THY1 Gene (Protein Coding)

Thy-1 Cell Surface Antigen

GC11M119417
GIFtS:
44
This gene encodes a cell surface glycoprotein and member of the immunoglobulin superfamily of proteins. The encoded protein is involved in cell adhesion and cell communication in numerous cell types, but particularly in cells of the immune and nervous systems. The encoded protein is widely used as a marker for hematopoietic stem cells. This gene may function as a tumor suppress... See more...

Aliases for THY1 Gene

Aliases for THY1 Gene

  • Thy-1 Cell Surface Antigen 2 3 5
  • Thy-1 Membrane Glycoprotein 3 4
  • Thy-1 Antigen 3 4
  • CDw90 3 4
  • CD90 2 3
  • Thy-1 T-Cell Antigen 3
  • CD90 Antigen 4
  • THY1 5

External Ids for THY1 Gene

Previous GeneCards Identifiers for THY1 Gene

  • GC11M121288
  • GC11M120800
  • GC11M119322
  • GC11M118826
  • GC11M118795
  • GC11M119288
  • GC11M115230

Summaries for THY1 Gene

Entrez Gene Summary for THY1 Gene

  • This gene encodes a cell surface glycoprotein and member of the immunoglobulin superfamily of proteins. The encoded protein is involved in cell adhesion and cell communication in numerous cell types, but particularly in cells of the immune and nervous systems. The encoded protein is widely used as a marker for hematopoietic stem cells. This gene may function as a tumor suppressor in nasopharyngeal carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

GeneCards Summary for THY1 Gene

THY1 (Thy-1 Cell Surface Antigen) is a Protein Coding gene. Diseases associated with THY1 include Central Retinal Artery Occlusion and Mesangial Proliferative Glomerulonephritis. Among its related pathways are Neuroscience and amb2 Integrin signaling. Gene Ontology (GO) annotations related to this gene include protein kinase binding and GTPase activator activity.

UniProtKB/Swiss-Prot Summary for THY1 Gene

  • May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.

Gene Wiki entry for THY1 Gene

Additional gene information for THY1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for THY1 Gene

Genomics for THY1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for THY1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around THY1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for THY1

Top Transcription factor binding sites by QIAGEN in the THY1 gene promoter:
  • AP-1
  • ATF-2
  • c-Fos
  • c-Jun
  • GR-beta
  • p53
  • STAT3

Genomic Locations for THY1 Gene

Genomic Locations for THY1 Gene
chr11:119,415,476-119,424,985
(GRCh38/hg38)
Size:
9,510 bases
Orientation:
Minus strand
chr11:119,288,090-119,295,695
(GRCh37/hg19)
Size:
7,606 bases
Orientation:
Minus strand

Genomic View for THY1 Gene

Genes around THY1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THY1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THY1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for THY1 Gene

Proteins for THY1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for THY1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04216-THY1_HUMAN
    Recommended name:
    Thy-1 membrane glycoprotein
    Protein Accession:
    P04216
    Secondary Accessions:
    • Q16008
    • Q9NSP1

    Protein attributes for THY1 Gene

    Size:
    161 amino acids
    Molecular mass:
    17935 Da
    Quaternary structure:
    No Data Available

neXtProt entry for THY1 Gene

Protein Expression for THY1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for THY1 Gene

  • Glycosylation at Asn42, Asn79, Asn119, and Asn139
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for THY1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Protein Products

  • Signalway Proteins for THY1

No data available for DME Specific Peptides for THY1 Gene

Domains & Families for THY1 Gene

Gene Families for THY1 Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for THY1 Gene

InterPro:
Blocks:
  • Immunoglobulin subtype
ProtoNet:

Suggested Antigen Peptide Sequences for THY1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ33677 fis, clone BRAWH2002125, highly similar to THY-1 MEMBRANE GLYCOPROTEIN (B0YJA4_HUMAN)
  • cDNA, FLJ94676, Homo sapiens Thy-1 co-transcribed (LOC94105), mRNA (Q9HBB0_HUMAN)
  • Thy-1 antigen (THY1_HUMAN)
genes like me logo Genes that share domains with THY1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for THY1 Gene

Function for THY1 Gene

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  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
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Molecular function for THY1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.
GENATLAS Biochemistry:
Thy-1 cell surface antigen

Phenotypes From GWAS Catalog for THY1 Gene

Gene Ontology (GO) - Molecular Function for THY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IBA,ISS --
GO:0005178 integrin binding IEA,IPI 15004192
GO:0005515 protein binding IPI 7513706
GO:0019899 enzyme binding IEA --
GO:0019901 protein kinase binding IBA 21873635
genes like me logo Genes that share ontologies with THY1: view
genes like me logo Genes that share phenotypes with THY1: view

Animal Models for THY1 Gene

MGI Knock Outs for THY1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for THY1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for THY1 Gene

Localization for THY1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for THY1 Gene

Cell membrane. Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for THY1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 4
cytoskeleton 3
nucleus 3
cytosol 3
mitochondrion 2
endosome 2
lysosome 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for THY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005623 cell IEA --
GO:0005783 endoplasmic reticulum IDA --
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with THY1: view

Pathways & Interactions for THY1 Gene

genes like me logo Genes that share pathways with THY1: view

Pathways by source for THY1 Gene

1 KEGG pathway for THY1 Gene
1 Qiagen pathway for THY1 Gene
  • Transendothelial Migration of Leukocytes
1 Cell Signaling Technology pathway for THY1 Gene

SIGNOR curated interactions for THY1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for THY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IBA,ISS --
GO:0001952 regulation of cell-matrix adhesion IMP 9749990
GO:0002693 positive regulation of cellular extravasation IDA 15004192
GO:0006469 negative regulation of protein kinase activity IBA,ISS --
GO:0007010 cytoskeleton organization ISS --
genes like me logo Genes that share ontologies with THY1: view

Drugs & Compounds for THY1 Gene

Products:

  1. Drug

(1) Drugs for THY1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for THY1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with THY1: view

Transcripts for THY1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for THY1 Gene

4 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for THY1

Alternative Splicing Database (ASD) splice patterns (SP) for THY1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c
SP1: - - - -
SP2: - - -
SP3: - - - - - - -
SP4: - - - -
SP5: - - - - - -
SP6: - - -
SP7: - - - - - - - -
SP8: - - - - -
SP9: - - - -
SP10: - - -
SP11: - - - - -
SP12: - -

Relevant External Links for THY1 Gene

GeneLoc Exon Structure for
THY1

Expression for THY1 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for THY1 Gene

mRNA expression in normal human tissues for THY1 Gene
mRNA expression by GTEx for THY1 GenemRNA expression by BioGPS for THY1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for THY1 Gene

This gene is overexpressed in Brain - Cortex (x5.3), Brain - Frontal Cortex (BA9) (x4.8), and Brain - Anterior cingulate cortex (BA24) (x4.3).

Protein differential expression in normal tissues from HIPED for THY1 Gene

This gene is overexpressed in Frontal cortex (17.5), Brain (11.3), and Cerebrospinal fluid (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for THY1 Gene



Protein tissue co-expression partners for THY1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for THY1

SOURCE GeneReport for Unigene cluster for THY1 Gene:

Hs.644697

Evidence on tissue expression from TISSUES for THY1 Gene

  • Nervous system(5)
  • Eye(4.9)
  • Liver(4.6)
  • Kidney(4.4)
  • Skin(4.2)
  • Lung(4.1)
  • Heart(3.9)
  • Bone(3.8)
  • Blood(3.7)
  • Intestine(3.6)
  • Spleen(3.5)
  • Bone marrow(3.5)
  • Lymph node(3.5)
  • Pancreas(3.4)
  • Muscle(3.4)
  • Thyroid gland(2.8)
  • Gall bladder(2.6)
  • Adrenal gland(2.4)
  • Stomach(2.4)
genes like me logo Genes that share expression patterns with THY1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for THY1 Gene

Orthologs for THY1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for THY1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia THY1 30 31
  • 99.59 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia THY1 30 31
  • 85.71 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia THY1 30 31
  • 80.12 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Thy1 30
  • 77.85 (n)
Mouse
(Mus musculus)
 Mammalia Thy1 30 17 31
  • 76.81 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia THY1 31
  • 60 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia THY1 31
  • 50 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves THY1 30
  • 65.83 (n)
gga-mir-1466 31
  • 49 (a)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia THY1 31
  • 48 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia thy1 30
  • 45.76 (n)
Species where no ortholog for THY1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for THY1 Gene

ENSEMBL:
Gene Tree for THY1 (if available)
TreeFam:
Gene Tree for THY1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for THY1: view image

Paralogs for THY1 Gene

No data available for Paralogs for THY1 Gene

Variants for THY1 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Additional dbSNP identifiers (rs#s) for THY1 Gene

Structural Variations from Database of Genomic Variants (DGV) for THY1 Gene

Variant ID Type Subtype PubMed ID
nsv832284 CNV gain 17160897

Variation tolerance for THY1 Gene

Residual Variation Intolerance Score: 54.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for THY1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
THY1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for THY1 Gene

Disorders for THY1 Gene

MalaCards: The human disease database

(29) MalaCards diseases for THY1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
central retinal artery occlusion
mesangial proliferative glomerulonephritis
  • glomerulonephritis - mesangial proliferative
proliferative glomerulonephritis
thymoma
  • thymus neoplasms
retinal artery occlusion
- elite association - COSMIC cancer census association via MalaCards
Search THY1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for THY1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Tumor Gene Database
(TGDB)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with THY1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for THY1 Gene

Publications for THY1 Gene

  1. Non-HLA genetic factors and insulin dependent diabetes mellitus in the Japanese: TCRA, TCRB and TCRG, INS, THY1, CD3D and ETS1. (PMID: 1982251) Aparicio JM … Yoshiki T (Disease markers 1990) 3 23 41
  2. The human Thy-1 gene: structure and chromosomal location. (PMID: 2864690) Seki T … Silver J (Proceedings of the National Academy of Sciences of the United States of America 1985) 2 3 4
  3. Evaluation of 6 candidate genes on chromosome 11q23 for coeliac disease susceptibility: a case control study. (PMID: 20478055) Brophy K … McManus R (BMC medical genetics 2010) 3 41
  4. A decreased positivity for CD90 on human mesenchymal stromal cells (MSCs) is associated with a loss of immunosuppressive activity by MSCs. (PMID: 18985728) Campioni D … Lanza F (Cytometry. Part B, Clinical cytometry 2009) 3 23
  5. Loss of Thy-1 (CD90) antigen expression on mesenchymal stromal cells from hematologic malignancies is induced by in vitro angiogenic stimuli and is associated with peculiar functional and phenotypic characteristics. (PMID: 18202976) Campioni D … Cuneo A (Cytotherapy 2008) 3 23

ExternalLinks

View latest publications for THY1 gene in Mastermind

Products for THY1 Gene

  • Addgene plasmids for THY1