Aliases for THOP1 Gene
External Ids for THOP1 Gene
Previous GeneCards Identifiers for THOP1 Gene
The protein encoded by this gene is a kininase that uses zinc as a cofactor. The encoded oligopeptidase cleaves cytosolic peptides, making them unavailable for display on antigen-presenting cells. This protein also cleaves neuropeptides under 20 aa in length and can degrade beta-amyloid precursor protein to amyloidogenic peptides. [provided by RefSeq, Nov 2015]
GeneCards Summary for THOP1 Gene
THOP1 (Thimet Oligopeptidase 1) is a Protein Coding gene. Diseases associated with THOP1 include Trypanosomiasis. Among its related pathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and African trypanosomiasis. Gene Ontology (GO) annotations related to this gene include peptidase activity and peptide binding. An important paralog of this gene is NLN.
UniProtKB/Swiss-Prot Summary for THOP1 Gene
Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments.