Aliases for THOP1 Gene
External Ids for THOP1 Gene
Previous GeneCards Identifiers for THOP1 Gene
The protein encoded by this gene is a kininase that uses zinc as a cofactor. The encoded oligopeptidase cleaves cytosolic peptides, making them unavailable for display on antigen-presenting cells. This protein also cleaves neuropeptides under 20 aa in length and can degrade beta-amyloid precursor protein to amyloidogenic peptides. [provided by RefSeq, Nov 2015]
GeneCards Summary for THOP1 Gene
THOP1 (Thimet Oligopeptidase 1) is a Protein Coding gene. Among its related pathways are African trypanosomiasis and ACE Inhibitor Pathway, Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include peptidase activity and peptide binding. An important paralog of this gene is NLN.
UniProtKB/Swiss-Prot Summary for THOP1 Gene
Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments.