Aliases for THOC7 Gene

Aliases for THOC7 Gene

  • THO Complex 7 2 3 5
  • Functional Spliceosome-Associated Protein 24 2 3 4
  • Ngg1-Interacting Factor 3-Like Protein 1-Binding Protein 1 3 4
  • Ngg1 Interacting Factor 3 Like 1 Binding Protein 1 2 3
  • THO Complex Subunit 7 Homolog 3 4
  • NIF3L1-Binding Protein 1 3 4
  • NIF3L1BP1 3 4
  • HTREX30 3 4
  • FSAP24 3 4
  • THO Complex 7 Homolog (Drosophila) 2
  • THO Complex 7 Homolog 3

External Ids for THOC7 Gene

Summaries for THOC7 Gene

GeneCards Summary for THOC7 Gene

THOC7 (THO Complex 7) is a Protein Coding gene. Diseases associated with THOC7 include Ogden Syndrome. Among its related pathways are Gene Expression and Transport of Mature Transcript to Cytoplasm. Gene Ontology (GO) annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot Summary for THOC7 Gene

  • Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway.
  • The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.

Additional gene information for THOC7 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for THOC7 Gene

Genomics for THOC7 Gene

GeneHancer (GH) Regulatory Elements for THOC7 Gene

Promoters and enhancers for THOC7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J063862 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +0.3 298 3.8 SIN3A NRF1 POLR2G PHF8 ZIC2 POLR2A ZBTB26 ZBTB7A SKI MYC ATXN7 ENSG00000285399 THOC7 PSMD6-AS1 PSMD6-AS2
GH03J063910 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 12.4 -48.3 -48254 4 SIN3A POLR2G NCOR1 PHF8 JUND ZIC2 POLR2A ZBTB11 ZBTB26 KLF4 5MWI_A-120 NONHSAG035318.2 SCAANT1 ATXN7 PSMD6-AS2 THOC7 THOC7-AS1 ENSG00000224479 ADAMTS9-AS2
GH03J063975 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 16.5 -114.6 -114645 8.3 EP300 NCOR1 FOS KLF4 RFX1 TEAD1 ZNF341 MYC WT1 CEBPB ATXN7 PSMD6-AS2 THOC7 THOC7-AS1 5MWI_A-120 NONHSAG035318.2
GH03J063966 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.2 -105.5 -105497 7.6 EP300 NRF1 POLR2G NCOR1 ZNF10 KDM6A TRIM28 ZBTB25 TGIF2 ATF2 ATXN7 PSMD6-AS2 THOC7 THOC7-AS1 5MWI_A-120 NONHSAG035318.2
GH03J063888 Enhancer 0.6 Ensembl 18.6 -25.9 -25942 3.1 FOXA1 TEAD1 TBX3 FOXA2 USF1 SAP130 HOMEZ HHEX SMARCA4 NFIL3 THOC7 THOC7-AS1 PSMD6-AS2 ENSG00000224479 SCAANT1 ATXN7 ENSG00000285399
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around THOC7 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for THOC7

Top Transcription factor binding sites by QIAGEN in the THOC7 gene promoter:
  • FOXL1
  • GATA-1
  • POU2F1a
  • PPAR-gamma1
  • PPAR-gamma2
  • TBP
  • TFIID

Genomic Locations for THOC7 Gene

Genomic Locations for THOC7 Gene
chr3:63,833,870-63,864,399
(GRCh38/hg38)
Size:
30,530 bases
Orientation:
Minus strand
chr3:63,819,546-63,849,597
(GRCh37/hg19)
Size:
30,052 bases
Orientation:
Minus strand

Genomic View for THOC7 Gene

Genes around THOC7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THOC7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THOC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THOC7 Gene

Proteins for THOC7 Gene

  • Protein details for THOC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6I9Y2-THOC7_HUMAN
    Recommended name:
    THO complex subunit 7 homolog
    Protein Accession:
    Q6I9Y2
    Secondary Accessions:
    • Q6P1L3
    • Q8WUF2
    • Q9H5H0

    Protein attributes for THOC7 Gene

    Size:
    204 amino acids
    Molecular mass:
    23743 Da
    Quaternary structure:
    • Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with NIF3L1 and THOC5.

neXtProt entry for THOC7 Gene

Post-translational modifications for THOC7 Gene

  • Ubiquitination at Lys32 and Lys36
  • Modification sites at PhosphoSitePlus

Other Protein References for THOC7 Gene

No data available for DME Specific Peptides for THOC7 Gene

Domains & Families for THOC7 Gene

Gene Families for THOC7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for THOC7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for THOC7 Gene

GenScript: Design optimal peptide antigens:
  • hTREX30 (THOC7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6I9Y2

UniProtKB/Swiss-Prot:

THOC7_HUMAN :
  • Belongs to the THOC7 family.
Family:
  • Belongs to the THOC7 family.
genes like me logo Genes that share domains with THOC7: view

Function for THOC7 Gene

Molecular function for THOC7 Gene

UniProtKB/Swiss-Prot Function:
Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway.
UniProtKB/Swiss-Prot Function:
The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.

