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This gene encodes a cell surface glycoprotein and member of the immunoglobulin superfamily of proteins. The encoded protein is involved in cell adhesion and cell communication in numerous cell types, but particularly in cells of the immune and nervous systems. The encoded protein is widely used as a marker for hematopoietic stem cells. This gene may function as a tumor suppress... See more...
Aliases for THY1 Gene
Aliases for THY1 Gene
External Ids for THY1 Gene
- HGNC: 11801
- NCBI Entrez Gene: 7070
- Ensembl: ENSG00000154096
- OMIM®: 188230
- UniProtKB/Swiss-Prot: P04216
Previous GeneCards Identifiers for THY1 Gene
- GC11M121288
- GC11M120800
- GC11M119322
- GC11M118826
- GC11M118795
- GC11M119288
- GC11M115230
Summaries for THY1 Gene
-
This gene encodes a cell surface glycoprotein and member of the immunoglobulin superfamily of proteins. The encoded protein is involved in cell adhesion and cell communication in numerous cell types, but particularly in cells of the immune and nervous systems. The encoded protein is widely used as a marker for hematopoietic stem cells. This gene may function as a tumor suppressor in nasopharyngeal carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
GeneCards Summary for THY1 Gene
THY1 (Thy-1 Cell Surface Antigen) is a Protein Coding gene. Diseases associated with THY1 include Central Retinal Artery Occlusion and Mesangial Proliferative Glomerulonephritis. Among its related pathways are IL4-mediated signaling events and Innate Lymphoid Cell Differentiation Pathways. Gene Ontology (GO) annotations related to this gene include protein kinase binding and GTPase activator activity.
UniProtKB/Swiss-Prot Summary for THY1 Gene
-
May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.
Additional gene information for THY1 Gene
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for THY1 Gene
Genomics for THY1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for THY1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around THY1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for THY1
- Top Transcription factor binding sites by QIAGEN in the THY1 gene promoter:
-
- AP-1
- ATF-2
- c-Fos
- c-Jun
- GR-beta
- p53
- STAT3
Genomic Locations for THY1 Gene
Latest Assembly
- chr11:119,415,476-119,424,985
- (GRCh38/hg38)
- Size:
- 9,510 bases
- Orientation:
- Minus strand
Previous Assembly
- chr11:119,286,186-119,295,695
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 9,510 bases
- Orientation:
- Minus strand
Genomic View for THY1 Gene
Genes around THY1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q23.3 by HGNC
- 11q23.3 by Entrez Gene
- 11q23.3 by Ensembl
THY1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for THY1 Gene
Proteins for THY1 Gene
-
Protein details for THY1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P04216-THY1_HUMAN
- Recommended name:
- Thy-1 membrane glycoprotein
- Protein Accession:
- P04216
- Q16008
- Q9NSP1
Protein attributes for THY1 Gene
- Size:
- 161 amino acids
- Molecular mass:
- 17935 Da
- Quaternary structure:
- No Data Available
Protein Expression for THY1 Gene
Post-translational modifications for THY1 Gene
Other Protein References for THY1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences THY1 / CD90 Monoclonal Antibody (LS-B3139) and THY1 / CD90 Monoclonal Antibody (LS-B11449)
- NSJ Bioreagents CD90 Antibody / Thy1 (Rabbit Monoclonal)
-
BioLegend
- CD90 (Thy1) Antibody (328107)
- CD90 (Thy1) Antibody (328114)
- CD90 (Thy1) Antibody (328106)
- CD90 (Thy1) Antibody (328108)
- CD90 (Thy1) Antibody (328113)
- CD90 (Thy1) Antibody (328110)
- CD90 (Thy1) Antibody (328112)
- CD90 (Thy1) Antibody (328116)
- CD90 (Thy1) Antibody (328111)
- CD90 (Thy1) Antibody (328109)
- CD90 (Thy1) Antibody (328102)
- CD90 (Thy1) Antibody (328101)
- PerCP/Cyanine5.5 CD90 (Thy1) Antibody (328117)
- PerCP/Cyanine5.5 CD90 (Thy1) Antibody (328118)
- CD90 (Thy1) Antibody (328115)
- CD90 (Thy1) Antibody (328119)
- CD90 (Thy1) Antibody (328120)
- CD90 (Thy1) Antibody (328121)
- CD90 (Thy1) Antibody (328122)
- CD90 (Thy1) Antibody (328124)
- CD90 (Thy1) Antibody (328123)
- CD90 (Thy1) Antibody (328128)
- CD90 (Thy1) Antibody (328125)
- CD90 (Thy1) (MaxPar(R) Ready) Antibody
- CD90 (Thy1) Antibody (328126)
- APC/Cyanine7 CD90 (Thy1) Antibody (328132)
- CD90 (Thy1) Antibody (328133)
- CD90 (Thy1) Antibody (328134)
- APC/Cyanine7 CD90 (Thy1) Antibody (328131)
- CD90 (Thy1) Antibody (328140)
- CD90 (Thy1) Antibody (328141)
- CD90 (Thy1) Antibody (328142)
- CD90 (Thy1) Antibody (328143)
- CD90 (Thy1) Antibody (328144)
- APC/Fire(TM) 750 CD90 (Thy1) Antibody (328137)
- CD90 (Thy1) Antibody (328139)
- APC/Fire(TM) 750 CD90 (Thy1) Antibody (328138)
- TotalSeq(TM)-A0060 CD90 (Thy1) Antibody
-
Custom Antibody ServicesOriGene Antibodies for THY1
- AM05504PU-N
- AM05504PU-T
- AM08054AC-N
- AM08054BT-N
- AM08054FC-N
- AM08054FC-S
- AM08054LE-N
- AM08054PU-N
- AM08054RP-N
- AM08055AC-N
- AM08055BT-N
- AM08055FC-N
- AM08055FC-S
- AM08055LE-N
- AM08055PU-N
- AM08055RP-N
- AM08055RP-S
- AM31867BT-L
- AM31867BT-N
- AM31867FC-L
- AM31867FC-N
- AM31867PU-N
- AM31867RP-L
- AM31867RP-N
- AM32319PU-N
- AM39071SU-N
- AP11926PU-N
- AP31642SU-N
- AP31644SU-L
- AP31644SU-N
- CL037
- CL037P
- CL037PS
- CL039
- CL039APC
- CL039B
- CL039BX
- CL039F
- CL039FX
- CL039P
- CL039R
- CL039RX
- CL039S
- SM049F
- SM049FS
- SM049FT
- SM049LE
- SM049P
- SM049PS
- SM049PT
- SM049PX
- SM049R
- SM1170A
- SM1170F
- SM1170FT
- SM1170P
- SM1170PT
- SM1170R
- SM1170RT
- SM2128P
- SM2128PT
- SM3158A
- SM3158R
- TA305663
- TA312308
- TA318204
- TA318808
- TA320475
- TA321756
- TA327285
- TA350842
- TA353507L
- Novus Biologicals Antibodies for THY1
-
Abcam antibodies for THY1
- Invitrogen Antibodies for THY1 (AFLGC-Thy1)
- antibodies-online: Show 334 available CD90 Antibodies ranked by validation data
- Compare Top CD90 Antibodies
-
Recommended
- 152 WB Antibodies (anti-human)
- 110 FACS Antibodies (anti-human)
- 70 IF Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 22 IP Antibodies (anti-human)
- 14 IHC Antibodies (anti-human)
- 9 IHC (p) Antibodies (anti-human)
- 7 IHC (fro) Antibodies (anti-human)
- 2 ICFC Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 61 WB Antibodies (anti-rat)
- 46 FACS Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 8 IHC (fro) Antibodies (anti-rat)
- 4 CyTox Antibodies (anti-rat)
- 4 IHC Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- 1 IF Antibody (anti-rat)
- 1 IHC (zinc) Antibody (anti-rat)
- 1 IP Antibody (anti-rat)
- 168 FACS Antibodies (anti-mouse)
- 67 WB Antibodies (anti-mouse)
- 36 IHC (fro) Antibodies (anti-mouse)
- 15 IHC Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 9 CyTox Antibodies (anti-mouse)
- 6 ICC Antibodies (anti-mouse)
- 6 IF Antibodies (anti-mouse)
- 4 IHC (p) Antibodies (anti-mouse)
- 4 IP Antibodies (anti-mouse)
- 4 in vitro Antibodies (anti-mouse)
- 3 IHC (zinc) Antibodies (anti-mouse)
- 2 IC Antibodies (anti-mouse)
- 2 ISt Antibodies (anti-mouse)
-
Boster Bio Antibodies for THY1
-
Custom Antibody ServicesProSci Antibodies for THY1
- Thy-1 cell surface antigen [18-520]
- Thy-1 cell surface antigen [42-767]
- Thy-1 cell surface antigen [33-213]
- Thy-1 membrane glycoprotein [61-007]
- Thy-1 cell surface antigen [76-066]
- Thy-1 cell surface antigen [76-067]
- Thy-1 cell surface antigen [76-068]
- Thy-1 cell surface antigen [76-069]
- thymus cell antigen 1, theta [76-070]
- thymus cell antigen 1, theta [76-071]
- thymus cell antigen 1, theta [76-072]
- thymus cell antigen 1, theta [76-073]
- thymus cell antigen 1, theta [76-074]
- thymus cell antigen 1, theta [76-075]
- thymus cell antigen 1, theta [76-076]
- thymus cell antigen 1, theta [76-077]
- thymus cell antigen 1, theta [76-082]
- thymus cell antigen 1, theta [98-860]
- thymus cell antigen 1, theta [98-861]
- thymus cell antigen 1, theta [98-862]
- thymus cell antigen 1, theta [98-863]
- thymus cell antigen 1, theta [98-864]
- thymus cell antigen 1, theta [98-865]
- thymus cell antigen 1, theta [98-866]
- thymus cell antigen 1, theta [98-867]
- thymus cell antigen 1, theta [98-868]
- thymus cell antigen 1, theta [98-869]
- thymus cell antigen 1, theta [98-870]
- thymus cell antigen 1, theta [98-871]
- thymus cell antigen 1, theta [98-872]
- thymus cell antigen 1, theta [98-873]
-
Santa Cruz Biotechnology (SCBT) Antibodies for THY1
- Sino Biological Antibodies for THY1
Protein products for research
- RayBiotech Recombinant Human Thy-1
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for THY1
- Origene Custom Protein Services for THY1
- Novus Biologicals proteins for THY1
- Sino Biological Cell Lysates for THY1
- Sino Biological Recombinant Proteins for THY1
- ProSpec Recombinant Proteins for THY1
-
Abcam proteins for THY1
Assay products for research
- G Biosciences Immunotagā¢ Thy-1 membrane glycoprotein ELISA Kit
- antibodies-online: Show 27 available CD90 Elisa Kits ranked by validation data
- Compare Top CD90 Elisa Kits
-
Quality Products:
- ABIN853147
- ABIN417633
- ABIN1572717
- ABIN456520
- ABIN5592496
- ABIN5659198
- ABIN2539556
- ABIN4973277
- ABIN6206804
- ABIN424807
- ABIN1572718
- ABIN853148
- ABIN5659199
- ABIN2539557
- ABIN4973278
- ABIN6206805
- ABIN6730258
- ABIN1161733
- ABIN432102
- ABIN1572719
- ABIN853149
- ABIN5659200
- ABIN2539558
- ABIN4973276
- ABIN6206806
- ABIN1161734
No data available for DME Specific Peptides for THY1 Gene
Domains & Families for THY1 Gene
Gene Families for THY1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- CD markers
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for THY1 Gene
- InterPro:
- Blocks:
-
- Immunoglobulin subtype
Suggested Antigen Peptide Sequences for THY1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ33677 fis, clone BRAWH2002125, highly similar to THY-1 MEMBRANE GLYCOPROTEIN (B0YJA4_HUMAN)
- cDNA, FLJ94676, Homo sapiens Thy-1 co-transcribed (LOC94105), mRNA (Q9HBB0_HUMAN)
- Thy-1 antigen (THY1_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for THY1 Gene
Function for THY1 Gene
Molecular function for THY1 Gene
- UniProtKB/Swiss-Prot Function:
- May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.
