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Aliases for THY1 Gene

Aliases for THY1 Gene

  • Thy-1 Cell Surface Antigen 2 3 5
  • Thy-1 Antigen 3 4
  • CDw90 3 4
  • Thy-1 Membrane Glycoprotein 3
  • Thy-1 T-Cell Antigen 3
  • CD90 Antigen 4
  • CD90 3

External Ids for THY1 Gene

Previous GeneCards Identifiers for THY1 Gene

  • GC11M121288
  • GC11M120800
  • GC11M119322
  • GC11M118826
  • GC11M118795
  • GC11M119288
  • GC11M115230

Summaries for THY1 Gene

Entrez Gene Summary for THY1 Gene

  • This gene encodes a cell surface glycoprotein and member of the immunoglobulin superfamily of proteins. The encoded protein is involved in cell adhesion and cell communication in numerous cell types, but particularly in cells of the immune and nervous systems. The encoded protein is widely used as a marker for hematopoietic stem cells. This gene may function as a tumor suppressor in nasopharyngeal carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

GeneCards Summary for THY1 Gene

THY1 (Thy-1 Cell Surface Antigen) is a Protein Coding gene. Diseases associated with THY1 include Thymoma and Nasopharyngeal Carcinoma. Among its related pathways are Metabolism of proteins and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include protein kinase binding and GTPase activator activity.

UniProtKB/Swiss-Prot for THY1 Gene

  • May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.

Gene Wiki entry for THY1 Gene

Additional gene information for THY1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THY1 Gene

Genomics for THY1 Gene

GeneHancer (GH) Regulatory Elements for THY1 Gene

Promoters and enhancers for THY1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I119421 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 576 +2.3 2316 2.3 SRF MXI1 SMAD5 BACH1 SIN3A ETS1 RELA POLR2A POLR3A IKZF1 THY1 HINFP ENSG00000263873 USP2-AS1
GH11I119423 Enhancer 0.6 ENCODE dbSUPER 570 +0.2 210 1.8 SMAD5 POLR3A POLR2A THY1 USP2 USP2-AS1 ENSG00000254740 HINFP C1QTNF5 MFRP ENSG00000263873
GH11I119426 Enhancer 0.4 ENCODE 570 -1.6 -1610 0.7 MITF USF1 THY1 USP2 USP2-AS1 ENSG00000254740 C1QTNF5 MFRP GC11M119445
GH11I119425 Enhancer 0.4 ENCODE 550.8 -1.1 -1062 0.2 MITF USF1 THY1 USP2 USP2-AS1 ENSG00000254740 C1QTNF5 MFRP GC11M119445
GH11I119374 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 22 +48.0 47971 5.5 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF143 SP5 NFYC USP2 THY1 MFRP C1QTNF5 ENSG00000254740
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around THY1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the THY1 gene promoter:

Genomic Locations for THY1 Gene

Genomic Locations for THY1 Gene
chr11:119,417,378-119,424,985
(GRCh38/hg38)
Size:
7,608 bases
Orientation:
Minus strand
chr11:119,288,090-119,295,695
(GRCh37/hg19)

Genomic View for THY1 Gene

Genes around THY1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THY1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THY1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THY1 Gene

Proteins for THY1 Gene

  • Protein details for THY1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04216-THY1_HUMAN
    Recommended name:
    Thy-1 membrane glycoprotein
    Protein Accession:
    P04216
    Secondary Accessions:
    • Q16008
    • Q9NSP1

    Protein attributes for THY1 Gene

    Size:
    161 amino acids
    Molecular mass:
    17935 Da
    Quaternary structure:
    No Data Available

neXtProt entry for THY1 Gene

Post-translational modifications for THY1 Gene

  • Glycosylation at posLast=4242, isoforms=79, isoforms=119, and posLast=139139

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for THY1 (THY1)

No data available for DME Specific Peptides for THY1 Gene

Domains & Families for THY1 Gene

Gene Families for THY1 Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Plasma proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with THY1: view

No data available for UniProtKB/Swiss-Prot for THY1 Gene

Function for THY1 Gene

Molecular function for THY1 Gene

GENATLAS Biochemistry:
Thy-1 cell surface antigen
UniProtKB/Swiss-Prot Function:
May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.

Phenotypes From GWAS Catalog for THY1 Gene

Gene Ontology (GO) - Molecular Function for THY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity ISS,IBA --
GO:0005178 integrin binding IEA,IPI 15004192
GO:0005515 protein binding IPI 7513706
GO:0019899 enzyme binding IEA --
GO:0019901 protein kinase binding IBA --
genes like me logo Genes that share ontologies with THY1: view
genes like me logo Genes that share phenotypes with THY1: view

Animal Models for THY1 Gene

MGI Knock Outs for THY1:

Animal Model Products

Clone Products

  • Addgene plasmids for THY1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for THY1 Gene

Localization for THY1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for THY1 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for THY1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 5
cytoskeleton 3
cytosol 3
nucleus 2
mitochondrion 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for THY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005783 endoplasmic reticulum IDA --
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane NAS,TAS --
GO:0005887 integral component of plasma membrane TAS 2864289
genes like me logo Genes that share ontologies with THY1: view

Pathways & Interactions for THY1 Gene

genes like me logo Genes that share pathways with THY1: view

Gene Ontology (GO) - Biological Process for THY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis ISS --
GO:0001952 regulation of cell-matrix adhesion IMP 9749990
GO:0002693 positive regulation of cellular extravasation IDA 15004192
GO:0006469 negative regulation of protein kinase activity ISS --
GO:0006501 C-terminal protein lipidation TAS --
genes like me logo Genes that share ontologies with THY1: view

No data available for SIGNOR curated interactions for THY1 Gene

Drugs & Compounds for THY1 Gene

(1) Drugs for THY1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for THY1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with THY1: view

Transcripts for THY1 Gene

Unigene Clusters for THY1 Gene

Thy-1 cell surface antigen:
Representative Sequences:

Clone Products

  • Addgene plasmids for THY1

Alternative Splicing Database (ASD) splice patterns (SP) for THY1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c
SP1: - - - -
SP2: - - -
SP3: - - - - - - -
SP4: - - - -
SP5: - - - - - -
SP6: - - -
SP7: - - - - - - - -
SP8: - - - - -
SP9: - - - -
SP10: - - -
SP11: - - - - -
SP12: - -

Relevant External Links for THY1 Gene

GeneLoc Exon Structure for
THY1
ECgene alternative splicing isoforms for
THY1

Expression for THY1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for THY1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for THY1 Gene

This gene is overexpressed in Brain - Cortex (x5.3), Brain - Frontal Cortex (BA9) (x4.8), and Brain - Anterior cingulate cortex (BA24) (x4.3).

Protein differential expression in normal tissues from HIPED for THY1 Gene

This gene is overexpressed in Frontal cortex (17.5), Brain (11.3), and Cerebrospinal fluid (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for THY1 Gene



Protein tissue co-expression partners for THY1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of THY1 Gene:

THY1

SOURCE GeneReport for Unigene cluster for THY1 Gene:

Hs.644697

Evidence on tissue expression from TISSUES for THY1 Gene

  • Nervous system(5)
  • Eye(4.8)
  • Liver(4.5)
  • Kidney(4.2)
  • Lung(3.9)
  • Skin(3.8)
  • Blood(3.3)
  • Heart(3.3)
  • Spleen(3.3)
  • Bone(3.2)
  • Bone marrow(3.1)
  • Lymph node(3)
  • Intestine(2.8)
  • Muscle(2.7)
  • Pancreas(2.6)
  • Thyroid gland(2.2)
  • Gall bladder(2.1)
genes like me logo Genes that share expression patterns with THY1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for THY1 Gene

Orthologs for THY1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for THY1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THY1 33 34
  • 99.59 (n)
dog
(Canis familiaris)
Mammalia THY1 33 34
  • 85.71 (n)
cow
(Bos Taurus)
Mammalia THY1 33 34
  • 80.12 (n)
rat
(Rattus norvegicus)
Mammalia Thy1 33
  • 77.85 (n)
mouse
(Mus musculus)
Mammalia Thy1 33 16 34
  • 76.81 (n)
oppossum
(Monodelphis domestica)
Mammalia THY1 34
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia THY1 34
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves THY1 33
  • 65.83 (n)
gga-mir-1466 34
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia THY1 34
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia thy1 33
  • 45.76 (n)
Species where no ortholog for THY1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for THY1 Gene

ENSEMBL:
Gene Tree for THY1 (if available)
TreeFam:
Gene Tree for THY1 (if available)

Paralogs for THY1 Gene

No data available for Paralogs for THY1 Gene

Variants for THY1 Gene

Sequence variations from dbSNP and Humsavar for THY1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000094024 -- 119,420,751(-) G/A intron_variant
rs1000641271 -- 119,421,637(-) C/T 5_prime_UTR_variant, intron_variant
rs1000953985 -- 119,425,655(-) G/A/C upstream_transcript_variant
rs1001205 -- 119,422,002(-) T/C 5_prime_UTR_variant, intron_variant
rs1001206595 -- 119,421,769(-) A/G 5_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for THY1 Gene

Variant ID Type Subtype PubMed ID
nsv832284 CNV gain 17160897

Variation tolerance for THY1 Gene

Residual Variation Intolerance Score: 54.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for THY1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
THY1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THY1 Gene

Disorders for THY1 Gene

MalaCards: The human disease database

(6) MalaCards diseases for THY1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
thymoma
  • thymus neoplasms
nasopharyngeal carcinoma
  • npca
warthin tumor
  • adenolymphoma
gerstmann-straussler disease
  • gsd
murray valley encephalitis
  • australian encephalitis
- elite association - COSMIC cancer census association via MalaCards
Search THY1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for THY1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Tumor Gene Database
(TGDB)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with THY1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for THY1 Gene

Publications for THY1 Gene

  1. Non-HLA genetic factors and insulin dependent diabetes mellitus in the Japanese: TCRA, TCRB and TCRG, INS, THY1, CD3D and ETS1. (PMID: 1982251) Aparicio JM … Yoshiki T (Disease markers 1990) 3 22 44 58
  2. The human Thy-1 gene: structure and chromosomal location. (PMID: 2864690) Seki T … Silver J (Proceedings of the National Academy of Sciences of the United States of America 1985) 2 3 4 58
  3. Evaluation of 6 candidate genes on chromosome 11q23 for coeliac disease susceptibility: a case control study. (PMID: 20478055) Brophy K … McManus R (BMC medical genetics 2010) 3 44 58
  4. A decreased positivity for CD90 on human mesenchymal stromal cells (MSCs) is associated with a loss of immunosuppressive activity by MSCs. (PMID: 18985728) Campioni D … Lanza F (Cytometry. Part B, Clinical cytometry 2009) 3 22 58
  5. Evidence for enhanced Thy-1 (CD90) expression in orbital fibroblasts of patients with Graves' ophthalmopathy. (PMID: 18976167) Khoo TK … Bahn RS (Thyroid : official journal of the American Thyroid Association 2008) 3 22 58

Products for THY1 Gene

  • Addgene plasmids for THY1

Sources for THY1 Gene

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