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Aliases for THOP1 Gene

Aliases for THOP1 Gene

  • Thimet Oligopeptidase 1 2 3 5
  • Endopeptidase 24.15 3 4
  • EC 4 56
  • MP78 3 4
  • Thimet Oligopeptidase 3
  • EC 3.4.24 56
  • EP24.15 3
  • TOP 3

External Ids for THOP1 Gene

Previous GeneCards Identifiers for THOP1 Gene

  • GC19P002848
  • GC19P002725
  • GC19P002736
  • GC19P002554

Summaries for THOP1 Gene

Entrez Gene Summary for THOP1 Gene

  • The protein encoded by this gene is a kininase that uses zinc as a cofactor. The encoded oligopeptidase cleaves cytosolic peptides, making them unavailable for display on antigen-presenting cells. This protein also cleaves neuropeptides under 20 aa in length and can degrade beta-amyloid precursor protein to amyloidogenic peptides. [provided by RefSeq, Nov 2015]

GeneCards Summary for THOP1 Gene

THOP1 (Thimet Oligopeptidase 1) is a Protein Coding gene. Among its related pathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and African trypanosomiasis. Gene Ontology (GO) annotations related to this gene include peptidase activity and peptide binding. An important paralog of this gene is NLN.

UniProtKB/Swiss-Prot for THOP1 Gene

  • Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments.

Gene Wiki entry for THOP1 Gene

Additional gene information for THOP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THOP1 Gene

Genomics for THOP1 Gene

GeneHancer (GH) Regulatory Elements for THOP1 Gene

Promoters and enhancers for THOP1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I002781 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 580.2 -1.1 -1130 4.9 CLOCK MLX DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC THOP1 SGTA ZNF554 SF3A2 APBA3 CACTIN-AS1 LOC100288123 ENSG00000267139 MOB3A DOT1L
GH19I002787 Enhancer 0.5 Ensembl 582.8 +1.8 1841 0.2 MITF GATA3 NR2F1 ZNF341 THOP1 GC19P002822
GH19I002819 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 23 +34.5 34542 1.6 ARID4B SIN3A ZNF2 IRF4 YY1 ZNF766 CBX5 E2F8 ZNF207 ZNF143 ZNF554 GC19P002822 ZNF77 CACTIN-AS1 THOP1 CACTIN SF3A2 LOC100288123 SPPL2B ZNF556
GH19I002738 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 13.5 -45.9 -45933 2.4 MLX ZFP64 DMAP1 IRF4 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC SLC39A3 ENSG00000267001 GC19P002738 SF3A2 LOC100288123 ZNF77 CACTIN-AS1 DOT1L ZNF555 CACTIN
GH19I002773 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 19.1 -10.1 -10086 2.9 ATF1 ARID4B RARA YY1 ZNF548 ATF7 RUNX3 CREM THAP11 RXRA GC19P002776 GC19M002770 THOP1 SF3A2 CACTIN-AS1 ZNF77 APBA3 GADD45B CACTIN LOC100288123
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around THOP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the THOP1 gene promoter:

Genomic Locations for THOP1 Gene

Genomic Locations for THOP1 Gene
30,348 bases
Plus strand

Genomic View for THOP1 Gene

Genes around THOP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THOP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THOP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THOP1 Gene

Proteins for THOP1 Gene

  • Protein details for THOP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Thimet oligopeptidase
    Protein Accession:
    Secondary Accessions:
    • B3KSE2
    • Q9UCB3

    Protein attributes for THOP1 Gene

    689 amino acids
    Molecular mass:
    78840 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for THOP1 Gene

    Alternative splice isoforms for THOP1 Gene


neXtProt entry for THOP1 Gene

Selected DME Specific Peptides for THOP1 Gene


Post-translational modifications for THOP1 Gene

  • Ubiquitination at posLast=220220, posLast=239239, isoforms=301, posLast=538538, and posLast=559559
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for THOP1 (Thimet Oligopeptidase/THOP1)

Domains & Families for THOP1 Gene

Gene Families for THOP1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for THOP1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase M3 family.
  • Belongs to the peptidase M3 family.
genes like me logo Genes that share domains with THOP1: view

Function for THOP1 Gene

Molecular function for THOP1 Gene

GENATLAS Biochemistry:
Thimet oligopeptidase 1,expressed in brain,homolog of the rat metalloendopeptidase 24.15,involved in antigen presentation via MHC class 1
UniProtKB/Swiss-Prot CatalyticActivity:
Preferential cleavage of bonds with hydrophobic residues at P1, P2 and P3 and a small residue at P1 in substrates of 5 to 15 residues.
UniProtKB/Swiss-Prot Function:
Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments.

Enzyme Numbers (IUBMB) for THOP1 Gene

Phenotypes From GWAS Catalog for THOP1 Gene

Gene Ontology (GO) - Molecular Function for THOP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity TAS,IEA --
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0042277 peptide binding IEA --
genes like me logo Genes that share ontologies with THOP1: view
genes like me logo Genes that share phenotypes with THOP1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for THOP1

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for THOP1 Gene

Localization for THOP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for THOP1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for THOP1 gene
Compartment Confidence
cytosol 5
mitochondrion 4
nucleus 3
plasma membrane 1
extracellular 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for THOP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005758 mitochondrial intermembrane space IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with THOP1: view

Pathways & Interactions for THOP1 Gene

genes like me logo Genes that share pathways with THOP1: view

Pathways by source for THOP1 Gene

2 KEGG pathways for THOP1 Gene

Gene Ontology (GO) - Biological Process for THOP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0006508 proteolysis IEA --
GO:0006518 peptide metabolic process IBA --
genes like me logo Genes that share ontologies with THOP1: view

No data available for SIGNOR curated interactions for THOP1 Gene

Drugs & Compounds for THOP1 Gene

(1) Drugs for THOP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for THOP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with THOP1: view

Transcripts for THOP1 Gene

Unigene Clusters for THOP1 Gene

Thimet oligopeptidase 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for THOP1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12a · 12b · 12c · 12d ^ 13 ^
SP1: - -
SP3: - - - -
SP4: -
SP6: -
SP7: - - -
SP8: - -
SP9: - -

ExUns: 14 ^ 15 ^ 16 ^ 17
SP1: - -
SP5: -

Relevant External Links for THOP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for THOP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for THOP1 Gene

Protein differential expression in normal tissues from HIPED for THOP1 Gene

This gene is overexpressed in Lymph node (13.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for THOP1 Gene

Protein tissue co-expression partners for THOP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of THOP1 Gene:


SOURCE GeneReport for Unigene cluster for THOP1 Gene:


Evidence on tissue expression from TISSUES for THOP1 Gene

  • Nervous system(4.7)
  • Liver(4.5)
  • Lung(4.4)
  • Blood(2.2)
  • Kidney(2)
genes like me logo Genes that share expression patterns with THOP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for THOP1 Gene

Orthologs for THOP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for THOP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia THOP1 33 34
  • 96.75 (n)
(Canis familiaris)
Mammalia THOP1 33 34
  • 87.67 (n)
(Bos Taurus)
Mammalia THOP1 33 34
  • 86.89 (n)
(Rattus norvegicus)
Mammalia Thop1 33
  • 84.55 (n)
(Mus musculus)
Mammalia Thop1 33 16 34
  • 84.24 (n)
(Ornithorhynchus anatinus)
Mammalia THOP1 34
  • 75 (a)
(Monodelphis domestica)
Mammalia THOP1 34
  • 70 (a)
(Gallus gallus)
Aves THOP1 34
  • 81 (a)
LOC426398 33
  • 78.45 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia thop1 33
  • 67.02 (n)
Str.15329 33
African clawed frog
(Xenopus laevis)
Amphibia LOC397806 33
(Danio rerio)
Actinopterygii thop1 34
  • 72 (a)
zgc:92139 33
  • 71.96 (n)
wufb74b01 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10066 33
fruit fly
(Drosophila melanogaster)
Insecta CG11771 35 34
  • 24 (a)
(Caenorhabditis elegans)
Secernentea ZK550.3 34
  • 17 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR406C 33
  • 48.36 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRD1 34 36
  • 35 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G67690 33
  • 45.28 (n)
(Oryza sativa)
Liliopsida Os01g0902200 33
  • 45 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4245 34
  • 59 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9293 33
Species where no ortholog for THOP1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for THOP1 Gene

Gene Tree for THOP1 (if available)
Gene Tree for THOP1 (if available)

Paralogs for THOP1 Gene

Paralogs for THOP1 Gene

genes like me logo Genes that share paralogs with THOP1: view

Variants for THOP1 Gene

Sequence variations from dbSNP and Humsavar for THOP1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000015330 -- 2,812,018(+) G/A intron_variant
rs1000040403 -- 2,785,824(+) C/G genic_upstream_transcript_variant, intron_variant
rs1000067817 -- 2,811,848(+) C/T intron_variant
rs1000111577 -- 2,796,027(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000340729 -- 2,785,772(+) C/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for THOP1 Gene

Variant ID Type Subtype PubMed ID
esv1006393 CNV deletion 20482838
esv1039020 CNV insertion 17803354
esv1432748 CNV deletion 17803354
esv2717912 CNV deletion 23290073
esv2717913 CNV deletion 23290073
nsv509714 CNV insertion 20534489
nsv509715 CNV insertion 20534489
nsv828397 CNV gain 20364138

Variation tolerance for THOP1 Gene

Residual Variation Intolerance Score: 14.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.10; 51.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for THOP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THOP1 Gene

Disorders for THOP1 Gene

Additional Disease Information for THOP1

No disorders were found for THOP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THOP1 Gene

Publications for THOP1 Gene

  1. Increased expression of the oligopeptidase THOP1 is a neuroprotective response to Abeta toxicity. (PMID: 18571100) Pollio G … Terstappen GC (Neurobiology of disease 2008) 3 22 58
  2. Swapping the substrate specificities of the neuropeptidases neurolysin and thimet oligopeptidase. (PMID: 17251185) Lim EJ … Rodgers DW (The Journal of biological chemistry 2007) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for THOP1 Gene

Sources for THOP1 Gene

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