | |||||||||||||
SP10: | |||||||||||||
SP11: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TIA1 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | TIA1 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | TIA1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | TIA1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Tia1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Tia1 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | TIA1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | TIA1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tia1 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | tia1l 31 |
|
ManyToMany | |
tia1 30 31 |
|
ManyToMany | |||
Dr.4576 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG4787 32 |
|
|
|
Rox8 31 |
|
ManyToMany | |||
CG34354 31 |
|
ManyToMany | |||
CG34362 31 |
|
ManyToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | C18A3.5a 32 |
|
|
|
C18A3.5b 32 |
|
|
|||
C07A4.1 32 |
|
|
|||
Y46G5A.13 32 |
|
|
|||
tiar-1 31 |
|
ManyToMany | |||
tiar-2 31 |
|
ManyToMany | |||
tiar-3 31 |
|
ManyToMany | |||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PUB1 30 31 |
|
OneToMany | |
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E08779g 30 |
|
||
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AGR390C 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.8430 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
Bread mold (Neurospora crassa) |
Ascomycetes | NCU07874 30 |
|
SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
647155 | Uncertain Significance: Welander distal myopathy | 70,236,181(-) | A/T | INTRON_VARIANT | |
651295 | Uncertain Significance: Welander distal myopathy | 70,212,802(-) | C/T | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT | |
656197 | Uncertain Significance: Welander distal myopathy | 70,229,258(-) | A/ACTT | INTRON_VARIANT | |
656352 | Uncertain Significance: Welander distal myopathy | 70,215,489(-) | T/A | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT | |
702253 | Benign: not provided | 70,236,172(-) | G/A | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
welander distal myopathy |
|
|
peripheral t-cell lymphoma |
|
|
aggressive nk-cell leukemia |
|
|
panniculitis |
|
|
lymphocytic gastritis |
|
|