This gene encodes a protein that is highly conserved among vertebrates and plant species and may be involved in the induction of apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] See more...

Aliases for THYN1 Gene

Aliases for THYN1 Gene

  • Thymocyte Nuclear Protein 1 2 3 4 5
  • THY28 2 3 4
  • Thymocyte Protein Thy28 3 4
  • HSPC144 3
  • THY28KD 3
  • MDS012 3
  • MY105 3
  • THYN1 5

External Ids for THYN1 Gene

Previous GeneCards Identifiers for THYN1 Gene

  • GC11M133624
  • GC11M134118
  • GC11M130072

Summaries for THYN1 Gene

Entrez Gene Summary for THYN1 Gene

  • This gene encodes a protein that is highly conserved among vertebrates and plant species and may be involved in the induction of apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for THYN1 Gene

THYN1 (Thymocyte Nuclear Protein 1) is a Protein Coding gene. Diseases associated with THYN1 include Myh-9 Related Disease and Jacobsen Syndrome.

UniProtKB/Swiss-Prot Summary for THYN1 Gene

  • Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

Gene Wiki entry for THYN1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for THYN1 Gene

Genomics for THYN1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for THYN1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around THYN1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for THYN1

Top Transcription factor binding sites by QIAGEN in the THYN1 gene promoter:
  • AhR
  • AML1a
  • Arnt
  • CREB
  • Evi-1
  • Pax-4a
  • RREB-1
  • TBP
  • TFIID

Genomic Locations for THYN1 Gene

Latest Assembly
chr11:134,248,279-134,253,370
(GRCh38/hg38)
Size:
5,092 bases
Orientation:
Minus strand

Previous Assembly
chr11:134,118,176-134,123,246
(GRCh37/hg19 by Entrez Gene)
Size:
5,071 bases
Orientation:
Minus strand

chr11:134,118,173-134,123,264
(GRCh37/hg19 by Ensembl)
Size:
5,092 bases
Orientation:
Minus strand

Genomic View for THYN1 Gene

Genes around THYN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THYN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THYN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THYN1 Gene

Proteins for THYN1 Gene

  • Protein details for THYN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P016-THYN1_HUMAN
    Recommended name:
    Thymocyte nuclear protein 1
    Protein Accession:
    Q9P016
    Secondary Accessions:
    • Q567Q2
    • Q9H3L4
    • Q9HC20

    Protein attributes for THYN1 Gene

    Size:
    225 amino acids
    Molecular mass:
    25697 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for THYN1 Gene

    Alternative splice isoforms for THYN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for THYN1 Gene

Post-translational modifications for THYN1 Gene

No data available for DME Specific Peptides for THYN1 Gene

Domains & Families for THYN1 Gene

Gene Families for THYN1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for THYN1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for THYN1 Gene

GenScript: Design optimal peptide antigens:
  • Thymocyte protein Thy28 (THYN1_HUMAN)
genes like me logo Genes that share domains with THYN1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for THYN1 Gene

Function for THYN1 Gene

Molecular function for THYN1 Gene

UniProtKB/Swiss-Prot Function:
Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

Phenotypes From GWAS Catalog for THYN1 Gene

genes like me logo Genes that share phenotypes with THYN1: view

Animal Models for THYN1 Gene

MGI Knock Outs for THYN1:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for THYN1

Clone products for research

  • Addgene plasmids for THYN1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for THYN1 Gene

Localization for THYN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for THYN1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for THYN1 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (3)
  • Nucleoplasm (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for THYN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS 14601557
genes like me logo Genes that share ontologies with THYN1: view

Pathways & Interactions for THYN1 Gene

PathCards logo

SuperPathways for THYN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for THYN1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for THYN1 Gene

Drugs & Compounds for THYN1 Gene

No Compound Related Data Available

Transcripts for THYN1 Gene

mRNA/cDNA for THYN1 Gene

5 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for THYN1

Clone products for research

  • Addgene plasmids for THYN1

Alternative Splicing Database (ASD) splice patterns (SP) for THYN1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - -
SP5: - - - -
SP6: - -
SP7:
SP8:

Relevant External Links for THYN1 Gene

GeneLoc Exon Structure for
THYN1

Expression for THYN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for THYN1 Gene

Protein differential expression in normal tissues from HIPED for THYN1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.4) and Uterus (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for THYN1 Gene



Protein tissue co-expression partners for THYN1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for THYN1

SOURCE GeneReport for Unigene cluster for THYN1 Gene:

Hs.13645

Evidence on tissue expression from TISSUES for THYN1 Gene

  • Nervous system(4.7)
  • Liver(4.4)
  • Blood(4.4)
genes like me logo Genes that share expression patterns with THYN1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for THYN1 Gene

Orthologs for THYN1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for THYN1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia THYN1 30 31
  • 99.7 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia THYN1 30 31
  • 85.56 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Thyn1 30
  • 84.89 (n)
Mouse
(Mus musculus)
Mammalia Thyn1 30 17 31
  • 84.15 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia THYN1 31
  • 72 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia THYN1 31
  • 69 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 66 (a)
OneToMany
-- 31
  • 61 (a)
OneToMany
Chicken
(Gallus gallus)
Aves THYN1 30 31
  • 68.18 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia THYN1 31
  • 65 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia thyn1 30
  • 72.29 (n)
Str.9991 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.19690 30
Zebrafish
(Danio rerio)
Actinopterygii thyn1 30 31
  • 68.93 (n)
OneToOne
zgc66269 30
Bread mold
(Neurospora crassa)
Ascomycetes NCU05893 30
  • 50.58 (n)
Species where no ortholog for THYN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for THYN1 Gene

ENSEMBL:
Gene Tree for THYN1 (if available)
TreeFam:
Gene Tree for THYN1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for THYN1: view image

Paralogs for THYN1 Gene

No data available for Paralogs for THYN1 Gene

Variants for THYN1 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for THYN1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for THYN1 Gene

Variant ID Type Subtype PubMed ID
esv3892114 CNV gain 25118596
nsv521581 CNV gain 19592680
nsv556598 CNV loss 21841781
nsv832299 CNV loss 17160897

Variation tolerance for THYN1 Gene

Residual Variation Intolerance Score: 37.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.73; 15.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for THYN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
THYN1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for THYN1 Gene

Disorders for THYN1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for THYN1 Gene - From: COP

Disorder Aliases PubMed IDs
myh-9 related disease
  • myh9-related disorders
jacobsen syndrome
  • jbs
- elite association - COSMIC cancer census association via MalaCards
Search THYN1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for THYN1

genes like me logo Genes that share disorders with THYN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for THYN1 Gene

Publications for THYN1 Gene

  1. Determining the DUF55-domain structure of human thymocyte nuclear protein 1 from crystals partially twinned by tetartohedry. (PMID: 19237743) Yu F … He J (Acta crystallographica. Section D, Biological crystallography 2009) 3 4 23
  2. Identification, expression, and purification of a unique stable domain from human HSPC144 protein. (PMID: 15939300) Song AX … Hu HY (Protein expression and purification 2005) 3 4 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Anti-IgM-induced down-regulation of nuclear Thy28 protein expression in Ramos B lymphoma cells. (PMID: 14601557) Jiang XZ … Mizuguchi J (Apoptosis : an international journal on programmed cell death 2003) 2 3
  5. Molecular cloning and characterization of the mouse thymocyte protein gene. (PMID: 12384300) Miyaji H … Mizuguchi J (Gene 2002) 2 3

Products for THYN1 Gene

Sources for THYN1 Gene