Aliases for THRAP3 Gene
External Ids for THRAP3 Gene
Previous GeneCards Identifiers for THRAP3 Gene
GeneCards Summary for THRAP3 Gene
THRAP3 (Thyroid Hormone Receptor Associated Protein 3) is a Protein Coding gene. Diseases associated with THRAP3 include Telangiectatic Osteogenic Sarcoma and Pseudosarcomatous Fibromatosis. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity. An important paralog of this gene is BCLAF1.
UniProtKB/Swiss-Prot Summary for THRAP3 Gene
Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-ARNTL/BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798).