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This gene encodes a cell surface glycoprotein and member of the immunoglobulin superfamily of proteins. The encoded protein is involved in cell adhesion and cell communication in numerous cell types, but particularly in cells of the immune and nervous systems. The encoded protein is widely used as a marker for hematopoietic stem cells. This gene may function as a tumor suppressor in nasopharyngeal carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
THY1 (Thy-1 Cell Surface Antigen) is a Protein Coding gene. Diseases associated with THY1 include Central Retinal Artery Occlusion and Mesangial Proliferative Glomerulonephritis. Among its related pathways are Neuroscience and amb2 Integrin signaling. Gene Ontology (GO) annotations related to this gene include protein kinase binding and GTPase activator activity.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005096 | GTPase activator activity | IBA,ISS | -- |
GO:0005178 | integrin binding | IEA,IPI | 15004192 |
GO:0005515 | protein binding | IPI | 7513706 |
GO:0019899 | enzyme binding | IEA | -- |
GO:0019901 | protein kinase binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005623 | cell | IEA | -- |
GO:0005783 | endoplasmic reticulum | IDA | -- |
GO:0005829 | cytosol | IEA | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001525 | angiogenesis | IBA,ISS | -- |
GO:0001952 | regulation of cell-matrix adhesion | IMP | 9749990 |
GO:0002693 | positive regulation of cellular extravasation | IDA | 15004192 |
GO:0006469 | negative regulation of protein kinase activity | IBA,ISS | -- |
GO:0007010 | cytoskeleton organization | ISS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
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ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9a | · | 9b | · | 9c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
SP6: | - | - | - | ||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
SP8: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
SP9: | - | - | - | - | |||||||||||||||||||||||||||||||||||
SP10: | - | - | - | ||||||||||||||||||||||||||||||||||||
SP11: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
SP12: | - | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | THY1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | THY1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | THY1 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Thy1 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Thy1 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | THY1 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | THY1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | THY1 30 |
|
||
gga-mir-1466 31 |
|
OneToOne | |||
Lizard (Anolis carolinensis) |
Reptilia | THY1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | thy1 30 |
|
Disorder | Aliases | PubMed IDs |
---|---|---|
central retinal artery occlusion |
|
|
mesangial proliferative glomerulonephritis |
|
|
proliferative glomerulonephritis |
|
|
thymoma |
|
|
retinal artery occlusion |
|
|