- GENATLAS Biochemistry:
- Thy-1 cell surface antigen
Phenotypes From GWAS Catalog for THY1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005096 | GTPase activator activity | IEA,ISS | -- |
| GO:0005178 | integrin binding | IEA,IPI | 15004192 |
| GO:0005515 | protein binding | IPI | 7513706 |
| GO:0019899 | enzyme binding | IEA | -- |
| GO:0019901 | protein kinase binding | IEA,IBA | 21873635 |
Phenotypes for THY1 Gene
- MGI mutant phenotypes for THY1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for THY1:
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for THY1 - Starting at $85 >
- * THY1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for THY1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for THY1
-
Santa Cruz Biotechnology (SCBT) CRISPR for THY1
miRNA for THY1 Gene
- miRTarBase miRNAs that target THY1
-
- hsa-miR-1-3p (MIRT024103)
- hsa-miR-1228-5p (MIRT490392)
- hsa-miR-139-3p (MIRT490393)
- hsa-miR-4781-5p (MIRT490394)
- hsa-miR-4706 (MIRT490395)
- hsa-miR-519d-3p (MIRT490396)
- hsa-miR-6836-3p (MIRT490397)
- hsa-miR-6825-5p (MIRT490398)
- hsa-miR-6729-5p (MIRT490399)
- hsa-miR-4649-5p (MIRT490400)
- hsa-miR-7106-5p (MIRT490401)
- hsa-miR-766-5p (MIRT490402)
- hsa-miR-6829-3p (MIRT490403)
- hsa-miR-6778-3p (MIRT490404)
- hsa-miR-6791-3p (MIRT490405)
- hsa-miR-4685-3p (MIRT490406)
- hsa-miR-4287 (MIRT490407)
- hsa-miR-519e-3p (MIRT490408)
- hsa-miR-515-3p (MIRT490409)
- hsa-miR-33b-3p (MIRT490410)
- hsa-miR-1287-5p (MIRT737076)
- hsa-miR-3135b (MIRT740139)
- hsa-miR-3692-5p (MIRT742537)
- hsa-miR-4269 (MIRT743543)
- hsa-miR-4514 (MIRT745729)
- hsa-miR-4692 (MIRT747135)
- hsa-miR-486-3p (MIRT749135)
- hsa-miR-6715b-5p (MIRT753697)
- hsa-miR-6721-5p (MIRT753841)
- hsa-miR-6808-5p (MIRT756608)
- hsa-miR-6893-5p (MIRT758753)
- hsa-miR-940 (MIRT760849)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for THY1
- Browse OriGene Inhibitory RNA Products For THY1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for THY1
Clone products for research
- Applied Biological Materials (abm): Clones for THY1 - Starting at $45 >
- * THY1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for THY1
- Addgene plasmids for THY1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for THY1
Cell Lines for research
-
Horizon Cell Lines for THY1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for THY1 Gene
Localization for THY1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for THY1 Gene
- Cell membrane. Lipid-anchor, GPI-anchor.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| endoplasmic reticulum | 4 |
| cytoskeleton | 3 |
| nucleus | 3 |
| mitochondrion | 2 |
| endosome | 2 |
| cytosol | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
| peroxisome | 1 |
- Nucleoplasm (2)
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005783 | endoplasmic reticulum | IDA | -- |
| GO:0005829 | cytosol | IEA | -- |
| GO:0005886 | plasma membrane | IEA,TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 2864289 |
Pathways & Interactions for THY1 Gene
Pathways by source for THY1 Gene
3 BioSystems pathways for THY1 Gene
3 Reactome pathways for THY1 Gene
1 KEGG pathway for THY1 Gene
4 R&D Systems pathways for THY1 Gene
1 Qiagen pathway for THY1 Gene
- Transendothelial Migration of Leukocytes
1 Cell Signaling Technology pathway for THY1 Gene
Interacting Proteins for THY1 Gene
Selected Interacting proteins:
P04216-THY1_HUMAN
ENSP00000284240
for THY1 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for THY1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001525 | angiogenesis | IEA,ISS | -- |
| GO:0001952 | regulation of cell-matrix adhesion | IMP | 9749990 |
| GO:0002693 | positive regulation of cellular extravasation | IDA | 15004192 |
| GO:0006469 | negative regulation of protein kinase activity | IEA,ISS | -- |
| GO:0007010 | cytoskeleton organization | IEA,ISS | -- |
Drugs & Compounds for THY1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug products for research
- RayBiotech Recombinant Human Thy-1
Transcripts for THY1 Gene
mRNA/cDNA for THY1 Gene
- 4 REFSEQ mRNAs :
- 15 NCBI additional mRNA sequence :
- 10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000284240 4502 nts (view in UCSC)
- ENST00000524659 570 nts (view in UCSC)
- ENST00000524970 581 nts (view in UCSC)
- ENST00000527590 609 nts (view in UCSC)
- ENST00000528295 897 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for THY1 - Starting at $85 >
- * THY1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for THY1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for THY1
-
Santa Cruz Biotechnology (SCBT) CRISPR for THY1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for THY1
- Browse OriGene Inhibitory RNA Products For THY1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for THY1
Clone products for research
- Applied Biological Materials (abm): Clones for THY1 - Starting at $45 >
- * THY1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for THY1
- Addgene plasmids for THY1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for THY1
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9a | · | 9b | · | 9c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP6: | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP12: | - | - |
Relevant External Links for THY1 Gene
- GeneLoc Exon Structure for
- THY1
Expression for THY1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Mesenchymal Stem Cells
- Mesenchymal Stem Cells Zeugopod Periosteum
- Mesenchymal Stem Cells Cord Blood
- Mesenchymal Stem Cells Microvessels
- Bone Marrow Stromal Cells Pelvic Girdle
- Adventitial Reticular Cells Bone Marrow
-
Bone (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
- Mesenchymal Stem Cells Zeugopod Periosteum
- Adventitial Reticular Cells Bone Marrow
- Bone Marrow Stromal Cells Bone Marrow
- Bone marrow-derived mesenchymal stromal cells
- Umbilical Cord (Extraembryonic Tissues)
-
Blood (Hematopoietic System)
- Mesenchymal Stem Cells Cord Blood
- Basophils Peripheral Blood
- B-cell Progenitor Cells Peripheral Blood
- Hematopoietic Stem Cells Liver Bud
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
-
Adipose (Muscoskeletal System)
- Stromal Cells Subcutaneous White Adipose
- Mesenchymal Stem Cells Subcutaneous White Adipose
- Adipose-derived stem cells (Adipoplus)
- Adipose-derived mesenchymal stem cells combined with allograft bone (AlloStem)
- Adipose-derived stromal cells
-
Fibroblasts
- Dermal Fibroblasts Ventral Dermis
- Dermal Fibroblasts Cranial Dermis
- Cardiac Fibroblasts Myocardium
- Dermal Fibroblasts Dorsal Dermis
- SR1 Dermal Fibroblasts
- Placenta (Extraembryonic Tissues)
- Tooth (Integumentary System)
-
Dermis (Integumentary System)
- Dermal Fibroblasts Ventral Dermis
- Dermal Fibroblasts Cranial Dermis
- Dermal Fibroblasts Dorsal Dermis
- SR1 Dermal Fibroblasts
- BH2 Dermal Fibroblasts
- Inner Cell Mass (Early Embryonic Tissues)
-
Eye (Sensory Organs)
- Glycinergic Amacrine Cells Inner Nuclear Layer
- nGnG Amacrine Cells Inner Nuclear Layer
- Limbal epithelial stem cells
- Limbal epithelial stem cells (family)
- Human corneal endothelial cells
- Brain (Nervous System)
- NULL (Nervous System)
- Endothelium (Cardiovascular System)
- Heart (Cardiovascular System)
-
Epithelial Cells
- Basal Keratinocytes Embryonic Epidermis
- Amniotic Epithelial Cells Amniotic Membrane
- Limbal epithelial stem cells
- Limbal epithelial stem cells (family)
-
Neurons
- Glycinergic Amacrine Cells Inner Nuclear Layer
- nGnG Amacrine Cells Inner Nuclear Layer
- Neural stem/progenitor cells (family)
-
Cartilage (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
- Mesenchymal Stem Cells Zeugopod Periosteum
- Bone Marrow Stromal Cells Bone Marrow
- Liver (Hepatobiliary System)
-
Hair
- Basal Keratinocytes Embryonic Epidermis
- Hair follicle-derived mesenchymal stem cells
- Hair follicle stem cells
-
Amnion (Extraembryonic Tissues)
- Mesenchymal Stem Cells Amniotic Fluid
- Amniotic Epithelial Cells Amniotic Membrane
- Neural Crest (Gastrulation Derivatives)
-
Limb (Muscoskeletal System)
- Bone Marrow Stromal Cells Pelvic Girdle
-
Chorion (Extraembryonic Tissues)
- Chorionic Mesenchymal Stromal Cells Chorionic Villus
-
Epidermis (Integumentary System)
- Basal Keratinocytes Embryonic Epidermis
- Neural Tube (Nervous System)
- Lower Urinary Tract (Urinary System)
- Kidney (Urinary System)
- Thymus (Hematopoietic System)
- Uterus (Reproductive System)
- Lymph (Cardiovascular System)
- Smooth Muscle (Muscoskeletal System)
- Intestine
- Lung (Respiratory System)
- Tendon & Ligament (Muscoskeletal System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
mRNA differential expression in normal tissues according to GTEx for THY1 Gene
This gene is overexpressed in Brain - Cortex (x5.3), Brain - Frontal Cortex (BA9) (x4.8), and Brain - Anterior cingulate cortex (BA24) (x4.3).
This gene is overexpressed in Frontal cortex (17.5), Brain (11.3), and Cerebrospinal fluid (7.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for THY1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for THY1
SOURCE GeneReport for Unigene cluster for THY1 Gene:
Hs.644697Evidence on tissue expression from TISSUES for THY1 Gene
- Nervous system(5)
- Eye(4.9)
- Liver(4.6)
- Kidney(4.3)
- Skin(4.1)
- Lung(4.1)
- Heart(3.7)
- Bone(3.5)
- Intestine(3.4)
- Blood(3.3)
- Pancreas(3.3)
- Lymph node(3.3)
- Spleen(3.3)
- Bone marrow(3.1)
- Muscle(3.1)
- Thyroid gland(2.7)
- Gall bladder(2.5)
- Adrenal gland(2.3)
- Stomach(2.2)
Primer products for research
-
OriGene qPCR primer pairs for THY1
-
OriGene qPCR primer pairs and template standards for THY1
Gene Expression Assays for research
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for THY1 Gene
Orthologs for THY1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | THY1 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | THY1 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | THY1 29 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Thy1 29 |
|
||
| Mouse (Mus musculus) |
Mammalia | Thy1 29 16 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | THY1 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | THY1 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | THY1 29 |
|
||
| gga-mir-1466 30 |
|
OneToOne | |||
| Lizard (Anolis carolinensis) |
Reptilia | THY1 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | thy1 29 |
|
- Species where no ortholog for THY1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for THY1 Gene
- ENSEMBL:
- Gene Tree for THY1 (if available)
- TreeFam:
- Gene Tree for THY1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for THY1: view image
- Alliance of Genome Resources:
- Additional Orthologs for THY1
Paralogs for THY1 Gene
No data available for Paralogs for THY1 Gene
Variants for THY1 Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
54.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.37;
8.18% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for THY1 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for THY1 Gene
Disorders for THY1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| central retinal artery occlusion |
|
|
| mesangial proliferative glomerulonephritis |
|
|
| proliferative glomerulonephritis |
|
|
| retinal artery occlusion |
|
|
| thymoma |
|
|
Search THY1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for THY1
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for THY1 Gene
Publications for THY1 Gene
- Non-HLA genetic factors and insulin dependent diabetes mellitus in the Japanese: TCRA, TCRB and TCRG, INS, THY1, CD3D and ETS1. (PMID: 1982251) Aparicio JM ā¦ Yoshiki T (Disease markers 1990) 3 22 40
- The human Thy-1 gene: structure and chromosomal location. (PMID: 2864690) Seki T ā¦ Silver J (Proceedings of the National Academy of Sciences of the United States of America 1985) 2 3 4
- Evaluation of 6 candidate genes on chromosome 11q23 for coeliac disease susceptibility: a case control study. (PMID: 20478055) Brophy K ā¦ McManus R (BMC medical genetics 2010) 3 40
- A decreased positivity for CD90 on human mesenchymal stromal cells (MSCs) is associated with a loss of immunosuppressive activity by MSCs. (PMID: 18985728) Campioni D ā¦ Lanza F (Cytometry. Part B, Clinical cytometry 2009) 3 22
- Evidence for enhanced Thy-1 (CD90) expression in orbital fibroblasts of patients with Graves' ophthalmopathy. (PMID: 18976167) Khoo TK ā¦ Bahn RS (Thyroid : official journal of the American Thyroid Association 2008) 3 22
ExternalLinks
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- Thy-1 cell surface antigen [18-520]
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- thymus cell antigen 1, theta [98-861]
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Sources for THY1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134)