Free for academic non-profit institutions. Other users need a Commercial license
Aliases for THRAP3 Gene
Aliases for THRAP3 Gene
External Ids for THRAP3 Gene
- HGNC: 22964
- Entrez Gene: 9967
- Ensembl: ENSG00000054118
- OMIM: 603809
- UniProtKB: Q9Y2W1
Previous GeneCards Identifiers for THRAP3 Gene
- GC01P036117
- GC01P036359
- GC01P036462
- GC01P036690
- GC01P034807
Summaries for THRAP3 Gene
GeneCards Summary for THRAP3 Gene
THRAP3 (Thyroid Hormone Receptor Associated Protein 3) is a Protein Coding gene. Diseases associated with THRAP3 include Telangiectatic Osteogenic Sarcoma and Pseudosarcomatous Fibromatosis. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity. An important paralog of this gene is BCLAF1.
UniProtKB/Swiss-Prot Summary for THRAP3 Gene
-
Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-ARNTL/BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798).
Additional gene information for THRAP3 Gene
- HGNC(22964)
- Entrez Gene(9967)
- Ensembl(ENSG00000054118)
- OMIM(603809)
- UniProtKB(Q9Y2W1)
- Open Targets Platform(ENSG00000054118)
- Search for THRAP3 at DataMed
- Search for THRAP3 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for THRAP3 Gene
Genomics for THRAP3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for THRAP3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around THRAP3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for THRAP3
- Top Transcription factor binding sites by QIAGEN in the THRAP3 gene promoter:
-
- AREB6
- C/EBPalpha
- COMP1
- CREB
- deltaCREB
- FOXO4
- Msx-1
- Sox9
- Spz1
- STAT1
Genomic Locations for THRAP3 Gene
Genomic Locations for THRAP3 Gene
- chr1:36,224,429-36,305,357
- (GRCh38/hg38)
- Size:
- 80,929 bases
- Orientation:
- Plus strand
- chr1:36,690,017-36,770,958
- (GRCh37/hg19)
- Size:
- 80,942 bases
- Orientation:
- Plus strand
Genomic View for THRAP3 Gene
Genes around THRAP3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p34.3 by HGNC
- 1p34.3 by Entrez Gene
- 1p34.3 by Ensembl
THRAP3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for THRAP3 Gene
Proteins for THRAP3 Gene
-
Protein details for THRAP3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y2W1-TR150_HUMAN
- Recommended name:
- Thyroid hormone receptor-associated protein 3
- Protein Accession:
- Q9Y2W1
- D3DPS5
- Q5VTK6
Protein attributes for THRAP3 Gene
- Size:
- 955 amino acids
- Molecular mass:
- 108666 Da
- Quaternary structure:
-
- Associated with the large multiprotein complex TRAP (Mediator complex-like). Interacts with SFPQ; the interaction is dependent on SFPQ phosphorylation at 'Thr-687' and inhibits binding of SFPQ to an ESS1 exonic splicing silencer element-containing RNA. Interacts with NXF1. Component of the SNARP complex which consists at least of SNIP1, SNW1, THRAP3, BCLAF1 and PNN. Associated with spliced mRNP complexes. Interacts with HELZ2 and PPARG. Interacts with CLOCK and ARNTL/BMAL1 (By similarity). Component of a MACOM-like complex, named WTAP complex, composed of WTAP, ZC3H13, CBLL1, KIAA1429, RBM15, BCLAF1 and THRAP3.
- SequenceCaution:
-
- Sequence=AAH37554.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
Protein Expression for THRAP3 Gene
Post-translational modifications for THRAP3 Gene
- ADP-ribosylation during genotoxic stress promotes accumulation in nuclear speckles.
-
Ubiquitination at Lys221, Lys470, Lys519, and Lys558
- NX_Q9Y2W1 (NX_Q9Y2W1-1)
- Modification sites at PhosphoSitePlus
Other Protein References for THRAP3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences THRAP3 / TRAP150 Antibody (LS-B1795) and THRAP3 / TRAP150 Antibody (LS-B11040)
- G Biosciences Immunotag™ THRAP3 Antibody
-
Custom Antibody ServicesOriGene Antibodies for THRAP3
- Novus Biologicals Antibodies for THRAP3
-
Abcam antibodies for THRAP3
- Invitrogen Antibodies for THRAP3 (AFLGC-THRAP3)
- antibodies-online: Show 19 available THRAP3 Antibodies ranked by validation data
- Compare Top THRAP3 Antibodies
-
Recommended
- 47 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 2 IP Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 15 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 1 IP Antibody (anti-mouse)
- 12 IF (p) Antibodies (anti-rat)
- 12 WB Antibodies (anti-rat)
-
Boster Bio Antibodies for THRAP3
-
Santa Cruz Biotechnology (SCBT) Antibodies for THRAP3
Protein Products
-
OriGene Purified Proteins for THRAP3
- Search Origene for MassSpec and Protein Over-expression Lysates for THRAP3
- Origene Custom Protein Services for THRAP3
No data available for DME Specific Peptides for THRAP3 Gene
Domains & Families for THRAP3 Gene
Gene Families for THRAP3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for THRAP3 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for THRAP3 Gene
- GenScript: Design optimal peptide antigens:
-
- THRAP3 protein (Q05D20_HUMAN)
- THRAP3 protein (Q6P0P7_HUMAN)
- THRAP3 protein (Q6PJV4_HUMAN)
- THRAP3 protein (Q7Z5U1_HUMAN)
- Thyroid hormone receptor-associated protein complex 150 kDa component (TR150_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9Y2W1- Family:
-
- Belongs to the BCLAF1/THRAP3 family.
Function for THRAP3 Gene
Molecular function for THRAP3 Gene
- UniProtKB/Swiss-Prot Function:
- Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-ARNTL/BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798).
Phenotypes From GWAS Catalog for THRAP3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | ISS | -- |
| GO:0003677 | DNA binding | IBA | 21873635 |
| GO:0003712 | transcription coregulator activity | IDA | 10198638 |
| GO:0003713 | transcription coactivator activity | IDA | 12037571 |
Phenotypes for THRAP3 Gene
- GenomeRNAi human phenotypes for THRAP3:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for THRAP3 - Select products 50% OFF >
- * THRAP3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for THRAP3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for THRAP3
-
Santa Cruz Biotechnology (SCBT) CRISPR for THRAP3
miRNA for THRAP3 Gene
- miRTarBase miRNAs that target THRAP3
-
- hsa-miR-877-3p (MIRT037155)
- hsa-miR-877-5p (MIRT037365)
- hsa-miR-615-3p (MIRT040217)
- hsa-miR-326 (MIRT043640)
- hsa-miR-125a-5p (MIRT045718)
- hsa-miR-125b-5p (MIRT046049)
- hsa-miR-559 (MIRT340664)
- hsa-miR-548b-5p (MIRT340665)
- hsa-miR-548a-5p (MIRT340666)
- hsa-miR-548c-5p (MIRT340667)
- hsa-miR-548d-5p (MIRT340668)
- hsa-miR-548j-5p (MIRT340669)
- hsa-miR-548h-5p (MIRT340670)
- hsa-miR-548i (MIRT340671)
- hsa-miR-3153 (MIRT340672)
- hsa-miR-548w (MIRT340673)
- hsa-miR-548y (MIRT340674)
- hsa-miR-548o-5p (MIRT340675)
- hsa-miR-548ab (MIRT340676)
- hsa-miR-548ad-5p (MIRT340677)
- hsa-miR-548ae-5p (MIRT340678)
- hsa-miR-548ak (MIRT340679)
- hsa-miR-548am-5p (MIRT340680)
- hsa-miR-3973 (MIRT340681)
- hsa-miR-548ap-5p (MIRT340682)
- hsa-miR-548aq-5p (MIRT340683)
- hsa-miR-548ar-5p (MIRT340684)
- hsa-miR-548as-5p (MIRT340685)
- hsa-miR-548au-5p (MIRT340686)
- hsa-miR-548ay-5p (MIRT340687)
- hsa-miR-6733-5p (MIRT340688)
- hsa-miR-6739-5p (MIRT340689)
- hsa-miR-6783-5p (MIRT340690)
- hsa-miR-548bb-5p (MIRT340691)
- hsa-miR-203a-3p (MIRT563698)
- hsa-miR-6838-5p (MIRT563699)
- hsa-miR-497-5p (MIRT563700)
- hsa-miR-424-5p (MIRT563701)
- hsa-miR-195-5p (MIRT563702)
- hsa-miR-16-5p (MIRT563703)
- hsa-miR-15b-5p (MIRT563704)
- hsa-miR-15a-5p (MIRT563705)
- hsa-miR-548p (MIRT563706)
- hsa-miR-5680 (MIRT563707)
- hsa-miR-625-3p (MIRT563708)
- hsa-miR-3936 (MIRT563709)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for THRAP3
- Browse OriGene Inhibitory RNA Products For THRAP3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for THRAP3
Clone Products
- Applied Biological Materials (abm): Clones for THRAP3 - Select products 50% OFF >
- * THRAP3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for THRAP3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for THRAP3
Cell Line Products
-
Horizon Cell Lines for THRAP3
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for THRAP3 Gene
Localization for THRAP3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for THRAP3 Gene
- Nucleus. Nucleus, nucleoplasm. Nucleus speckle.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| extracellular | 4 |
| cytosol | 2 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
- Nuclear speckles (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 10235267 |
| GO:0005654 | nucleoplasm | IEA,IDA | 24100041 |
| GO:0016592 | mediator complex | IDA | 10198638 |
| GO:0016607 | nuclear speck | IEA,IDA | 24100041 |
| GO:0035145 | colocalizes_with exon-exon junction complex | IDA | 20123736 |
Pathways & Interactions for THRAP3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||
| 2 | Metabolism |
.40
|
|
| 3 | PEDF Induced Signaling |
Glucocorticoid Receptor Signaling
.43
|
|
| 4 | Developmental Biology | ||
| 5 | Circadian rythm related genes | ||
Pathways by source for THRAP3 Gene
2 BioSystems pathways for THRAP3 Gene
7 Reactome pathways for THRAP3 Gene
1 Qiagen pathway for THRAP3 Gene
- Glucocorticoid Receptor Signaling
Interacting Proteins for THRAP3 Gene
Selected Interacting proteins:
Q9Y2W1-TR150_HUMAN
ENSP00000346634
for THRAP3 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for THRAP3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000381 | regulation of alternative mRNA splicing, via spliceosome | IMP | 20932480 |
| GO:0000956 | nuclear-transcribed mRNA catabolic process | IDA | 20123736 |
| GO:0006367 | transcription initiation from RNA polymerase II promoter | IDA | 12218053 |
| GO:0006397 | mRNA processing | IEA | -- |
| GO:0007623 | circadian rhythm | IEA | -- |
Transcripts for THRAP3 Gene
mRNA/cDNA for THRAP3 Gene
- 3 REFSEQ mRNAs :
- 14 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000354618 4405 nts (view in UCSC)
- ENST00000466743 537 nts (view in UCSC)
- ENST00000469141 3339 nts (view in UCSC)
- ENST00000648638 3825 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for THRAP3 - Select products 50% OFF >
- * THRAP3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for THRAP3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for THRAP3
-
Santa Cruz Biotechnology (SCBT) CRISPR for THRAP3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for THRAP3
- Browse OriGene Inhibitory RNA Products For THRAP3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for THRAP3
Clone Products
- Applied Biological Materials (abm): Clones for THRAP3 - Select products 50% OFF >
- * THRAP3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for THRAP3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for THRAP3
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP7: | - | - | |||||||||||||||||||||||||||||||||||
| SP8: | - |
Relevant External Links for THRAP3 Gene
- GeneLoc Exon Structure for
- THRAP3
Expression for THRAP3 Gene
This gene is overexpressed in Nasal epithelium (14.3) and Peripheral blood mononuclear cells (12.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for THRAP3 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for THRAP3
SOURCE GeneReport for Unigene cluster for THRAP3 Gene:
Hs.744057mRNA Expression by UniProt/SwissProt for THRAP3 Gene:
Q9Y2W1-TR150_HUMAN
Tissue specificity:
Ubiquitous.
Evidence on tissue expression from TISSUES for THRAP3 Gene
- Nervous system(4.5)
- Liver(4.5)
- Blood(4.3)
- Muscle(2.6)
- Kidney(2.5)
- Heart(2.5)
- Skin(2.4)
- Thyroid gland(2.4)
- Intestine(2)
- Spleen(2)
Primer Products
-
OriGene qPCR primer pairs for THRAP3
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for THRAP3 Gene
Orthologs for THRAP3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | THRAP3 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | THRAP3 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | THRAP3 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Thrap3 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Thrap3 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | THRAP3 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Chicken (Gallus gallus) |
Aves | THRAP3 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | THRAP3 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | thrap3 30 |
|
||
| LOC394509 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.7745 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | thrap3b 31 |
|
OneToMany | |
| BX321921.1 31 |
|
OneToMany | |||
| thrap3a 31 |
|
OneToMany | |||
| -- 30 |
|
- Species where no ortholog for THRAP3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for THRAP3 Gene
- ENSEMBL:
- Gene Tree for THRAP3 (if available)
- TreeFam:
- Gene Tree for THRAP3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for THRAP3: view image
Paralogs for THRAP3 Gene
(1) SIMAP similar genes for THRAP3 Gene using alignment to 6 proteins:
- TR150_HUMAN
- E9PML1_HUMAN
- Q05D20_HUMAN
- Q6P0P7_HUMAN
- Q6PJV4_HUMAN
- Q7Z5U1_HUMAN
Pseudogenes.org Pseudogenes for THRAP3 Gene
Variants for THRAP3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for THRAP3 Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs6425977 | - | p.Ala201Val |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv74n106 | OTHER | inversion | 24896259 |
| esv1002750 | CNV | deletion | 20482838 |
| esv1414937 | CNV | deletion | 17803354 |
| esv2045078 | CNV | deletion | 18987734 |
| esv2125715 | CNV | deletion | 18987734 |
| esv2544592 | CNV | deletion | 19546169 |
| esv2663119 | CNV | deletion | 23128226 |
| esv2746830 | CNV | deletion | 23290073 |
| esv2746841 | CNV | deletion | 23290073 |
| esv2746852 | CNV | deletion | 23290073 |
| esv2746863 | CNV | deletion | 23290073 |
| esv2758931 | CNV | loss | 17122850 |
| esv3560737 | CNV | deletion | 23714750 |
| esv3560748 | CNV | deletion | 23714750 |
| esv3585731 | CNV | loss | 21293372 |
| nsv1077758 | OTHER | inversion | 25765185 |
| nsv1122329 | CNV | deletion | 24896259 |
| nsv1133839 | CNV | deletion | 24896259 |
| nsv160040 | CNV | deletion | 16902084 |
| nsv444 | CNV | deletion | 18451855 |
| nsv545994 | CNV | loss | 21841781 |
| nsv545995 | CNV | loss | 21841781 |
| nsv545997 | CNV | loss | 21841781 |
| nsv834691 | CNV | loss | 17160897 |
| nsv834702 | CNV | loss | 17160897 |
| nsv945880 | CNV | duplication | 23825009 |
| nsv945882 | CNV | duplication | 23825009 |
| nsv955436 | CNV | deletion | 24416366 |
| nsv956790 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
10% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.79;
47.39% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for THRAP3 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THRAP3 Gene
Disorders for THRAP3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| telangiectatic osteogenic sarcoma |
|
|
| pseudosarcomatous fibromatosis |
|
|
| wilms tumor 1 |
|
|
| osteoblastoma |
|
|
Search THRAP3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for THRAP3
No data available for UniProtKB/Swiss-Prot and Genatlas for THRAP3 Gene
Publications for THRAP3 Gene
- Identification of Wilms' tumor 1-associating protein complex and its role in alternative splicing and the cell cycle. (PMID: 24100041) Horiuchi K … Hamakubo T (The Journal of biological chemistry 2013) 3 4
- THRAP3 interacts with HELZ2 and plays a novel role in adipocyte differentiation. (PMID: 23525231) Katano-Toki A … Mori M (Molecular endocrinology (Baltimore, Md.) 2013) 3 4
- Proteome-wide identification of poly(ADP-Ribosyl)ation targets in different genotoxic stress responses. (PMID: 24055347) Jungmichel S … Nielsen ML (Molecular cell 2013) 3 4
- A positive feedback loop links circadian clock factor CLOCK-BMAL1 to the basic transcriptional machinery. (PMID: 24043798) Lande-Diner L … Weitz CJ (Proceedings of the National Academy of Sciences of the United States of America 2013) 3 4
- Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response. (PMID: 22424773) Beli P … Choudhary C (Molecular cell 2012) 3 4
ExternalLinks
Products for THRAP3 Gene
- Custom Antibody ServicesOriGene Antibodies for THRAP3
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for THRAP3
- Search Origene for MassSpec and Protein Over-expression Lysates for THRAP3
- Origene Custom Protein Services for THRAP3
- Origene shrna, sirna, and RNAi products in human, mouse, rat for THRAP3
- Browse OriGene Inhibitory RNA Products For THRAP3
- OriGene qPCR primer pairs for THRAP3
- OriGene CRISPR knockouts for THRAP3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For THRAP3
- Sino Biological Human cDNA Clone for THRAP3
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for THRAP3
- Novus Biologicals proteins and lysates for THRAP3
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for THRAP3
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for THRAP3 (AFLGC-THRAP3)
- VectorBuilder Custom and pre-made DNA vectors for THRAP3 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for THRAP3 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for THRAP3 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for THRAP3 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for THRAP3
- antibodies-online: Show 19 available THRAP3 Antibodies ranked by validation data
- Compare Top THRAP3 Antibodies
- Recommended
- 47 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 2 IP Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 15 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 1 IP Antibody (anti-mouse)
- 12 IF (p) Antibodies (anti-rat)
- 12 WB Antibodies (anti-rat)
- antibodies-online: Search results for available THRAP3 related products ranked by validation data
- antibodies-online: Search results for available THRAP3 related products ranked by validation data
- Santa Cruz Biotechnology (SCBT) Antibodies for THRAP3
- Search Santa Cruz Biotechnology (SCBT) for THRAP3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for THRAP3
- Horizon Cell Lines for THRAP3
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for THRAP3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for THRAP3
- Search GeneCopoeia for miRNA 3'UTR Target clone products for THRAP3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for THRAP3
- Boster Bio Antibodies for THRAP3
- Browse Boster Bio ELISA Kits
Sources for THRAP3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB