Free for academic non-profit institutions. Other users need a Commercial license
THRAP3 (Thyroid Hormone Receptor Associated Protein 3) is a Protein Coding gene. Diseases associated with THRAP3 include Telangiectatic Osteogenic Sarcoma and Pseudosarcomatous Fibromatosis. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity. An important paralog of this gene is BCLAF1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | ISS | -- |
GO:0003677 | DNA binding | IBA | 21873635 |
GO:0003712 | transcription coregulator activity | IDA | 10198638 |
GO:0003713 | transcription coactivator activity | IDA | 12037571 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA,IDA | 10235267 |
GO:0005654 | nucleoplasm | IEA,IDA | 24100041 |
GO:0016592 | mediator complex | IDA | 10198638 |
GO:0016607 | nuclear speck | IEA,IDA | 24100041 |
GO:0035145 | colocalizes_with exon-exon junction complex | IDA | 20123736 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||
2 | Metabolism |
.40
|
|
3 | PEDF Induced Signaling |
Glucocorticoid Receptor Signaling
.43
|
|
4 | Developmental Biology | ||
5 | Circadian rythm related genes |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000381 | regulation of alternative mRNA splicing, via spliceosome | IMP | 20932480 |
GO:0000956 | nuclear-transcribed mRNA catabolic process | IDA | 20123736 |
GO:0006367 | transcription initiation from RNA polymerase II promoter | IDA | 12218053 |
GO:0006397 | mRNA processing | IEA | -- |
GO:0007623 | circadian rhythm | IEA | -- |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||||||||||||||||||||
SP2: | |||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||||||||||||
SP5: | |||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | |||||||||||||||||||||||||||||||||
SP7: | - | - | |||||||||||||||||||||||||||||||||||
SP8: | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | THRAP3 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | THRAP3 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | THRAP3 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Thrap3 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Thrap3 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | THRAP3 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Chicken (Gallus gallus) |
Aves | THRAP3 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | THRAP3 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | thrap3 30 |
|
||
LOC394509 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.7745 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | thrap3b 31 |
|
OneToMany | |
BX321921.1 31 |
|
OneToMany | |||
thrap3a 31 |
|
OneToMany | |||
-- 30 |
|
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs6425977 | - | p.Ala201Val |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv74n106 | OTHER | inversion | 24896259 |
esv1002750 | CNV | deletion | 20482838 |
esv1414937 | CNV | deletion | 17803354 |
esv2045078 | CNV | deletion | 18987734 |
esv2125715 | CNV | deletion | 18987734 |
esv2544592 | CNV | deletion | 19546169 |
esv2663119 | CNV | deletion | 23128226 |
esv2746830 | CNV | deletion | 23290073 |
esv2746841 | CNV | deletion | 23290073 |
esv2746852 | CNV | deletion | 23290073 |
esv2746863 | CNV | deletion | 23290073 |
esv2758931 | CNV | loss | 17122850 |
esv3560737 | CNV | deletion | 23714750 |
esv3560748 | CNV | deletion | 23714750 |
esv3585731 | CNV | loss | 21293372 |
nsv1077758 | OTHER | inversion | 25765185 |
nsv1122329 | CNV | deletion | 24896259 |
nsv1133839 | CNV | deletion | 24896259 |
nsv160040 | CNV | deletion | 16902084 |
nsv444 | CNV | deletion | 18451855 |
nsv545994 | CNV | loss | 21841781 |
nsv545995 | CNV | loss | 21841781 |
nsv545997 | CNV | loss | 21841781 |
nsv834691 | CNV | loss | 17160897 |
nsv834702 | CNV | loss | 17160897 |
nsv945880 | CNV | duplication | 23825009 |
nsv945882 | CNV | duplication | 23825009 |
nsv955436 | CNV | deletion | 24416366 |
nsv956790 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
telangiectatic osteogenic sarcoma |
|
|
pseudosarcomatous fibromatosis |
|
|
wilms tumor 1 |
|
|
osteoblastoma |
|
|