Aliases for THRAP3 Gene
Aliases for THRAP3 Gene
- Thyroid Hormone Receptor Associated Protein 3 2 3 5
- BCLAF1 And THRAP3 Family Member 2 2 3 4
- Thyroid Hormone Receptor-Associated Protein Complex 150 KDa Component 3 4
- TR-Associated Protein, 150-KDa 2 3
- TRAP150 3 4
- BCLAF2 3 4
- Thyroid Hormone Receptor-Associated Protein, 150 KDa Subunit 3
- Thyroid Hormone Receptor-Associated Protein 3 3
External Ids for THRAP3 Gene
- HGNC: 22964
- Entrez Gene: 9967
- Ensembl: ENSG00000054118
- OMIM: 603809
- UniProtKB: Q9Y2W1
Previous GeneCards Identifiers for THRAP3 Gene
- GC01P036117
- GC01P036359
- GC01P036462
- GC01P036690
- GC01P034807
Summaries for THRAP3 Gene
GeneCards Summary for THRAP3 Gene
THRAP3 (Thyroid Hormone Receptor Associated Protein 3) is a Protein Coding gene. Diseases associated with THRAP3 include Wilms Tumor 1. Among its related pathways are PEDF Induced Signaling and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). Gene Ontology (GO) annotations related to this gene include transcription coactivator activity. An important paralog of this gene is BCLAF1.
UniProtKB/Swiss-Prot for THRAP3 Gene
-
Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-ARNTL/BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798).
Additional gene information for THRAP3 Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THRAP3 Gene
Genomics for THRAP3 Gene
GeneHancer (GH) Regulatory Elements for THRAP3 Gene
Promoters and enhancers for THRAP3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around THRAP3 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for THRAP3 Gene
Genomic Locations for THRAP3 Gene
- chr1:36,224,416-36,305,357
- (GRCh38/hg38)
- Size:
- 80,942 bases
- Orientation:
- Plus strand
- chr1:36,690,017-36,770,958
- (GRCh37/hg19)
Genomic View for THRAP3 Gene
Genes around THRAP3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p34.3 by Ensembl
- 1p34.3 by Entrez Gene
- 1p34.3 by HGNC
THRAP3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for THRAP3 Gene
Proteins for THRAP3 Gene
-
Protein details for THRAP3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y2W1-TR150_HUMAN
- Recommended name:
- Thyroid hormone receptor-associated protein 3
- Protein Accession:
- Q9Y2W1
- D3DPS5
- Q5VTK6
Protein attributes for THRAP3 Gene
- Size:
- 955 amino acids
- Molecular mass:
- 108666 Da
- Quaternary structure:
-
- Associated with the large multiprotein complex TRAP (Mediator complex-like). Interacts with SFPQ; the interaction is dependent on SFPQ phosphorylation at Thr-687 and inhibits binding of SFPQ to an ESS1 exonic splicing silencer element-containing RNA. Interacts with NXF1. Component of the SNARP complex which consists at least of SNIP1, SNW1, THRAP3, BCLAF1 and PNN. Associated with spliced mRNP complexes. Interacts with HELZ2 and PPARG. Interacts with CLOCK and ARNTL/BMAL1 (By similarity). Component of the WTAP complex composed of WTAP, ZC3H13, CBLL1, KIAA1429, RBM15, BCLAF1 and THRAP3.
- SequenceCaution:
-
- Sequence=AAH37554.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
Protein Expression for THRAP3 Gene
Post-translational modifications for THRAP3 Gene
- ADP-ribosylation during genotoxic stress promotes accumulation in nuclear speckles.
- Ubiquitination at isoforms=221, posLast=470470, isoforms=519, and posLast=558558
- Modification sites at PhosphoSitePlus
Other Protein References for THRAP3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for THRAP3
- Novus Biologicals Antibodies for THRAP3
-
Abcam antibodies for THRAP3
- Invitrogen Antibodies for THRAP3
- antibodies-online: Search results for 63 available THRAP3 Antibodies ranked by validation data
- Compare Top THRAP3 Antibodies
-
Recommended
- 1 IP Antibody (anti-mouse)
- 12 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 IF Antibody (anti-human)
- 2 IP Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 44 WB Antibodies (anti-human)
- 11 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- Search GeneTex for Antibodies for THRAP3
-
Santa Cruz Biotechnology (SCBT) Antibodies for THRAP3
Protein Products
-
OriGene Purified Proteins for THRAP3
- Search Origene for MassSpec and Protein Over-expression Lysates for THRAP3
- Origene Custom Protein Services for THRAP3
- Search GeneTex for Proteins for THRAP3
Assay Products
No data available for DME Specific Peptides for THRAP3 Gene
Domains & Families for THRAP3 Gene
Gene Families for THRAP3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for THRAP3 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for THRAP3 Gene
Graphical View of Domain Structure for InterPro Entry
Q9Y2W1- Family:
-
- Belongs to the BCLAF1/THRAP3 family.
Function for THRAP3 Gene
Molecular function for THRAP3 Gene
- UniProtKB/Swiss-Prot Function:
- Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-ARNTL/BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798).
Phenotypes From GWAS Catalog for THRAP3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001046 | core promoter sequence-specific DNA binding | ISS | -- |
| GO:0001104 | RNA polymerase II transcription cofactor activity | IDA | 10198638 |
| GO:0003712 | transcription cofactor activity | IDA | 12218053 |
| GO:0003713 | transcription coactivator activity | IDA | 12037571 |
| GO:0003723 | RNA binding | HDA,IDA | 22658674 |
Phenotypes for THRAP3 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for THRAP3
-
-
ViGene Biosciences lentiviral particle packaged cDNA for THRAP3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for THRAP3 gene
- Search ViGene Biosciences for THRAP3
CRISPR Products
-
OriGene CRISPR knockouts for THRAP3
- genomics-online: gRNA clones - Search results for 93 available THRAP3 gene related products
- Overview of 93 available THRAP3 gene related products
- Applied Biological Materials CRISPR for THRAP3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for THRAP3
- GenScript: Design CRISPR guide RNA sequences for THRAP3
miRNA for THRAP3 Gene
- miRTarBase miRNAs that target THRAP3
-
- hsa-mir-877-3p (MIRT037155)
- hsa-mir-877-5p (MIRT037365)
- hsa-mir-615-3p (MIRT040217)
- hsa-mir-326 (MIRT043640)
- hsa-mir-125a-5p (MIRT045718)
- hsa-mir-125b-5p (MIRT046049)
- hsa-mir-559 (MIRT340664)
- hsa-mir-548b-5p (MIRT340665)
- hsa-mir-548a-5p (MIRT340666)
- hsa-mir-548c-5p (MIRT340667)
- hsa-mir-548d-5p (MIRT340668)
- hsa-mir-548j-5p (MIRT340669)
- hsa-mir-548h-5p (MIRT340670)
- hsa-mir-548i (MIRT340671)
- hsa-mir-3153 (MIRT340672)
- hsa-mir-548w (MIRT340673)
- hsa-mir-548y (MIRT340674)
- hsa-mir-548o-5p (MIRT340675)
- hsa-mir-548ab (MIRT340676)
- hsa-mir-548ad-5p (MIRT340677)
- hsa-mir-548ae-5p (MIRT340678)
- hsa-mir-548ak (MIRT340679)
- hsa-mir-548am-5p (MIRT340680)
- hsa-mir-3973 (MIRT340681)
- hsa-mir-548ap-5p (MIRT340682)
- hsa-mir-548aq-5p (MIRT340683)
- hsa-mir-548ar-5p (MIRT340684)
- hsa-mir-548as-5p (MIRT340685)
- hsa-mir-548au-5p (MIRT340686)
- hsa-mir-548ay-5p (MIRT340687)
- hsa-mir-6733-5p (MIRT340688)
- hsa-mir-6739-5p (MIRT340689)
- hsa-mir-6783-5p (MIRT340690)
- hsa-mir-548bb-5p (MIRT340691)
- hsa-mir-203a-3p (MIRT563698)
- hsa-mir-6838-5p (MIRT563699)
- hsa-mir-497-5p (MIRT563700)
- hsa-mir-424-5p (MIRT563701)
- hsa-mir-195-5p (MIRT563702)
- hsa-mir-16-5p (MIRT563703)
- hsa-mir-15b-5p (MIRT563704)
- hsa-mir-15a-5p (MIRT563705)
- hsa-mir-548p (MIRT563706)
- hsa-mir-5680 (MIRT563707)
- hsa-mir-625-3p (MIRT563708)
- hsa-mir-3936 (MIRT563709)
miRNA Products
- Search ViGene Biosciences for THRAP3
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for THRAP3
- Browse OriGene Inhibitory RNA Products For THRAP3
- genomics-online: shRNA clones - Search results for 93 available THRAP3 gene related products
- Overview of 93 available THRAP3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for THRAP3 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for THRAP3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for THRAP3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for THRAP3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for THRAP3
-
ViGene Biosciences adenoviral particle packaged cDNA for THRAP3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for THRAP3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for THRAP3 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for THRAP3 Gene
Localization for THRAP3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for THRAP3 Gene
- Nucleus. Nucleus, nucleoplasm. Nucleus speckle.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 2 |
- Nuclear speckles (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 10235267 |
| GO:0005654 | nucleoplasm | IEA,IDA | 24100041 |
| GO:0016592 | mediator complex | IDA | 10198638 |
| GO:0016607 | nuclear speck | IEA,IDA | 24100041 |
| GO:0035145 | colocalizes_with exon-exon junction complex | IDA | 20123736 |
Pathways & Interactions for THRAP3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||
| 2 | Metabolism |
.37
|
|
| 3 | PEDF Induced Signaling | ||
| 4 | Developmental Biology | ||
| 5 | Circadian rythm related genes | ||
Pathways by source for THRAP3 Gene
2 BioSystems pathways for THRAP3 Gene
7 Reactome pathways for THRAP3 Gene
1 Qiagen pathway for THRAP3 Gene
Interacting Proteins for THRAP3 Gene
Selected Interacting proteins:
ENSP00000346634
Q9Y2W1-TR150_HUMAN
for THRAP3 Gene via
STRING
UniProtKB
IID
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000381 | regulation of alternative mRNA splicing, via spliceosome | IMP | 20932480 |
| GO:0000956 | nuclear-transcribed mRNA catabolic process | IDA | 20123736 |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006367 | transcription initiation from RNA polymerase II promoter | IDA | 12218053 |
Transcripts for THRAP3 Gene
mRNA/cDNA for THRAP3 Gene
- (4) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (363) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for THRAP3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for THRAP3
- genomics-online: gRNA clones - Search results for 93 available THRAP3 gene related products
- Overview of 93 available THRAP3 gene related products
- Applied Biological Materials CRISPR for THRAP3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for THRAP3
- GenScript: Design CRISPR guide RNA sequences for THRAP3
miRNA Products
- Search ViGene Biosciences for THRAP3
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for THRAP3
- Browse OriGene Inhibitory RNA Products For THRAP3
- genomics-online: shRNA clones - Search results for 93 available THRAP3 gene related products
- Overview of 93 available THRAP3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for THRAP3 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for THRAP3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for THRAP3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for THRAP3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 |
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| SP3: | - | - | - | ||||||||||||||||||||||||||||||||||
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| SP6: | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP7: | - | - | |||||||||||||||||||||||||||||||||||
| SP8: | - |
Expression for THRAP3 Gene
This gene is overexpressed in Nasal epithelium (14.3) and Peripheral blood mononuclear cells (12.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for THRAP3 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of THRAP3 Gene:
THRAP3SOURCE GeneReport for Unigene cluster for THRAP3 Gene:
Hs.744057mRNA Expression by UniProt/SwissProt for THRAP3 Gene:
Q9Y2W1-TR150_HUMAN
Tissue specificity:
Ubiquitous.
Evidence on tissue expression from TISSUES for THRAP3 Gene
- Liver(4.4)
- Nervous system(4.4)
- Blood(4.1)
- Muscle(2.1)
- Spleen(2)
Primer Products
-
OriGene qPCR primer pairs for THRAP3
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for THRAP3 Gene
Orthologs for THRAP3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | THRAP3 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | THRAP3 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | THRAP3 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Thrap3 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Thrap3 33 16 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | THRAP3 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| chicken (Gallus gallus) |
Aves | THRAP3 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | THRAP3 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | thrap3 33 |
|
||
| LOC394509 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.7745 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | thrap3b 34 |
|
OneToMany | |
| BX321921.1 34 |
|
OneToMany | |||
| thrap3a 34 |
|
OneToMany | |||
| -- 33 |
|
- Species where no ortholog for THRAP3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for THRAP3 Gene
(1) SIMAP similar genes for THRAP3 Gene using alignment to 6 proteins:
Pseudogenes.org Pseudogenes for THRAP3 Gene
Variants for THRAP3 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000010642 | -- | 36,274,430(+) | C/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000050607 | -- | 36,250,195(+) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000079332 | -- | 36,280,835(+) | C/T | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000130909 | -- | 36,241,049(+) | A/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000132971 | -- | 36,239,463(+) | C/T | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv74n106 | OTHER | inversion | 24896259 |
| esv1002750 | CNV | deletion | 20482838 |
| esv1414937 | CNV | deletion | 17803354 |
| esv2045078 | CNV | deletion | 18987734 |
| esv2125715 | CNV | deletion | 18987734 |
| esv2544592 | CNV | deletion | 19546169 |
| esv2663119 | CNV | deletion | 23128226 |
| esv2746830 | CNV | deletion | 23290073 |
| esv2746841 | CNV | deletion | 23290073 |
| esv2746852 | CNV | deletion | 23290073 |
| esv2746863 | CNV | deletion | 23290073 |
| esv2758931 | CNV | loss | 17122850 |
| esv3560737 | CNV | deletion | 23714750 |
| esv3560748 | CNV | deletion | 23714750 |
| esv3585731 | CNV | loss | 21293372 |
| nsv1077758 | OTHER | inversion | 25765185 |
| nsv1122329 | CNV | deletion | 24896259 |
| nsv1133839 | CNV | deletion | 24896259 |
| nsv160040 | CNV | deletion | 16902084 |
| nsv444 | CNV | deletion | 18451855 |
| nsv545994 | CNV | loss | 21841781 |
| nsv545995 | CNV | loss | 21841781 |
| nsv545997 | CNV | loss | 21841781 |
| nsv834691 | CNV | loss | 17160897 |
| nsv834702 | CNV | loss | 17160897 |
| nsv945880 | CNV | duplication | 23825009 |
| nsv945882 | CNV | duplication | 23825009 |
| nsv955436 | CNV | deletion | 24416366 |
| nsv956790 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
10% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.79;
47.39% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for THRAP3 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THRAP3 Gene
Disorders for THRAP3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| wilms tumor 1 |
|
|
Search THRAP3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for THRAP3
No data available for UniProtKB/Swiss-Prot and Genatlas for THRAP3 Gene
Publications for THRAP3 Gene
- THRAP3 interacts with HELZ2 and plays a novel role in adipocyte differentiation. (PMID: 23525231) Katano-Toki A … Mori M (Molecular endocrinology (Baltimore, Md.) 2013) 3 4 58
- A positive feedback loop links circadian clock factor CLOCK-BMAL1 to the basic transcriptional machinery. (PMID: 24043798) Lande-Diner L … Weitz CJ (Proceedings of the National Academy of Sciences of the United States of America 2013) 3 4 58
- Proteome-wide identification of poly(ADP-Ribosyl)ation targets in different genotoxic stress responses. (PMID: 24055347) Jungmichel S … Nielsen ML (Molecular cell 2013) 3 4 58
- Identification of Wilms' tumor 1-associating protein complex and its role in alternative splicing and the cell cycle. (PMID: 24100041) Horiuchi K … Hamakubo T (The Journal of biological chemistry 2013) 3 4 58
- Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response. (PMID: 22424773) Beli P … Choudhary C (Molecular cell 2012) 3 4 58
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