Phenotypes From GWAS Catalog for THOC7 Gene

Gene Ontology (GO) - Molecular Function for THOC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 12951069
genes like me logo Genes that share ontologies with THOC7: view
genes like me logo Genes that share phenotypes with THOC7: view

Animal Model Products

CRISPR Products

miRNA for THOC7 Gene

miRTarBase miRNAs that target THOC7

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for THOC7

Clone Products

  • Addgene plasmids for THOC7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for THOC7 Gene

Localization for THOC7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for THOC7 Gene

Cytoplasm. Nucleus. Nucleus speckle. Note=Interaction with THOC5 is required for nuclear localization. {ECO:0000269 PubMed:19059247}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for THOC7 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nuclear speckles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for THOC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000346 transcription export complex IDA 15833825
GO:0000347 THO complex IDA 15998806
GO:0000445 THO complex part of transcription export complex IDA,IEA 15998806
GO:0000784 colocalizes_with nuclear chromosome, telomeric region IDA 24270157
GO:0005634 nucleus IDA,IEA 12951069
genes like me logo Genes that share ontologies with THOC7: view

Pathways & Interactions for THOC7 Gene

genes like me logo Genes that share pathways with THOC7: view

Gene Ontology (GO) - Biological Process for THOC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0006405 RNA export from nucleus TAS --
GO:0006406 mRNA export from nucleus IBA,TAS --
GO:0008380 RNA splicing IEA --
GO:0031124 mRNA 3'-end processing TAS --
genes like me logo Genes that share ontologies with THOC7: view

No data available for SIGNOR curated interactions for THOC7 Gene

Drugs & Compounds for THOC7 Gene

No Compound Related Data Available

Transcripts for THOC7 Gene

mRNA/cDNA for THOC7 Gene

3 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for THOC7

Clone Products

  • Addgene plasmids for THOC7

Alternative Splicing Database (ASD) splice patterns (SP) for THOC7 Gene

No ASD Table

Relevant External Links for THOC7 Gene

GeneLoc Exon Structure for
THOC7

Expression for THOC7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for THOC7 Gene

Protein differential expression in normal tissues from HIPED for THOC7 Gene

This gene is overexpressed in Liver (48.7) and Monocytes (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for THOC7 Gene



Protein tissue co-expression partners for THOC7 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for THOC7

SOURCE GeneReport for Unigene cluster for THOC7 Gene:

Hs.288151

Evidence on tissue expression from TISSUES for THOC7 Gene

  • Intestine(4.3)
  • Skin(4.3)
  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with THOC7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for THOC7 Gene

Orthologs for THOC7 Gene

This gene was present in the common ancestor of animals.

Orthologs for THOC7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THOC7 31 30
  • 100 (n)
OneToOne
cow
(Bos Taurus)
Mammalia THOC7 31
  • 100 (a)
OneToMany
-- 31
  • 100 (a)
OneToMany
dog
(Canis familiaris)
Mammalia THOC7 31 30
  • 92.9 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Thoc7 17 31 30
  • 91.01 (n)
oppossum
(Monodelphis domestica)
Mammalia THOC7 31
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Thoc7 30
  • 88.89 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia THOC7 31
  • 40 (a)
OneToOne
chicken
(Gallus gallus)
Aves THOC7 31 30
  • 81.12 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia THOC7 31
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia thoc7 30
  • 79.25 (n)
Nif3l1bp1-prov 30
African clawed frog
(Xenopus laevis)
Amphibia nif3l1bp1-prov 30
zebrafish
(Danio rerio)
Actinopterygii thoc7 31 30
  • 73.03 (n)
OneToOne
wufa20e08 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003870 30
  • 47.93 (n)
fruit fly
(Drosophila melanogaster)
Insecta thoc7 31 30
  • 47.64 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea B0513.2 31
  • 23 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.685 31
  • 45 (a)
OneToOne
Species where no ortholog for THOC7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for THOC7 Gene

ENSEMBL:
Gene Tree for THOC7 (if available)
TreeFam:
Gene Tree for THOC7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for THOC7: view image

Paralogs for THOC7 Gene

No data available for Paralogs for THOC7 Gene

Variants for THOC7 Gene

Additional dbSNP identifiers (rs#s) for THOC7 Gene

Structural Variations from Database of Genomic Variants (DGV) for THOC7 Gene

Variant ID Type Subtype PubMed ID
nsv1008751 CNV gain 25217958
nsv1072696 CNV deletion 25765185
nsv1118973 CNV deletion 24896259

Variation tolerance for THOC7 Gene

Residual Variation Intolerance Score: 28.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 11.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for THOC7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
THOC7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for THOC7 Gene

Disorders for THOC7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for THOC7 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ogden syndrome
  • ogdns
- elite association - COSMIC cancer census association via MalaCards
Search THOC7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for THOC7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with THOC7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for THOC7 Gene

Publications for THOC7 Gene

  1. Recruitment of the human TREX complex to mRNA during splicing. (PMID: 15998806) Masuda S … Reed R (Genes & development 2005) 2 3 4 54
  2. Identification and characterization of NIF3L1 BP1, a novel cytoplasmic interaction partner of the NIF3L1 protein. (PMID: 12951069) Tascou S … Burfeind P (Biochemical and biophysical research communications 2003) 2 3 4 54
  3. Aly and THO are required for assembly of the human TREX complex and association of TREX components with the spliced mRNA. (PMID: 23222130) Chi B … Cheng H (Nucleic acids research 2013) 3 4 54
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  5. Nuclear localization of the pre-mRNA associating protein THOC7 depends upon its direct interaction with Fms tyrosine kinase interacting protein (FMIP). (PMID: 19059247) El Bounkari O … Tamura T (FEBS letters 2009) 3 4 54

Products for THOC7 Gene

Sources for THOC7 Gene